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Peter R. Hoffmann, PhD

Faculty RankProfessor
InstitutionUniversity of Hawaii
DepartmentCell and Molecular Biology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Langenbucher A, Hoffmann P, Cayless A, Wendelstein J, Szentm?ry N. Limitations of constant optimization with disclosed intraocular lens power formulae. J Cataract Refract Surg. 2024 Mar 01; 50(3):201-208. PMID: 37847110.
      Citations:    Fields:    Translation:Humans
    2. Brampton C, Pomozi V, Le Corre Y, Zoll J, Kauffenstein G, Ma C, Hoffmann PR, Martin L, Le Saux O. Bone Marrow-Derived ABCC6 Is an Essential Regulator of Ectopic Calcification In PXE. J Invest Dermatol. 2024 Feb 15. PMID: 38367909.
      Citations:    Fields:    
    3. Ma C, Hoffmann FW, Shay AE, Koo I, Green KA, Green WR, Hoffmann PR. Upregulated Selenoprotein I during LPS-induced B cell activation promotes lipidomic changes and is required for effective differentiation into IgM secreting plasma B cells. J Leukoc Biol. 2024 Jan 30. PMID: 38289835.
      Citations:    Fields:    
    4. Sukjoi W, Young C, Acland M, Siritutsoontorn S, Roytrakul S, Klingler-Hoffmann M, Hoffmann P, Jitrapakdee S. Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism. Front Mol Biosci. 2023; 10:1250423. PMID: 38283944.
    5. Nunes LGA, Cain A, Comyns C, Hoffmann PR, Krahn N. Deciphering the Role of Selenoprotein M. Antioxidants (Basel). 2023 Oct 25; 12(11). PMID: 38001759.
    6. Sebastian S, Hoffmann MK, Howard D, Young C, Washington J, Unterweger H, Alexiou C, Turnbull T, D'Andrea R, Hoffmann P, Kempson I. Kinetic Effects of Transferrin-Conjugated Gold Nanoparticles on the Antioxidant Glutathione-Thioredoxin Pathway. Antioxidants (Basel). 2023 Aug 15; 12(8). PMID: 37627612.
    7. Morosky P, Comyns C, Nunes LGA, Chung CZ, Hoffmann PR, S?ll D, Vargas-Rodriguez O, Krahn N. Dual incorporation of non-canonical amino acids enables production of post-translationally modified selenoproteins. Front Mol Biosci. 2023; 10:1096261. PMID: 36762212.
    8. Diamond AM, Hoffmann PR. Advances in the biology of selenium and selenoproteins. Arch Biochem Biophys. 2023 02; 735:109514. PMID: 36609072.
      Citations:    Fields:    
    9. Nunes LGA, Pitts MW, Hoffmann PR. Selenoprotein I (selenoi) as a critical enzyme in the central nervous system. Arch Biochem Biophys. 2022 10 30; 729:109376. PMID: 36007576.
      Citations: 2     Fields:    Translation:HumansAnimals
    10. Ma C, Hoffmann FW, Nunes LG, Urena F, Andrukhiv A, Gerschenson M, Pitts MW, Hoffmann PR. Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology. J Leukoc Biol. 2022 12; 112(6):1387-1397. PMID: 35916034.
      Citations:    Fields:    Translation:AnimalsCells
    11. Cai Z, Zhang Y, Zhang W, Ye J, Ling Q, Xing Z, Zhang S, Hoffmann PR, Liu Y, Yang W, Huang Z. Arsenic retention in erythrocytes and excessive erythrophagocytosis is related to low selenium status by impaired redox homeostasis. Redox Biol. 2022 06; 52:102321. PMID: 35500533.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    12. Donnellan L, Young C, Simpson BS, Dhillon VS, Costabile M, Hoffmann P, Fenech M, Deo P. Methylglyoxal Impairs Sister Chromatid Separation in Lymphocytes. Int J Mol Sci. 2022 Apr 08; 23(8). PMID: 35456956.
      Citations: 1     Fields:    Translation:HumansCells
    13. Donnellan L, Young C, Simpson BS, Acland M, Dhillon VS, Costabile M, Fenech M, Hoffmann P, Deo P. Proteomic Analysis of Methylglyoxal Modifications Reveals Susceptibility of Glycolytic Enzymes to Dicarbonyl Stress. Int J Mol Sci. 2022 Mar 28; 23(7). PMID: 35409048.
      Citations: 6     Fields:    Translation:Cells
    14. Urena F, Ma C, Hoffmann FW, Nunes LGA, Urschitz J, Moisyadi S, Khadka VS, Deng Y, Hoffmann PR. T-cell activation decreases miRNA-15a/16 levels to promote MEK1-ERK1/2-Elk1 signaling and proliferative capacity. J Biol Chem. 2022 03; 298(3):101634. PMID: 35085550.
      Citations: 2     Fields:    Translation:AnimalsCells
    15. Pitts MW, Hoffmann PR, Schomburg L. Editorial: Selenium and Selenoproteins in Brain Development, Function, and Disease. Front Neurosci. 2021; 15:821140. PMID: 35095409.
    16. Ma C, Martinez-Rodriguez V, Hoffmann PR. Roles for Selenoprotein I and Ethanolamine Phospholipid Synthesis in T Cell Activation. Int J Mol Sci. 2021 Oct 16; 22(20). PMID: 34681834.
