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Loyda M. Meléndez

TitlePhD
Faculty RankProfessor
InstitutionUniversity of Puerto Rico
DepartmentMicrobiology and Medical Zoology
AddressUPR-Medical Sciences Campus
School of Medicine
P.O. Box 365067
San Juan PR
Phone7877582525 xt 2816
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    Other Positions
    TitleDirector
    InstitutionUniversity of Puerto Rico-Medical Sciences Campus
    DepartmentHIV Neuroimmunology Laboratory

    TitleDirector
    InstitutionUniversity of Puerto Rico-Medical Sciences Campus
    DepartmentRCMI Translational Proteomics Center


    Collapse Biography 
    Collapse awards and honors
    1979 - 1981Award for MS degree studies, PR Development Company -PRIDCO
    1985 - 1990MARC Award for pre-doctoral studies, NIH
    1996Professional Excellence Award , School of Allied Health
    1999Research Award , Glaxo-Wellcome
    2001Research article in the NIH news, NIH
    2009 - 2011ARRA Award for research, NIH
    2011Research Work Highlighted ISNV Newsletter, International Society for Neurovirology
    2012 - 2013Member of the local organizing committee of the 19th Society for Neuroimmune Pharmacology meeting, Society for Neuroimmune Pharmacology

    Collapse Overview 
    Collapse overview
    Dr. Loyda M. Meléndez is Professor in the Department of Microbiology, School of Medicine and directs the RCMI Clinical Proteomics Discovery Core Facility at the University of Puerto Rico Medical Sciences Campus (UPR-MSC). The Facility provides clinical and basic researchers the proteomics instrumentation and ser-vices necessary to determine biomarkers for diseases that involve health disparities. Dr. Meléndez earned her Ph.D. degree in Experimental Pathology & Immunology cum laude from Emory University School of Medicine, where she also completed post-doctoral training in Hematology and Pediatric Infectious Diseas-es in collaboration with the Centers for Disease Control. She also has a M.S. degree magna cum laude in Microbiology from University of Georgia, Athens, and a Medical Technology degree magna cum laude from University of Puerto Rico Medical Sciences Campus. She worked in the industry from 1981-82 as Quality Control Microbiologist, and thereafter joined the UPR-MSC as Professor of Microbiologist in the School of Allied Health. After three years of teaching (1982-85), she was awarded a pre-doctoral MARC faculty fel-lowship. After completion of her PhD and Post-doctoral experience, she joined the Department of Microbi-ology and Medical Zoology of the School of Medicine at the UPR-MSC. She was Director of the Biosafety Committee at this Institution for six years. She is currently Professor of Virology and Principal Investigator of and NIH funded study to understand the mechanisms of macrophage-induced HIV neuropathogenesis using proteomics approaches. Dr. Meléndez has been a mentor of more than 30 graduate and undergrad-uate students in the field of HIV, macrophages, and vertical transmission with active funding from NIH-NCRR-RCMI (Role of HIV variants in vertical transmission), MBRS (Role of the placenta in vertical transmis-sion and protein profiling of “putative” anti-retroviral factors in placental macrophages). Since 2001 she joined the Specialized Neuroscience Program in NeuroAIDS sponsored by NIH-NINDS as a PI in the project entitled: Monocyte immunity and HIV Dementia. With this interdisciplinary project, knowledge transfer of proteomic technology was achieved from her collaborator, Dr. Howard Gendelman’s Laboratory at Univer-sity of Nebraska Medical Center. The development of five publications in the field of NeuroAIDS and prote-omics was instrumental in obtaining funding for an RCMI Core in Proteomics at UPR-MSC and subsequent R01 funding from NIHMH for the study entitled Cystatins and Cathepsins in HIV Neuropathogenesis. Dr. Meléndez is a co-inventor of one patent, has written two book chapters, and is an ad hoc reviewer for NIDA, NIMH, and NIAID and the Journals of PlosONE, Leukocyte Biology, and Placenta. She has published 43 manuscripts in National and International Journals in the areas of HIV and macrophages, and NeuroAIDS.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Santana-Rivera Y, Rabelo-Fernández RJ, Quiñones-Díaz BI, Grafals-Ruíz N, Santiago-Sánchez G, Lozada-Delgado EL, Echevarría-Vargas IM, Apiz J, Soto D, Rosado A, Meléndez L, Valiyeva F, Vivas-Mejía PE. Reduced expression of enolase-1 correlates with high intracellular glucose levels and increased senescence in cisplatin-resistant ovarian cancer cells. Am J Transl Res. 2020; 12(4):1275-1292. PMID: 32355541.
