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Deok-Soo Son

TitlePhD
Faculty RankAssociate Professor
InstitutionMeharry Medical College
DepartmentBiochem, Cancer Biology, Neuroscience & Pharmacology
Address1005 Dr DB Todd Jr Blvd
Nashville TN 37208
Phone6153276501
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    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    SC1AI089073     (SON, DEOK-SOO)Sep 30, 2009 - Aug 31, 2016
    NIH
    Roles of inflammation-driven chemokines in the pathogenesis of ovarian cancer
    Role: Principal Investigator

    SC1CA200519     (SON, DEOK-SOO)Aug 1, 2015 - Jul 31, 2021
    NIH
    Roles of proinflammatory chemokines linking obesity and breast cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pajarillo E, Johnson J, Rizor A, Nyarko-Danquah I, Adinew G, Bornhorst J, Stiboller M, Schwerdtle T, Son DS, Aschner M, Lee E. Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity. J Biol Chem. 2020 Nov 13; 295(46):15662-15676. PMID: 32893191.
      Citations: 1     Fields:    
    2. Son DS, Lee ES, Adunyah SE. The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs. Immune Netw. 2020 Aug; 20(4):e29. PMID: 32895616.
      Citations:    
    3. Son D, Alday JG, Chu Y, Lee EJ, Park S, Lee H. Plant species colonization in newly created road habitats of South Korea: Insights for more effective restoration. Sci Total Environ. 2020 Jun 01; 719:137476. PMID: 32114236.
      Citations:    Fields:    Translation:Animals
    4. Pajarillo E, Rizor A, Son DS, Aschner M, Lee E. The transcription factor REST up-regulates tyrosine hydroxylase and antiapoptotic genes and protects dopaminergic neurons against manganese toxicity. J Biol Chem. 2020 03 06; 295(10):3040-3054. PMID: 32001620.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Ignacio RMC, Lee ES, Son DS. Potential Roles of Innate Immune Chemokine and Cytokine Network on Lipopolysaccharide-Based Therapeutic Approach in Ovarian Cancer. Immune Netw. 2019 Jun; 19(3):e22. PMID: 31281719.
      Citations:    
    6. Kim J, Pajarillo E, Rizor A, Son DS, Lee J, Aschner M, Lee E. LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PLoS One. 2019; 14(1):e0210248. PMID: 30645642.
      Citations: 7     Fields:    Translation:HumansCells
    7. Ignacio RMC, Gibbs CR, Kim S, Lee ES, Adunyah SE, Son DS. Serum amyloid A predisposes inflammatory tumor microenvironment in triple negative breast cancer. Oncotarget. 2019 Jan 11; 10(4):511-526. PMID: 30728901.
      Citations: 3     Fields:    
    8. Ignacio RMC, Lee ES, Wilson AJ, Beeghly-Fadiel A, Whalen MM, Son DS. Obesity-Induced Peritoneal Dissemination of Ovarian Cancer and Dominant Recruitment of Macrophages in Ascites. Immune Netw. 2018 Dec; 18(6):e47. PMID: 30619633.
      Citations:    
    9. Ignacio RMC, Lee ES, Wilson AJ, Beeghly-Fadiel A, Whalen MM, Son DS. Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer. Immune Netw. 2018 Aug; 18(4):e29. PMID: 30181917.
      Citations:    
    10. Ignacio RMC, Gibbs CR, Lee ES, Son DS. The TGFa-EGFR-Akt signaling axis plays a role in enhancing proinflammatory chemokines in triple-negative breast cancer cells. Oncotarget. 2018 Jun 29; 9(50):29286-29303. PMID: 30034618.
      Citations: 2     Fields:    
    11. Song U, Son D, Kang C, Lee EJ, Lee K, Park JS. Mowing: A cause of invasion, but also a potential solution for management of the invasive, alien plant species Erigeron annuus (L.) Pers. J Environ Manage. 2018 Oct 01; 223:530-536. PMID: 29960189.
