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Maarit Tiirikainen

TitleCore Director
InstitutionUniversity of Hawaii
DepartmentCancer Center
Address701 Ilalo St
Genomics Shared Resource
Honolulu HI 96813
Phone8084404570
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lin M, Caberto C, Wan P, Li Y, Lum-Jones A, Tiirikainen M, Pooler L, Nakamura B, Sheng X, Porcel J, Lim U, Setiawan VW, Le Marchand L, Wilkens LR, Haiman CA, Cheng I, Chiang CWK. Population-specific reference panels are crucial for genetic analyses: an example of the CREBRF locus in Native Hawaiians. Hum Mol Genet. 2020 Aug 03; 29(13):2275-2284. PMID: 32491157.
      Citations:    Fields:    
    2. Go RCP, Corley MJ, Ross GW, Petrovitch H, Masaki KH, Maunakea AK, He Q, Tiirikainen MI. Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson's disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity. BMC Neurosci. 2020 Jul 10; 21(1):31. PMID: 32650713.
      Citations:    Fields:    
    3. Park SL, Li Y, Sheng X, Hom V, Xia L, Zhao K, Pooler L, Setiawan VW, Lim U, Monroe KR, Wilkens LR, Kristal BS, Lampe JW, Hullar M, Shepherd J, Loo LLM, Ernst T, Franke AA, Tiirikainen M, Haiman CA, Stram DO, Le Marchand L, Cheng I. Genome-Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype Study. Hepatol Commun. 2020 Aug; 4(8):1112-1123. PMID: 32766472.
      Citations:    
    4. Roman Y, Tiirikainen M, Prom-Wormley E. The prevalence of the gout-associated polymorphism rs2231142 G>T in ABCG2 in a pregnant female Filipino cohort. Clin Rheumatol. 2020 Aug; 39(8):2387-2392. PMID: 32107664.
      Citations:    Fields:    
    5. Roy D, Tiirikainen M. Diagnostic Power of DNA Methylation Classifiers for Early Detection of Cancer. Trends Cancer. 2020 Feb; 6(2):78-81. PMID: 32061307.
      Citations:    Fields:    
    6. Seale LA, Khadka VS, Menor M, Xie G, Watanabe LM, Sasuclark A, Guirguis K, Ha HY, Hashimoto AC, Peplowska K, Tiirikainen M, Jia W, Berry MJ, Deng Y. Combined Omics Reveals That Disruption of the Selenocysteine Lyase Gene Affects Amino Acid Pathways in Mice. Nutrients. 2019 Oct 26; 11(11). PMID: 31717805.
      Citations:    Fields:    Translation:AnimalsCells
    7. Wang Z, Katsaros D, Biglia N, Shen Y, Fu Y, Tiirikainen M, Yu H. Low expression of WWC1, a tumor suppressor gene, is associated with aggressive breast cancer and poor survival outcome. FEBS Open Bio. 2019 07; 9(7):1270-1280. PMID: 31102318.
      Citations:    Fields:    Translation:HumansCells
    8. Kwee SA, Tiirikainen M, Sato MM, Acoba JD, Wei R, Jia W, Le Marchand L, Wong LL. Transcriptomics Associates Molecular Features with 18F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma. Cancer Res. 2019 04 01; 79(7):1696-1704. PMID: 30760520.
      Citations:    Fields:    Translation:HumansCells
    9. Donlon TA, Morris BJ, Chen R, Masaki KH, Allsopp RC, Willcox DC, Tiirikainen M, Willcox BJ. Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. J Gerontol A Biol Sci Med Sci. 2018 10 08; 73(11):1459-1464. PMID: 29300832.
      Citations: 4     Fields:    Translation:Humans
    10. Song MA, Ernst T, Tiirikainen M, Tost J, Wilkens LR, Chang L, Kolonel LN, Le Marchand L, Lim U. Methylation of imprinted IGF2 regions is associated with total, visceral, and hepatic adiposity in postmenopausal women. Epigenetics. 2018; 13(8):858-865. PMID: 30277114.
