HSP90 Heat-Shock Proteins

"HSP90 Heat-Shock Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of MOLECULAR CHAPERONES whose members act in the mechanism of SIGNAL TRANSDUCTION by STEROID RECEPTORS.

Descriptor ID	D018841
MeSH Number(s)	D12.776.580.216.380
Concept/Terms	HSP90 Heat-Shock Proteins HSP90 Heat-Shock Proteins HSP90 Heat Shock Proteins Heat-Shock Proteins, HSP90 Heat-Shock Proteins 90 Heat Shock Proteins 90

Below are MeSH descriptors whose meaning is more general than "HSP90 Heat-Shock Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Molecular Chaperones [D12.776.580]
Heat-Shock Proteins [D12.776.580.216]
HSP90 Heat-Shock Proteins [D12.776.580.216.380]

Below are MeSH descriptors whose meaning is related to "HSP90 Heat-Shock Proteins".

Below are MeSH descriptors whose meaning is more specific than "HSP90 Heat-Shock Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "HSP90 Heat-Shock Proteins" by people in this website by year, and whether "HSP90 Heat-Shock Proteins" was a major or minor topic of these publications.

Bar chart showing 40 publications over 19 distinct years, with a maximum of 6 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	1	2
2003	1	0	1
2004	2	0	2
2005	0	1	1
2006	0	1	1
2007	1	2	3
2008	2	0	2
2010	1	1	2
2011	4	2	6
2012	2	2	4
2013	2	1	3
2014	0	1	1
2015	2	0	2
2016	2	0	2
2017	2	0	2
2018	2	1	3
2019	0	1	1
2020	1	0	1
2023	1	0	1

Below are the most recent publications written about "HSP90 Heat-Shock Proteins" by people in Profiles.

Ortiz NR, Guy N, Garcia YA, Sivils JC, Galigniana MD, Cox MB. Functions of the Hsp90-Binding FKBP Immunophilins. Subcell Biochem. 2023; 101:41-80.

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Singh JK, Hutt DM, Tait B, Guy NC, Sivils JC, Ortiz NR, Payan AN, Komaragiri SK, Owens JJ, Culbertson D, Blair LJ, Dickey C, Kuo SY, Finley D, Dyson HJ, Cox MB, Chaudhary J, Gestwicki JE, Balch WE. Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone. Cell Chem Biol. 2020 03 19; 27(3):292-305.e6.

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Harris DC, Garcia YA, Samaniego CS, Rowlett VW, Ortiz NR, Payan AN, Maehigashi T, Cox MB. Functional Comparison of Human and Zebra Fish FKBP52 Confirms the Importance of the Proline-Rich Loop for Regulation of Steroid Hormone Receptor Activity. Int J Mol Sci. 2019 Oct 28; 20(21).

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Gangula PR, Challagundla KB, Ravella K, Mukhopadhyay S, Chinnathambi V, Mittal MK, Sekhar KR, Sampath C. Sepiapterin alleviates impaired gastric nNOS function in spontaneous diabetic female rodents through NRF2 mRNA turnover and miRNA biogenesis pathway. Am J Physiol Gastrointest Liver Physiol. 2018 12 01; 315(6):G980-G990.

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Lee H, Saini N, Howard EW, Parris AB, Ma Z, Zhao Q, Zhao M, Liu B, Edgerton SM, Thor AD, Yang X. Ganetespib targets multiple levels of the receptor tyrosine kinase signaling cascade and preferentially inhibits ErbB2-overexpressing breast cancer cells. Sci Rep. 2018 05 01; 8(1):6829.

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Cox MB, Johnson JL. Evidence for Hsp90 Co-chaperones in Regulating Hsp90 Function and Promoting Client Protein Folding. Methods Mol Biol. 2018; 1709:397-422.

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Lee H, Saini N, Parris AB, Zhao M, Yang X. Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signaling. Int J Oncol. 2017 Sep; 51(3):967-974.

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Li QQ, Hao JJ, Zhang Z, Krane LS, Hammerich KH, Sanford T, Trepel JB, Neckers L, Agarwal PK. Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics. Sci Rep. 2017 03 15; 7(1):201.

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Ali YO, Allen HM, Yu L, Li-Kroeger D, Bakhshizadehmahmoudi D, Hatcher A, McCabe C, Xu J, Bjorklund N, Taglialatela G, Bennett DA, De Jager PL, Shulman JM, Bellen HJ, Lu HC. NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies. PLoS Biol. 2016 06; 14(6):e1002472.

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Park EJ, Sang-Ngern M, Chang LC, Pezzuto JM. Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4?-hydroxywithanolide E isolated from Physalis peruviana. Mol Nutr Food Res. 2016 06; 60(6):1482-500.

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