Establishment and characterization of bortezomib-resistant U266 cell line: constitutive activation of NF-?B-mediated cell signals and/or alterations of ubiquitylation-related genes reduce bortezomib-induced apoptosis.

Park J, Bae EK, Lee C, Choi JH, Jung WJ, Ahn KS, Yoon SS. Establishment and characterization of bortezomib-resistant U266 cell line: constitutive activation of NF-?B-mediated cell signals and/or alterations of ubiquitylation-related genes reduce bortezomib-induced apoptosis. BMB Rep. 2014 May; 47(5):274-9.

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subject areas

Antineoplastic Agents
Apoptosis
Boronic Acids
Cell Line, Tumor
Drug Resistance, Neoplasm
Gene Expression Regulation, Neoplastic
Humans
Multiple Myeloma
NF-kappa B
Pyrazines
Signal Transduction
Syndecan-1
Thalidomide
Ubiquitination

authors with profiles

Juwon Park

RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

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