      Citations: 6     Fields:    Translation:HumansCells
    17. Jia SZ, Xu XW, Zhang ZH, Chen C, Chen YB, Huang SL, Liu Q, Hoffmann PR, Song GL. Selenoprotein K deficiency-induced apoptosis: A role for calpain and the ERS pathway. Redox Biol. 2021 11; 47:102154. PMID: 34601426.
      Citations: 16     Fields:    Translation:AnimalsCells
    18. Bastow CR, Bunting MD, Kara EE, McKenzie DR, Caon A, Devi S, Tolley L, Mueller SN, Frazer IH, Harvey N, Condina MR, Young C, Hoffmann P, McColl SR, Comerford I. Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration. Proc Natl Acad Sci U S A. 2021 04 27; 118(17). PMID: 33875601.
      Citations: 12     Fields:    Translation:AnimalsCells
    19. Ma C, Hoffmann FW, Marciel MP, Page KE, Williams-Aduja MA, Akana ENL, Gojanovich GS, Gerschenson M, Urschitz J, Moisyadi S, Khadka VS, Rozovsky S, Deng Y, Horgen FD, Hoffmann PR. Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation. Mol Metab. 2021 05; 47:101170. PMID: 33484950.
      Citations: 10     Fields:    Translation:AnimalsCells
    20. Ma C, Hoffmann PR. Selenoproteins as regulators of T cell proliferation, differentiation, and metabolism. Semin Cell Dev Biol. 2021 07; 115:54-61. PMID: 33214077.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    21. Lee YR, Briggs MT, Condina MR, Puddy H, Anderson PH, Hoffmann P, Kuliwaba JS. Mass Spectrometry Imaging as a Potential Tool to Investigate Human Osteoarthritis at the Tissue Level. Int J Mol Sci. 2020 Sep 03; 21(17). PMID: 32899238.
      Citations: 4     Fields:    Translation:Humans
    22. Lorthiois E, Roache J, Barnes-Seeman D, Altmann E, Hassiepen U, Turner G, Duvadie R, Hornak V, Karki RG, Schiering N, Weihofen WA, Perruccio F, Calhoun A, Fazal T, Dedic D, Durand C, Dussauge S, Fettis K, Tritsch F, Dentel C, Druet A, Liu D, Kirman L, Lachal J, Namoto K, Bevan D, Mo R, Monnet G, Muller L, Zessis R, Huang X, Lindsley L, Currie T, Chiu YH, Fridrich C, Delgado P, Wang S, Hollis-Symynkywicz M, Berghausen J, Williams E, Liu H, Liang G, Kim H, Hoffmann P, Hein A, Ramage P, D'Arcy A, Harlfinger S, Renatus M, Ruedisser S, Feldman D, Elliott J, Sedrani R, Maibaum J, Adams CM. Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach. J Med Chem. 2020 08 13; 63(15):8088-8113. PMID: 32551603.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    23. Zhang ZH, Chen C, Jia SZ, Cao XC, Liu M, Tian J, Hoffmann PR, Xu HX, Ni JZ, Song GL. Selenium Restores Synaptic Deficits by Modulating NMDA Receptors and Selenoprotein K in an Alzheimer's Disease Model. Antioxid Redox Signal. 2021 10 10; 35(11):863-884. PMID: 32475153.
      Citations: 12     Fields:    Translation:AnimalsCells
    24. Avery JC, Yamazaki Y, Hoffmann FW, Folgelgren B, Hoffmann PR. Selenoprotein I is essential for murine embryogenesis. Arch Biochem Biophys. 2020 08 15; 689:108444. PMID: 32502470.
      Citations: 11     Fields:    Translation:Animals
    25. Cai Z, Dong L, Song C, Zhang Y, Zhu C, Zhang Y, Ling Q, Hoffmann PR, Li J, Huang Z, Li W. Author Correction: Methylseleninic Acid Provided at Nutritional Selenium Levels Inhibits Angiogenesis by Down-regulating Integrin ?3 Signaling. Sci Rep. 2020 Mar 24; 10(1):5673. PMID: 32214221.
      Citations: 1     Fields:    
    26. Schoenefuss F, Hoffmann P. Serum ?-globulin and albumin concentrations predict secondary loss of response to anti-TNFa in inflammatory bowel disease patients. Eur J Gastroenterol Hepatol. 2019 Dec; 31(12):1563-1568. PMID: 31567711.
      Citations: 6     Fields:    Translation:Humans
    27. Klingler-Hoffmann M, Mittal P, Hoffmann P. The Emerging Role of Cytoskeletal Proteins as Reliable Biomarkers. Proteomics. 2019 11; 19(21-22):e1800483. PMID: 31525818.
      Citations: 5     Fields:    Translation:HumansCells
    28. Hoffmann PR, Hoffmann FW, Premeaux TA, Fujita T, Soprana E, Panigada M, Chew GM, Richard G, Hindocha P, Menor M, Khadka VS, Deng Y, Moise L, Ndhlovu LC, Siccardi A, Weinberg AD, De Groot AS, Bertino P. Multi-antigen Vaccination With Simultaneous Engagement of the OX40 Receptor Delays Malignant Mesothelioma Growth and Increases Survival in Animal Models. Front Oncol. 2019; 9:720. PMID: 31428586.
