SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.

Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. 2011 Mar 03; 471(7336):104-9.

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subject areas

Amino Acid Sequence
Animals
Apoptosis
Benzenesulfonates
Biphenyl Compounds
Cell Cycle Proteins
Cell Line, Tumor
F-Box Proteins
Glycogen Synthase Kinase 3
Humans
Mice
Molecular Sequence Data
Niacinamide
Nitrophenols
Phenylurea Compounds
Phosphorylation
Piperazines
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Protein Binding
Proto-Oncogene Proteins c-bcl-2
Pyridines
SKP Cullin F-Box Protein Ligases
Sulfonamides
Tumor Suppressor Proteins
Ubiquitination
Ubiquitin-Protein Ligases

authors with profiles

Alan F. Lau, PhD

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