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Scott Kuwada, MD

TitleChief, Div. of Gastroenterology
Faculty RankProfessor
InstitutionUniversity of Hawaii
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shiosaki J, Tiirikainen M, Peplowska K, Shaeffer D, Machida M, Sakamoto K, Takahashi M, Kojima K, Machi J, Bryant-Greenwood P, Kuwada SK. Serum micro-RNA Identifies Early Stage Colorectal Cancer in a Multi-Ethnic Population. Asian Pac J Cancer Prev. 2020 Oct 01; 21(10):3019-3026. PMID: 33112562.
      Citations: 1     Fields:    
    2. Pattison RJ, Esteban JP, Sempokuya T, Kewcharoen J, Kalathil S, Kuwada SK. Nonalcoholic Fatty Liver Disease: An Important Consideration for Primary Care Providers in Hawai'i. Hawaii J Health Soc Welf. 2020 06 01; 79(6):180-186. PMID: 32524096.
      Citations:    Fields:    
    3. Samadder NJ, Kuwada SK, Boucher KM, Byrne K, Kanth P, Samowitz W, Jones D, Tavtigian SV, Westover M, Berry T, Jasperson K, Pappas L, Smith L, Sample D, Burt RW, Neklason DW. Association of Sulindac and Erlotinib vs Placebo With Colorectal Neoplasia in Familial Adenomatous Polyposis: Secondary Analysis of a Randomized Clinical Trial. JAMA Oncol. 2018 05 01; 4(5):671-677. PMID: 29423501.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    4. Samadder NJ, Neklason DW, Boucher KM, Byrne KR, Kanth P, Samowitz W, Jones D, Tavtigian SV, Done MW, Berry T, Jasperson K, Pappas L, Smith L, Sample D, Davis R, Topham MK, Lynch P, Strait E, McKinnon W, Burt RW, Kuwada SK. Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial. JAMA. 2016 Mar 22-29; 315(12):1266-75. PMID: 27002448.
      Citations: 33     Fields:    Translation:Humans
    5. Kaalekahi JM, Gandhi KR, Chen JJ, Kuwada SK. Colonoscopy Screening among Native Hawaiians at Queen's Medical Center between August 2011 and January 2013. Hawaii J Med Public Health. 2016 Jan; 75(1):13-7. PMID: 26870602.
      Citations:    Fields:    Translation:HumansPHPublic Health
    6. Shen Y, Zificsak CA, Shea JE, Lao X, Bollt O, Li X, Lisko JG, Theroff JP, Scaife CL, Ator MA, Ruggeri BA, Dorsey BD, Kuwada SK. Design, synthesis, and biological evaluation of sulfonyl acrylonitriles as novel inhibitors of cancer metastasis and spread. J Med Chem. 2015 Feb 12; 58(3):1140-58. PMID: 25581261.
      Citations:    Fields:    Translation:HumansAnimalsCells
    7. Xu C, Li X, Topham MK, Kuwada SK. Regulation of sonic hedgehog expression by integrin ß1 and epidermal growth factor receptor in intestinal epithelium. IUBMB Life. 2014 Oct; 66(10):694-703. PMID: 25355554.
      Citations: 2     Fields:    Translation:AnimalsCells
    8. Lopez KT, Kuwada SK, Wong LL. Consequences of needle tract seeding of hepatocellular cancer after liver transplant. Clin Transplant. 2013 Jul-Aug; 27(4):E400-6. PMID: 23837571.
      Citations: 7     Fields:    Translation:Humans
    9. Li X, Kuang J, Shen Y, Majer MM, Nelson CC, Parsawar K, Heichman KA, Kuwada SK. The atypical histone macroH2A1.2 interacts with HER-2 protein in cancer cells. J Biol Chem. 2012 Jun 29; 287(27):23171-83. PMID: 22589551.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    10. Zificsak CA, Shen Y, Lisko JG, Theroff JP, Lao X, Bollt O, Li X, Dorsey BD, Kuwada SK. Synthesis and biological evaluation of sulfonyl acrylonitriles as novel inhibitors to peritoneal carcinomatosis. Bioorg Med Chem Lett. 2012 Mar 01; 22(5):1850-3. PMID: 22326395.
      Citations:    Fields:    Translation:HumansAnimalsCells
    11. Kuwada SK, Burt R. A rationale for mTOR inhibitors as chemoprevention agents in Peutz-Jeghers syndrome. Fam Cancer. 2011 Sep; 10(3):469-72. PMID: 21826537.
      Citations: 6     Fields:    Translation:HumansCells
    12. Shen Y, Herde R, Doxey BW, Xu C, Gray PD, Kuwada SK. Pharmacologic downregulation of c-FLIP(L) restores juxtacrine death receptor-mediated apoptosis in cancer cells in a peritoneal carcinomatosis model. Int J Cancer. 2012 Apr 01; 130(7):1494-503. PMID: 21480219.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    13. Neklason DW, Tuohy TM, Stevens J, Otterud B, Baird L, Kerber RA, Samowitz WS, Kuwada SK, Leppert MF, Burt RW. Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer. J Med Genet. 2010 Oct; 47(10):692-9. PMID: 20522424.
      Citations: 7     Fields:    Translation:HumansCells
    14. Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, Abel ED, Wang L. Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol. 2010 Mar; 30(6):1341-56. PMID: 20065042.
