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Richard Noel

TitleChair of Basic Sciences
Faculty RankProfessor
InstitutionPonce Health Sciences University
DepartmentBasic Sciences
AddressP.O. Box 7029
Ponce PR 00741
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    Other Positions
    InstitutionPonce Research Institute
    DepartmentBasic Sciences

    InstitutionPonce Health Sciences University
    DepartmentDepartment of Basic Sciences

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    2015Distinguished Service Award, Society on NeuroImmune Pharmacology

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    Richard J. Noel Jr., PhD is the Chair of the Basic Sciences Department and a Professor of Biochemistry for the Ponce Health Sciences University (PHSU). At the affiliated Ponce Research Institute, he serves as the Associate PI for the RCMI Program and is the Director of the Molecular and Genomics Core Laboratory (http://www.psm.edu/MAGIC/index.html) which is supported by the RCMI program. Dr. Noel is a member of the HIV and Neuro/Mental Health clusters and has served in the leadership of the latter.

    Dr. Noel is originally from Troy, New York and received a BS in Biology from Boston College in 1993 and a PhD in Biochemistry from the University of Wisconsin, Madison in 1998. In 2001, after post-doctoral work in the Department of Pharmacology at the Ponce School of Medicine (now Ponce Health Sciences University), Dr. Noel joined the Department of Biochemistry as an Assistant Professor and began working in the AIDS Research Program to study the structure/function relationship of the HIV Tat protein. This work led to his current interests in HIV neuropathogenesis by viral neurotoxins as well as synergistic neurotoxicity by drugs of abuse. He has graduated five PhD students and trained nearly 100 students from high school, undergraduate, graduate and medical school. In addition, he has mentored junior faculty at PHSU and other RCMI institutions in Puerto Rico and currently serves as the director of the RCMI Research Pilot Project Program and is a member of the PHSU Institutional Research Advisory Council.

    Outside of PHSU, Richard Noel has served as the national chairperson for the Meetings Committee for the Society on NeuroImmune Pharmacology (SNIP, www.s-nip.org). He also serves as a reviewer for a handful of journals focused on HIV/AIDS, HIV neuropathology, and neuroinflammation as well as a grant reviewer for several organizations and programs across and outside of the RTRN network.

    The lab currently has projects focused on the role of HIV-1 Nef in causing learning deficits as well as inflammation in the brain when expressed from astrocytes. Most of the studies involve a rat model system or in vitro cell culture to look at the mechanism of Nef neurotoxicity. The model has also developed some interesting side projects to look at neuroprotective factors as well as an interesting finding that the brain inflammation generates a systemic inflammatory response affecting GI and lung tissue. The lab is also working with the HIV-1 neurotoxins Vpr and Tat along similar approaches. The lab is always seeking new collaborators interested in expanding the work on the model to better understand the pathology of HIV proteins both in the brain and periphery.

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    U54MD007579     (NOEL, RICHARD J.;TORRES-RUIZ, JOSE A)Aug 25, 1997 - Feb 29, 2024
    PHSU Specialized Center in Health Disparities.
    Role: Co-Principal Investigator

    R03DA026722     (NOEL, RICHARD J.)Apr 1, 2009 - Mar 31, 2012
    Synergistic neurotoxicity of speedball and HIV toxins
    Role: Principal Investigator