      Citations: 1     Fields:    Translation:HumansCells
    11. Park SL, Patel YM, Loo LWM, Mullen DJ, Offringa IA, Maunakea A, Stram DO, Siegmund K, Murphy SE, Tiirikainen M, Le Marchand L. Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations. Clin Epigenetics. 2018 08 23; 10(1):110. PMID: 30139389.
      Citations: 2     Fields:    Translation:HumansCells
    12. Murphy SE, von Weymarn LB, Parenteau M, Stepanov I, Tiirikainen M, LeMarchand L, Park SL. Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N-glucuronide by African American Smokers. Chem Res Toxicol. 2018 03 19; 31(3):168-175. PMID: 29460622.
      Citations: 1     Fields:    Translation:Humans
    13. Nishioka ST, Sato MM, Wong LL, Tiirikainen M, Kwee SA. Clinical and molecular sub-classification of hepatocellular carcinoma relative to alpha-fetoprotein level in an Asia-Pacific island cohort. Hepatoma Res. 2018; 4. PMID: 29376136.
      Citations:    
    14. Boldry EJ, Patel YM, Kotapati S, Esades A, Park SL, Tiirikainen M, Stram DO, Le Marchand L, Tretyakova N. Genetic Determinants of 1,3-Butadiene Metabolism and Detoxification in Three Populations of Smokers with Different Risks of Lung Cancer. Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1034-1042. PMID: 28292921.
      Citations: 1     Fields:    Translation:Humans
    15. Lu L, McCurdy S, Huang S, Zhu X, Peplowska K, Tiirikainen M, Boisvert WA, Garmire LX. Time Series miRNA-mRNA integrated analysis reveals critical miRNAs and targets in macrophage polarization. Sci Rep. 2016 12 16; 6:37446. PMID: 27981970.
      Citations: 6     Fields:    Translation:AnimalsCells
    16. Okimoto G, Zeinalzadeh A, Wenska T, Loomis M, Nation JB, Fabre T, Tiirikainen M, Hernandez B, Chan O, Wong L, Kwee S. Joint analysis of multiple high-dimensional data types using sparse matrix approximations of rank-1 with applications to ovarian and liver cancer. BioData Min. 2016; 9:24. PMID: 27478503.
      Citations:    
    17. Song MA, Kwee SA, Tiirikainen M, Hernandez BY, Okimoto G, Tsai NC, Wong LL, Yu H. Comparison of genome-scale DNA methylation profiles in hepatocellular carcinoma by viral status. Epigenetics. 2016 06 02; 11(6):464-74. PMID: 27248055.
      Citations:    Fields:    Translation:HumansCells
    18. Ching T, Peplowska K, Huang S, Zhu X, Shen Y, Molnar J, Yu H, Tiirikainen M, Fogelgren B, Fan R, Garmire LX. Pan-Cancer Analyses Reveal Long Intergenic Non-Coding RNAs Relevant to Tumor Diagnosis, Subtyping and Prognosis. EBioMedicine. 2016 May; 7:62-72. PMID: 27322459.
      Citations: 8     Fields:    Translation:HumansCells
    19. Kwee SA, Okimoto GS, Chan OT, Tiirikainen M, Wong LL. Metabolic characteristics distinguishing intrahepatic cholangiocarcinoma: a negative pilot study of (18)F-fluorocholine PET/CT clarified by transcriptomic analysis. Am J Nucl Med Mol Imaging. 2016; 6(1):73-83. PMID: 27069767.
      Citations:    
    20. Park SL, Tiirikainen MI, Patel YM, Wilkens LR, Stram DO, Le Marchand L, Murphy SE. Genetic determinants of CYP2A6 activity across racial/ethnic groups with different risks of lung cancer and effect on their smoking intensity. Carcinogenesis. 2016 Mar; 37(3):269-279. PMID: 26818358.
      Citations: 18     Fields:    Translation:Humans
    21. Nasu M, Emi M, Pastorino S, Tanji M, Powers A, Luk H, Baumann F, Zhang YA, Gazdar A, Kanodia S, Tiirikainen M, Flores E, Gaudino G, Becich MJ, Pass HI, Yang H, Carbone M. High Incidence of Somatic BAP1 alterations in sporadic malignant mesothelioma. J Thorac Oncol. 2015 Apr; 10(4):565-76. PMID: 25658628.
