Interleukin-18

"Interleukin-18" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

Descriptor ID	D020382
MeSH Number(s)	D12.644.276.374.465.518 D12.776.467.374.465.518 D23.529.374.465.518
Concept/Terms	Interleukin-18 Interleukin-18 Interleukin 18 IFN-gamma-Inducing Factor IL-18 Interferon-gamma Inducing Factor Inducing Factor, Interferon-gamma Interferon gamma Inducing Factor Interferon-gamma-Inducing Factor IFN-gamma Inducing Factor IFN gamma Inducing Factor Inducing Factor, IFN-gamma IL18

Below are MeSH descriptors whose meaning is more general than "Interleukin-18".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-18 [D12.644.276.374.465.518]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-18 [D12.776.467.374.465.518]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-18 [D23.529.374.465.518]

Below are MeSH descriptors whose meaning is related to "Interleukin-18".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-18".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-18" by people in this website by year, and whether "Interleukin-18" was a major or minor topic of these publications.

Bar chart showing 13 publications over 13 distinct years, with a maximum of 1 publications in 2001 and 2004 and 2005 and 2007 and 2008 and 2009 and 2010 and 2011 and 2015 and 2016 and 2017 and 2021 and 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2004	1	0	1
2005	1	0	1
2007	1	0	1
2008	1	0	1
2009	0	1	1
2010	1	0	1
2011	1	0	1
2015	0	1	1
2016	1	0	1
2017	0	1	1
2021	1	0	1
2023	0	1	1

Below are the most recent publications written about "Interleukin-18" by people in Profiles.

Sugawara S, Hueber B, Woolley G, Terry K, Kroll K, Manickam C, Ram DR, Ndhlovu LC, Goepfert P, Jost S, Reeves RK. Multiplex interrogation of the NK cell signalome reveals global downregulation of CD16 signaling during lentivirus infection through an IL-18/ADAM17-dependent mechanism. PLoS Pathog. 2023 09; 19(9):e1011629.

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Gupta A, Fei YD, Kim TY, Xie A, Batai K, Greener I, Tang H, Ciftci-Yilmaz S, Juneman E, Indik JH, Shi G, Christensen J, Gupta G, Hillery C, Kansal MM, Parikh DS, Zhou T, Yuan JX, Kanthi Y, Bronk P, Koren G, Kittles R, Duarte JD, Garcia JGN, Machado RF, Dudley SC, Choi BR, Desai AA. IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias. Blood. 2021 03 04; 137(9):1208-1218.

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Leite JA, Pessenda G, Guerra-Gomes IC, de Santana AKM, Andr? Pereira C, Ribeiro Campos Costa F, Ramos SG, Sim?es Zamboni D, Caetano Faria AM, Candido de Almeida D, Olsen Saraiva C?mara N, Tostes RC, Santana Silva J, Carlos D. The DNA Sensor AIM2 Protects against Streptozotocin-Induced Type 1 Diabetes by Regulating Intestinal Homeostasis via the IL-18 Pathway. Cells. 2020 04 14; 9(4).

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McCurdy S, Liu CA, Yap J, Boisvert WA. Potential role of IL-37 in atherosclerosis. Cytokine. 2019 10; 122:154169.

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Chang YW, Assari S, Prossin AR, Stertz L, McInnis MG, Evans SJ. Bipolar disorder moderates associations between linoleic acid and markers of inflammation. J Psychiatr Res. 2017 02; 85:29-36.

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Duarte JD, Desai AA, Sysol JR, Abbasi T, Patel AR, Lang RM, Gupta A, Garcia JG, Gordeuk VR, Machado RF. Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease. PLoS One. 2016; 11(9):e0163013.

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Liu D, Wen Y, Tang TT, Lv LL, Tang RN, Liu H, Ma KL, Crowley SD, Liu BC. Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation. J Biol Chem. 2015 Jul 17; 290(29):18018-18028.

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Ghose P, Ali AQ, Fang R, Forbes D, Ballard B, Ismail N. The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria. J Immunol. 2011 Aug 01; 187(3):1333-46.

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Rivera-Amill V, Kumar R, Noel RJ, Garcia Y, Rodriguez IV, Martinez M, Sariol CA, Kraiselburd E, Iszard M, Mukherji M, Kumar S, Giavedoni LD, Kumar A. Short communication: Lack of immune response in rapid progressor morphine-dependent and SIV/SHIV-infected rhesus macaques is correlated with downregulation of TH1 cytokines. AIDS Res Hum Retroviruses. 2010 Aug; 26(8):919-22.

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Milush JM, Long BR, Snyder-Cappione JE, Cappione AJ, York VA, Ndhlovu LC, Lanier LL, Micha?lsson J, Nixon DF. Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4. Blood. 2009 Nov 26; 114(23):4823-31.

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