      Citations: 58     Fields:    Translation:AnimalsCells
    15. Kuwada SK. Stopping cancer cells in their tracks... Hawaii Med J. 2009 Nov; 68(10):259-60. PMID: 19998700.
      Citations:    Fields:    Translation:HumansAnimalsCells
    16. LaBarbera DV, Modzelewska K, Glazar AI, Gray PD, Kaur M, Liu T, Grossman D, Harper MK, Kuwada SK, Moghal N, Ireland CM. The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells. Anticancer Drugs. 2009 Jul; 20(6):425-36. PMID: 19369860.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    17. Neklason DW, Thorpe BL, Ferrandez A, Tumbapura A, Boucher K, Garibotti G, Kerber RA, Solomon CH, Samowitz WS, Fang JC, Mineau GP, Leppert MF, Burt RW, Kuwada SK. Colonic adenoma risk in familial colorectal cancer--a study of six extended kindreds. Am J Gastroenterol. 2008 Oct; 103(10):2577-84. PMID: 18671820.
      Citations: 11     Fields:    Translation:Humans
    18. Majer M, Akerley W, Kuwada SK. Oncologists' current opinion on the treatment of colon carcinoma. Anticancer Agents Med Chem. 2007 Sep; 7(5):492-503. PMID: 17896910.
      Citations: 4     Fields:    Translation:Humans
    19. Mackenzie SH, Fang JC, Kuwada SK. Severe upper-GI bleeding in a patient with PEG tube placement by the radiologic push method. Gastrointest Endosc. 2007 May; 65(6):935-7. PMID: 17382941.
      Citations: 1     Fields:    Translation:Humans
    20. Kuwada SK. Drug evaluation: Volociximab, an angiogenesis-inhibiting chimeric monoclonal antibody. Curr Opin Mol Ther. 2007 Feb; 9(1):92-8. PMID: 17330407.
      Citations: 15     Fields:    Translation:HumansAnimals
    21. Jones RG, Li X, Gray PD, Kuang J, Clayton F, Samowitz WS, Madison BB, Gumucio DL, Kuwada SK. Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality. J Cell Biol. 2006 Nov 06; 175(3):505-14. PMID: 17088430.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    22. Ferrández A, Pho L, Solomon C, Samowitz WS, Kuwada SK, Knecht TP, Gilfeather M, Burt RW. An evidence-based, multidisciplinary approach to the clinical considerations, management, and surveillance of adrenal lesions in familial adenomatous polyposis: report of three cases. Dis Colon Rectum. 2006 Nov; 49(11):1781-90. PMID: 17041748.
      Citations: 1     Fields:    Translation:Humans
    23. Maul JS, Warner NR, Kuwada SK, Burt RW, Cannon-Albright LA. Extracolonic cancers associated with hereditary nonpolyposis colorectal cancer in the Utah Population Database. Am J Gastroenterol. 2006 Jul; 101(7):1591-6. PMID: 16863565.
      Citations: 12     Fields:    Translation:Humans
    24. Alonso-Coello P, Wong RF, Kuwada SK. Other strategies for evaluating rectal bleeding in younger patients. J Fam Pract. 2005 Aug; 54(8):688-9; author reply 689. PMID: 16061054.
      Citations: 1     Fields:    Translation:Humans
    25. Doxey BW, Kuwada SK, Burt RW. Inherited polyposis syndromes: molecular mechanisms, clinicopathology, and genetic testing. Clin Gastroenterol Hepatol. 2005 Jul; 3(7):633-41. PMID: 16206494.
      Citations: 4     Fields:    Translation:Humans
    26. Kuwada SK, Kuang J, Li X. Integrin alpha5/beta1 expression mediates HER-2 down-regulation in colon cancer cells. J Biol Chem. 2005 May 13; 280(19):19027-35. PMID: 15757908.
      Citations: 14     Fields:    Translation:HumansCells
    27. Wong RF, Khosla R, Moore JH, Kuwada SK. Consider colonoscopy for young patients with hematochezia. J Fam Pract. 2004 Nov; 53(11):879-84. PMID: 15527724.
      Citations: 14     Fields:    Translation:Humans
    28. Burt RW, Leppert MF, Slattery ML, Samowitz WS, Spirio LN, Kerber RA, Kuwada SK, Neklason DW, Disario JA, Lyon E, Hughes JP, Chey WY, White RL. Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis. Gastroenterology. 2004 Aug; 127(2):444-51. PMID: 15300576.
      Citations: 45     Fields:    Translation:Humans
    29. Kuwada SK, Scaife CL, Kuang J, Li X, Wong RF, Florell SR, Coffey RJ, Gray PD. Effects of trastuzumab on epidermal growth factor receptor-dependent and -independent human colon cancer cells. Int J Cancer. 2004 Mar 20; 109(2):291-301. PMID: 14750183.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    30. Neklason DW, Solomon CH, Dalton AL, Kuwada SK, Burt RW. Intron 4 mutation in APC gene results in splice defect and attenuated FAP phenotype. Fam Cancer. 2004; 3(1):35-40. PMID: 15131404.
      Citations: 16     Fields:    Translation:HumansCells
    31. Rice PL, Kelloff J, Sullivan H, Driggers LJ, Beard KS, Kuwada S, Piazza G, Ahnen DJ. Sulindac metabolites induce caspase- and proteasome-dependent degradation of beta-catenin protein in human colon cancer cells. . 2003 Sep; 2(9):885-92. PMID: 14555707.
    32. Scaife CL, Kuang J, Wills JC, Trowbridge DB, Gray P, Manning BM, Eichwald EJ, Daynes RA, Kuwada SK. Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer Res. 2002 Dec 01; 62(23):6870-8. PMID: 12460901.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    33. Wills JC, Kuwada SK, Burt RW. "Hot spots" can burn you. Am J Gastroenterol. 2002 Mar; 97(3):757-8. PMID: 11922576.
      Citations:    Fields:    Translation:Humans
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