      Citations: 55     Fields:    Translation:HumansCells
    22. Ching T, Ha J, Song MA, Tiirikainen M, Molnar J, Berry MJ, Towner D, Garmire LX. Genome-scale hypomethylation in the cord blood DNAs associated with early onset preeclampsia. Clin Epigenetics. 2015; 7:21. PMID: 25806090.
      Citations: 11     Fields:    
    23. Shvetsov YB, Song MA, Cai Q, Tiirikainen M, Xiang YB, Shu XO, Yu H. Intraindividual variation and short-term temporal trend in DNA methylation of human blood. Cancer Epidemiol Biomarkers Prev. 2015 Mar; 24(3):490-7. PMID: 25538225.
      Citations: 10     Fields:    Translation:HumansCells
    24. Park SL, Kotapati S, Wilkens LR, Tiirikainen M, Murphy SE, Tretyakova N, Le Marchand L. 1,3-Butadiene exposure and metabolism among Japanese American, Native Hawaiian, and White smokers. Cancer Epidemiol Biomarkers Prev. 2014 Nov; 23(11):2240-9. PMID: 25368399.
      Citations: 6     Fields:    Translation:Humans
    25. Ching T, Song MA, Tiirikainen M, Molnar J, Berry M, Towner D, Garmire LX. Genome-wide hypermethylation coupled with promoter hypomethylation in the chorioamniotic membranes of early onset pre-eclampsia. Mol Hum Reprod. 2014 Sep; 20(9):885-904. PMID: 24944161.
      Citations: 12     Fields:    Translation:HumansCells
    26. Lim U, Kocarnik JM, Bush WS, Matise TC, Caberto C, Park SL, Carlson CS, Deelman E, Duggan D, Fesinmeyer M, Haiman CA, Henderson BE, Hindorff LA, Kolonel LN, Peters U, Stram DO, Tiirikainen M, Wilkens LR, Wu C, Kooperberg C, Le Marchand L. Pleiotropy of cancer susceptibility variants on the risk of non-Hodgkin lymphoma: the PAGE consortium. PLoS One. 2014; 9(3):e89791. PMID: 24598796.
      Citations: 5     Fields:    Translation:Humans
    27. Qi F, Okimoto G, Jube S, Napolitano A, Pass HI, Laczko R, Demay RM, Khan G, Tiirikainen M, Rinaudo C, Croce A, Yang H, Gaudino G, Carbone M. Continuous exposure to chrysotile asbestos can cause transformation of human mesothelial cells via HMGB1 and TNF-a signaling. Am J Pathol. 2013 Nov; 183(5):1654-66. PMID: 24160326.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    28. Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Gafà R, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen JF, Beverloo BH, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn GA, Gotley DC, Bhardwaj V, Shureiqi I, Sen S, Multani AS, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau SN, Le Marchand L, Tiirikainen M, Mani SA, Zhang W, Davuluri RV, Mimori K, Mori M, Sieuwerts AM, Martens JW, Tomlinson I, Negrini M, Berindan-Neagoe I, Foekens JA, Hamilton SR, Lanza G, Kopetz S, Fodde R, Calin GA. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res. 2013 Sep; 23(9):1446-61. PMID: 23796952.
      Citations: 186     Fields:    Translation:HumansAnimalsCells
    29. Rocha FG, Slavin TP, Li D, Tiirikainen MI, Bryant-Greenwood GD. Genetic associations of relaxin: preterm birth and premature rupture of fetal membranes. Am J Obstet Gynecol. 2013 Sep; 209(3):258.e1-8. PMID: 23727041.
      Citations: 3     Fields:    Translation:HumansCells
    30. Song MA, Tiirikainen M, Kwee S, Okimoto G, Yu H, Wong LL. Elucidating the landscape of aberrant DNA methylation in hepatocellular carcinoma. PLoS One. 2013; 8(2):e55761. PMID: 23437062.
