Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis.

Zhang H, Gay SC, Shah M, Foroozesh M, Liu J, Osawa Y, Zhang Q, Stout CD, Halpert JR, Hollenberg PF. Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis. Biochemistry. 2013 Jan 15; 52(2):355-64.

View in: PubMed

subject areas

Allosteric Regulation
Animals
Aryl Hydrocarbon Hydroxylases
Catalytic Domain
Crystallography, X-Ray
Kinetics
Phenanthrenes
Protein Binding
Protein Conformation
Rabbits

authors with profiles

Maryam Foroozesh

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