Catechol O-Methyltransferase

"Catechol O-Methyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine.

Descriptor ID	D002394
MeSH Number(s)	D08.811.913.555.500.250
Concept/Terms	Catechol O-Methyltransferase Catechol O-Methyltransferase O-Methyltransferase, Catechol Catechol-O-Methyltransferase Catechol O Methyltransferase Catechol Methyltransferase Methyltransferase, Catechol

Below are MeSH descriptors whose meaning is more general than "Catechol O-Methyltransferase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
One-Carbon Group Transferases [D08.811.913.555]
Methyltransferases [D08.811.913.555.500]
Catechol O-Methyltransferase [D08.811.913.555.500.250]

Below are MeSH descriptors whose meaning is related to "Catechol O-Methyltransferase".

Below are MeSH descriptors whose meaning is more specific than "Catechol O-Methyltransferase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Catechol O-Methyltransferase" by people in this website by year, and whether "Catechol O-Methyltransferase" was a major or minor topic of these publications.

Bar chart showing 16 publications over 13 distinct years, with a maximum of 2 publications in 2007 and 2017 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
2001	1	0	1
2004	1	0	1
2006	0	1	1
2007	1	1	2
2011	1	0	1
2013	0	1	1
2014	1	0	1
2017	2	0	2
2021	1	0	1
2022	1	0	1
2024	2	0	2
2025	1	0	1

Below are the most recent publications written about "Catechol O-Methyltransferase" by people in Profiles.

Taylor MK, Hern?ndez LM, Allsopp RC, Fraser JJ. A catechol-O-methyltransferase genetic variant impacts functional movement in tactical athletes. PLoS One. 2025; 20(2):e0316127.

View in: PubMed
Islam AR, Kiros GE, Ajiboye RO, Powell-Roach K, Ezenwa MO, Reams RR, Molokie RE, Wang ZJ, Yao Y, Wilkie DJ. Association of COMT rs4680 Genotype With Chronic Neuropathic Pain Experience in Patients With Sickle Cell Disease. Pain Manag Nurs. 2025 Jun; 26(3):e287-e292.

View in: PubMed
Fekih-Romdhane F, Kerbage G, Hachem N, El Murr M, Haddad G, Loch AA, Abou Khalil R, El Hayek E, Hallit S. The moderating role of COMT gene rs4680 polymorphism between maladaptive metacognitive beliefs and negative symptoms in patients with schizophrenia. BMC Psychiatry. 2024 Nov 20; 24(1):831.

View in: PubMed
Frois T, Faria LO, Souza RP, da Silva Cunha AE, de Holanda Marinho Nogueira NG, Tavares Lim V, de Sousa Fortes L, de Miranda DM, Bertollo M, Albuquerque MR. Are COMT Val158Met (rs4680), DRD2 TaqIA (rs1800497), and BDNF Val66Met (rs6265) polymorphisms associated with executive functions performance at rest and during physical exercise? Physiol Behav. 2022 12 01; 257:113973.

View in: PubMed
Chitrala KN, Nagarkatti P, Nagarkatti M. Computational analysis of deleterious single nucleotide polymorphisms in catechol O-Methyltransferase conferring risk to post-traumatic stress disorder. J Psychiatr Res. 2021 06; 138:207-218.

View in: PubMed
Cunningham CL, Wu Z, Jafari A, Zhao B, Schrode K, Harkins-Perry S, Lauer A, M?ller U. The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells. Elife. 2017 05 15; 6.

View in: PubMed
Hayes JP, Logue MW, Reagan A, Salat D, Wolf EJ, Sadeh N, Spielberg JM, Sperbeck E, Hayes SM, McGlinchey RE, Milberg WP, Verfaellie M, Stone A, Schichman SA, Miller MW. COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume. J Psychiatry Neurosci. 2017 03; 42(2):95-102.

View in: PubMed
Smith ML, King J, Dent L, Mackey V, Muthian G, Griffin B, Charlton CG. Effects of acute and sub-chronic L-dopa therapy on striatal L-dopa methylation and dopamine oxidation in an MPTP mouse model of Parkinsons disease. Life Sci. 2014 Aug 06; 110(1):1-7.

View in: PubMed
Wang P, Vadgama JV, Said JW, Magyar CE, Doan N, Heber D, Henning SM. Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea. J Nutr Biochem. 2014 Jan; 25(1):73-80.

View in: PubMed
Nair S, Al-Hendy A, Tamboli RA, Marks-Shulman PA, Abumrad NN. Increased COMT expression in PCOS biology. Mol Cell Endocrinol. 2012 May 15; 355(1):188-9.

View in: PubMed

People

Explore

Similar Concepts

Top Journals