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Minu Chaudhuri

TitlePhD
Faculty RankProfessor
InstitutionMeharry Medical College
DepartmentMicrobiology, Immunology and Microbiology, Immunology, & Physiology
AddressNashville TN 37208
Phone6153275726
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    T32AI007281     (CHAUDHURI, MINU)Jun 25, 1985 - Jun 30, 2026
    NIH
    Molecular Microbial Pathogenesis Training Program
    Role: Principal Investigator
    K01HL003839     (CHAUDHURI, MINU)Jun 1, 1998 - May 31, 2004
    NIH
    MITOCHONDRIAL PROTEIN IMPORT IN AFRICAN TRYPANOSOMES
    Role: Principal Investigator
    SC1GM081146     (CHAUDHURI, MINU)Aug 1, 2007 - Aug 31, 2016
    NIH
    Mitochondrial inner membrane protein translocase in Trypanosoma brucei
    Role: Principal Investigator
    R01AI125662     (CHAUDHURI, MINU)Jun 22, 2016 - May 31, 2021
    NIH
    Structure and function of the Trypanosome TIM complex
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nes WD, Chaudhuri M, Leaver DJ. Druggable Sterol Metabolizing Enzymes in Infectious Diseases: Cell Targets to Therapeutic Leads. Biomolecules. 2024 Feb 20; 14(3). PMID: 38540670.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Qui?ones LS, Gonzalez FS, Darden C, Khan M, Tripathi A, Smith JT, Davis J, Misra S, Chaudhuri M. Unique Interactions of the Small Translocases of the Mitochondrial Inner Membrane (Tims) in Trypanosoma brucei. Int J Mol Sci. 2024 Jan 24; 25(3). PMID: 38338692.
      Citations:    Fields:    Translation:AnimalsCells
    3. Darden C, Donkor JE, Korolkova O, Barozai MYK, Chaudhuri M. Distinct structural motifs are necessary for targeting and import of Tim17 in Trypanosoma brucei mitochondrion. mSphere. 2024 Jan 30; 9(1):e0055823. PMID: 38193679.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Darden C, Donkor J, Korolkova O, Khan Barozai MY, Chaudhuri M. Distinct structural motifs are necessary for targeting and import of Tim17 in Trypanosoma brucei mitochondrion. bioRxiv. 2023 Jul 07. PMID: 37461662.
      Citations:    
    5. Qui?ones Guill?n LS, Gonzalez FS, Darden C, Khan M, Tripathi A, Smith JT, Cooley A, Paromov V, Davis J, Misra S, Chaudhuri M. Unique interactions and functions of the mitochondrial small Tims in Trypanosoma brucei. bioRxiv. 2023 May 31. PMID: 37398442.
      Citations:    
    6. Soto-Gonzalez F, Tripathi A, Cooley A, Paromov V, Rana T, Chaudhuri M. A novel connection between Trypanosoma brucei mitochondrial proteins TbTim17 and TbTRAP1 is discovered using Biotinylation Identification (BioID). J Biol Chem. 2022 12; 298(12):102647. PMID: 36309084.
      Citations: 2     Fields:    Translation:AnimalsCells
    7. Chaudhuri M, Tripathi A, Gonzalez FS. Correction: Chaudhuri et al. Diverse Functions of Tim50, a Component of the Mitochondrial Inner Membrane Protein Translocase. Int. J. Mol. Sci. 2021, 22, 7779. Int J Mol Sci. 2022 Jul 06; 23(14). PMID: 35887402.
      Citations:    Fields:    
    8. Chaudhuri M, Singha UK, Vanderloop BH, Tripathi A, Nes WD. Steroidal Antimetabolites Protect Mice against Trypanosoma brucei. Molecules. 2022 Jun 25; 27(13). PMID: 35807334.
      Citations: 2     Fields:    Translation:HumansAnimals
    9. Tripathi A, Singha UK, Cooley A, Gillyard T, Krystofiak E, Pratap S, Davis J, Chaudhuri M. Trypanosoma brucei Tim50 Possesses PAP Activity and Plays a Critical Role in Cell Cycle Regulation and Parasite Infectivity. mBio. 2021 10 26; 12(5):e0159221. PMID: 34517757.
