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Jamaine Davis

Faculty RankAssistant Professor
InstitutionMeharry Medical College
DepartmentBiochem, Cancer Biology, Neuroscience & Pharmacology
Address1005 Dr. DB Todd Blvd
2007 West Basic Sciences Bldg
Nashville TN 37208
ORCID ORCID Icon0000-0002-5078-1306 Additional info
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    Other Positions
    InstitutionVanderbilt University
    DepartmentCenter for Structural Biology

    Collapse Biography 
    Collapse awards and honors
    2007Cancer Research Training Award Postdoctoral Fellow, National Cancer Institute, Center for
    2009New Investigators Scholarship, International AIDS Society/ National Institutes of Health
    2010Black Rose Award Service & Leadership in Education, Sigma Gamma Rho Sorority, Inc
    2015Keystone Symposia Fellow, Keystone Symposia on Molecular and Cellular Biology
    2015Faculty Research Education & Development Fellow, American Society for Cell Biology

    Collapse Overview 
    Collapse overview
    My lab is one of the few in the world that directly links deep-sequencing to structural biology in an effort to advance discoveries in precision medicine. Our approach uses interdisciplinary techniques to elucidate mechanisms of genomic maintenance and regulation in diseases, such as cancer. Our challenge is to understand how genomic and proteomic variations affect health, disease and drug response. To address this, we seek to define protein-protein interaction networks in patient data and model these observations in cell systems to determine the best course of therapy. Our aim is to determine the three-dimensional structural details of dynamic protein assemblies known to influence tumorigenesis. This understanding is crucial for more effective detection, treatment and prevention of disease. As a postdoctoral scholar at the National Cancer Institute, I discovered a novel truncation product of the DNA damage mediator protein, Pax transactivation domain-interacting protein (PTIP/PAXIP1), which has an important role in preserving genomic stability and is essential for cell survival following DNA damage. I have worked on the structural characterization of PTIP constructs and have obtained protein crystals that deteriorate due to radiation damage. I have been the sole person responsible for moving this project forward, which has affected my publication record. As an Early Stage Investigator, I have the experience and resources necessary to successfully carry out the proposed work. My laboratory’s work extends on the discovery of this PTIP neoform to further our understanding how DNA damage mediator proteins work together to protect the cellular genome. Currently, we are characterizing the changes in the levels of DNA damage mediator proteins across breast cancer subtypes. Our central hypothesis is that the expression levels of DNA damage mediators, like PTIP, are important indicators of the cells DNA repair capacity and ultimately tumorigenesis. Our future plans will include characterizing the proteinprotein interactions that mediate the assembly of functional DNA repair complexes.