    29. Cai Z, Zhang Y, Zhang Y, Miao X, Li S, Yang H, Ling Q, Hoffmann PR, Huang Z. Use of a Mouse Model and Human Umbilical Vein Endothelial Cells to Investigate the Effect of Arsenic Exposure on Vascular Endothelial Function and the Associated Role of Calpains. Environ Health Perspect. 2019 07; 127(7):77003. PMID: 31274337.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    30. Marciel MP, Hoffmann PR. Molecular Mechanisms by Which Selenoprotein K Regulates Immunity and Cancer. Biol Trace Elem Res. 2019 Nov; 192(1):60-68. PMID: 31187393.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    31. Bertino P, Premeaux TA, Fujita T, Haun BK, Marciel MP, Hoffmann FW, Garcia A, Yiang H, Pastorino S, Carbone M, Niki T, Berestecky J, Hoffmann PR, Ndhlovu LC. Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion. Oncoimmunology. 2019; 8(8):1601482. PMID: 31413910.
      Citations: 11     Fields:    
    32. Li YQ, Ngo A, Hoffmann P, Ferrante A, Hii CS. Regulation of endothelial cell survival and death by the MAP kinase/ERK kinase kinase 3 - glyceraldehyde-3-phosphate dehydrogenase signaling axis. Cell Signal. 2019 06; 58:20-33. PMID: 30831195.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    33. Zolekar A, Lin VJT, Mishra NM, Ho YY, Hayatshahi HS, Parab A, Sampat R, Liao X, Hoffmann P, Liu J, Emmitte KA, Wang YC. Stress and interferon signalling-mediated apoptosis contributes to pleiotropic anticancer responses induced by targeting NGLY1. Br J Cancer. 2018 12; 119(12):1538-1551. PMID: 30385822.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    34. Avery JC, Hoffmann PR. Selenium, Selenoproteins, and Immunity. Nutrients. 2018 Sep 01; 10(9). PMID: 30200430.
      Citations: 260     Fields:    Translation:HumansAnimalsCells
    35. Marciel MP, Khadka VS, Deng Y, Kilicaslan P, Pham A, Bertino P, Lee K, Chen S, Glibetic N, Hoffmann FW, Matter ML, Hoffmann PR. Correction: Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget. 2018 07 20; 9(56):30937. PMID: 30112120.
      Citations: 2     Fields:    
    36. Marciel MP, Khadka VS, Deng Y, Kilicaslan P, Pham A, Bertino P, Lee K, Chen S, Glibetic N, Hoffmann FW, Matter ML, Hoffmann PR. Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget. 2018 03 02; 9(17):13407-13422. PMID: 29568366.
      Citations: 14     Fields:    
    37. Fredericks GJ, Hoffmann FW, Hondal RJ, Rozovsky S, Urschitz J, Hoffmann PR. Selenoprotein K Increases Efficiency of DHHC6 Catalyzed Protein Palmitoylation by Stabilizing the Acyl-DHHC6 Intermediate. Antioxidants (Basel). 2017 Dec 29; 7(1). PMID: 29286308.
    38. Marciel MP, Rose AH, Martinez V, Horio DT, Hashimoto AS, Hoffmann FW, Bertino P, Hoffmann PR. Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. Cancer Med. 2018 01; 7(1):175-183. PMID: 29210197.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    39. Marciel MP, Hoffmann PR. Selenoproteins and Metastasis. Adv Cancer Res. 2017; 136:85-108. PMID: 29054423.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    40. Cai Z, Dong L, Song C, Zhang Y, Zhu C, Zhang Y, Ling Q, Hoffmann PR, Li J, Huang Z, Li W. Methylseleninic Acid Provided at Nutritional Selenium Levels Inhibits Angiogenesis by Down-regulating Integrin ?3 Signaling. Sci Rep. 2017 08 25; 7(1):9445. PMID: 28842587.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    41. Pitts MW, Hoffmann PR. Endoplasmic reticulum-resident selenoproteins as regulators of calcium signaling and homeostasis. Cell Calcium. 2018 03; 70:76-86. PMID: 28506443.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    42. Ng YS, Sorvina A, Bader CA, Weiland F, Lopez AF, Hoffmann P, Shandala T, Brooks DA. Proteome Analysis of Drosophila Mutants Identifies a Regulatory Role for 14-3-3e in Metabolic Pathways. J Proteome Res. 2017 05 05; 16(5):1976-1987. PMID: 28365999.
      Citations: 1     Fields:    Translation:Animals
    43. Ricciardelli C, Lokman NA, Pyragius CE, Ween MP, Macpherson AM, Ruszkiewicz A, Hoffmann P, Oehler MK. Keratin 5 overexpression is associated with serous ovarian cancer recurrence and chemotherapy resistance. Oncotarget. 2017 Mar 14; 8(11):17819-17832. PMID: 28147318.
      Citations: 28     Fields:    Translation:HumansCells
    44. Zhu C, Zhang S, Song C, Zhang Y, Ling Q, Hoffmann PR, Li J, Chen T, Zheng W, Huang Z. Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-?B mediated hyper inflammation. J Nanobiotechnology. 2017 Mar 07; 15(1):20. PMID: 28270147.
