Amyloid Precursor Protein Secretases

"Amyloid Precursor Protein Secretases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.

Descriptor ID	D053829
MeSH Number(s)	D08.811.277.656.300.032
Concept/Terms	Amyloid Precursor Protein Secretases Amyloid Precursor Protein Secretases Secretases Secretase Amyloid Precursor Protein Secretase APP Secretase Secretase, APP beta-Secretase beta-Secretase beta Secretase gamma-Secretase gamma-Secretase gamma Secretase alpha-Secretase alpha-Secretase alpha Secretase

Below are MeSH descriptors whose meaning is more general than "Amyloid Precursor Protein Secretases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Amyloid Precursor Protein Secretases [D08.811.277.656.300.032]

Below are MeSH descriptors whose meaning is related to "Amyloid Precursor Protein Secretases".

Below are MeSH descriptors whose meaning is more specific than "Amyloid Precursor Protein Secretases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Amyloid Precursor Protein Secretases" by people in this website by year, and whether "Amyloid Precursor Protein Secretases" was a major or minor topic of these publications.

Bar chart showing 27 publications over 15 distinct years, with a maximum of 4 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2002	0	1	1
2003	0	1	1
2004	0	1	1
2005	0	1	1
2006	1	2	3
2007	2	0	2
2009	1	2	3
2010	3	1	4
2012	2	1	3
2013	1	0	1
2015	1	2	3
2016	1	0	1
2017	1	0	1
2019	0	1	1

Below are the most recent publications written about "Amyloid Precursor Protein Secretases" by people in Profiles.

Neupane RP, Parrish SM, Neupane JB, Yoshida WY, Yip MLR, Turkson J, Harper MK, Head JD, Williams PG. Cytotoxic Sesquiterpenoid Quinones and Quinols, and an 11-Membered Heterocycle, Kauamide, from the Hawaiian Marine Sponge Dactylospongia elegans. Mar Drugs. 2019 Jul 19; 17(7).

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Kapur N, Mir H, Sonpavde GP, Jain S, Bae S, Lillard JW, Singh S. Prostate cancer cells hyper-activate CXCR6 signaling by cleaving CXCL16 to overcome effect of docetaxel. Cancer Lett. 2019 07 10; 454:1-13.

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Jean-Louis T, Rockwell P, Figueiredo-Pereira ME. Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by a- and ?-secretases: relevance to Alzheimer's disease. Neurobiol Aging. 2018 02; 62:130-145.

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Zhang ZH, Chen C, Wu QY, Zheng R, Liu Q, Ni JZ, Hoffmann PR, Song GL. Selenomethionine reduces the deposition of beta-amyloid plaques by modulating ?-secretase and enhancing selenoenzymatic activity in a mouse model of Alzheimer's disease. Metallomics. 2016 08 01; 8(8):782-9.

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Sharoar MG, Shi Q, Ge Y, He W, Hu X, Perry G, Zhu X, Yan R. Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease. Mol Psychiatry. 2016 09; 21(9):1263-71.

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Dai J, Parrish SM, Yoshida WY, Yip MLR, Turkson J, Kelly M, Williams P. Bromotyrosine-derived metabolites from an Indonesian marine sponge in the family Aplysinellidae (Order Verongiida). Bioorg Med Chem Lett. 2016 Jan 15; 26(2):499-504.

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Mir H, Singh R, Kloecker GH, Lillard JW, Singh S. CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases. Oncotarget. 2015 Apr 30; 6(12):9985-98.

View in: PubMed
Clayton KL, Douglas-Vail MB, Nur-ur Rahman AK, Medcalf KE, Xie IY, Chew GM, Tandon R, Lanteri MC, Norris PJ, Deeks SG, Ndhlovu LC, Ostrowski MA. Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression. J Virol. 2015 Apr; 89(7):3723-36.

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Bailey AR, Hou H, Song M, Obregon DF, Portis S, Barger S, Shytle D, Stock S, Mori T, Sanberg PG, Murphy T, Tan J. GFAP expression and social deficits in transgenic mice overexpressing human sAPPa. Glia. 2013 Sep; 61(9):1556-69.

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Koike MA, Lin AJ, Pham J, Nguyen E, Yeh JJ, Rahimian R, Tromberg BJ, Choi B, Green KN, LaFerla FM. APP knockout mice experience acute mortality as the result of ischemia. PLoS One. 2012; 7(8):e42665.

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