      Citations: 42     Fields:    Translation:HumansCells
    31. Loo LW, Tiirikainen M, Cheng I, Lum-Jones A, Seifried A, Church JM, Gryfe R, Weisenberger DJ, Lindor NM, Gallinger S, Haile RW, Duggan DJ, Thibodeau SN, Casey G, Le Marchand L. Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer. Genes Chromosomes Cancer. 2013 May; 52(5):450-66. PMID: 23341073.
      Citations: 21     Fields:    Translation:HumansCells
    32. Lim U, Wilkens LR, Monroe KR, Caberto C, Tiirikainen M, Cheng I, Park SL, Stram DO, Henderson BE, Kolonel LN, Haiman CA, Le Marchand L. Susceptibility variants for obesity and colorectal cancer risk: the multiethnic cohort and PAGE studies. Int J Cancer. 2012 Sep 15; 131(6):E1038-43. PMID: 22511254.
      Citations: 7     Fields:    Translation:Humans
    33. Kwee S, Song MA, Cheng I, Loo L, Tiirikainen M. Measurement of circulating cell-free DNA in relation to 18F-fluorocholine PET/CT imaging in chemotherapy-treated advanced prostate cancer. Clin Transl Sci. 2012 Feb; 5(1):65-70. PMID: 22376260.
      Citations: 12     Fields:    Translation:HumansCells
    34. Loo LW, Cheng I, Tiirikainen M, Lum-Jones A, Seifried A, Dunklee LM, Church JM, Gryfe R, Weisenberger DJ, Haile RW, Gallinger S, Duggan DJ, Thibodeau SN, Casey G, Le Marchand L. cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue. PLoS One. 2012; 7(2):e30477. PMID: 22363440.
      Citations: 28     Fields:    Translation:Humans
    35. Lacher MD, Shiina M, Chang P, Keller D, Tiirikainen MI, Korn WM. ZEB1 limits adenoviral infectability by transcriptionally repressing the coxsackie virus and adenovirus receptor. Mol Cancer. 2011 Jul 27; 10:91. PMID: 21791114.
      Citations: 8     Fields:    Translation:HumansCells
    36. Cheng I, Caberto CP, Lum-Jones A, Seifried A, Wilkens LR, Schumacher FR, Monroe KR, Lim U, Tiirikainen M, Kolonel LN, Henderson BE, Stram DO, Haiman CA, Le Marchand L. Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies. Gut. 2011 Dec; 60(12):1703-11. PMID: 21602532.
      Citations: 12     Fields:    Translation:Humans
    37. Le Marchand L, White KK, Nomura AM, Wilkens LR, Selhub JS, Tiirikainen M, Goodman MT, Murphy SP, Henderson BE, Kolonel LN. Plasma levels of B vitamins and colorectal cancer risk: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 2009 Aug; 18(8):2195-201. PMID: 19661077.
      Citations: 26     Fields:    Translation:Humans
    38. Epplein M, Wilkens LR, Tiirikainen M, Dyba M, Chung FL, Goodman MT, Murphy SP, Henderson BE, Kolonel LN, Le Marchand L. Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev. 2009 Jan; 18(1):314-20. PMID: 19124514.
      Citations: 13     Fields:    Translation:HumansAnimals
    39. Le Marchand L, Derby KS, Murphy SE, Hecht SS, Hatsukami D, Carmella SG, Tiirikainen M, Wang H. Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. Cancer Res. 2008 Nov 15; 68(22):9137-40. PMID: 19010884.
      Citations: 81     Fields:    Translation:Humans
    40. Poynter JN, Figueiredo JC, Conti DV, Kennedy K, Gallinger S, Siegmund KD, Casey G, Thibodeau SN, Jenkins MA, Hopper JL, Byrnes GB, Baron JA, Goode EL, Tiirikainen M, Lindor N, Grove J, Newcomb P, Jass J, Young J, Potter JD, Haile RW, Duggan DJ, Le Marchand L. Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry. Cancer Res. 2007 Dec 01; 67(23):11128-32. PMID: 18056436.
