"Integrin alphaVbeta3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
| Descriptor ID |
D039302
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| MeSH Number(s) |
D12.776.395.550.625.439 D12.776.543.550.625.439 D12.776.543.750.705.408.460.870.500 D12.776.543.750.705.675.541
|
| Concept/Terms |
Integrin alphaVbeta3- Integrin alphaVbeta3
- alphaVbeta3, Integrin
- alpha-v beta-3 Integrin Receptors
- alpha v beta 3 Integrin Receptors
- Receptors, alpha-v beta-3 Integrin
- Receptors, alpha v beta 3 Integrin
- Vitronectin Receptor
- Receptor, Vitronectin
- Integrin alpha-v beta-3
- Integrin alpha v beta 3
- alpha-v beta-3, Integrin
- beta-3, Integrin alpha-v
|
Below are MeSH descriptors whose meaning is more general than "Integrin alphaVbeta3".
Below are MeSH descriptors whose meaning is more specific than "Integrin alphaVbeta3".
This graph shows the total number of publications written about "Integrin alphaVbeta3" by people in this website by year, and whether "Integrin alphaVbeta3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 2 | 1 | 3 |
| 2006 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alphaVbeta3" by people in Profiles.
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Okada T, Suzuki H, Travis ZD, Altay O, Tang J, Zhang JH. SPARC Aggravates Blood-Brain Barrier Disruption via Integrin aV?3/MAPKs/MMP-9 Signaling Pathway after Subarachnoid Hemorrhage. Oxid Med Cell Longev. 2021; 2021:9739977.
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Maldonado H, Calderon C, Burgos-Bravo F, Kobler O, Zuschratter W, Ramirez O, H?rtel S, Schneider P, Quest AF, Herrera-Molina R, Leyton L. Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway. Biochim Biophys Acta Mol Cell Res. 2017 Feb; 1864(2):243-254.
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Singh R, Kapur N, Mir H, Singh N, Lillard JW, Singh S. CXCR6-CXCL16 axis promotes prostate cancer by mediating cytoskeleton rearrangement via Ezrin activation and av?3 integrin clustering. Oncotarget. 2016 Feb 09; 7(6):7343-53.
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Xie H, Diagaradjane P, Deorukhkar AA, Goins B, Bao A, Phillips WT, Wang Z, Schwartz J, Krishnan S. Integrin av?3-targeted gold nanoshells augment tumor vasculature-specific imaging and therapy. Int J Nanomedicine. 2011; 6:259-69.
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Kim TJ, Landen CN, Lin YG, Mangala LS, Lu C, Nick AM, Stone RL, Merritt WM, Armaiz-Pena G, Jennings NB, Coleman RL, Tice DA, Sood AK. Combined anti-angiogenic therapy against VEGF and integrin alphaVbeta3 in an orthotopic model of ovarian cancer. Cancer Biol Ther. 2009 Dec; 8(23):2263-72.
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Borza CM, Pozzi A, Borza DB, Pedchenko V, Hellmark T, Hudson BG, Zent R. Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3. J Biol Chem. 2006 Jul 28; 281(30):20932-20939.
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Wadehra M, Forbes A, Pushkarna N, Goodglick L, Gordon LK, Williams CJ, Braun J. Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium. Dev Biol. 2005 Nov 15; 287(2):336-45.
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Burnett CA, Xie J, Quijano J, Shen Z, Hunter F, Bur M, Li KC, Danthi SN. Synthesis, in vitro, and in vivo characterization of an integrin alpha(v)beta(3)-targeted molecular probe for optical imaging of tumor. Bioorg Med Chem. 2005 Jun 01; 13(11):3763-71.
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Tarzami ST, Hsieh SS, Esterman MA, Singh JP. Staurosporine promotes endothelial cell assembly and FAK phosphorylation during in vitro angiogenesis. J Cardiovasc Pharmacol. 2005 Jan; 45(1):22-9.