      Citations:    Fields:    Translation:Animals
    12. Johnson J, Pajarillo E, Karki P, Kim J, Son DS, Aschner M, Lee E. Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity. Neurotoxicology. 2018 07; 67:112-120. PMID: 29778792.
      Citations: 9     Fields:    Translation:AnimalsCells
    13. Ignacio RMC, Dong YL, Kabir SM, Choi H, Lee ES, Wilson AJ, Beeghly-Fadiel A, Whalen MM, Son DS. CXCR2 is a negative regulator of p21 in p53-dependent and independent manner via Akt-mediated Mdm2 in ovarian cancer. Oncotarget. 2018 Feb 09; 9(11):9751-9765. PMID: 29515768.
      Citations: 3     Fields:    
    14. Pajarillo E, Johnson J, Kim J, Karki P, Son DS, Aschner M, Lee E. 17ß-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity. Neurotoxicology. 2018 03; 65:280-288. PMID: 29183790.
      Citations: 8     Fields:    Translation:AnimalsCells
    15. Karki P, Hong P, Johnson J, Pajarillo E, Son DS, Aschner M, Lee EY. Arundic Acid Increases Expression and Function of Astrocytic Glutamate Transporter EAAT1 Via the ERK, Akt, and NF-?B Pathways. Mol Neurobiol. 2018 Jun; 55(6):5031-5046. PMID: 28812276.
      Citations: 7     Fields:    Translation:HumansCells
    16. Choi H, Ignacio RMC, Lee ES, Roby KF, Terranova PF, Son DS. Localization of Serum Amyloid A3 in the Mouse Ovary. Immune Netw. 2017 Aug; 17(4):261-268. PMID: 28860955.
      Citations:    
    17. Johnson J, Pajarillo EAB, Taka E, Reams R, Son DS, Aschner M, Lee E. Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice. Neurotoxicology. 2018 01; 64:230-239. PMID: 28610743.
      Citations: 11     Fields:    Translation:AnimalsCells
    18. Choi H, Ignacio RMC, Lee ES, Wilson AJ, Khabele D, Son DS. Augmented Serum Amyloid A1/2 Mediated by TNF-induced NF-?B in Human Serous Ovarian Epithelial Tumors. Immune Netw. 2017 Apr; 17(2):121-127. PMID: 28458624.
      Citations:    
    19. Ignacio RM, Kabir SM, Lee ES, Adunyah SE, Son DS. NF-?B-Mediated CCL20 Reigns Dominantly in CXCR2-Driven Ovarian Cancer Progression. PLoS One. 2016; 11(10):e0164189. PMID: 27723802.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    20. Ignacio RM, Gibbs CR, Lee ES, Son DS. Differential Chemokine Signature between Human Preadipocytes and Adipocytes. Immune Netw. 2016 Jun; 16(3):189-94. PMID: 27340388.
      Citations:    
    21. Karki P, Johnson J, Son DS, Aschner M, Lee E. Transcriptional Regulation of Human Transforming Growth Factor-a in Astrocytes. Mol Neurobiol. 2017 03; 54(2):964-976. PMID: 26797516.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    22. Wilson AJ, Fadare O, Beeghly-Fadiel A, Son DS, Liu Q, Zhao S, Saskowski J, Uddin MJ, Daniel C, Crews B, Lehmann BD, Pietenpol JA, Crispens MA, Marnett LJ, Khabele D. Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer. Oncotarget. 2015 Aug 28; 6(25):21353-68. PMID: 25972361.
      Citations: 16     Fields:    Translation:HumansCells
    23. Karki P, Kim C, Smith K, Son DS, Aschner M, Lee E. Transcriptional Regulation of the Astrocytic Excitatory Amino Acid Transporter 1 (EAAT1) via NF-?B and Yin Yang 1 (YY1). J Biol Chem. 2015 Sep 25; 290(39):23725-37. PMID: 26269591.
