An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).

Descriptor ID	D039302
MeSH Number(s)	D12.776.395.550.625.439 D12.776.543.550.625.439 D12.776.543.750.705.408.460.870.500 D12.776.543.750.705.675.541
Concept/Terms	Integrin alphaVbeta3 Integrin alphaVbeta3 alphaVbeta3, Integrin alpha-v beta-3 Integrin Receptors alpha v beta 3 Integrin Receptors Receptors, alpha-v beta-3 Integrin Receptors, alpha v beta 3 Integrin Vitronectin Receptor Receptor, Vitronectin Integrin alpha-v beta-3 Integrin alpha v beta 3 alpha-v beta-3, Integrin beta-3, Integrin alpha-v

Below are MeSH descriptors whose meaning is more general than "Integrin alphaVbeta3".

Below are MeSH descriptors whose meaning is related to "Integrin alphaVbeta3".

Below are MeSH descriptors whose meaning is more specific than "Integrin alphaVbeta3".