RCMI Coordinating Center (RCMI CC) Header Logo

Jamaine Davis

Faculty RankAssistant Professor
InstitutionMeharry Medical College
DepartmentBiochem, Cancer Biology, Neuroscience & Pharmacology
Address1005 Dr. DB Todd Blvd
2007 West Basic Sciences Bldg
Nashville TN 37208
vCardDownload vCard
    Other Positions
    InstitutionVanderbilt University
    DepartmentCenter for Structural Biology

    Collapse Biography 
    Collapse awards and honors
    2007Cancer Research Training Award Postdoctoral Fellow, National Cancer Institute, Center for
    2009New Investigators Scholarship, International AIDS Society/ National Institutes of Health
    2010Black Rose Award Service & Leadership in Education, Sigma Gamma Rho Sorority, Inc
    2015Keystone Symposia Fellow, Keystone Symposia on Molecular and Cellular Biology
    2015Faculty Research Education & Development Fellow, American Society for Cell Biology

    Collapse Overview 
    Collapse overview
    My lab is one of the few in the world that directly links deep-sequencing to structural biology in an effort to advance discoveries in precision medicine. Our approach uses interdisciplinary techniques to elucidate mechanisms of genomic maintenance and regulation in diseases, such as cancer. Our challenge is to understand how genomic and proteomic variations affect health, disease and drug response. To address this, we seek to define protein-protein interaction networks in patient data and model these observations in cell systems to determine the best course of therapy. Our aim is to determine the three-dimensional structural details of dynamic protein assemblies known to influence tumorigenesis. This understanding is crucial for more effective detection, treatment and prevention of disease. As a postdoctoral scholar at the National Cancer Institute, I discovered a novel truncation product of the DNA damage mediator protein, Pax transactivation domain-interacting protein (PTIP/PAXIP1), which has an important role in preserving genomic stability and is essential for cell survival following DNA damage. I have worked on the structural characterization of PTIP constructs and have obtained protein crystals that deteriorate due to radiation damage. I have been the sole person responsible for moving this project forward, which has affected my publication record. As an Early Stage Investigator, I have the experience and resources necessary to successfully carry out the proposed work. My laboratory’s work extends on the discovery of this PTIP neoform to further our understanding how DNA damage mediator proteins work together to protect the cellular genome. Currently, we are characterizing the changes in the levels of DNA damage mediator proteins across breast cancer subtypes. Our central hypothesis is that the expression levels of DNA damage mediators, like PTIP, are important indicators of the cells DNA repair capacity and ultimately tumorigenesis. Our future plans will include characterizing the proteinprotein interactions that mediate the assembly of functional DNA repair complexes.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bhaumik P, Davis J, Tropea JE, Cherry S, Johnson PF, Miller M. Structural insights into interactions of C/EBP transcriptional activators with the Taz2 domain of p300. Acta Crystallogr D Biol Crystallogr. 2014 Jul; 70(Pt 7):1914-21. PMID: 25004968.
      Citations: 11     Fields:    Translation:Cells
    2. Davis J, Wang J, Tropea JE, Zhang D, Dauter Z, Waugh DS, Wlodawer A. Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri. Protein Sci. 2008 Dec; 17(12):2167-73. PMID: 18787201.
      Citations: 9     Fields:    Translation:Cells
    3. Uppsten M, Davis J, Rubin H, Uhlin U. Crystal structure of the biologically active form of class Ib ribonucleotide reductase small subunit from Mycobacterium tuberculosis. FEBS Lett. 2004 Jul 02; 569(1-3):117-22. PMID: 15225619.
      Citations: 9     Fields:    Translation:Cells
    4. He S, Bauman D, Davis JS, Loyola A, Nishioka K, Gronlund JL, Reinberg D, Meng F, Kelleher N, McCafferty DG. Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12033-8. PMID: 14530408.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    Davis's Networks
    Click the
    buttons for more information and interactive visualizations!
    Concepts (33)
    Similar People (60)
    Same Department Expand Description
    RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

    For technical support please contact support