      Citations: 54     Fields:    Translation:HumansCells
    41. Lacher MD, Tiirikainen MI, Saunier EF, Christian C, Anders M, Oft M, Balmain A, Akhurst RJ, Korn WM. Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition. Cancer Res. 2006 Feb 01; 66(3):1648-57. PMID: 16452224.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    42. Jensen RH, Tiirikainen M, You L, Ginzinger D, He B, Uematsu K, Xu Z, Treseler P, McCormick F, Jablons DM. Genomic alterations in human mesothelioma including high resolution mapping of common regions of DNA loss in chromosome arm 6q. Anticancer Res. 2003 May-Jun; 23(3B):2281-9. PMID: 12894504.
      Citations: 9     Fields:    Translation:HumansCells
    43. Zardo G, Tiirikainen MI, Hong C, Misra A, Feuerstein BG, Volik S, Collins CC, Lamborn KR, Bollen A, Pinkel D, Albertson DG, Costello JF. Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. Nat Genet. 2002 Nov; 32(3):453-8. PMID: 12355068.
      Citations: 38     Fields:    Translation:HumansCells
    44. Tiirikainen MI, Mullaney BP, Holly EA, Pallavicini MG, Jensen RH. DNA copy number alterations in HIV-positive and HIV-negative patients with diffuse large-cell lymphomas. J Acquir Immune Defic Syndr. 2001 Jul 01; 27(3):272-6. PMID: 11464147.
      Citations:    Fields:    Translation:HumansCells
    45. Kanerva J, Tiirikainen MI, Mäkipernaa A, Riikonen P, Möttönen M, Salmi TT, Krusius T, Saarinen-Pihkala UM. Initial P-glycoprotein expression in childhood acute lymphoblastic leukemia: no evidence of prognostic impact in follow-up. Pediatr Hematol Oncol. 2001 Jan-Feb; 18(1):27-36. PMID: 11205837.
      Citations: 1     Fields:    Translation:Humans
    46. Kanerva J, Tiirikainen M, Mäkipernaa A, Riikonen P, Möttönen M, Salmi TT, Krusius T, Saarinen-Pihkala UM. Multiple drug resistance mediated by P-glycoprotein is not a major factor in a slow response to therapy in childhood ALL. Pediatr Hematol Oncol. 1998 Jan-Feb; 15(1):11-21. PMID: 9509502.
      Citations:    Fields:    Translation:Humans
    47. Tiirikainen MI. Evaluation of red blood cell lysing solutions for the detection of intracellular antigens by flow cytometry. Cytometry. 1995 Aug 01; 20(4):341-8. PMID: 7587722.
      Citations: 6     Fields:    Translation:HumansCells
    48. Tiirikainen MI, Elonen E, Syrjälä MT, Jansson SE, Krusius T. Flow cytometric analysis of glutathione-S-transferase-pi in acute leukemia. Leukemia. 1994 Jun; 8(6):978-84. PMID: 7516031.
      Citations: 3     Fields:    Translation:HumansCells
    49. Tiirikainen MI, Elonen E, Ruutu T, Jansson SE, Krusius T. Clinical significance of P-glycoprotein expression in acute leukaemia as analysed by immunocytochemistry. Eur J Haematol. 1993 May; 50(5):279-85. PMID: 8100537.
      Citations:    Fields:    Translation:Humans
    50. Syrjälä MT, Tiirikainen M, Jansson SE, Krusius T. Flow cytometric analysis of terminal deoxynucleotidyl transferase. A simplified method. Am J Clin Pathol. 1993 Mar; 99(3):298-303. PMID: 8447292.
      Citations: 4     Fields:    Translation:HumansCells
    51. Tiirikainen MI, Syrjälä MT, Jansson SE, Krusius T. Flow cytometric analysis of P-glycoprotein in normal and leukemic cells. Ann Hematol. 1992 Sep; 65(3):124-30. PMID: 1356449.
      Citations: 3     Fields:    Translation:HumansCells
    52. Tiirikainen MI, Krusius T. Multidrug resistance. Ann Med. 1991; 23(5):509-20. PMID: 1684512.
      Citations: 1     Fields:    Translation:HumansCells
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