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Joshua Rosenthal

TitleAltissimo Rey de los Calamares
InstitutionUniversity of Puerto Rico
DepartmentInstitute of Neurobiology
AddressInstitute of Neurobiology
201 Blvd. del Valle
San Juan PR 00901
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    Dr. Joshua Rosenthal is an assistant professor at the Institute of Neurobiogy, part of the University of Puerto Rico’s Medical Sciences Campus. His research focuses on the process of RNA editing and how it recodes key molecules in the nervous system. Current projects look at how editing changes the properties of ion pumps and voltage-dependent ion channels and examine how the editing enzymes themselves target their mRNA substrates.

    Dr. Rosenthal received a bachelor’s degree in biology from Haverford College. He received a Ph.D. in Biology from Stanford University with Dr. William Gilly as a mentor. He then went on to complete postdoctoral training at UCLA with Dr. Francisco Bezanilla.

    He has over twenty publications in scientific journals and has been supported by both the National Institute of Health and the National Science Foundation. Dr. Rosenthal’s research has been conducted at diverse sites including Chile, California, Venezuela, Baja California, Newfoundland, Scotland, the Svalbard archipelago and Antarctica.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Crawford K, Diaz Quiroz JF, Koenig KM, Ahuja N, Albertin CB, Rosenthal JJC. Highly Efficient Knockout of a Squid Pigmentation Gene. Curr Biol. 2020 Jul 26. PMID: 32735817.
      Citations:    Fields:    
    2. Vallecillo-Viejo IC, Liscovitch-Brauer N, Diaz Quiroz JF, Montiel-Gonzalez MF, Nemes SE, Rangan KJ, Levinson SR, Eisenberg E, Rosenthal JJC. Spatially regulated editing of genetic information within a neuron. Nucleic Acids Res. 2020 05 07; 48(8):3999-4012. PMID: 32201888.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Gilly WF, Renken C, Rosenthal JJC, Kier WM. Specialization for rapid excitation in fast squid tentacle muscle involves action potentials absent in slow arm muscle. J Exp Biol. 2020 02 12; 223(Pt 3). PMID: 31900349.
      Citations:    Fields:    
    4. Mansour TA, Rosenthal JJC, Brown CT, Roberson LM. Correction to: Transcriptome of the caribbean stony coral Porites astreoides from three developmental stages. Gigascience. 2019 11 01; 8(11). PMID: 31730696.
      Citations:    Fields:    
    5. Geffeney SL, Williams BL, Rosenthal JJC, Birk MA, Felkins J, Wisell CM, Curry ER, Hanifin CT. Convergent and parallel evolution in a voltage-gated sodium channel underlies TTX-resistance in the Greater Blue-ringed Octopus: Hapalochlaena lunulata. Toxicon. 2019 Dec; 170:77-84. PMID: 31550451.
      Citations:    Fields:    Translation:Animals
    6. Messerli MA, Raihan MJ, Kobylkevich BM, Benson AC, Bruening KS, Shribak M, Rosenthal JJC, Sohn JJ. Construction and Composition of the Squid Pen from Doryteuthis pealeii. Biol Bull. 2019 08; 237(1):1-15. PMID: 31441702.
      Citations:    Fields:    Translation:Animals
    7. Williams TL, Senft SL, Yeo J, Martín-Martínez FJ, Kuzirian AM, Martin CA, DiBona CW, Chen CT, Dinneen SR, Nguyen HT, Gomes CM, Rosenthal JJC, MacManes MD, Chu F, Buehler MJ, Hanlon RT, Deravi LF. Dynamic pigmentary and structural coloration within cephalopod chromatophore organs. Nat Commun. 2019 03 01; 10(1):1004. PMID: 30824708.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Montiel-Gonzalez MF, Diaz Quiroz JF, Rosenthal JJC. Current strategies for Site-Directed RNA Editing using ADARs. Methods. 2019 03 01; 156:16-24. PMID: 30502398.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. Quinn A, Bruce N, Puzzolo E, Dickinson K, Sturke R, Jack DW, Mehta S, Shankar A, Sherr K, Rosenthal J. An analysis of efforts to scale up clean household energy for cooking around the world. Energy Sustain Dev. 2018 Oct; 46:1-10. PMID: 30886466.
      Citations:    
    10. Vallecillo-Viejo IC, Liscovitch-Brauer N, Montiel-Gonzalez MF, Eisenberg E, Rosenthal JJC. Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme. RNA Biol. 2018 01 02; 15(1):104-114. PMID: 29099293.