      Citations:    
    2. López OV, Gorantla S, Segarra AC, Andino Norat MC, Álvarez M, Skolasky RL, Meléndez LM. Sigma-1 Receptor Antagonist (BD1047) Decreases Cathepsin B Secretion in HIV-Infected Macrophages Exposed to Cocaine. J Neuroimmune Pharmacol. 2019 06; 14(2):226-240. PMID: 30306495.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    3. Rosario-Rodríguez LJ, Colón K, Borges-Vélez G, Negrón K, Meléndez LM. Dimethyl Fumarate Prevents HIV-Induced Lysosomal Dysfunction and Cathepsin B Release from Macrophages. J Neuroimmune Pharmacol. 2018 09; 13(3):345-354. PMID: 29987592.
      Citations: 2     Fields:    Translation:HumansCells
    4. Cantres-Rosario YM, Acevedo-Mariani FM, Pérez-Laspiur J, Haskins WE, Plaud M, Cantres-Rosario YM, Skolasky R, Méndez-Bermúdez I, Wojna V, Meléndez LM. Microwave & magnetic proteomics of macrophages from patients with HIV-associated cognitive impairment. PLoS One. 2017; 12(7):e0181779. PMID: 28746408.
      Citations: 1     Fields:    Translation:HumansCells
    5. Martínez-Rivera FJ, Pérez-Laspiur J, Santiago-Gascot ME, Alemán-Reyes AG, García-Santiago E, Rodríguez-Pérez Y, Calo-Guadalupe C, Otero-Pagán I, Ayala-Pagán RN, Martínez M, Cantres-Rosario YM, Meléndez LM, Barreto-Estrada JL. Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids. PLoS One. 2017; 12(7):e0180409. PMID: 28719635.
      Citations:    Fields:    Translation:AnimalsCells
    6. Rivera LE, Kraiselburd E, Meléndez LM. J Neurovirol. Cystatin B and HIV regulate the STAT-1 signaling circuit in HIV-infected and INF-ß-treated human macrophages. 2016; 22(5):666-673.
    7. Delgado-Vélez M, Báez-Pagán CA, Gerena Y, Quesada O, Santiago-Pérez LI, Capó-Vélez CM, Wojna V, Meléndez L, León-Rivera R, Silva W, Lasalde-Dominicci JA. Clin Transl Immunology. The a7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response. 2015; 4(12):e53.
    8. Delgado-Vélez M, Báez-Pagán CA, Gerena Y, Quesada O, Santiago-Pérez LI, Capó-Vélez CM, Wojna V, Meléndez L, León-Rivera R, Silva W, Lasalde-Dominicci JA. The a7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response. Clin Transl Immunology. 2015 Dec; 4(12):e53. PMID: 26719799.
      Citations:    
    9. Zenón F, Jorge I, Cruz A, Suárez E, Segarra AC, Vázquez J, Meléndez LM, Serrano H. 18O proteomics reveal increased human apolipoprotein CIII in Hispanic HIV-1+ women with HAART that use cocaine. Proteomics Clin Appl. 2016 Feb; 10(2):144-55. PMID: 26255783.
      Citations: 2     Fields:    Translation:Humans
    10. Zenón F, Jorge I, Cruz A, Suárez E, Segarra AC, Vázquez J, Meléndez LM, Serrano H. . Proteomics Clin Appl. 18O proteomics reveal increased human apolipoprotein CIII in Hispanic HIV-1+ women with HAART that use cocaine. 2015; 10(2):144-55.