    SC3GM106970     (NOEL, RICHARD J.)Aug 1, 2013 - Jul 31, 2018
    Astrocytic HIV Nef causes learning impairment via inflammation and TGF signaling
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pla-Tenorio J, Roig AM, Garc?a-Cesan? PA, Santiago LA, Sepulveda-Orengo MT, Noel RJ. Astrocytes: Role in pathogenesis and effect of commonly misused drugs in the HIV infected brain. Curr Res Neurobiol. 2023; 5:100108. PMID: 38020814.
    2. Rivera-Ortiz J, Pla-Tenorio J, Cruz ML, Colon K, Perez-Morales J, Rodriguez JA, Martinez-Sicari J, Noel RJ. Blockade of beta adrenergic receptors protects the blood brain barrier and reduces systemic pathology caused by HIV-1 Nef protein. PLoS One. 2021; 16(11):e0259446. PMID: 34784367.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Noel RJ, Torres-Ruiz JA. Integrity and resilience in the face of multiple crises: commentary from Puerto Rico. Forensic Sci Res. 2021; 6(4):316-319. PMID: 35111350.
    4. Yanagihara R, Berry MJ, Carson MJ, Chang SP, Corliss H, Cox MB, Haddad G, Hohmann C, Kelley ST, Lee ESY, Link BG, Noel RJ, Pickrel J, Porter JT, Quirk GJ, Samuel T, Stiles JK, Sy AU, Taira DA, Trepka MJ, Villalta F, Wiese TE. Building a Diverse Workforce and Thinkforce to Reduce Health Disparities. Int J Environ Res Public Health. 2021 02 07; 18(4). PMID: 33562262.
      Citations: 6     Fields:    Translation:Humans
    5. Chompre G, Martinez-Orengo N, Cruz M, Porter JT, Noel RJ. TGF?RI antagonist inhibits HIV-1 Nef-induced CC chemokine family ligand 2 (CCL2) in the brain and prevents spatial learning impairment. J Neuroinflammation. 2019 Dec 11; 16(1):262. PMID: 31829243.
      Citations: 6     Fields:    Translation:AnimalsCells
    6. Rivera J, Isidro RA, Loucil-Alicea RY, Cruz ML, Appleyard CB, Isidro AA, Chompre G, Colon-Rivera K, Noel RJ. Infusion of HIV-1 Nef-expressing astrocytes into the rat hippocampus induces enteropathy and interstitial pneumonitis and increases blood-brain-barrier permeability. PLoS One. 2019; 14(11):e0225760. PMID: 31774879.
      Citations: 9     Fields:    Translation:AnimalsCells
    7. Ofili EO, Tchounwou PB, Fernandez-Repollet E, Yanagihara R, Akintobi TH, Lee JE, Malouhi M, Garner ST, Hayes TT, Baker AR, Dent AL, Abdelrahim M, Rollins L, Chang SP, Sy A, Hernandez BY, Bullard PL, Noel RJ, Shiramizu B, Hedges JR, Berry MJ, Bond VC, Lima MF, Mokuau N, Kirken RA, Cruz-Correa M, Sarpong DF, Vadgama J, Yates C, Kahn SA, Soliman KF, Perry G, Pezzano M, Luciano CA, Barnett ME, Oyekan A, Kumar D, Norris KC. The Research Centers in Minority Institutions (RCMI) Translational Research Network: Building and Sustaining Capacity for Multi-Site Basic Biomedical, Clinical and Behavioral Research. Ethn Dis. 2019; 29(Suppl 1):135-144. PMID: 30906162.
      Citations: 18     Fields:    Translation:Humans
    8. Martinez-Orengo N, Cruz ML, Velazquez B, Noel RJ, Appleyard CB. Nurturing interest in science and understanding the role of a scientist by teaching younger students how to apply scientific thinking during daily activities. Adv Physiol Educ. 2018 Sep 01; 42(3):466-472. PMID: 29972061.
      Citations:    Fields:    Translation:Humans
    9. Noel RJ, Kaul M. The 22nd Scientific Conference of the Society on Neuroimmune Pharmacology. J Neuroimmune Pharmacol. 2016 Apr; 11 Suppl 1:S1-2. PMID: 26968848.
      Citations:    Fields:    
    10. Col?n K, V?zquez-Santiago F, Rivera-Amill V, Delgado G, Massey SE, Wojna V, Noel RJ, Mel?ndez LM. HIV gp120 sequence variability associated with HAND in Hispanic Women. J Virol Antivir Res. 2015; 4(3). PMID: 27358904.
    11. Pacheco WI, Noel RJ, Porter JT, Appleyard CB. Beyond the GRE: using a composite score to predict ?the success of Puerto Rican students in a biomedical ?PhD program. CBE Life Sci Educ. 2015; 14(2). PMID: 25828404.
      Citations: 6     Fields:    Translation:Humans
    12. V?zquez-Santiago F, Garc?a Y, Rivera-Rom?n I, Noel RJ, Wojna V, Mel?ndez LM, Rivera-Amill V. Longitudinal Analysis of Cerebrospinal Fluid and Plasma HIV-1 Envelope Sequences Isolated From a Single Donor with HIV Asymptomatic Neurocognitive Impairment. J Virol Antivir Res. 2015; 4(1). PMID: 26167513.