      Citations: 4     Fields:    Translation:HumansCells
    11. Porath HT, Schaffer AA, Kaniewska P, Alon S, Eisenberg E, Rosenthal J, Levanon EY, Levy O. A-to-I RNA Editing in the Earliest-Diverging Eumetazoan Phyla. Mol Biol Evol. 2017 08 01; 34(8):1890-1901. PMID: 28453786.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    12. Liscovitch-Brauer N, Alon S, Porath HT, Elstein B, Unger R, Ziv T, Admon A, Levanon EY, Rosenthal JJC, Eisenberg E. Trade-off between Transcriptome Plasticity and Genome Evolution in Cephalopods. Cell. 2017 04 06; 169(2):191-202.e11. PMID: 28388405.
      Citations: 36     Fields:    Translation:AnimalsCells
    13. Ferrick-Kiddie EA, Rosenthal JJ, Ayers GD, Emeson RB. Mutations underlying Episodic Ataxia type-1 antagonize Kv1.1 RNA editing. Sci Rep. 2017 02 20; 7:41095. PMID: 28216637.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    14. Rosenthal J, Balakrishnan K, Bruce N, Chambers D, Graham J, Jack D, Kline L, Masera O, Mehta S, Mercado IR, Neta G, Pattanayak S, Puzzolo E, Petach H, Punturieri A, Rubinstein A, Sage M, Sturke R, Shankar A, Sherr K, Smith K, Yadama G. Implementation Science to Accelerate Clean Cooking for Public Health. Environ Health Perspect. 2017 01 01; 125(1):A3-A7. PMID: 28055947.
      Citations: 14     Fields:    Translation:HumansPHPublic Health
    15. Montiel-González MF, Vallecillo-Viejo IC, Rosenthal JJ. An efficient system for selectively altering genetic information within mRNAs. Nucleic Acids Res. 2016 12 01; 44(21):e157. PMID: 27557710.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    16. Mansour TA, Rosenthal JJ, Brown CT, Roberson LM. Transcriptome of the Caribbean stony coral Porites astreoides from three developmental stages. Gigascience. 2016 08 02; 5(1):33. PMID: 27485233.
      Citations: 1     Fields:    Translation:Animals
    17. Stanley CM, Gagnon DG, Bernal A, Meyer DJ, Rosenthal JJ, Artigas P. Importance of the Voltage Dependence of Cardiac Na/K ATPase Isozymes. Biophys J. 2015 Nov 03; 109(9):1852-62. PMID: 26536262.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    18. Rosenthal JJ. The emerging role of RNA editing in plasticity. J Exp Biol. 2015 Jun; 218(Pt 12):1812-21. PMID: 26085659.
      Citations: 18     Fields:    Translation:AnimalsCells
    19. Rosenthal J. The real challenge for cookstoves and health: more evidence. Ecohealth. 2015 Mar; 12(1):8-11. PMID: 25691140.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    20. Alon S, Garrett SC, Levanon EY, Olson S, Graveley BR, Rosenthal JJ, Eisenberg E. The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing. Elife. 2015 Jan 08; 4. PMID: 25569156.
      Citations: 33     Fields:    Translation:AnimalsCells
    21. Holmgren M, Rosenthal JJ. Regulation of Ion Channel and Transporter Function Through RNA Editing. Curr Issues Mol Biol. 2015; 17:23-36. PMID: 25347917.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    22. Montiel-Gonzalez MF, Vallecillo-Viejo I, Yudowski GA, Rosenthal JJ. Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18285-90. PMID: 24108353.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    23. Garrett SC, Rosenthal JJ. A role for A-to-I RNA editing in temperature adaptation. Physiology (Bethesda). 2012 Dec; 27(6):362-9. PMID: 23223630.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    24. Albertin CB, Bonnaud L, Brown CT, Crookes-Goodson WJ, da Fonseca RR, Di Cristo C, Dilkes BP, Edsinger-Gonzales E, Freeman RM, Hanlon RT, Koenig KM, Lindgren AR, Martindale MQ, Minx P, Moroz LL, Nödl MT, Nyholm SV, Ogura A, Pungor JR, Rosenthal JJ, Schwarz EM, Shigeno S, Strugnell JM, Wollesen T, Zhang G, Ragsdale CW. Cephalopod genomics: A plan of strategies and organization. Stand Genomic Sci. 2012 Oct 10; 7(1):175-88. PMID: 23451296.