    11. Colon K, Perez-Laspiur J, Quiles R, Rodriguez Y, Wojna V, Shaffer SA, Leszyk J, Skolasky RL Jr, Melendez LM. . Proteomics Clin Appl. Macrophage secretome from women with HIV-associated neurocognitive disorders. 2015; 10(2):136-43.
    12. Cantres-Rosario YM, Hernandez N, Negron K, Perez-Laspiur J, Leszyk J, Shaffer SA, Meléndez LM. . J Virol Antivir Res. Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis. 2015; 29(16):2081-92.
    13. Cantres-Rosario YM, Hernandez N, Negron K, Perez-Laspiur J, Leszyk J, Shaffer SA, Meléndez LM. Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis. AIDS. 2015 Oct 23; 29(16):2081-92. PMID: 26208400.
      Citations: 3     Fields:    Translation:HumansCells
    14. Colón K, Vázquez-Santiago F, Rivera-Amill V, Delgado G, Massey SE, Wojna V, Noel RJ Jr, Meléndez LM. J Virol Antivir Res. HIV gp120 sequence variability associated with HAND in Hispanic Women. 2015; 4(3):143.
    15. Colón K, Vázquez-Santiago F, Rivera-Amill V, Delgado G, Massey SE, Wojna V, Noel RJ, Meléndez LM. HIV gp120 sequence variability associated with HAND in Hispanic Women. J Virol Antivir Res. 2015; 4(3). PMID: 27358904.
      Citations:    
    16. Vázquez-Santiago F, García Y, Rivera-Román I, Noel RJ Jr, Wojna V, Meléndez LM, Rivera-Amill V. . J Virol Antivir Res. Longitudinal Analysis of Cerebrospinal Fluid and Plasma HIV-1 Envelope Sequences Isolated From a Single Donor with HIV Asymptomatic Neurocognitive Impairment. 2015; 4(1).
    17. Zenón F, Cantres-Rosario Y, Adiga R, Gonzalez M, Rodriguez-Franco E, Langford D, Melendez LM. . J Neurovirol. HIV-infected microglia mediate cathepsin B-induced neurotoxicity. 2015; 21(5):544-58.
    18. Vázquez-Santiago F, García Y, Rivera-Román I, Noel RJ, Wojna V, Meléndez LM, Rivera-Amill V. Longitudinal Analysis of Cerebrospinal Fluid and Plasma HIV-1 Envelope Sequences Isolated From a Single Donor with HIV Asymptomatic Neurocognitive Impairment. J Virol Antivir Res. 2015; 4(1). PMID: 26167513.
      Citations:    
    19. Rivera LE, Colon K, Cantres-Rosario YM, Zenon FM, Melendez LM. Curr HIV Res. Macrophage derived cystatin B/cathepsin B in HIV replication and neuropathogenesis. 2014; 12(2):111-20.
    20. Zenon F, Segarra A, Gonzalez M, and Meléndez LM*, 2014. J Neuroimmune Pharmacology. P. J Neuroimmune Pharmacology. Cocaine Potentiates Cathepsin B Secretion and Neuronal Apoptosis from in HIV-infected Macrophages. 2014; 9(5):703-15.
    21. Zenón F, Segarra AC, Gonzalez M, Meléndez LM. Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIV-infected macrophages. J Neuroimmune Pharmacol. 2014 Dec; 9(5):703-15. PMID: 25209871.
      Citations: 8     Fields:    Translation:HumansCells
    22. Agsalda-Garcia M, Shiramizu B, Melendez L, Plaud M, Liang CY, Wojna V. Different levels of HIV DNA copy numbers in cerebrospinal fluid cellular subsets. J Health Care Poor Underserved. 2013 Nov; 24(4 Suppl):8-16. PMID: 24241256.
      Citations: 3     Fields:    Translation:HumansCells
    23. Cantres-Rosario Y, Plaud-Valentín M, Gerena Y, Skolasky RL, Wojna V, Meléndez LM. Cathepsin B and cystatin B in HIV-seropositive women are associated with infection and HIV-1-associated neurocognitive disorders. AIDS. 2013 Jan 28; 27(3):347-56. PMID: 23291538.