      Citations: 3     Fields:    Translation:AnimalsCells
    10. Chaudhuri M, Tripathi A, Gonzalez FS. Diverse Functions of Tim50, a Component of the Mitochondrial Inner Membrane Protein Translocase. Int J Mol Sci. 2021 Jul 21; 22(15). PMID: 34360547.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    11. Chaudhuri M, Darden C, Gonzalez FS, Singha UK, Quinones L, Tripathi A. Tim17 Updates: A Comprehensive Review of an Ancient Mitochondrial Protein Translocator. Biomolecules. 2020 12 07; 10(12). PMID: 33297490.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    12. Singha UK, Tripathi A, Smith JT, Quinones L, Saha A, Singha T, Chaudhuri M. Novel IM-associated protein Tim54 plays a role in the mitochondrial import of internal signal-containing proteins in Trypanosoma brucei. Biol Cell. 2021 Jan; 113(1):39-57. PMID: 33084070.
      Citations: 5     Fields:    Translation:AnimalsCells
    13. Barozai MYK, Chaudhuri M. Role of the translocase of the mitochondrial inner membrane in the import of tRNAs into mitochondria in Trypanosoma brucei. Gene. 2020 Jul 20; 748:144705. PMID: 32339625.
      Citations: 5     Fields:    Translation:AnimalsCells
    14. Ellison M, Mittal M, Chaudhuri M, Chaudhuri G, Misra S. The role of the redox/miR-6855-3p/PRDX5A axis in reversing SLUG-mediated BRCA2 silencing in breast cancer cells. Cell Commun Signal. 2020 Jan 27; 18(1):15. PMID: 31987042.
      Citations: 2     Fields:    Translation:HumansCells
    15. Tripathi A, Singha UK, Paromov V, Hill S, Pratap S, Rose K, Chaudhuri M. Erratum for Tripathi et al., "The Cross Talk between TbTim50 and PIP39, Two Aspartate-Based Protein Phosphatases, Maintains Cellular Homeostasis in Trypanosoma brucei". mSphere. 2019 Sep 04; 4(5). PMID: 31484745.
      Citations:    Fields:    
    16. Tripathi A, Singha UK, Paromov V, Hill S, Pratap S, Rose K, Chaudhuri M. The Cross Talk between TbTim50 and PIP39, Two Aspartate-Based Protein Phosphatases, Maintains Cellular Homeostasis in Trypanosoma brucei. mSphere. 2019 08 07; 4(4). PMID: 31391278.
      Citations: 4     Fields:    Translation:AnimalsCells
    17. Zhou W, Ramos E, Zhu X, Fisher PM, Kidane ME, Vanderloop BH, Thomas CD, Yan J, Singha U, Chaudhuri M, Nagel MT, Nes WD. Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications. J Lipid Res. 2019 05; 60(5):981-994. PMID: 30709898.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    18. Zhou W, Debnath A, Jennings G, Hahn HJ, Vanderloop BH, Chaudhuri M, Nes WD, Podust LM. Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri. PLoS Pathog. 2018 09; 14(9):e1007245. PMID: 30212566.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    19. Smith JT, Singha UK, Misra S, Chaudhuri M. Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei. mSphere. 2018 06 27; 3(3). PMID: 29925672.
      Citations: 12     Fields:    Translation:AnimalsCells
    20. Kidane ME, Vanderloop BH, Zhou W, Thomas CD, Ramos E, Singha U, Chaudhuri M, Nes WD. Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design. J Lipid Res. 2017 12; 58(12):2310-2323. PMID: 29042405.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    21. Weems E, Singha UK, Smith JT, Chaudhuri M. The divergent N-terminal domain of Tim17 is critical for its assembly in the TIM complex in Trypanosoma brucei. Mol Biochem Parasitol. 2017 12; 218:4-15. PMID: 28965880.
      Citations: 4     Fields:    Translation:AnimalsCells
    22. Miller MB, Patkar P, Singha UK, Chaudhuri M, David Nes W. 24-Methylenecyclopropane steroidal inhibitors: A Trojan horse in ergosterol biosynthesis that prevents growth of Trypanosoma brucei. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Mar; 1862(3):305-313. PMID: 27939999.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    23. Leaver DJ, Patkar P, Singha UK, Miller MB, Haubrich BA, Chaudhuri M, Nes WD. Fluorinated Sterols Are Suicide Inhibitors of Ergosterol Biosynthesis and Growth in Trypanosoma brucei. Chem Biol. 2015 Oct 22; 22(10):1374-83. PMID: 26496686.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    24. Singha UK, Hamilton V, Chaudhuri M. Tim62, a Novel Mitochondrial Protein in Trypanosoma brucei, Is Essential for Assembly and Stability of the TbTim17 Protein Complex. J Biol Chem. 2015 Sep 18; 290(38):23226-39. PMID: 26240144.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    25. Fullerton M, Singha UK, Duncan M, Chaudhuri M. Down regulation of Tim50 in Trypanosoma brucei increases tolerance to oxidative stress. Mol Biochem Parasitol. 2015 Jan-Feb; 199(1-2):9-18. PMID: 25791316.