      Citations:    
    25. Dymowska AK, Manfredi T, Rosenthal JJ, Seibel BA. Temperature compensation of aerobic capacity and performance in the Antarctic pteropod, Clione antarctica, compared with its northern congener, C. limacina. J Exp Biol. 2012 Oct 01; 215(Pt 19):3370-8. PMID: 22693034.
      Citations: 2     Fields:    Translation:AnimalsCells
    26. Rosenthal JJ, Seeburg PH. A-to-I RNA editing: effects on proteins key to neural excitability. Neuron. 2012 May 10; 74(3):432-9. PMID: 22578495.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    27. Palavicini JP, Correa-Rojas RA, Rosenthal JJ. Extra double-stranded RNA binding domain (dsRBD) in a squid RNA editing enzyme confers resistance to high salt environment. J Biol Chem. 2012 May 18; 287(21):17754-64. PMID: 22457361.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    28. Garrett S, Rosenthal JJ. RNA editing underlies temperature adaptation in K+ channels from polar octopuses. Science. 2012 Feb 17; 335(6070):848-51. PMID: 22223739.
      Citations: 55     Fields:    Translation:AnimalsCells
    29. Castillo JP, De Giorgis D, Basilio D, Gadsby DC, Rosenthal JJ, Latorre R, Holmgren M, Bezanilla F. Energy landscape of the reactions governing the Na+ deeply occluded state of the Na+/K+-ATPase in the giant axon of the Humboldt squid. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20556-61. PMID: 22143771.
      Citations: 7     Fields:    Translation:AnimalsCells
    30. Gonzalez C, Lopez-Rodriguez A, Srikumar D, Rosenthal JJ, Holmgren M. Editing of human K(V)1.1 channel mRNAs disrupts binding of the N-terminus tip at the intracellular cavity. Nat Commun. 2011 Aug 16; 2:436. PMID: 21847110.
      Citations: 17     Fields:    Translation:HumansCells
    31. Galarza-Muñoz G, Soto-Morales SI, Holmgren M, Rosenthal JJ. Physiological adaptation of an Antarctic Na+/K+-ATPase to the cold. J Exp Biol. 2011 Jul 01; 214(Pt 13):2164-74. PMID: 21653810.
      Citations: 7     Fields:    Translation:AnimalsCells
    32. Keegan LP, McGurk L, Palavicini JP, Brindle J, Paro S, Li X, Rosenthal JJ, O'Connell MA. Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects. Nucleic Acids Res. 2011 Sep 01; 39(16):7249-62. PMID: 21622951.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    33. Colina C, Palavicini JP, Srikumar D, Holmgren M, Rosenthal JJ. Regulation of Na+/K+ ATPase transport velocity by RNA editing. PLoS Biol. 2010 Nov 23; 8(11):e1000540. PMID: 21124885.
      Citations: 16     Fields:    Translation:AnimalsCells
    34. Reyes-Colón D, Vázquez-Acevedo N, Rivera NM, Jezzini SH, Rosenthal J, Ruiz-Rodríguez EA, Baro DJ, Kohn AB, Moroz LL, Sosa MA. Cloning and distribution of a putative octopamine/tyramine receptor in the central nervous system of the freshwater prawn Macrobrachium rosenbergii. Brain Res. 2010 Aug 12; 1348:42-54. PMID: 20558147.
      Citations: 5     Fields:    Translation:AnimalsCells
    35. Rosenthal J. Climate change and the geographic distribution of infectious diseases. Ecohealth. 2009 Dec; 6(4):489-95. PMID: 20499130.
      Citations: 18     Fields:    Translation:HumansAnimalsPHPublic Health
    36. Palavicini JP, O'Connell MA, Rosenthal JJ. An extra double-stranded RNA binding domain confers high activity to a squid RNA editing enzyme. RNA. 2009 Jun; 15(6):1208-18. PMID: 19390115.
      Citations: 16     Fields:    Translation:AnimalsCells
    37. Vázquez-Acevedo N, Reyes-Colón D, Ruíz-Rodríguez EA, Rivera NM, Rosenthal J, Kohn AB, Moroz LL, Sosa MA. Cloning and immunoreactivity of the 5-HT 1Mac and 5-HT 2Mac receptors in the central nervous system of the freshwater prawn Macrobrachium rosenbergii. J Comp Neurol. 2009 Apr 01; 513(4):399-416. PMID: 19184976.
      Citations: 4     Fields:    Translation:AnimalsCells
    38. Rosenthal JJ, Seibel BA, Dymowska A, Bezanilla F. Trade-off between aerobic capacity and locomotor capability in an Antarctic pteropod. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6192-6. PMID: 19325127.
