"Pregnenolone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.
| Descriptor ID |
D011284
|
| MeSH Number(s) |
D04.210.500.745.745.725 D06.472.040.585.745 D06.472.334.851.687.500
|
| Concept/Terms |
Pregnenolone- Pregnenolone
- 5-Pregnen-3-beta-ol-20-one
- 5 Pregnen 3 beta ol 20 one
|
Below are MeSH descriptors whose meaning is more general than "Pregnenolone".
Below are MeSH descriptors whose meaning is more specific than "Pregnenolone".
This graph shows the total number of publications written about "Pregnenolone" by people in this website by year, and whether "Pregnenolone" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Pregnenolone" by people in Profiles.
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Salanga MC, Brun NR, Francolini RD, Stegeman JJ, Goldstone JV. CRISPR-Cas9-Mutated Pregnane X Receptor (pxr) Retains Pregnenolone-induced Expression of cyp3a65 in Zebrafish (Danio rerio) Larvae. Toxicol Sci. 2020 03 01; 174(1):51-62.
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Hwang GS, Chen CC, Chou JC, Chang LL, Kan SF, Lai WH, Lieu FK, Hu S, Wang PS, Wang SW. Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats. Sci Rep. 2017 08 22; 7(1):9035.
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Yeh YH, Chou JC, Weng TC, Lieu FK, Lin JY, Yeh CC, Hu S, Wang PS, Idova G, Wang SW. Effects of acrolein on the production of corticosterone in male rats. Steroids. 2016 07; 111:139-147.
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Ramos G, Loperena Y, Ortiz G, Reyes F, Szeto A, Vera J, Velez J, Morales J, Morrero D, Castillo L, Dharmawardhane S, Melendez E, Washington AV. The addition of a pregnenolone pendant group enhances the anticancer properties of titanocene dichloride in a mcf-7 xenograft model. Anticancer Res. 2014 Apr; 34(4):1609-15.
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Martinez PE, Rubinow DR, Nieman LK, Koziol DE, Morrow AL, Schiller CE, Cintron D, Thompson KD, Khine KK, Schmidt PJ. 5a-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder. Neuropsychopharmacology. 2016 Mar; 41(4):1093-102.
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Yu PL, Lin TM, Wang SW, Wang PS. Antisteroidogenic effects of hydrogen peroxide on rat granulosa cells. Free Radic Res. 2012 Jun; 46(6):718-25.
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Chang LL, Wun WS, Wang PS. Effects of nonylphenol on aldosterone release from rat zona glomerulosa cells. Chem Biol Interact. 2012 Jan 05; 195(1):11-7.
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Yu PL, Lin HW, Wang SW, Wang PS. Effects of nonylphenol on the production of progesterone on the rats granulosa cells. J Cell Biochem. 2011 Sep; 112(9):2627-36.
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Chen MC, Wang SW, Kan SF, Tsai SC, Wu YC, Wang PS. Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic acute regulatory protein expression in rat granulosa cells. Toxicol Sci. 2010 Dec; 118(2):667-74.
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Chang LL, Alfred Wun WS, Wang PS. Effects and mechanisms of nonylphenol on corticosterone release in rat zona fasciculata-reticularis cells. Toxicol Sci. 2010 Dec; 118(2):411-9.