      Citations: 17     Fields:    Translation:AnimalsCells
    24. Khabele D, Kabir SM, Dong Y, Lee E, Rice VM, Son DS. Preferential effect of akt2-dependent signaling on the cellular viability of ovarian cancer cells in response to EGF. J Cancer. 2014; 5(8):670-8. PMID: 25258648.
      Citations:    
    25. Karki P, Webb A, Zerguine A, Choi J, Son DS, Lee E. Mechanism of raloxifene-induced upregulation of glutamate transporters in rat primary astrocytes. Glia. 2014 Aug; 62(8):1270-83. PMID: 24782323.
      Citations: 24     Fields:    Translation:AnimalsCells
    26. Kabir SM, Lee ES, Son DS. Chemokine network during adipogenesis in 3T3-L1 cells: Differential response between growth and proinflammatory factor in preadipocytes vs. adipocytes. Adipocyte. 2014 Apr 01; 3(2):97-106. PMID: 24719782.
      Citations: 19     Fields:    
    27. Karki P, Webb A, Smith K, Johnson J, Lee K, Son DS, Aschner M, Lee E. Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes. Mol Cell Biol. 2014 Apr; 34(7):1280-9. PMID: 24469401.
      Citations: 32     Fields:    Translation:AnimalsCells
    28. Dong YL, Kabir SM, Lee ES, Son DS. CXCR2-driven ovarian cancer progression involves upregulation of proinflammatory chemokines by potentiating NF-?B activation via EGFR-transactivated Akt signaling. PLoS One. 2013; 8(12):e83789. PMID: 24376747.
      Citations: 23     Fields:    Translation:HumansCells
    29. Cho M, Kabir SM, Dong Y, Lee E, Rice VM, Khabele D, Son DS. Aspirin Blocks EGF-stimulated Cell Viability in a COX-1 Dependent Manner in Ovarian Cancer Cells. J Cancer. 2013; 4(8):671-8. PMID: 24155779.
      Citations:    
    30. Karki P, Webb A, Smith K, Lee K, Son DS, Aschner M, Lee E. cAMP response element-binding protein (CREB) and nuclear factor ?B mediate the tamoxifen-induced up-regulation of glutamate transporter 1 (GLT-1) in rat astrocytes. J Biol Chem. 2013 Oct 04; 288(40):28975-86. PMID: 23955341.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    31. Son DS, Kabir SM, Dong Y, Lee E, Adunyah SE. Characteristics of chemokine signatures elicited by EGF and TNF in ovarian cancer cells. J Inflamm (Lond). 2013 Jun 25; 10(1):25. PMID: 23800251.
      Citations:    
    32. Son DS, Kabir SM, Dong YL, Lee E, Adunyah SE. Inhibitory effect of tumor suppressor p53 on proinflammatory chemokine expression in ovarian cancer cells by reducing proteasomal degradation of I?B. PLoS One. 2012; 7(12):e51116. PMID: 23300534.
      Citations: 21     Fields:    Translation:HumansCells
    33. Lee E, Sidoryk-Wêgrzynowicz M, Wang N, Webb A, Son DS, Lee K, Aschner M. GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes. J Biol Chem. 2012 Aug 03; 287(32):26817-28. PMID: 22645130.
      Citations: 33     Fields:    Translation:AnimalsCells
    34. Lee E, Sidoryk-Wegrzynowicz M, Yin Z, Webb A, Son DS, Aschner M. Transforming growth factor-a mediates estrogen-induced upregulation of glutamate transporter GLT-1 in rat primary astrocytes. Glia. 2012 Jul; 60(7):1024-36. PMID: 22488924.
      Citations: 25     Fields:    Translation:AnimalsCells
    35. Son DS, Wilson AJ, Parl AK, Khabele D. The effects of the histone deacetylase inhibitor romidepsin (FK228) are enhanced by aspirin (ASA) in COX-1 positive ovarian cancer cells through augmentation of p21. . 2010 Jun 01; 9(11):928-35. PMID: 20404564.