    13. V?zquez-Santiago FJ, Noel RJ, Porter JT, Rivera-Amill V. Glutamate metabolism and HIV-associated neurocognitive disorders. J Neurovirol. 2014 Aug; 20(4):315-31. PMID: 24867611.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    14. Torres L, Noel RJ. Astrocytic expression of HIV-1 viral protein R in the hippocampus causes chromatolysis, synaptic loss and memory impairment. J Neuroinflammation. 2014 Mar 22; 11:53. PMID: 24655810.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    15. Gangwani MR, Noel RJ, Shah A, Rivera-Amill V, Kumar A. Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways. J Neuroinflammation. 2013 Nov 13; 10:136. PMID: 24225433.
      Citations: 17     Fields:    Translation:HumansCells
    16. Nookala AR, Shah A, Noel RJ, Kumar A. HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-?B, AP-1, C/EBPa and C/EBP? transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways. PLoS One. 2013; 8(11):e78855. PMID: 24244375.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    17. Rivera I, Garc?a Y, Gangwani MR, Noel RJ, Maldonado L, Kumar A, Rivera-Amill V. Identification and molecular characterization of SIV Vpr R50G mutation associated with long term survival in SIV-infected morphine dependent and control macaques. Virology. 2013 Nov; 446(1-2):144-51. PMID: 24074576.
      Citations: 3     Fields:    Translation:AnimalsCells
    18. Chompre G, Cruz E, Maldonado L, Rivera-Amill V, Porter JT, Noel RJ. Astrocytic expression of HIV-1 Nef impairs spatial and recognition memory. Neurobiol Dis. 2013 Jan; 49:128-36. PMID: 22926191.
      Citations: 46     Fields:    Translation:AnimalsCells
    19. Gonzalez-Hernandez MJ, Swanson MD, Contreras-Galindo R, Cookinham S, King SR, Noel RJ, Kaplan MH, Markovitz DM. Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1. J Virol. 2012 Aug; 86(15):7790-805. PMID: 22593154.
      Citations: 71     Fields:    Translation:HumansCells
    20. Shah A, Verma AS, Patel KH, Noel R, Rivera-Amill V, Silverstein PS, Chaudhary S, Bhat HK, Stamatatos L, Singh DP, Buch S, Kumar A. HIV-1 gp120 induces expression of IL-6 through a nuclear factor-kappa B-dependent mechanism: suppression by gp120 specific small interfering RNA. PLoS One. 2011; 6(6):e21261. PMID: 21712995.
      Citations: 55     Fields:    Translation:HumansCells
    21. Rivera-Amill V, Kumar R, Noel RJ, Garcia Y, Rodriguez IV, Martinez M, Sariol CA, Kraiselburd E, Iszard M, Mukherji M, Kumar S, Giavedoni LD, Kumar A. Short communication: Lack of immune response in rapid progressor morphine-dependent and SIV/SHIV-infected rhesus macaques is correlated with downregulation of TH1 cytokines. AIDS Res Hum Retroviruses. 2010 Aug; 26(8):919-22. PMID: 20672973.
      Citations: 5     Fields:    Translation:AnimalsCells
    22. Rivera-Amill V, Noel RJ, Garc?a Y, Rivera I, Iszard M, Buch S, Kumar A. Accelerated evolution of SIV env within the cerebral compartment in the setting of morphine-dependent rapid disease progression. Virology. 2010 Mar 15; 398(2):201-7. PMID: 20042209.
      Citations: 6     Fields:    Translation:AnimalsCells
    23. Rivera-Amill V, Silverstein PS, Noel RJ, Kumar S, Kumar A. Morphine and rapid disease progression in nonhuman primate model of AIDS: inverse correlation between disease progression and virus evolution. J Neuroimmune Pharmacol. 2010 Mar; 5(1):122-32. PMID: 20013315.
      Citations: 14     Fields:    Translation:AnimalsCells
    24. Rivera-Amill V, Noel RJ, Rom?n IR, Flores YG, Buch S, Kumar A. Analysis of the V1V2 region of the SIV envelope in the brains of morphine-dependent and control SIV/SHIV-infected macaques. AIDS Res Hum Retroviruses. 2009 May; 25(5):531-4. PMID: 19397400.
      Citations: 3     Fields:    Translation:AnimalsCells
    25. Noel RJ, Rivera-Amill V, Buch S, Kumar A. Opiates, immune system, acquired immunodeficiency syndrome, and nonhuman primate model. J Neurovirol. 2008 Aug; 14(4):279-85. PMID: 18780228.
      Citations: 16     Fields:    Translation:Animals
    26. P?rez-Casanova A, Husain K, Noel RJ, Rivera-Amill V, Kumar A. Interaction of SIV/SHIV infection and morphine on plasma oxidant/antioxidant balance in macaque. Mol Cell Biochem. 2008 Jan; 308(1-2):169-75. PMID: 17934700.
      Citations: 14     Fields:    Translation:AnimalsCells