      Citations: 50     Fields:    Translation:Animals
    45. Zhang ZH, Wu QY, Zheng R, Chen C, Chen Y, Liu Q, Hoffmann PR, Ni JZ, Song GL. Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model. J Neurosci. 2017 03 01; 37(9):2449-2462. PMID: 28137967.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    46. Mittal P, Klingler-Hoffmann M, Arentz G, Winderbaum L, Kaur G, Anderson L, Scurry J, Leung Y, Stewart CJ, Carter J, Hoffmann P, Oehler MK. Annexin A2 and alpha actinin 4 expression correlates with metastatic potential of primary endometrial cancer. Biochim Biophys Acta Proteins Proteom. 2017 Jul; 1865(7):846-857. PMID: 27784647.
      Citations: 12     Fields:    Translation:HumansCells
    47. Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovic M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y. Selenoprotein Gene Nomenclature. J Biol Chem. 2016 Nov 11; 291(46):24036-24040. PMID: 27645994.
      Citations: 104     Fields:    Translation:Humans
    48. Norton RL, Fredericks GJ, Huang Z, Fay JD, Hoffmann FW, Hoffmann PR. Selenoprotein K regulation of palmitoylation and calpain cleavage of ASAP2 is required for efficient Fc?R-mediated phagocytosis. J Leukoc Biol. 2017 02; 101(2):439-448. PMID: 27601625.
      Citations: 22     Fields:    Translation:AnimalsCells
    49. Yamada K, Park HM, Rigel DF, DiPetrillo K, Whalen EJ, Anisowicz A, Beil M, Berstler J, Brocklehurst CE, Burdick DA, Caplan SL, Capparelli MP, Chen G, Chen W, Dale B, Deng L, Fu F, Hamamatsu N, Harasaki K, Herr T, Hoffmann P, Hu QY, Huang WJ, Idamakanti N, Imase H, Iwaki Y, Jain M, Jeyaseelan J, Kato M, Kaushik VK, Kohls D, Kunjathoor V, LaSala D, Lee J, Liu J, Luo Y, Ma F, Mo R, Mowbray S, Mogi M, Ossola F, Pandey P, Patel SJ, Raghavan S, Salem B, Shanado YH, Trakshel GM, Turner G, Wakai H, Wang C, Weldon S, Wielicki JB, Xie X, Xu L, Yagi YI, Yasoshima K, Yin J, Yowe D, Zhang JH, Zheng G, Monovich L. Small-molecule WNK inhibition regulates cardiovascular and renal function. Nat Chem Biol. 2016 Nov; 12(11):896-898. PMID: 27595330.
      Citations: 59     Fields:    Translation:HumansAnimals
    50. Zhong W, Yi Q, Xu B, Li S, Wang T, Liu F, Zhu B, Hoffmann PR, Ji G, Lei P, Li G, Li J, Li J, Olkkonen VM, Yan D. ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival. Nat Commun. 2016 09 01; 7:12702. PMID: 27581363.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    51. Zhang ZH, Chen C, Wu QY, Zheng R, Liu Q, Ni JZ, Hoffmann PR, Song GL. Selenomethionine reduces the deposition of beta-amyloid plaques by modulating ?-secretase and enhancing selenoenzymatic activity in a mouse model of Alzheimer's disease. Metallomics. 2016 08 01; 8(8):782-9. PMID: 27465436.
      Citations: 13     Fields:    Translation:AnimalsCells
    52. Zhang C, Arentz G, Winderbaum L, Lokman NA, Klingler-Hoffmann M, Mittal P, Carter C, Oehler MK, Hoffmann P. MALDI Mass Spectrometry Imaging Reveals Decreased CK5 Levels in Vulvar Squamous Cell Carcinomas Compared to the Precursor Lesion Differentiated Vulvar Intraepithelial Neoplasia. Int J Mol Sci. 2016 Jul 08; 17(7). PMID: 27399691.
      Citations: 4     Fields:    Translation:Humans
    53. Zhu C, Ling Q, Cai Z, Wang Y, Zhang Y, Hoffmann PR, Zheng W, Zhou T, Huang Z. Selenium-Containing Phycocyanin from Se-Enriched Spirulina platensis Reduces Inflammation in Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-?B Activation. J Agric Food Chem. 2016 Jun 22; 64(24):5060-70. PMID: 27223481.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    54. Eyre NS, Hampton-Smith RJ, Aloia AL, Eddes JS, Simpson KJ, Hoffmann P, Beard MR. Phosphorylation of NS5A Serine-235 is essential to hepatitis C virus RNA replication and normal replication compartment formation. Virology. 2016 Apr; 491:27-44. PMID: 26874015.
      Citations: 19     Fields:    Translation:HumansCells
    55. Rose AH, Huang Z, Mafnas C, Hara JH, Hoffmann FW, Hashimoto AS, Bertino P, Hoffmann PR. Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer. Inflamm Bowel Dis. 2015 Sep; 21(9):2005-15. PMID: 26076056.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    56. Rose AH, Hoffmann FW, Hara JH, Urschitz J, Moisyadi S, Hoffmann PR, Bertino P. Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses. Hum Vaccin Immunother. 2015; 11(9):2305-11. PMID: 26091088.