      Citations:    
    36. Son DS, Terranova PF, Roby KF. Interaction of adenosine 3',5'-cyclic monophosphate and tumor necrosis factor-alpha on serum amyloid A3 expression in mouse granulosa cells: dependence on CCAAT-enhancing binding protein-beta isoform. Endocrinology. 2010 Jul; 151(7):3407-19. PMID: 20444945.
      Citations: 7     Fields:    Translation:AnimalsCells
    37. Lyshchik A, Hobbs SB, Fleischer AC, Khabele D, Son DS, Gore JC, Price RR. Ovarian volume measurements in mice with high-resolution ultrasonography. J Ultrasound Med. 2007 Oct; 26(10):1419-25. PMID: 17901144.
      Citations: 3     Fields:    Translation:Animals
    38. Son DS, Parl AK, Rice VM, Khabele D. Keratinocyte chemoattractant (KC)/human growth-regulated oncogene (GRO) chemokines and pro-inflammatory chemokine networks in mouse and human ovarian epithelial cancer cells. . 2007 Aug; 6(8):1302-12. PMID: 17712227.
      Citations:    
    39. Khabele D, Son DS, Parl AK, Goldberg GL, Augenlicht LH, Mariadason JM, Rice VM. Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy. . 2007 May; 6(5):795-801. PMID: 17387270.
      Citations:    
    40. Son DS, Roby KF. Interleukin-1alpha-induced chemokines in mouse granulosa cells: impact on keratinocyte chemoattractant chemokine, a CXC subfamily. Mol Endocrinol. 2006 Nov; 20(11):2999-3013. PMID: 16825293.
      Citations: 10     Fields:    Translation:AnimalsCells
    41. Roby KF, Son DS, Taylor CC, Montgomery-Rice V, Kirchoff J, Tang S, Terranova PF. Alterations in reproductive function in SRC tyrosine kinase knockout mice. Endocrine. 2005 Mar; 26(2):169-76. PMID: 15888929.
      Citations: 7     Fields:    Translation:Animals
    42. Son DS, Roby KF, Terranova PF. Tumor necrosis factor-alpha induces serum amyloid A3 in mouse granulosa cells. Endocrinology. 2004 May; 145(5):2245-52. PMID: 14749357.
      Citations: 14     Fields:    Translation:AnimalsCells
    43. Williams SR, Son DS, Terranova PF. Protein kinase C delta is activated in mouse ovarian surface epithelial cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicology. 2004 Jan 15; 195(1):1-17. PMID: 14698564.
      Citations: 3     Fields:    Translation:AnimalsCells
    44. Son DS, Arai KY, Roby KF, Terranova PF. Tumor necrosis factor alpha (TNF) increases granulosa cell proliferation: dependence on c-Jun and TNF receptor type 1. Endocrinology. 2004 Mar; 145(3):1218-26. PMID: 14617571.
      Citations: 10     Fields:    Translation:AnimalsCells
    45. Son DS, Roby KF, Rozman KK, Terranova PF. Estradiol enhances and estriol inhibits the expression of CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a mouse ovarian cancer cell line. Toxicology. 2002 Jul 15; 176(3):229-43. PMID: 12093619.
      Citations: 2     Fields:    Translation:AnimalsCells
    46. Son DS, Rozman KK. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces plasminogen activator inhibitor-1 through an aryl hydrocarbon receptor-mediated pathway in mouse hepatoma cell lines. Arch Toxicol. 2002 Jul; 76(7):404-13. PMID: 12111005.
      Citations: 11     Fields:    Translation:AnimalsCells
    47. Mizuyachi K, Son DS, Rozman KK, Terranova PF. Alteration in ovarian gene expression in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin: reduction of cyclooxygenase-2 in the blockage of ovulation. Reprod Toxicol. 2002 May-Jun; 16(3):299-307. PMID: 12128104.
