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Terry Watt

TitleFaculty, Department of Chemistry
Faculty RankAssociate Professor
InstitutionXavier University of Louisiana
Departmentchemistry
AddressXavier University of Louisiana
1 Drexel Drive
Chemistry
New Orleans LA 70125
Phone5045205271
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    Collapse Biography 
    Collapse awards and honors
    2004 - 2007National Defense Science & Engineering Graduate Fellowship, Georgia Institute of Technology
    2006American Chemical Society Travel Award (Biological Chemistry Division), Georgia Institute of Technology

    Collapse Overview 
    Collapse overview
    The goal of the my research program is to investigate the molecular determinants of the interactions between lysine deacetylase (KDAC) isozymes and their substrates, with the ultimate goal of learning the pathways controlled by each KDAC and applying that information in disease models.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Toro TB, Skripnikova EV, Bornes KE, Zhang K, Watt TJ. Endogenous expression of inactive lysine deacetylases reveals deacetylation-dependent cellular mechanisms. PLoS One. 2023; 18(9):e0291779. PMID: 37721967.
      Citations:    Fields:    Translation:Cells
    2. Toro TB, Bornes KE, Watt TJ. Lysine Deacetylase Substrate Selectivity: Distinct Interaction Surfaces Drive Positive and Negative Selection for Residues Following Acetyllysine. Biochemistry. 2023 05 02; 62(9):1464-1483. PMID: 37043688.
      Citations: 1     Fields:    Translation:Cells
    3. Toro TB, Swanier JS, Bezue JA, Broussard CG, Watt TJ. Lysine Deacetylase Substrate Selectivity: A Dynamic Ionic Interaction Specific to KDAC8. Biochemistry. 2021 08 24; 60(33):2524-2536. PMID: 34357750.
      Citations: 2     Fields:    Translation:Cells
    4. Toro TB, Watt TJ. Critical review of non-histone human substrates of metal-dependent lysine deacetylases. FASEB J. 2020 10; 34(10):13140-13155. PMID: 32862458.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    5. Toro TB, Edenfield SA, Hylton BJ, Watt TJ. Chelatable trace zinc causes low, irreproducible KDAC8 activity. Anal Biochem. 2018 01 01; 540-541:9-14. PMID: 29100752.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    6. Toro TB, Painter RG, Haynes RA, Glotser EY, Bratton MR, Bryant JR, Nichols KA, Matthew-Onabanjo AN, Matthew AN, Bratcher DR, Perry CD, Watt TJ. Purification of metal-dependent lysine deacetylases with consistently high activity. Protein Expr Purif. 2018 Jan; 141:1-6. PMID: 28843507.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    7. Toro TB, Bryant JR, Watt TJ. Lysine Deacetylases Exhibit Distinct Changes in Activity Profiles Due to Fluorophore Conjugation of Substrates. Biochemistry. 2017 08 29; 56(34):4549-4558. PMID: 28749131.
      Citations: 8     Fields:    Translation:Humans
    8. Toro TB, Pingali S, Nguyen TP, Garrett DS, Dodson KA, Nichols KA, Haynes RA, Payton-Stewart F, Watt TJ. KDAC8 with High Basal Velocity Is Not Activated by N-Acetylthioureas. PLoS One. 2016; 11(1):e0146900. PMID: 26745872.
      Citations: 6     Fields:    Translation:Humans
    9. Johanson KE, Watt TJ. Inquiry-based experiments for large-scale introduction to PCR and restriction enzyme digests. Biochem Mol Biol Educ. 2015 Nov-Dec; 43(6):441-8. PMID: 26503481.
      Citations:    Fields:    Translation:Humans
    10. Toro TB, Watt TJ. KDAC8 substrate specificity quantified by a biologically relevant, label-free deacetylation assay. Protein Sci. 2015 Dec; 24(12):2020-32. PMID: 26402585.
      Citations: 14     Fields:    Translation:HumansCells
    11. Toro TB, Nguyen TP, Watt TJ. An improved 96-well turbidity assay for T4 lysozyme activity. MethodsX. 2015; 2:256-62. PMID: 26150996.
      Citations:    
    12. Johanson KE, Watt TJ, McIntyre NR, Thompson M. Purification and characterization of enzymes from yeast: an extended undergraduate laboratory sequence for large classes. Biochem Mol Biol Educ. 2013 Jul-Aug; 41(4):251-61. PMID: 23868379.
      Citations: 2     Fields:    Translation:HumansAnimals
    13. Hougland JL, Hicks KA, Hartman HL, Kelly RA, Watt TJ, Fierke CA. Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities. J Mol Biol. 2010 Jan 08; 395(1):176-90. PMID: 19878682.
      Citations: 40     Fields:    Translation:HumansCells
    14. Watt TJ, Doyle DF. ESPSearch: a program for finding exact sequences and patterns in DNA, RNA, or protein. Biotechniques. 2005 Jan; 38(1):109-15. PMID: 15679092.
      Citations: 2     Fields:    
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