      Citations: 4     Fields:    Translation:AnimalsCells
    57. Fredericks GJ, Hoffmann PR. Selenoprotein K and protein palmitoylation. Antioxid Redox Signal. 2015 Oct 01; 23(10):854-62. PMID: 26058750.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    58. Ricciardelli C, Lokman NA, Cheruvu S, Tan IA, Ween MP, Pyragius CE, Ruszkiewicz A, Hoffmann P, Oehler MK. Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation. Clin Exp Metastasis. 2015 Jun; 32(5):441-55. PMID: 25895698.
      Citations: 27     Fields:    Translation:HumansCells
    59. Berry MJ, Astern J, Bellinger F, Brampton C, Cann R, Gerschenson M, Haymer D, James NG, Jameson DM, LeSaux O, Hoffmann PR, Nichols R, Pitts M, Seale L, Seifried S, Stokes AJ, Todorovic C. Medical school hotline: the research mission of the cell and molecular biology department and program at the john a. Burns school of medicine. Hawaii J Med Public Health. 2015 Apr; 74(4):150-3. PMID: 25954603.
      Citations:    Fields:    Translation:Humans
    60. Turvey ME, Klingler-Hoffmann M, Hoffmann P, McColl SR. p84 forms a negative regulatory complex with p110? to control PI3K? signalling during cell migration. Immunol Cell Biol. 2015 Sep; 93(8):735-43. PMID: 25753393.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    61. Hoffmann PR, Panigada M, Soprana E, Terry F, Bandar IS, Napolitano A, Rose AH, Hoffmann FW, Ndhlovu LC, Belcaid M, Moise L, De Groot AS, Carbone M, Gaudino G, Matsui T, Siccardi A, Bertino P. Preclinical development of HIvax: Human survivin highly immunogenic vaccines. Hum Vaccin Immunother. 2015; 11(7):1585-95. PMID: 26042612.
      Citations: 10     Fields:    Translation:HumansCellsPHPublic Health
    62. Fredericks GJ, Hoffmann FW, Rose AH, Osterheld HJ, Hess FM, Mercier F, Hoffmann PR. Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16478-83. PMID: 25368151.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    63. Berry MJ, Cann R, Haymer D, Hoffmann P, Jameson D, LeSaux O, Nichols R, Seifried S, Stokes A, Todorovic C. Medical school hotline: The educational mission of the cell and molecular biology department and program at the John A. Burns School of Medicine. Hawaii J Med Public Health. 2014 Nov; 73(11):362-4. PMID: 25414807.
      Citations:    Fields:    Translation:Humans
    64. Rose AH, Hoffmann PR. Selenoproteins and cardiovascular stress. Thromb Haemost. 2015 Mar; 113(3):494-504. PMID: 25354851.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    65. Hughes PA, Moretta M, Lim A, Grasby DJ, Bird D, Brierley SM, Liebregts T, Adam B, Blackshaw LA, Holtmann G, Bampton P, Hoffmann P, Andrews JM, Zola H, Krumbiegel D. Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients. Brain Behav Immun. 2014 Nov; 42:191-203. PMID: 25063707.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    66. Turvey ME, Koudelka T, Comerford I, Greer JM, Carroll W, Bernard CC, Hoffmann P, McColl SR. Quantitative proteome profiling of CNS-infiltrating autoreactive CD4+ cells reveals selective changes during experimental autoimmune encephalomyelitis. J Proteome Res. 2014 Aug 01; 13(8):3655-70. PMID: 24933266.
      Citations: 9     Fields:    Translation:AnimalsCells
    67. Humphries JM, Penno MA, Weiland F, Klingler-Hoffmann M, Zuber A, Boussioutas A, Ernst M, Hoffmann P. Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer. Biochim Biophys Acta. 2014 May; 1844(5):1051-8. PMID: 24512919.
      Citations: 25     Fields:    Translation:HumansAnimals
    68. Bertino P, Urschitz J, Hoffmann FW, You BR, Rose AH, Park WH, Moisyadi S, Hoffmann PR. Vaccination with a piggyBac plasmid with transgene integration potential leads to sustained antigen expression and CD8(+) T cell responses. Vaccine. 2014 Mar 26; 32(15):1670-7. PMID: 24513010.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    69. Rose AH, Bertino P, Hoffmann FW, Gaudino G, Carbone M, Hoffmann PR. Increasing dietary selenium elevates reducing capacity and ERK activation associated with accelerated progression of select mesothelioma tumors. Am J Pathol. 2014 Apr; 184(4):1041-1049. PMID: 24492200.
      Citations: 9     Fields:    Translation:AnimalsCells
    70. Hoffmann P, Beckman D, McLean LA, Yan JH. Aliskiren toxicity in juvenile rats is determined by ontogenic regulation of intestinal P-glycoprotein expression. Toxicol Appl Pharmacol. 2014 Feb 15; 275(1):36-43. PMID: 24388840.
      Citations: 2     Fields:    Translation:AnimalsCells
    71. Youngren SR, Tekade RK, Gustilo B, Hoffmann PR, Chougule MB. STAT6 siRNA matrix-loaded gelatin nanocarriers: formulation, characterization, and ex vivo proof of concept using adenocarcinoma cells. Biomed Res Int. 2013; 2013:858946. PMID: 24191252.
