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Nawal M. Boukli

TitleDirector of Biomedical Proteomics Facility
Faculty RankFull Professor
InstitutionUniversidad Central Del Caribe
DepartmentMicrobiology and Immunology
AddressDepartment of Microbiology and Immunology
Universidad Central del Caribe
P.O. Box 60327, PR, USA
Bayamon PR 00960
Phone787-798-3001 ext. 2080
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    Collapse Biography 
    Collapse awards and honors
    2005Invited speaker, Addiction Technology Transfer Center Symposium. “Effect of the stress on the immu, San Juan
    2005Invited speaker, high-throughput Proteomics: Protein Expression and Purification in the Postgenomi, SANOFI-Aventis
    2005Keynote speaker: Fifth Student Scientific Research Symposium. “Proteomics in the Medical Field”, Natural Science Department, University of Puerto Rico, Aguadilla
    2006Presenter/Panel discussion member, Spoke about: “How to Develop Your Research Question”. Grant Wri, National Hispanic Science Network on Drug Abuse 6th Annual Conference
    2009Invited speaker at the Institute of NeuroImmune Pharmacology, Florida International University
    2018 - 2022Executive Board Member , Association of the Southeastern Association of Shared Resources (SEASR)/ABRF)
    2019 Invited speaker: Patterns of Unfolded Protein Response Protein Signatures in Cancer, 4th P.R Cancer conference
    2020 - 2021HIV Brain Cancer (Principal Investigator), Puerto Rico Trust Grant
    2020Travel Award Frontiers Stem Cells in Cancer advanced training , Sponsored by the NIH/National Cancer Institute (NCI)

    Collapse Overview 
    Collapse overview
    Dr. Boukli is a Professor in the department of microbiology and immunology and is the Director of the Biomedical Proteomics Facility at the Universidad Central del Caribe, School of Medicine, PR, USA. Dr. Boukli got her Doctoral degree in Molecular Biology from the University of Geneva, Switzerland, where she worked in early molecular signaling events such as the type three secretion pathway in Rhyzobium bacteria. Dr. Boukli did her postdoctoral fellowship at the University of Missouri where she gained more expertise in proteomics technology. She then joined the Universidad Central Del Caribe where she organized a high-throughput Proteomic Core Facility. Dr. Boukli’s research uses the latest technologies, including quantitative proteomics multiplexing with isobaric tags approaches and molecular and flow cytometric analyses for the detection of biomarkers and molecular signatures in HIV, drug and alcohol of abuse, cancer and multiple sclerosis. Dr. Boukli has numerous peer-review articles and NIH funded grants on these and related topics. Dr. Boukli is also interested in how endoplasmic reticulum stress responses and cell fate decision can regulate the network of apoptotic and survival signal events in different cells and systems and the anti-cancer and anti-HIV mechanistic effects of natural compounds for cancer and HIV treatment as some of her publications demonstrate (Boukli et al, 2010, Boukli et al, 2011, Boukli et al, 2012, Rivera et al, and Boukli, 2016, Lopez et al, and Boukli, 2017, Rodriguez et al, and Boukli, 2018), see publications below).
    In addition to her research pursuits, Dr. Boukli has been active in training young investigators, both individually (as a mentor and proteomics facility resource, post-doctoral fellows, medical students, Master and PhD trainees) and in the classroom (where she has developed a proteomics graduate-level course and several workshops on proteomics in clinical research). 

    Language Skills:

    • French (native)
    • Arabic (native)
    • English (Fluent, speaking, Fluent reading, Fluent writing)
    • Spanish (Fluent, speaking, Fluent reading, Fluent writing)
    • Italian (Fluent, speaking, Fluent reading, intermediate writing)

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Alvarez-Rivera E, Ortiz-Hern?ndez EJ, Lugo E, Lozada-Reyes LM, Boukli NM. Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms. Proteomes. 2023 Jul 04; 11(3). PMID: 37489388.
    2. Alvarez-Rivera E, Rodr?guez-Valent?n M, Boukli NM. The Antiviral Compound PSP Inhibits HIV-1 Entry via PKR-Dependent Activation in Monocytic Cells. Viruses. 2023 03 22; 15(3). PMID: 36992512.
      Citations: 3     Fields:    Translation:HumansCells
    3. Bagchi P, Boukli NM, Browner N, Daria D, Griffiths L, Mesa TE, Phipps J, Pitre A, Schafer J, Somasundaram T, Seagroves TN. Connect, Collaborate, and Succeed: The Ninth Annual Meeting of the Southeastern Association of Shared Resources (SEASR) Nashville, TN, USA, June 8-10, 2022. J Biomol Tech. 2023 Mar 31; 34(1). PMID: 37089872.