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stewart EC, Davis JS, Walters TS, Chen Z, Miller ST, Duke JM, Alexander LR, Akohoue SA, Russell R, Rowan N, Campbell L, Baxter I, Tolbert S, Erves JC. Development of strategies for community engaged research dissemination by basic scientists: a case study. Transl Res. 2022 Sep 13. PMID: 36108910.
    2. Cunningham-Erves J, Brandt HM, Sanderson M, Clarkson K, Lee O, Schlundt D, Bonnet K, Davis J. Development of a Theory-Based, Culturally Appropriate Message Library for Use in Interventions to Promote COVID-19 Vaccination Among African Americans: Formative Research. JMIR Form Res. 2022 Jul 28; 6(7):e38781. PMID: 35781223.
    3. Cunningham-Erves J, Parham I, Alexander L, Moss J, Barre I, Gillyard T, Davis J. African Americans and the COVID-19 pandemic: A qualitative inquiry of preparedness, challenges, and strategies on how we can move forward. Soc Sci Med. 2022 Aug; 307:115185. PMID: 35793594.
    4. Kas-Osoka C, Moss J, Alexander L, Davis J, Parham I, Barre I, Cunningham-Erves J. African Americans views of COVID-19 contact tracing and testing. Am J Infect Control. 2022 May; 50(5):577-580. PMID: 35263614.
    5. Gillyard T, Davis J, Parham I, Moss J, Barre I, Alexander L, Cunningham-Erves J. Psychosocial Stressors and Coping Strategies Among African Americans During Early Stages of the COVID-19 Pandemic: a Qualitative Study. J Racial Ethn Health Disparities. 2022 Jan 24; 1-14. PMID: 35072945.
    6. Murray SA, Davis J, Shuler HD, Spencer EC, Hinton A. Time management for STEMM students during the continuing pandemic. Trends Biochem Sci. 2022 Apr; 47(4):279-283. PMID: 35027254.
    7. Stepler KE, Gillyard TR, Reed CB, Avery TM, Davis JS, Robinson RAS. ABCA7, a Genetic Risk Factor Associated with Alzheimer's Disease Risk in African Americans. J Alzheimers Dis. 2022; 86(1):5-19. PMID: 35034901.
    8. Cunningham-Erves J, Stewart EC, Duke J, Alexander L, Davis J, Wilus D, Wyche-Etheridge K, Miller ST. Use of Community Listening Sessions to Disseminate Research Findings to Past Participants and Communities. J Community Health. 2021 Oct 08. PMID: 34625863.
      Citations:    Fields:    Translation:Humans
    9. Tripathi A, Singha UK, Cooley A, Gillyard T, Krystofiak E, Pratap S, Davis J, Chaudhuri M. Trypanosoma brucei Tim50 Possesses PAP Activity and Plays a Critical Role in Cell Cycle Regulation and Parasite Infectivity. mBio. 2021 Oct 26; 12(5):e0159221. PMID: 34517757.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Gillyard T, Davis J. DNA double-strand break repair in cancer: A path to achieving precision medicine. Int Rev Cell Mol Biol. 2021; 364:111-137. PMID: 34507781.
    11. Gibbs T, Washington MK, Eng C, Idrees K, Davis J, Holowatyj AN. Histologic and Racial/Ethnic Patterns of Appendiceal Cancer among Young Patients. Cancer Epidemiol Biomarkers Prev. 2021 Jun; 30(6):1149-1155. PMID: 33795212.
    12. Termini CM, Hinton AO, Garza-López E, Koomoa DL, Davis JS, Martínez-Montemayor MM. Building Diverse Mentoring Networks that Transcend Boundaries in Cancer Research. Trends Cancer. 2021 May; 7(5):385-388. PMID: 33563577.
    13. McIntosh DJ, Walters TS, Arinze IJ, Davis J. Arkadia (RING Finger Protein 111) Mediates Sumoylation-Dependent Stabilization of Nrf2 Through K48-Linked Ubiquitination. Cell Physiol Biochem. 2018; 46(1):418-430. PMID: 29597191.
      Citations: 9     Fields:    Translation:HumansCells
    14. Bhaumik P, Davis J, Tropea JE, Cherry S, Johnson PF, Miller M. Structural insights into interactions of C/EBP transcriptional activators with the Taz2 domain of p300. Acta Crystallogr D Biol Crystallogr. 2014 Jul; 70(Pt 7):1914-21. PMID: 25004968.
      Citations: 13     Fields:    Translation:Cells
    15. Davis J, Wang J, Tropea JE, Zhang D, Dauter Z, Waugh DS, Wlodawer A. Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri. Protein Sci. 2008 Dec; 17(12):2167-73. PMID: 18787201.
      Citations: 9     Fields:    Translation:Cells
    16. Uppsten M, Davis J, Rubin H, Uhlin U. Crystal structure of the biologically active form of class Ib ribonucleotide reductase small subunit from Mycobacterium tuberculosis. FEBS Lett. 2004 Jul 02; 569(1-3):117-22. PMID: 15225619.
      Citations: 9     Fields:    Translation:Cells
    17. He S, Bauman D, Davis JS, Loyola A, Nishioka K, Gronlund JL, Reinberg D, Meng F, Kelleher N, McCafferty DG. Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12033-8. PMID: 14530408.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
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    RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

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