      Citations: 10     Fields:    Translation:AnimalsCells
    26. Weems E, Singha UK, Hamilton V, Smith JT, Waegemann K, Mokranjac D, Chaudhuri M. Functional complementation analyses reveal that the single PRAT family protein of trypanosoma brucei is a divergent homolog of Tim17 in saccharomyces cerevisiae. Eukaryot Cell. 2015 Mar; 14(3):286-96. PMID: 25576485.
      Citations: 11     Fields:    Translation:AnimalsCells
    27. Haubrich BA, Singha UK, Miller MB, Nes CR, Anyatonwu H, Lecordier L, Patkar P, Leaver DJ, Villalta F, Vanhollebeke B, Chaudhuri M, Nes WD. Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth. J Lipid Res. 2015 Feb; 56(2):331-41. PMID: 25424002.
      Citations: 16     Fields:    Translation:Animals
    28. Hamilton V, Singha UK, Smith JT, Weems E, Chaudhuri M. Trypanosome alternative oxidase possesses both an N-terminal and internal mitochondrial targeting signal. Eukaryot Cell. 2014 Apr; 13(4):539-47. PMID: 24562910.
      Citations: 8     Fields:    Translation:AnimalsCells
    29. Duncan MR, Fullerton M, Chaudhuri M. Tim50 in Trypanosoma brucei possesses a dual specificity phosphatase activity and is critical for mitochondrial protein import. J Biol Chem. 2013 Feb 01; 288(5):3184-97. PMID: 23212919.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    30. Nes CR, Singha UK, Liu J, Ganapathy K, Villalta F, Waterman MR, Lepesheva GI, Chaudhuri M, Nes WD. Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms. Biochem J. 2012 Apr 01; 443(1):267-77. PMID: 22176028.
      Citations: 28     Fields:    Translation:AnimalsCells
    31. Singha UK, Hamilton V, Duncan MR, Weems E, Tripathi MK, Chaudhuri M. Protein translocase of mitochondrial inner membrane in Trypanosoma brucei. J Biol Chem. 2012 Apr 27; 287(18):14480-93. PMID: 22408251.
      Citations: 28     Fields:    Translation:AnimalsCells
    32. Hall M, Misra S, Chaudhuri M, Chaudhuri G. Peptide aptamer mimicking RAD51-binding domain of BRCA2 inhibits DNA damage repair and survival in Trypanosoma brucei. Microb Pathog. 2011 May; 50(5):252-62. PMID: 21296653.
      Citations: 5     Fields:    Translation:AnimalsCells
    33. Sharma S, Singha UK, Chaudhuri M. Role of Tob55 on mitochondrial protein biogenesis in Trypanosoma brucei. Mol Biochem Parasitol. 2010 Dec; 174(2):89-100. PMID: 20659504.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    34. Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR. Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. J Biol Chem. 2010 Jan 15; 285(3):1773-80. PMID: 19923211.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    35. Singha UK, Sharma S, Chaudhuri M. Downregulation of mitochondrial porin inhibits cell growth and alters respiratory phenotype in Trypanosoma brucei. Eukaryot Cell. 2009 Sep; 8(9):1418-28. PMID: 19617393.
      Citations: 25     Fields:    Translation:AnimalsCells
    36. Singha UK, Peprah E, Williams S, Walker R, Saha L, Chaudhuri M. Characterization of the mitochondrial inner membrane protein translocator Tim17 from Trypanosoma brucei. Mol Biochem Parasitol. 2008 May; 159(1):30-43. PMID: 18325611.
      Citations: 34     Fields:    Translation:AnimalsCells
    37. Jones C, Anderson S, Singha UK, Chaudhuri M. Protein phosphatase 5 is required for Hsp90 function during proteotoxic stresses in Trypanosoma brucei. Parasitol Res. 2008 Apr; 102(5):835-44. PMID: 18193284.
      Citations: 12     Fields:    Translation:AnimalsCells
    38. Williams S, Saha L, Singha UK, Chaudhuri M. Trypanosoma brucei: differential requirement of membrane potential for import of proteins into mitochondria in two developmental stages. Exp Parasitol. 2008 Mar; 118(3):420-33. PMID: 18021773.
      Citations: 14     Fields:    Translation:AnimalsCells
    39. Anderson S, Jones C, Saha L, Chaudhuri M. Functional characterization of the serine/threonine protein phosphatase 5 from Trypanosoma brucei. J Parasitol. 2006 Dec; 92(6):1152-61. PMID: 17304789.