      Citations: 9     Fields:    Translation:HumansCells
    72. Huang Z, Rose AH, Hoffmann FW, Hashimoto AS, Bertino P, Denk T, Takano J, Iwata N, Saido TC, Hoffmann PR. Calpastatin prevents NF-?B-mediated hyperactivation of macrophages and attenuates colitis. J Immunol. 2013 Oct 01; 191(7):3778-88. PMID: 23986533.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    73. Lee BC, P?terfi Z, Hoffmann FW, Moore RE, Kaya A, Avanesov A, Tarrago L, Zhou Y, Weerapana E, Fomenko DE, Hoffmann PR, Gladyshev VN. MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. Mol Cell. 2013 Aug 08; 51(3):397-404. PMID: 23911929.
      Citations: 111     Fields:    Translation:AnimalsCells
    74. Lokman NA, Elder AS, Ween MP, Pyragius CE, Hoffmann P, Oehler MK, Ricciardelli C. Annexin A2 is regulated by ovarian cancer-peritoneal cell interactions and promotes metastasis. Oncotarget. 2013 Aug; 4(8):1199-211. PMID: 23945256.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    75. Meiler S, Baumer Y, Huang Z, Hoffmann FW, Fredericks GJ, Rose AH, Norton RL, Hoffmann PR, Boisvert WA. Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis. J Leukoc Biol. 2013 May; 93(5):771-80. PMID: 23444136.
      Citations: 30     Fields:    Translation:AnimalsCells
    76. Bertino P, Panigada M, Soprana E, Bianchi V, Bertilaccio S, Sanvito F, Rose AH, Yang H, Gaudino G, Hoffmann PR, Siccardi A, Carbone M. Fowlpox-based survivin vaccination for malignant mesothelioma therapy. Int J Cancer. 2013 Aug 01; 133(3):612-23. PMID: 23335100.
      Citations: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    77. Niu M, Klingler-Hoffmann M, Brazzatti JA, Forbes B, Akekawatchai C, Hoffmann P, McColl SR. Comparative proteomic analysis implicates eEF2 as a novel target of PI3K? in the MDA-MB-231 metastatic breast cancer cell line. Proteome Sci. 2013 Jan 15; 11(1):4. PMID: 23320409.
    78. Weiland F, Martin K, Oehler MK, Hoffmann P. Deciphering the molecular nature of ovarian cancer biomarker CA125. Int J Mol Sci. 2012; 13(8):10568-10582. PMID: 22949880.
      Citations: 10     Fields:    Translation:HumansAnimals
    79. Weiland F, Fritz K, Oehler MK, Hoffmann P. Methods for identification of CA125 from ovarian cancer ascites by high resolution mass spectrometry. Int J Mol Sci. 2012; 13(8):9942-9958. PMID: 22949840.
      Citations: 13     Fields:    Translation:Humans
    80. Penno MA, Klingler-Hoffmann M, Brazzatti JA, Boussioutas A, Putoczki T, Ernst M, Hoffmann P. 2D-DIGE analysis of sera from transgenic mouse models reveals novel candidate protein biomarkers for human gastric cancer. J Proteomics. 2012 Dec 21; 77:40-58. PMID: 22789672.
      Citations: 9     Fields:    Translation:HumansAnimalsCTClinical Trials
    81. Huang Z, Rose AH, Hoffmann PR. The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2012 Apr 01; 16(7):705-43. PMID: 21955027.
      Citations: 283     Fields:    Translation:HumansAnimalsCells
    82. Huang Z, Hoffmann FW, Fay JD, Hashimoto AC, Chapagain ML, Kaufusi PH, Hoffmann PR. Stimulation of unprimed macrophages with immune complexes triggers a low output of nitric oxide by calcium-dependent neuronal nitric-oxide synthase. J Biol Chem. 2012 Feb 10; 287(7):4492-502. PMID: 22205701.
      Citations: 28     Fields:    Translation:AnimalsCells
    83. Norton RL, Hoffmann PR. Selenium and asthma. Mol Aspects Med. 2012 Feb; 33(1):98-106. PMID: 22024250.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    84. Huang Z, Hoffmann FW, Norton RL, Hashimoto AC, Hoffmann PR. Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages. J Biol Chem. 2011 Oct 07; 286(40):34830-8. PMID: 21849499.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    85. Hoffmann FW, Hashimoto AS, Lee BC, Rose AH, Shohet RV, Hoffmann PR. Specific antioxidant selenoproteins are induced in the heart during hypertrophy. Arch Biochem Biophys. 2011 Aug 01; 512(1):38-44. PMID: 21621505.
      Citations: 18     Fields:    Translation:AnimalsCells
    86. Hoffmann P, Sturm A, Stein J, Dignass AU. Interferon-? modulates intestinal epithelial cell function in-vitro through a TGF?-dependent mechanism. Regul Pept. 2011 Jun 07; 168(1-3):27-31. PMID: 21385594.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    87. Fung KY, Brierley GV, Henderson S, Hoffmann P, McColl SR, Lockett T, Head R, Cosgrove L. Butyrate-induced apoptosis in HCT116 colorectal cancer cells includes induction of a cell stress response. J Proteome Res. 2011 Apr 01; 10(4):1860-9. PMID: 21235278.
      Citations: 29     Fields:    Translation:HumansCells
    88. Gustafsson JO, Oehler MK, Ruszkiewicz A, McColl SR, Hoffmann P. MALDI Imaging Mass Spectrometry (MALDI-IMS)-application of spatial proteomics for ovarian cancer classification and diagnosis. Int J Mol Sci. 2011 Jan 21; 12(1):773-94. PMID: 21340013.