      Citations: 14     Fields:    Translation:AnimalsCells
    48. Petroff BK, Gao X, Ohshima K, Shi F, Son DS, Roby KF, Rozman KK, Watanabe G, Taya K, Terranova PF. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on serum inhibin concentrations and inhibin immunostaining during follicular development in female Sprague-Dawley rats. Reprod Toxicol. 2002 Mar-Apr; 16(2):97-105. PMID: 11955940.
      Citations: 1     Fields:    Translation:Animals
    49. Kuroha M, Son DS, Shimoda M. Effects of altered plasma alpha-1-acid glycoprotein levels on pharmacokinetics of some basic antibiotics in pigs: simulation analysis. J Vet Pharmacol Ther. 2001 Dec; 24(6):423-31. PMID: 11903873.
      Citations: 2     Fields:    Translation:AnimalsCells
    50. Son DS, Ikenoue N, Tagawa Y, Shimoda M, Kokue E. Non-linear pharmacokinetics of ofloxacin after a single intravenous bolus dose in pigs. J Vet Pharmacol Ther. 2000 Oct; 23(5):311-5. PMID: 11107005.
      Citations:    Fields:    Translation:Animals
    51. Roby KF, Son DS, Terranova PF. Alterations of events related to ovarian function in tumor necrosis factor receptor type I knockout mice. Biol Reprod. 1999 Dec; 61(6):1616-21. PMID: 10570011.
      Citations: 11     Fields:    Translation:Animals
    52. Son DS, Ushinohama K, Gao X, Taylor CC, Roby KF, Rozman KK, Terranova PF. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) blocks ovulation by a direct action on the ovary without alteration of ovarian steroidogenesis: lack of a direct effect on ovarian granulosa and thecal-interstitial cell steroidogenesis in vitro. Reprod Toxicol. 1999 Nov-Dec; 13(6):521-30. PMID: 10613400.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    53. Son DS, Osabe M, Shimoda M, Kokue E. Contribution of alpha 1-acid glycoprotein to species difference in lincosamides-plasma protein binding kinetics. J Vet Pharmacol Ther. 1998 Feb; 21(1):34-40. PMID: 9507455.
      Citations: 3     Fields:    Translation:HumansAnimals
    54. Shimoda M, Okamoto K, Sikazwe G, Fujii C, Son DS. Deacetylation as a determinant of sulphonamide pharmacokinetics in pigs. Vet Q. 1997 Nov; 19(4):186-91. PMID: 9413118.
      Citations: 1     Fields:    Translation:AnimalsCells
    55. Son DS, Hariya S, Shimoda M, Kokue E. Contribution of alpha 1-acid glycoprotein to plasma protein binding of some basic antimicrobials in pigs. J Vet Pharmacol Ther. 1996 Jun; 19(3):176-83. PMID: 8803875.
      Citations: 4     Fields:    Translation:AnimalsCells
    56. Son DS, Shimoda M, Kokve E. Implication of altered levels of plasma alpha(1)-acid glycoprotein and its derived sialic acid on plasma protein binding of trimethoprim in pigs in physiological and pathological states. Vet Q. 1996 Mar; 18(1):10-3. PMID: 8833605.
      Citations: 2     Fields:    Translation:AnimalsCells
    57. Kinoshita T, Son DS, Shimoda M, Kokue E. Impact of age-related alteration of plasma alpha 1-acid glycoprotein concentration on erythromycin pharmacokinetics in pigs. Am J Vet Res. 1995 Mar; 56(3):362-5. PMID: 7771705.
      Citations: 1     Fields:    Translation:AnimalsCells
    58. Tagawa Y, Kokue E, Shimoda M, Son DS. Alpha 1-acid glycoprotein-binding as a factor in age-related changes in the pharmacokinetics of trimethoprim in piglets. Vet Q. 1994 Mar; 16(1):13-7. PMID: 8009812.
      Citations: 1     Fields:    Translation:AnimalsCells
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