      Citations: 5     Fields:    Translation:Animals
    40. Ott R, Chibale K, Anderson S, Chipeleme A, Chaudhuri M, Guerrah A, Colowick N, Hill GC. Novel inhibitors of the trypanosome alternative oxidase inhibit Trypanosoma brucei brucei growth and respiration. Acta Trop. 2006 Dec; 100(3):172-84. PMID: 17126803.
      Citations: 10     Fields:    Translation:AnimalsCells
    41. Chaudhuri M, Ott RD, Hill GC. Trypanosome alternative oxidase: from molecule to function. Trends Parasitol. 2006 Oct; 22(10):484-91. PMID: 16920028.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    42. Misra S, Bennett J, Friew YN, Abdulghani J, Irvin-Wilson CV, Tripathi MK, Williams S, Chaudhuri M, Chaudhuri G. A type II ribonuclease H from Leishmania mitochondria: an enzyme essential for the growth of the parasite. Mol Biochem Parasitol. 2005 Oct; 143(2):135-45. PMID: 15978682.
      Citations: 5     Fields:    Translation:AnimalsCells
    43. Chaudhuri M, Ott RD, Saha L, Williams S, Hill GC. The trypanosome alternative oxidase exists as a monomer in Trypanosoma brucei mitochondria. Parasitol Res. 2005 Jun; 96(3):178-83. PMID: 15864649.
      Citations: 3     Fields:    Translation:AnimalsCells
    44. Walker R, Saha L, Hill GC, Chaudhuri M. The effect of over-expression of the alternative oxidase in the procyclic forms of Trypanosoma brucei. Mol Biochem Parasitol. 2005 Feb; 139(2):153-62. PMID: 15664650.
      Citations: 6     Fields:    Translation:AnimalsCells
    45. Roberts CW, Roberts F, Henriquez FL, Akiyoshi D, Samuel BU, Richards TA, Milhous W, Kyle D, McIntosh L, Hill GC, Chaudhuri M, Tzipori S, McLeod R. Evidence for mitochondrial-derived alternative oxidase in the apicomplexan parasite Cryptosporidium parvum: a potential anti-microbial agent target. Int J Parasitol. 2004 Mar 09; 34(3):297-308. PMID: 15003491.
      Citations: 28     Fields:    Translation:AnimalsCells
    46. Chaudhuri M, Nargang FE. Import and assembly of Neurospora crassa Tom40 into mitochondria of Trypanosoma brucei in vivo. Curr Genet. 2003 Nov; 44(2):85-94. PMID: 12898181.
      Citations: 7     Fields:    Translation:AnimalsCells
    47. Chaudhuri M, Sharan R, Hill GC. Trypanosome alternative oxidase is regulated post-transcriptionally at the level of RNA stability. J Eukaryot Microbiol. 2002 Jul-Aug; 49(4):263-9. PMID: 12188215.
      Citations: 8     Fields:    Translation:AnimalsCells
    48. Ajayi WU, Chaudhuri M, Hill GC. Site-directed mutagenesis reveals the essentiality of the conserved residues in the putative diiron active site of the trypanosome alternative oxidase. J Biol Chem. 2002 Mar 08; 277(10):8187-93. PMID: 11751873.
      Citations: 10     Fields:    Translation:AnimalsCells
    49. Chaudhuri M. Cloning and characterization of a novel serine/threonine protein phosphatase type 5 from Trypanosoma brucei. Gene. 2001 Mar 21; 266(1-2):1-13. PMID: 11290414.
      Citations: 27     Fields:    Translation:AnimalsCells
    50. Chaudhuri M, Ajayi W, Hill GC. Biochemical and molecular properties of the Trypanosoma brucei alternative oxidase. Mol Biochem Parasitol. 1998 Sep 01; 95(1):53-68. PMID: 9763289.
      Citations: 37     Fields:    Translation:AnimalsCells
    51. Chaudhuri M, Hill GC. Cloning, sequencing, and functional activity of the Trypanosoma brucei brucei alternative oxidase. Mol Biochem Parasitol. 1996 Dec 02; 83(1):125-9. PMID: 9010848.
      Citations: 14     Fields:    Translation:AnimalsCells
    52. Chaudhuri M, Ajayi W, Temple S, Hill GC. Identification and partial purification of a stage-specific 33 kDa mitochondrial protein as the alternative oxidase of the Trypanosoma brucei brucei bloodstream trypomastigotes. J Eukaryot Microbiol. 1995 Sep-Oct; 42(5):467-72. PMID: 7581322.
      Citations: 12     Fields:    Translation:AnimalsCells
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