Spheroids, Cellular

"Spheroids, Cellular" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Spherical, heterogeneous aggregates of proliferating, quiescent, and necrotic cells in culture that retain three-dimensional architecture and tissue-specific functions. The ability to form spheroids is a characteristic trait of CULTURED TUMOR CELLS derived from solid TUMORS. Cells from normal tissues can also form spheroids. They represent an in-vitro model for studies of the biology of both normal and malignant cells. (From Bjerkvig, Spheroid Culture in Cancer Research, 1992, p4)

Descriptor ID	D018874
MeSH Number(s)	A11.251.800
Concept/Terms	Spheroids, Cellular Spheroids, Cellular Cellular Spheroid Cellular Spheroids Spheroid, Cellular Multicellular Spheroids Multicellular Spheroid Spheroid, Multicellular Spheroids, Multicellular

Below are MeSH descriptors whose meaning is more general than "Spheroids, Cellular".

Anatomy [A]
Cells [A11]
Cells, Cultured [A11.251]
Spheroids, Cellular [A11.251.800]

Below are MeSH descriptors whose meaning is related to "Spheroids, Cellular".

Below are MeSH descriptors whose meaning is more specific than "Spheroids, Cellular".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Spheroids, Cellular" by people in this website by year, and whether "Spheroids, Cellular" was a major or minor topic of these publications.

Bar chart showing 29 publications over 14 distinct years, with a maximum of 6 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2004	1	1	2
2005	1	1	2
2011	1	2	3
2012	1	0	1
2013	1	0	1
2014	0	1	1
2015	0	1	1
2016	0	2	2
2017	1	5	6
2018	0	1	1
2019	0	2	2
2021	2	1	3
2025	1	2	3

Below are the most recent publications written about "Spheroids, Cellular" by people in Profiles.

Lazarte JMS, Ofosu-Asante K, Tilghman SL, Lamango NS. PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion. Oncotarget. 2025 Jul 29; 16:621-641.

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Battle D, Qiu X, Alex M, Rivers L, Hamilton JAG, Takayama S, Zhao X. Caki-1 Spheroids as a Renal Model for Studying Free Fatty Acid-Induced Lipotoxicity. Cells. 2025 02 27; 14(5).

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Waly AA, Harper L, Fleming JM, Costantini LM. CRY?B2 alters cell adhesion to promote invasion in a triple-negative breast cancer cell line. BMC Res Notes. 2025 Jan 21; 18(1):26.

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Ortiz-Hernandez GL, Sanchez-Hernandez ES, Ochoa PT, Elix CC, Alkashgari HR, McMullen JRW, Soto U, Martinez SR, Diaz Osterman CJ, Mahler M, Roy S, Casiano CA. The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells. Cells. 2021 10 12; 10(10).

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Borrero-Garc?a LD, Del Mar Maldonado M, Medina-Vel?zquez J, Troche-Torres AL, Velazquez L, Grafals-Ruiz N, Dharmawardhane S. Rac inhibition as a novel therapeutic strategy for EGFR/HER2 targeted therapy resistant breast cancer. BMC Cancer. 2021 Jun 01; 21(1):652.

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Cab?n-Rivera J, Chard?n-Col?n C, Pedraza-Torres A, Rodr?guez YE, Qui?ones-Alvarado R, Santiago-Cardona PG. Creation of Formalin-Fixed, Paraffin-Embedded 3D Lung Cancer Cellular Spheroids for the Optimization of Immunohistochemistry Staining Procedures. Methods Mol Biol. 2021; 2279:59-73.

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Jeon SJ, Ahn JH, Halder D, Cho HS, Lim JH, Jun SY, Lee JJ, Yoon JY, Choi MH, Jung CR, Kim JM, Kim NS. TIPRL potentiates survival of lung cancer by inducing autophagy through the eIF2a-ATF4 pathway. Cell Death Dis. 2019 12 20; 10(12):959.

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Nkembo AT, Amissah F, Ntantie E, Poku RA, Salako OO, Ikpatt OF, Lamango NS. Polyisoprenylated Cysteinyl Amide Inhibitors Deplete K-Ras and Induce Caspase-dependent Apoptosis in Lung Cancer Cells. Curr Cancer Drug Targets. 2019; 19(10):838-851.

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Motoike S, Kajiya M, Komatsu N, Takewaki M, Horikoshi S, Matsuda S, Ouhara K, Iwata T, Takeda K, Fujita T, Kurihara H. Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration. Stem Cell Res Ther. 2018 03 21; 9(1):73.

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Moroni L, Boland T, Burdick JA, De Maria C, Derby B, Forgacs G, Groll J, Li Q, Malda J, Mironov VA, Mota C, Nakamura M, Shu W, Takeuchi S, Woodfield TBF, Xu T, Yoo JJ, Vozzi G. Biofabrication: A Guide to Technology and Terminology. Trends Biotechnol. 2018 04; 36(4):384-402.

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