"Ligands" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
| Descriptor ID |
D008024
|
| MeSH Number(s) |
D27.720.470.480
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Ligands".
Below are MeSH descriptors whose meaning is more specific than "Ligands".
This graph shows the total number of publications written about "Ligands" by people in this website by year, and whether "Ligands" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 6 | 6 |
| 2001 | 0 | 7 | 7 |
| 2002 | 0 | 14 | 14 |
| 2003 | 0 | 17 | 17 |
| 2004 | 0 | 16 | 16 |
| 2005 | 1 | 19 | 20 |
| 2006 | 0 | 10 | 10 |
| 2007 | 0 | 15 | 15 |
| 2008 | 0 | 15 | 15 |
| 2009 | 0 | 14 | 14 |
| 2010 | 1 | 8 | 9 |
| 2011 | 1 | 10 | 11 |
| 2012 | 2 | 8 | 10 |
| 2013 | 0 | 17 | 17 |
| 2014 | 0 | 18 | 18 |
| 2015 | 3 | 11 | 14 |
| 2016 | 0 | 13 | 13 |
| 2017 | 0 | 15 | 15 |
| 2018 | 1 | 10 | 11 |
| 2019 | 0 | 10 | 10 |
| 2020 | 0 | 14 | 14 |
| 2021 | 0 | 8 | 8 |
| 2022 | 0 | 14 | 14 |
| 2023 | 0 | 8 | 8 |
| 2024 | 0 | 3 | 3 |
| 2025 | 0 | 4 | 4 |
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click here.
Below are the most recent publications written about "Ligands" by people in Profiles.
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Maniaci B, Mealka M, Bobkov AA, Stec B, Huxford T, Love JJ. Incorporating Metal-Ligand and Salt-Bridge Interactions in the Design of Protein Heterodimers. Biochemistry. 2025 Aug 05; 64(15):3237-3247.
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Okpattah D, Karki A, Pillarsetty NVK, Harding WW. Synthesis and evaluation of aporphinoid 5-HT7AR ligands as inhibitors of PC3 prostate cancer cell growth. Bioorg Med Chem Lett. 2025 Dec 01; 128:130328.
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Iniguez E, Rodriguez F, Husseneder C, Foil L, Maldonado RA. Ligand-lytic peptides for specific targeting of Leishmania major and Trypanosoma cruzi parasites. Front Cell Infect Microbiol. 2025; 15:1595333.
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Kiaei N, Malik A, Idahosa SO, Lee KK, Endo-Umeda K, Makishima M, Kawamura A, Higuchi S. Python-derived 16a-Hydroxylated Bile Acid, Pythocholic Acid is a ligand for TGR5, not farnesoid X receptors and vitamin D receptors. Biochem Biophys Res Commun. 2025 03 05; 751:151453.
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Delaitre C, Boisbrun M, Acherar S, Dias A, Kleinclauss A, Achard M, Colin M, Nguyen TM, Humbert N, Chmeis K, Martinez KL, Gilles N, Robin P, Lecat S, Dupuis F. Synthesis and Pharmacological Characterization of Fluorescent Ligands Targeting the Angiotensin II Receptors Derived from Agonists, ?-Arrestin-Biased Agonists, and Antagonists. J Med Chem. 2024 Nov 28; 67(22):20275-20297.
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Dorogan M, Namballa HK, Harding WW. Natural Product-Inspired Dopamine Receptor Ligands. J Med Chem. 2024 08 08; 67(15):12463-12484.
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Wang B, Kobeissy F, Golpich M, Cai G, Li X, Abedi R, Haskins W, Tan W, Benner SA, Wang KKW. Aptamer Technologies in Neuroscience, Neuro-Diagnostics and Neuro-Medicine Development. Molecules. 2024 Mar 02; 29(5).
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Wu K, Karapetyan E, Schloss J, Vadgama J, Wu Y. Advancements in small molecule drug design: A structural perspective. Drug Discov Today. 2023 10; 28(10):103730.
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Namballa HK, Dorogan M, Gudipally AR, Okafor S, Gadhiya S, Harding WW. Discovery of Selective Dopamine Receptor Ligands Derived from (-)-Stepholidine via C-3 Alkoxylation and C-3/C-9 Dialkoxylation. J Med Chem. 2023 07 27; 66(14):10060-10079.
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Deng S, Jin P, Liu S, He Y, Sherchan P, Zhang JH, Gong Y, Tang J. Recruitment of regulatory T cells with rCCL17 promotes M2 microglia/macrophage polarization through TGF?/TGF?R/Smad2/3 pathway in a mouse model of intracerebral hemorrhage. Exp Neurol. 2023 09; 367:114451.