      Citations: 3     Fields:    Translation:AnimalsCells
    39. Seibel BA, Dymowska A, Rosenthal J. Metabolic temperature compensation and coevolution of locomotory performance in pteropod molluscs. Integr Comp Biol. 2007 Dec; 47(6):880-91. PMID: 21669767.
      Citations: 7     Fields:    
    40. Colina C, Rosenthal JJ, DeGiorgis JA, Srikumar D, Iruku N, Holmgren M. Structural basis of Na(+)/K(+)-ATPase adaptation to marine environments. Nat Struct Mol Biol. 2007 May; 14(5):427-31. PMID: 17460695.
      Citations: 16     Fields:    Translation:Animals
    41. Keegan LP, Rosenthal JJ, Roberson LM, O'Connell MA. Purification and assay of ADAR activity. Methods Enzymol. 2007; 424:301-17. PMID: 17662847.
      Citations: 6     Fields:    Translation:AnimalsCells
    42. Roberson LM, Rosenthal JJ. An accurate fluorescent assay for quantifying the extent of RNA editing. RNA. 2006 Oct; 12(10):1907-12. PMID: 16957279.
      Citations: 10     Fields:    Translation:AnimalsCells
    43. Soto I, Rosenthal JJ, Blagburn JM, Blanco RE. Fibroblast growth factor 2 applied to the optic nerve after axotomy up-regulates BDNF and TrkB in ganglion cells by activating the ERK and PKA signaling pathways. J Neurochem. 2006 Jan; 96(1):82-96. PMID: 16269011.
      Citations: 21     Fields:    Translation:AnimalsCells
    44. Bhalla T, Rosenthal JJ, Holmgren M, Reenan R. Control of human potassium channel inactivation by editing of a small mRNA hairpin. Nat Struct Mol Biol. 2004 Oct; 11(10):950-6. PMID: 15361858.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    45. Rosenthal JJ, Gilly WF. Identified ion channels in the squid nervous system. Neurosignals. 2003 May-Jun; 12(3):126-41. PMID: 12904686.
      Citations: 4     Fields:    Translation:AnimalsCells
    46. Rosenthal JJ, Bezanilla F. A comparison of propagated action potentials from tropical and temperate squid axons: different durations and conduction velocities correlate with ionic conductance levels. J Exp Biol. 2002 Jun; 205(Pt 12):1819-30. PMID: 12042340.
      Citations: 14     Fields:    Translation:AnimalsCells
    47. Rosenthal JJ, Bezanilla F. Extensive editing of mRNAs for the squid delayed rectifier K+ channel regulates subunit tetramerization. Neuron. 2002 May 30; 34(5):743-57. PMID: 12062021.
      Citations: 31     Fields:    Translation:AnimalsCells
    48. Liu TI, Lebaric ZN, Rosenthal JJ, Gilly WF. Natural substitutions at highly conserved T1-domain residues perturb processing and functional expression of squid Kv1 channels. J Neurophysiol. 2001 Jan; 85(1):61-71. PMID: 11152706.
      Citations: 8     Fields:    Translation:AnimalsCells
    49. Rosenthal JJ, Bezanilla F. Seasonal variation in conduction velocity of action potentials in squid giant axons. Biol Bull. 2000 Oct; 199(2):135-43. PMID: 11081712.
      Citations: 8     Fields:    Translation:AnimalsCells
    50. Rosenthal JJ, Liu TI, Gilly WF. A family of delayed rectifier Kv1 cDNAs showing cell type-specific expression in the squid stellate ganglion/giant fiber lobe complex. J Neurosci. 1997 Jul 01; 17(13):5070-9. PMID: 9185544.
      Citations: 4     Fields:    Translation:AnimalsCells
    51. Mathes C, Rosenthal JJ, Armstrong GM, Gilly WF. Fast inactivation of delayed rectifier K conductance in squid giant axon and its cell bodies. J Gen Physiol. 1997 Apr; 109(4):435-48. PMID: 9101403.
      Citations: 3     Fields:    Translation:AnimalsCells
    52. Rosenthal JJ, Vickery RG, Gilly WF. Molecular identification of SqKv1A. A candidate for the delayed rectifier K channel in squid giant axon. J Gen Physiol. 1996 Sep; 108(3):207-19. PMID: 8882864.
      Citations: 13     Fields:    Translation:AnimalsCells
    53. Rosenthal JJ, Gilly WF. Amino acid sequence of a putative sodium channel expressed in the giant axon of the squid Loligo opalescens. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):10026-30. PMID: 8234251.
      Citations: 8     Fields:    Translation:AnimalsCells
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