      Citations: 21     Fields:    Translation:Humans
    89. Martin K, Ricciardelli C, Hoffmann P, Oehler MK. Exploring the immunoproteome for ovarian cancer biomarker discovery. Int J Mol Sci. 2011 Jan 14; 12(1):410-28. PMID: 21339995.
      Citations: 3     Fields:    Translation:Humans
    90. Verma S, Hoffmann FW, Kumar M, Huang Z, Roe K, Nguyen-Wu E, Hashimoto AS, Hoffmann PR. Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. J Immunol. 2011 Feb 15; 186(4):2127-37. PMID: 21220695.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    91. H?lper P, Schulz-Schaeffer W, Dullin C, Hoffmann P, Harper J, Kurtzberg L, Lonning S, Kugler W, Lakomek M, Erdlenbruch B. Tumor localization of an anti-TGF-? antibody and its effects on gliomas. Int J Oncol. 2011 Jan; 38(1):51-9. PMID: 21109925.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    92. Scholz RP, Gustafsson JO, Hoffmann P, Jaiswal M, Ahmadian MR, Eisler SA, Erlmann P, Schmid S, Hausser A, Olayioye MA. The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation. Exp Cell Res. 2011 Feb 15; 317(4):496-503. PMID: 21087603.
      Citations: 9     Fields:    Translation:HumansCells
    93. Mrozik KM, Zilm PS, Bagley CJ, Hack S, Hoffmann P, Gronthos S, Bartold PM. Proteomic characterization of mesenchymal stem cell-like populations derived from ovine periodontal ligament, dental pulp, and bone marrow: analysis of differentially expressed proteins. Stem Cells Dev. 2010 Oct; 19(10):1485-99. PMID: 20050811.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    94. Ween MP, Lokman NA, Hoffmann P, Rodgers RJ, Ricciardelli C, Oehler MK. Transforming growth factor-beta-induced protein secreted by peritoneal cells increases the metastatic potential of ovarian cancer cells. Int J Cancer. 2011 Apr 01; 128(7):1570-84. PMID: 20521251.
      Citations: 43     Fields:    Translation:HumansCells
    95. Hoffmann FW, Hashimoto AC, Shafer LA, Dow S, Berry MJ, Hoffmann PR. Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols. J Nutr. 2010 Jun; 140(6):1155-61. PMID: 20375261.
      Citations: 87     Fields:    Translation:AnimalsCells
    96. Hoffmann P, Hoeck K, Deters S, Werner-Martini I, Schmidt WE. Substance P and calcitonin gene related peptide induce TGF-alpha expression in epithelial cells via mast cells and fibroblasts. Regul Pept. 2010 Apr 09; 161(1-3):33-7. PMID: 20079377.
      Citations: 3     Fields:    Translation:AnimalsCells
    97. Bulut K, Felderbauer P, Hoeck K, Schmidt WE, Hoffmann P. Carbachol induces TGF-alpha expression and colonic epithelial cell proliferation in sensory-desensitised rats. Int J Colorectal Dis. 2010 Mar; 25(3):335-41. PMID: 20012300.
      Citations: 1     Fields:    Translation:AnimalsCells
    98. Penno MA, Bacic A, Colegate SM, Hoffmann P, Michalski WP. Identifying candidate serum biomarkers of exposure to tunicamycins in rats using two-dimensional electrophoresis. J Proteome Res. 2009 Jun; 8(6):2812-26. PMID: 19317491.
      Citations: 1     Fields:    Translation:AnimalsCells
    99. Barry EF, Felquer FA, Powell JA, Biggs L, Stomski FC, Urbani A, Ramshaw H, Hoffmann P, Wilce MC, Grimbaldeston MA, Lopez AF, Guthridge MA. 14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival. J Biol Chem. 2009 May 01; 284(18):12080-90. PMID: 19218246.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    100. Hoffmann PR, Berry MJ. The influence of selenium on immune responses. Mol Nutr Food Res. 2008 Nov; 52(11):1273-80. PMID: 18384097.
      Citations: 156     Fields:    Translation:Humans
    101. Bulut K, Felderbauer P, Hoeck K, Schmidt WE, Hoffmann P. Increased duodenal expression of transforming growth factor-alpha and epidermal growth factor during experimental colitis in rats. Eur J Gastroenterol Hepatol. 2008 Oct; 20(10):989-94. PMID: 18787466.
      Citations: 1     Fields:    Translation:Animals
    102. Bulut K, Felderbauer P, Deters S, Hoeck K, Schmidt-Choudhury A, Schmidt WE, Hoffmann P. Sensory neuropeptides and epithelial cell restitution: the relevance of SP- and CGRP-stimulated mast cells. Int J Colorectal Dis. 2008 May; 23(5):535-41. PMID: 18274763.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    103. Ecroyd H, Koudelka T, Thorn DC, Williams DM, Devlin G, Hoffmann P, Carver JA. Dissociation from the oligomeric state is the rate-limiting step in fibril formation by kappa-casein. J Biol Chem. 2008 Apr 04; 283(14):9012-22. PMID: 18245081.
