Immunoglobulin Joining Region
"Immunoglobulin Joining Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.
| Descriptor ID |
D007133
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| MeSH Number(s) |
D12.644.541.500.650.500.590 D12.776.124.486.485.680.650.500.590 D12.776.124.486.485.797.590 D12.776.124.790.651.680.650.500.590 D12.776.124.790.651.797.590 D12.776.377.715.548.680.650.500.590 D12.776.377.715.548.797.590
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Joining Region".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Joining Region".
This graph shows the total number of publications written about "Immunoglobulin Joining Region" by people in this website by year, and whether "Immunoglobulin Joining Region" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immunoglobulin Joining Region" by people in Profiles.
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Pan PY, Lieber MR, Teale JM. The role of recombination signal sequences in the preferential joining by deletion in DH-JH recombination and in the ordered rearrangement of the IgH locus. Int Immunol. 1997 Apr; 9(4):515-22.
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Medina CA, Teale JM. Restricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinations. J Exp Med. 1993 May 01; 177(5):1317-30.
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Bangs LA, Sanz IE, Teale JM. Comparison of D, JH, and junctional diversity in the fetal, adult, and aged B cell repertoires. J Immunol. 1991 Mar 15; 146(6):1996-2004.
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Aguilera RJ, Akira S, Okazaki K, Sakano H. A pre-B cell nuclear protein that specifically interacts with the immunoglobulin V-J recombination sequences. Cell. 1987 Dec 24; 51(6):909-17.