      Citations:    Fields:    
    4. Seagroves TN, Bagarozzi D, Bagchi P, Boukli NM, Browner N, Colton-Lee F, Constable S, Dahlman KB, Griffiths L, Mesa TE, Somasundaram T. The Eighth Annual Meeting of the Southeastern Association of Shared Resources (SEASR), Atlanta, GA, June 10-11, 2021. J Biomol Tech. 2021 12 15; 32(4). PMID: 35837271.
      Citations:    Fields:    
    5. Dahlman KB, Bagarozzi D, Bagchi P, Blum D, Boukli NM, Colton-Lee F, Constable S, Seagroves TN, Somasundaram T. "Making the Right Decisions: Adapting to Emerging Needs": The 7th Annual Meeting of the Southeastern Association of Shared Resources, Atlanta, GA, USA, June 12-14, 2019. J Biomol Tech. 2020 12; 31(4):165-167. PMID: 33223965.
      Citations:    Fields:    Translation:Humans
    6. Alves JM, Martins AH, Lameu C, Glaser T, Boukli NM, Bassaneze V, Dariolli R, Nascimento IC, Martins PCM, de Souza HDN, Krieger JE, Casarini DE, Sales VM, Pesquero JB, Ulrich H. Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation. Stem Cell Rev Rep. 2019 02; 15(1):48-58. PMID: 30338498.
      Citations: 6     Fields:    Translation:AnimalsCells
    7. Valent?n-Guillama G, L?pez S, Kucheryavykh YV, Chorna NE, P?rez J, Ortiz-Rivera J, Inyushin M, Makarov V, Valent?n-Acevedo A, Quinones-Hinojosa A, Boukli N, Kucheryavykh LY. HIV-1 Envelope Protein gp120 Promotes Proliferation and the Activation of Glycolysis in Glioma Cell. Cancers (Basel). 2018 Sep 01; 10(9). PMID: 30200472.
    8. Rodr?guez-Valent?n M, L?pez S, Rivera M, R?os-Olivares E, Cubano L, Boukli NM. Naturally Derived Anti-HIV Polysaccharide Peptide (PSP) Triggers a Toll-Like Receptor 4-Dependent Antiviral Immune Response. J Immunol Res. 2018; 2018:8741698. PMID: 30116757.
      Citations: 13     Fields:    Translation:HumansCells
    9. L?pez SN, Rodr?guez-Valent?n M, Rivera M, Rodr?guez M, Babu M, Cubano LA, Xiong H, Wang G, Kucheryavykh L, Boukli NM. HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma. Oncotarget. 2017 Sep 15; 8(40):68415-68438. PMID: 28978127.
      Citations: 5     Fields:    
    10. Rivera M, Ramos Y, Rodr?guez-Valent?n M, L?pez-Acevedo S, Cubano LA, Zou J, Zhang Q, Wang G, Boukli NM. Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells. PLoS One. 2017; 12(6):e0179587. PMID: 28628644.
      Citations: 25     Fields:    Translation:AnimalsCells
    11. Sep?lveda-Torres LDC, Rishishwar L, Rogers ML, R?os-Olivares E, Boukli N, Jordan IK, Cubano LA. A decade of viral mutations and associated drug resistance in a population of HIV-1+ Puerto Ricans: 2002-2011. PLoS One. 2017; 12(5):e0177452. PMID: 28493944.
      Citations: 2     Fields:    Translation:HumansCells
    12. Burton LJ, Rivera M, Hawsawi O, Zou J, Hudson T, Wang G, Zhang Q, Cubano L, Boukli N, Odero-Marah V. Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis. PLoS One. 2016; 11(10):e0164115. PMID: 27755556.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    13. Ricaurte M, Schizas NV, Ciborowski P, Boukli NM. Proteomic analysis of bleached and unbleached Acropora palmata, a threatened coral species of the Caribbean. Mar Pollut Bull. 2016 Jun 15; 107(1):224-232. PMID: 27105725.
      Citations: 7     Fields:    Translation:AnimalsPHPublic Health
    14. Berr?os VO, Boukli NM, Rodriguez JW, Negraes PD, Schwindt TT, Trujillo CA, Oliveira SL, Cubano LA, Ferchmin PA, Eterovic VA, Ulrich H, Martins AH. Paraoxon and Pyridostigmine Interfere with Neural Stem Cell Differentiation. Neurochem Res. 2015 Oct; 40(10):2091-101. PMID: 25758980.