    27. P?rez-Casanova A, Noel RJ, Rivera-Amill V, Husain K, Kumar A. Morphine-mediated deterioration of oxidative stress leads to rapid disease progression in SIV/SHIV-infected macaques. AIDS Res Hum Retroviruses. 2007 Aug; 23(8):1004-7. PMID: 17725417.
      Citations: 15     Fields:    Translation:AnimalsCells
    28. Noel RJ, Kumar A. SIV Vpr evolution is inversely related to disease progression in a morphine-dependent rhesus macaque model of AIDS. Virology. 2007 Mar 15; 359(2):397-404. PMID: 17064752.
      Citations: 8     Fields:    Translation:AnimalsCells
    29. Rivera-Amill V, Noel RJ, Orsini S, Tirado G, Garc?a JM, Buch S, Kumar A. Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV. Virology. 2007 Feb 20; 358(2):373-83. PMID: 17011009.
      Citations: 9     Fields:    Translation:AnimalsCells
    30. Noel RJ, Toro-Bahamonde A, Marrero-Otero Z, Orsini S, Verma AS, Kumar R, Kumar A. Lack of correlation between SIV-Nef evolution and rapid disease progression in morphine-dependent nonhuman primate model of AIDS. AIDS Res Hum Retroviruses. 2006 Aug; 22(8):817-23. PMID: 16910840.
      Citations: 7     Fields:    Translation:AnimalsCells
    31. Noel RJ, Marrero-Otero Z, Kumar R, Chompre-Gonz?lez GS, Verma AS, Kumar A. Correlation between SIV Tat evolution and AIDS progression in cerebrospinal fluid of morphine-dependent and control macaques infected with SIV and SHIV. Virology. 2006 Jun 05; 349(2):440-52. PMID: 16643974.
      Citations: 14     Fields:    Translation:AnimalsCells
    32. Noel RJ, Tipnis NA. Eosinophilic esophagitis -- a mimic of GERD. Int J Pediatr Otorhinolaryngol. 2006 Jul; 70(7):1147-53. PMID: 16504309.
      Citations: 8     Fields:    Translation:Humans
    33. Noel RJ, Kumar A. Virus replication and disease progression inversely correlate with SIV tat evolution in morphine-dependent and SIV/SHIV-infected Indian rhesus macaques. Virology. 2006 Mar 01; 346(1):127-38. PMID: 16313937.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    34. Kumar R, Perez-Casanova AE, Tirado G, Noel RJ, Torres C, Rodriguez I, Martinez M, Staprans S, Kraiselburd E, Yamamura Y, Higley JD, Kumar A. Increased viral replication in simian immunodeficiency virus/simian-HIV-infected macaques with self-administering model of chronic alcohol consumption. J Acquir Immune Defic Syndr. 2005 Aug 01; 39(4):386-90. PMID: 16010157.
      Citations: 39     Fields:    Translation:AnimalsCells
    35. Tirado G, Jove G, Kumar R, Noel RJ, Reyes E, Sepulveda G, Yamamura Y, Kumar A. Differential virus evolution in blood and genital tract of HIV-infected females: evidence for the involvement of drug and non-drug resistance-associated mutations. Virology. 2004 Jul 01; 324(2):577-86. PMID: 15207642.
      Citations: 14     Fields:    Translation:HumansCellsPHPublic Health
    36. Tirado G, Jove G, Kumar R, Noel RJ, Reyes E, Sepulveda G, Yamamura Y, Kumar A. Compartmentalization of drug resistance-associated mutations in a treatment-naive HIV-infected female. AIDS Res Hum Retroviruses. 2004 Jun; 20(6):684-6. PMID: 15242547.
      Citations: 10     Fields:    Translation:HumansCells
    37. Noel RJ, Chaudhary S, Rodriguez N, Kumar A, Yamamura Y. Phylogenetic relationships between Puerto Rico and continental USA HIV-1 pol sequences: a shared HIV-1 infection. Cell Mol Biol (Noisy-le-grand). 2003 Dec; 49(8):1193-8. PMID: 14983986.
      Citations: 4     Fields:    Translation:HumansCells
    38. Noel RJ, Reznikoff WS. Structural studies of lacUV5-RNA polymerase interactions in vitro. Ethylation interference and missing nucleoside analysis. J Biol Chem. 2000 Mar 17; 275(11):7708-12. PMID: 10713082.
      Citations: 5     Fields:    Translation:Cells
    39. Noel RJ, Reznikoff WS. CAP, the -45 region, and RNA polymerase: three partners in transcription initiation at lacP1 in Escherichia coli. J Mol Biol. 1998 Sep 25; 282(3):495-504. PMID: 9737918.
      Citations: 6     Fields:    Translation:Cells
    40. Czarniecki D, Noel RJ, Reznikoff WS. The -45 region of the Escherichia coli lac promoter: CAP-dependent and CAP-independent transcription. J Bacteriol. 1997 Jan; 179(2):423-9. PMID: 8990294.
      Citations: 12     Fields:    Translation:Cells
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