      Citations: 14     Fields:    Translation:HumansCells
    24. Rodriguez-Franco EJ, Cantres-Rosario YM, Plaud-Valentin M, Romeu R, Rodríguez Y, Skolasky R, Meléndez V, Cadilla CL, Melendez LM. Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis. PLoS One. 2012; 7(5):e36571. PMID: 22693552.
      Citations: 17     Fields:    Translation:HumansCells
    25. Meléndez LM, Colon K, Rivera L, Rodriguez-Franco E, Toro-Nieves D. Proteomic analysis of HIV-infected macrophages. J Neuroimmune Pharmacol. 2011 Mar; 6(1):89-106. PMID: 21153888.
      Citations: 13     Fields:    Translation:HumansCells
    26. Kraft-Terry S, Gerena Y, Wojna V, Plaud-Valentin M, Rodriguez Y, Ciborowski P, Mayo R, Skolasky R, Gendelman HE, Meléndez LM. Proteomic analyses of monocytes obtained from Hispanic women with HIV-associated dementia show depressed antioxidants. Proteomics Clin Appl. 2010 Sep; 4(8-9):706-14. PMID: 21137088.
      Citations: 16     Fields:    Translation:HumansCells
    27. Velázquez I, Plaud M, Wojna V, Skolasky R, Laspiur JP, Meléndez LM. Antioxidant enzyme dysfunction in monocytes and CSF of Hispanic women with HIV-associated cognitive impairment. J Neuroimmunol. 2009 Jan 03; 206(1-2):106-11. PMID: 19101040.
      Citations: 23     Fields:    Translation:HumansCells
    28. Wojna V, Robles L, Skolasky RL, Mayo R, Selnes O, de la Torre T, Maldonado E, Nath A, Meléndez LM, Lasalde-Dominicci J. Associations of cigarette smoking with viral immune and cognitive function in human immunodeficiency virus-seropositive women. J Neurovirol. 2007 Dec; 13(6):561-8. PMID: 18097887.
      Citations: 27     Fields:    Translation:HumansCells
    29. Laspiur JP, Anderson ER, Ciborowski P, Wojna V, Rozek W, Duan F, Mayo R, Rodríguez E, Plaud-Valentín M, Rodríguez-Orengo J, Gendelman HE, Meléndez LM. CSF proteomic fingerprints for HIV-associated cognitive impairment. J Neuroimmunol. 2007 Dec; 192(1-2):157-70. PMID: 17950469.
      Citations: 35     Fields:    Translation:Humans
    30. Rozek W, Ricardo-Dukelow M, Holloway S, Gendelman HE, Wojna V, Melendez LM, Ciborowski P. Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment. J Proteome Res. 2007 Nov; 6(11):4189-99. PMID: 17929958.
      Citations: 53     Fields:    Translation:HumansCells
    31. Nieves DM, Plaud M, Wojna V, Skolasky R, Meléndez LM. Characterization of peripheral blood human immunodeficiency virus isolates from Hispanic women with cognitive impairment. J Neurovirol. 2007 Aug; 13(4):315-27. PMID: 17849315.
      Citations: 7     Fields:    Translation:HumansCells
    32. Wojna V, Skolasky RL, Hechavarría R, Mayo R, Selnes O, McArthur JC, Meléndez LM, Maldonado E, Zorrilla CD, García H, Kraiselburd E, Nath A. Prevalence of human immunodeficiency virus-associated cognitive impairment in a group of Hispanic women at risk for neurological impairment. J Neurovirol. 2006 Oct; 12(5):356-64. PMID: 17065128.
      Citations: 52     Fields:    Translation:Humans
    33. Wojna V, Carlson KA, Luo X, Mayo R, Meléndez LM, Kraiselburd E, Gendelman HE. Proteomic fingerprinting of human immunodeficiency virus type 1-associated dementia from patient monocyte-derived macrophages: A case study. J Neurovirol. 2004; 10 Suppl 1:74-81. PMID: 14982743.
      Citations: 13     Fields:    Translation:HumansCells
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