      Citations: 2     Fields:    Translation:AnimalsCells
    15. Yang J, Hu D, Xia J, Liu J, Zhang G, Gendelman HE, Boukli NM, Xiong H. Enhancement of NMDA receptor-mediated excitatory postsynaptic currents by gp120-treated macrophages: implications for HIV-1-associated neuropathology. J Neuroimmune Pharmacol. 2013 Sep; 8(4):921-33. PMID: 23660833.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    16. Miranda MT, Su?rez E, Abbas M, Chinea A, Tosado R, Mej?as IA, Boukli N, Dunston GM. HLA class I & II alleles in multiple sclerosis patients from Puerto Rico. Bol Asoc Med P R. 2013; 105(1):18-23. PMID: 23767380.
      Citations: 4     Fields:    Translation:Humans
    17. Boukli NM, Shetty V, Cubano L, Ricaurte M, Coelho-Dos-Reis J, Nickens Z, Shah P, Talal AH, Philip R, Jain P. Unique and differential protein signatures within the mononuclear cells of HIV-1 and HCV mono-infected and co-infected patients. Clin Proteomics. 2012 Sep 07; 9(1):11. PMID: 22958358.
    18. Sep?lveda-Torres Ldel C, De La Rosa A, Cumba L, Boukli N, R?os-Olivares E, Cubano LA. Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006-2010. AIDS Res Treat. 2012; 2012:934041. PMID: 22593823.
    19. Mazzio EA, Boukli N, Rivera N, Soliman KF. Pericellular pH homeostasis is a primary function of the Warburg effect: inversion of metabolic systems to control lactate steady state in tumor cells. Cancer Sci. 2012 Mar; 103(3):422-32. PMID: 22320183.
      Citations: 31     Fields:    Translation:AnimalsCells
    20. Kurapati KR, Samikkannu T, Kadiyala DB, Zainulabedin SM, Gandhi N, Sathaye SS, Indap MA, Boukli N, Rodriguez JW, Nair MP. Combinatorial cytotoxic effects of Curcuma longa and Zingiber officinale on the PC-3M prostate cancer cell line. J Basic Clin Physiol Pharmacol. 2012; 23(4):139-46. PMID: 23072849.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    21. Boukli NM, Delgado B, Ricaurte M, Espino AM. Fasciola hepatica and Schistosoma mansoni: identification of common proteins by comparative proteomic analysis. J Parasitol. 2011 Oct; 97(5):852-61. PMID: 21506812.
      Citations: 11     Fields:    Translation:HumansAnimals
    22. Rao, K., Boukli, N., Samikkannu, T., Cubano, L., Dakshayani, K, Nair, M. . Profiling in PC-3M Prostate Cancer Cell Line and Cytotoxic Effects of Cucurma Longa. 2011.
    23. Boukli NM, Saiyed ZM, Ricaurte M, Rodriguez JW, R?os Olivares E, Cubano LA, Nair MP. Implications of ER stress, the unfolded protein response, and pro- and anti-apoptotic protein fingerprints in human monocyte-derived dendritic cells treated with alcohol. Alcohol Clin Exp Res. 2010 Dec; 34(12):2081-8. PMID: 20860616.
      Citations: 9     Fields:    Translation:HumansCells
    24. Cubano LA, Cumba L, del Sep?lveda-Torres LC, Boukli N, R?os-Olivares E. Prevalence of drug resistance and associated mutations in a population of Hiv-1+ Puerto Ricans in 2005. Bol Asoc Med P R. 2010 Jul-Sep; 102(3):13-7. PMID: 23875516.
      Citations: 3     Fields:    Translation:HumansCells
    25. Nair MP, Saiyed ZM, Nair N, Gandhi NH, Rodriguez JW, Boukli N, Provencio-Vasquez E, Malow RM, Miguez-Burbano MJ. Methamphetamine enhances HIV-1 infectivity in monocyte derived dendritic cells. J Neuroimmune Pharmacol. 2009 Mar; 4(1):129-39. PMID: 18958626.
      Citations: 61     Fields:    Translation:HumansCells
    26. Cubano LA, Sep?lveda-Torres Ldel C, Sosa G, Boukli N, Robles R, Rodriguez JW, Guzm?n L, R?os-Olivares E. Prevalence of drug resistance and associated mutations in HIV-positive Puerto Ricans: sex variations. Ethn Dis. 2008; 18(2 Suppl 2):S2-132-6. PMID: 18646335.
