"Bicuculline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
| Descriptor ID |
D001640
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| MeSH Number(s) |
D03.132.098.077 D03.633.100.531.085.077
|
| Concept/Terms |
Bicuculline- Bicuculline
- 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one
|
Below are MeSH descriptors whose meaning is more general than "Bicuculline".
Below are MeSH descriptors whose meaning is more specific than "Bicuculline".
This graph shows the total number of publications written about "Bicuculline" by people in this website by year, and whether "Bicuculline" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 5 | 6 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Bicuculline" by people in Profiles.
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Kenney MJ, Ganta CK, Fels RJ. Disinhibition of RVLM neural circuits and regulation of sympathetic nerve discharge at peak hyperthermia. J Appl Physiol (1985). 2013 Nov 01; 115(9):1297-303.
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Mack SO, Wu M, Kc P, Haxhiu MA. Stimulation of the hypothalamic paraventricular nucleus modulates cardiorespiratory responses via oxytocinergic innervation of neurons in pre-Botzinger complex. J Appl Physiol (1985). 2007 Jan; 102(1):189-99.
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Gdovin MJ, Jackson VV, Zamora DA, Leiter JC. Effect of prevention of lung inflation on metamorphosis and respiration in the developing bullfrog tadpole, Rana catesbeiana. J Exp Zool A Comp Exp Biol. 2006 Apr 01; 305(4):335-47.
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Valles R, Rocha A, Cardon A, Bratton GR, Nation JR. The effects of the GABAA antagonist bicuculline on cocaine self-administration in rats exposed to lead during gestation/lactation. Pharmacol Biochem Behav. 2005 Apr; 80(4):611-9.
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Kenney MJ, Weiss ML, Mendes T, Wang Y, Fels RJ. Role of paraventricular nucleus in regulation of sympathetic nerve frequency components. Am J Physiol Heart Circ Physiol. 2003 May; 284(5):H1710-20.
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Chappell RL, Schuette E, Anton R, Ripps H. GABA(C) receptors modulate the rod-driven ERG b-wave of the skate retina. Doc Ophthalmol. 2002 Sep; 105(2):179-88.
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Cheng Q, Burkat PM, Kulli JC, Yang J. GABA(C) rho(1) subunits form functional receptors but not functional synapses in hippocampal neurons. J Neurophysiol. 2001 Nov; 86(5):2605-15.
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Gulledge AT, Jaffe DB. Multiple effects of dopamine on layer V pyramidal cell excitability in rat prefrontal cortex. J Neurophysiol. 2001 Aug; 86(2):586-95.
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Phelix CF, Chen H, Trevino G, Lara JR, Liu G, Wayner MJ. Bicuculline sensitive depressor response to ethanol infusion into the lateral hypothalamus. Alcohol. 1999 Oct; 19(2):177-85.
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Heinbockel T, Pape HC. Modulatory effects of adenosine on inhibitory postsynaptic potentials in the lateral amygdala of the rat. Br J Pharmacol. 1999 Sep; 128(1):190-6.