      Citations: 9     Fields:    Translation:Animals
    104. Le Saux CJ, Teeters K, Miyasato SK, Hoffmann PR, Bollt O, Douet V, Shohet RV, Broide DH, Tam EK. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. J Biol Chem. 2008 Feb 29; 283(9):5760-8. PMID: 18056268.
      Citations: 28     Fields:    Translation:AnimalsCells
    105. Bulut K, Pennartz C, Felderbauer P, Meier JJ, Banasch M, Bulut D, Schmitz F, Schmidt WE, Hoffmann P. Glucagon like peptide-2 induces intestinal restitution through VEGF release from subepithelial myofibroblasts. Eur J Pharmacol. 2008 Jan 14; 578(2-3):279-85. PMID: 17920582.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    106. Hoffmann PR, Jourdan-Le Saux C, Hoffmann FW, Chang PS, Bollt O, He Q, Tam EK, Berry MJ. A role for dietary selenium and selenoproteins in allergic airway inflammation. J Immunol. 2007 Sep 01; 179(5):3258-67. PMID: 17709542.
      Citations: 44     Fields:    Translation:AnimalsCells
    107. Hoffmann PR. Mechanisms by which selenium influences immune responses. Arch Immunol Ther Exp (Warsz). 2007 Sep-Oct; 55(5):289-97. PMID: 18219759.
      Citations: 33     Fields:    Translation:HumansAnimals
    108. Hoffmann PR, Gurary A, Hoffmann FW, Jourdan-Le Saux C, Teeters K, Hashimoto AC, Tam EK, Berry MJ. A new approach for analyzing cellular infiltration during allergic airway inflammation. J Immunol Methods. 2007 Dec 01; 328(1-2):21-33. PMID: 17825315.
      Citations: 9     Fields:    Translation:AnimalsCells
    109. Olayioye MA, Buchholz M, Schmid S, Sch?ffler P, Hoffmann P, Pomorski T. Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity. J Biol Chem. 2007 Aug 03; 282(31):22492-8. PMID: 17561512.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    110. Hoffmann PR, H?ge SC, Li PA, Hoffmann FW, Hashimoto AC, Berry MJ. The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply. Nucleic Acids Res. 2007; 35(12):3963-73. PMID: 17553827.
      Citations: 55     Fields:    Translation:Animals
    111. Felderbauer P, Bulut K, Hoeck K, Deters S, Schmidt WE, Hoffmann P. Substance P induces intestinal wound healing via fibroblasts--evidence for a TGF-beta-dependent effect. Int J Colorectal Dis. 2007 Dec; 22(12):1475-80. PMID: 17520266.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    112. de Jesus LA, Hoffmann PR, Michaud T, Forry EP, Small-Howard A, Stillwell RJ, Morozova N, Harney JW, Berry MJ. Nuclear assembly of UGA decoding complexes on selenoprotein mRNAs: a mechanism for eluding nonsense-mediated decay? Mol Cell Biol. 2006 Mar; 26(5):1795-805. PMID: 16478999.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    113. Hoffmann PR, Berry MJ. Selenoprotein synthesis: a unique translational mechanism used by a diverse family of proteins. Thyroid. 2005 Aug; 15(8):769-75. PMID: 16131320.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    114. Hoffmann P, Olayioye MA, Moritz RL, Lindeman GJ, Visvader JE, Simpson RJ, Kemp BE. Breast cancer protein StarD10 identified by three-dimensional separation using free-flow electrophoresis, reversed-phase high-performance liquid chromatography, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Electrophoresis. 2005 Mar; 26(6):1029-37. PMID: 15704244.
      Citations:    Fields:    Translation:AnimalsCells
    115. Hoffmann PR, Kench JA, Vondracek A, Kruk E, Daleke DL, Jordan M, Marrack P, Henson PM, Fadok VA. Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol. 2005 Feb 01; 174(3):1393-404. PMID: 15661897.
      Citations: 80     Fields:    Translation:AnimalsCells
    116. Hoffmann PR, Woodrow RJ, Calimlim PS, Sciulli R, Effler PV, Miyamoto V, Imrie A, Yanagihara R, Nerurkar VR. West Nile virus surveillance: A simple method for verifying the integrity of RNA in mosquito (Diptera: Culicidae) pools. J Med Entomol. 2004 Jul; 41(4):731-5. PMID: 15311468.
      Citations: 9     Fields:    Translation:AnimalsCells
    117. Olayioye MA, Hoffmann P, Pomorski T, Armes J, Simpson RJ, Kemp BE, Lindeman GJ, Visvader JE. The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation. Cancer Res. 2004 May 15; 64(10):3538-44. PMID: 15150109.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    118. Felderbauer P, Hoffmann P, Einw?chter H, Bulut K, Ansorge N, Schmitz F, Schmidt WE. A novel mutation of the calcium sensing receptor gene is associated with chronic pancreatitis in a family with heterozygous SPINK1 mutations. BMC Gastroenterol. 2003 Nov 29; 3:34. PMID: 14641934.
      Citations: 24     Fields:    Translation:Humans
    119. Vandivier RW, Fadok VA, Hoffmann PR, Bratton DL, Penvari C, Brown KK, Brain JD, Accurso FJ, Henson PM. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest. 2002 Mar; 109(5):661-70. PMID: 11877474.
      Citations: 132     Fields:    Translation:HumansCells
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