Dual mechanisms of action of the retinoid CD437: nuclear retinoic acid receptor-mediated suppression of squamous differentiation and receptor-independent induction of apoptosis in UMSCC22B human head and neck squamous cell carcinoma cells.

Sun SY, Yue P, Chandraratna RA, Tesfaigzi Y, Hong WK, Lotan R. Dual mechanisms of action of the retinoid CD437: nuclear retinoic acid receptor-mediated suppression of squamous differentiation and receptor-independent induction of apoptosis in UMSCC22B human head and neck squamous cell carcinoma cells. Mol Pharmacol. 2000 Sep; 58(3):508-14.

View in: PubMed

subject areas

Antineoplastic Agents
Apoptosis
Carcinoma, Squamous Cell
Cell Differentiation
Gene Expression Regulation, Neoplastic
Head and Neck Neoplasms
Humans
Naphthalenes
Phenotype
Receptors, Retinoic Acid
Retinoids
Signal Transduction
Tumor Cells, Cultured

authors with profiles

Yohannes Tesfaigzi

RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

For technical support please contact support