Glycogen Synthase Kinase 3

"Glycogen Synthase Kinase 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.

Descriptor ID	D038362
MeSH Number(s)	D05.500.117.875 D08.811.913.696.620.682.700.429.500 D08.811.913.696.620.682.700.646.625 D12.644.360.300.500 D12.776.476.081.875 D12.776.476.300.500
Concept/Terms	Glycogen Synthase Kinase 3 Glycogen Synthase Kinase 3 gsk-3 Gene Product GSK-3

Below are MeSH descriptors whose meaning is more general than "Glycogen Synthase Kinase 3".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Axin Signaling Complex [D05.500.117]
Glycogen Synthase Kinase 3 [D05.500.117.875]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Glycogen Synthase Kinases [D08.811.913.696.620.682.700.429]
Glycogen Synthase Kinase 3 [D08.811.913.696.620.682.700.429.500]
Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
Glycogen Synthase Kinase 3 [D08.811.913.696.620.682.700.646.625]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Glycogen Synthase Kinases [D12.644.360.300]
Glycogen Synthase Kinase 3 [D12.644.360.300.500]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Axin Signaling Complex [D12.776.476.081]
Glycogen Synthase Kinase 3 [D12.776.476.081.875]
Glycogen Synthase Kinases [D12.776.476.300]
Glycogen Synthase Kinase 3 [D12.776.476.300.500]

Below are MeSH descriptors whose meaning is related to "Glycogen Synthase Kinase 3".

Below are MeSH descriptors whose meaning is more specific than "Glycogen Synthase Kinase 3".

Glycogen Synthase Kinase 3
Glycogen Synthase Kinase 3 beta

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Glycogen Synthase Kinase 3" by people in this website by year, and whether "Glycogen Synthase Kinase 3" was a major or minor topic of these publications.

Bar chart showing 30 publications over 15 distinct years, with a maximum of 6 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2002	0	1	1
2003	0	1	1
2004	1	0	1
2005	0	2	2
2006	3	3	6
2008	1	0	1
2009	2	0	2
2011	0	1	1
2012	3	2	5
2014	1	2	3
2015	1	0	1
2016	2	0	2
2018	1	0	1
2022	0	2	2

Below are the most recent publications written about "Glycogen Synthase Kinase 3" by people in Profiles.

Umbarkar P, Tousif S, Singh AP, Anderson JC, Zhang Q, Tallquist MD, Woodgett J, Lal H. Fibroblast GSK-3a Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart. Circ Res. 2022 09 16; 131(7):620-636.

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Sampath C, Raju AV, Freeman ML, Srinivasan S, Gangula PR. Nrf2 attenuates hyperglycemia-induced nNOS impairment in adult mouse primary enteric neuronal crest cells and normalizes stomach function. Am J Physiol Gastrointest Liver Physiol. 2022 03 01; 322(3):G368-G382.

View in: PubMed
Wei H, Landgraf D, Wang G, McCarthy MJ. Inositol polyphosphates contribute to cellular circadian rhythms: Implications for understanding lithium's molecular mechanism. Cell Signal. 2018 04; 44:82-91.

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Tran CW, Saibil SD, Le Bihan T, Hamilton SR, Lang KS, You H, Lin AE, Garza KM, Elford AR, Tai K, Parsons ME, Wigmore K, Vainberg MG, Penninger JM, Woodgett JR, Mak TW, Ohashi PS. Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation. J Immunol. 2017 12 15; 199(12):4056-4065.

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Liang Z, Zhang B, Su WW, Williams PG, Li QX. C-Glycosylflavones Alleviate Tau Phosphorylation and Amyloid Neurotoxicity through GSK3? Inhibition. ACS Chem Neurosci. 2016 07 20; 7(7):912-23.

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Liu S, Zhang Q, Chen C, Ge D, Qu Y, Chen R, Fan YM, Li N, Tang WW, Zhang W, Zhang K, Wang AR, Rowan BG, Hill SM, Sartor O, Abdel-Mageed AB, Myers L, Lin Q, You Z. Hyperinsulinemia enhances interleukin-17-induced inflammation to promote prostate cancer development in obese mice through inhibiting glycogen synthase kinase 3-mediated phosphorylation and degradation of interleukin-17 receptor. Oncotarget. 2016 Mar 22; 7(12):13651-66.

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Deng J, Habib A, Obregon DF, Barger SW, Giunta B, Wang YJ, Hou H, Sawmiller D, Tan J. Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3? signaling pathway. J Neurochem. 2015 Nov; 135(3):630-7.

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Li L, Klebe D, Doycheva D, McBride DW, Krafft PR, Flores J, Zhou C, Zhang JH, Tang J. G-CSF ameliorates neuronal apoptosis through GSK-3? inhibition in neonatal hypoxia-ischemia in rats. Exp Neurol. 2015 Jan; 263:141-9.

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Dai X, Liu P, Lau AW, Liu Y, Inuzuka H. Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis. Cancer Med. 2014 Oct; 3(5):1211-24.

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Wang ER, Jarrah AA, Benard L, Chen J, Schwarzkopf M, Hadri L, Tarzami ST. Deletion of CXCR4 in cardiomyocytes exacerbates cardiac dysfunction following isoproterenol administration. Gene Ther. 2014 May; 21(5):496-506.

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