      Citations: 5     Fields:    Translation:HumansCells
    27. Rodr?guez JW, Pagan NO, Ocasio MC, R?os Z, Cubano LA, Boukli NM, Otero M, Hunter R, Nair MP, Rios-Olivares E. Induction of a Soluble Anti-HIV-1 factor (s) with IFN-?, IL-10, and ?-Chemokine Modulating Activity by an Influenza-Bacterial Polyantigenic Mixture. Am J Infect Dis. 2007; 3(4). PMID: 24327810.
    28. Rodríguez, J.W., Rodríguez, L.A., Font, G., Nieves, K., Cubano, L.A., Boukli, N., Otero, M., Hunter, R., Nair, M.P., and Ríos-Olivares, E. . Co-Expression of Apoptosis-Related Molecules on Activated CD8+CD38+ T-Cells is Associated with HIV-1 Disease Progression. American Journal of Infectious Disease. 2007; 4(3):208-216.
    29. R?os-Olivares E, Vil? LM, Reyes JC, Rodr?guez JW, Col?n JH, Pag?n NO, Marrero A, R?os-Orraca ZM, Boukli NM, Shapshak P, Robles RR. Impaired cytokine production and suppressed lymphocyte proliferation activity in HCV-infected cocaine and heroin ("speedball") users. Drug Alcohol Depend. 2006 Dec 01; 85(3):236-43. PMID: 16766138.
      Citations: 11     Fields:    Translation:HumansCells
    30. Boukli NM, Sunderasan E, Bartsev A, Hochstrasser D, Perret X, Bjourson AJ, Krause A, Broughton WJ. Early legume responses to inoculation with Rhizobium sp. NGR234. J Plant Physiol. 2007 Jun; 164(6):794-806. PMID: 16887234.
      Citations:    Fields:    Translation:AnimalsCells
    31. Skorpil P, Saad MM, Boukli NM, Kobayashi H, Ares-Orpel F, Broughton WJ, Deakin WJ. NopP, a phosphorylated effector of Rhizobium sp. strain NGR234, is a major determinant of nodulation of the tropical legumes Flemingia congesta and Tephrosia vogelii. Mol Microbiol. 2005 Sep; 57(5):1304-17. PMID: 16102002.
      Citations: 63     Fields:    Translation:AnimalsCells
    32. Boukli, N. M., Deakin, J.W., Kambara, K., Kobayashi, H., Marie, C., Perret, X., Le Quéré, A., Reuhs, B., Saad, M., Schumpp, O., Skorpil, P., Staehelin, C., Streit, W., and Broughton, W.J. . Springer Verlag, Berlin. “Rhizobial Control of Host-specificity”. Proceedings of the 14th International Congress on Nitrogen Fixation". 2005; 217-218.
    33. Lariguet, P., Pankhurst, C.E., Porch, T., Silue, S., Boukli, N.M., Ishitani, M., Rao, I.M., Beebe, S., Triplett, E.W., Baudoin, J.P., Blair, M.W., and Broughton, W.J. . “Tilling Beans for Changes in Nodule and Seed Development as well as Tolerance to Aluminium”. In Proc. Phaseomics IV. 2005; 252:175-179.
    34. Bartsev AV, Deakin WJ, Boukli NM, McAlvin CB, Stacey G, Malno? P, Broughton WJ, Staehelin C. NopL, an effector protein of Rhizobium sp. NGR234, thwarts activation of plant defense reactions. Plant Physiol. 2004 Feb; 134(2):871-9. PMID: 14966249.
      Citations: 53     Fields:    Translation:AnimalsCells
    35. Boukli, N.M., W.J. Deakin, K. Kambara, H. Kobayashi, C. Marie, X. Perret, A. Le Quéré, B. Reuhs*, M. Saad, O. Schumpp, P. Skorpil, C. Staehelin, W. Streit, & W.J. Broughton. . "Cell and Molecular Biology of Plant Root-Hairs". Springer-Verlag, Tokyo. 2004; 79-91.
    36. Bartsev AV, Boukli NM, Deakin WJ, Staehelin C, Broughton WJ. Purification and phosphorylation of the effector protein NopL from Rhizobium sp. NGR234. FEBS Lett. 2003 Nov 20; 554(3):271-4. PMID: 14623078.
      Citations: 28     Fields:    Translation:AnimalsCells
    37. Naturally Derived Anti-HIV Polysaccharide Peptide (PSP) Triggers a Toll-Like Receptor 4-Dependent Antiviral Immune Response. View Publication.
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