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Kevin Williams

TitleProfessor
Faculty RankProfessor
InstitutionNorth Carolina Central University
DepartmentJulius L. Chambers Bimedical/Biotechnology Research Institute (BBRI)
Address700 George Street
Durham NC 27707
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    SC2CA137844     (WILLIAMS, KEVIN PETER)Aug 1, 2008 - Jul 31, 2012
    NIH
    The Hedgehog Pathway and Inflammatory Breast Cancer
    Role: Principal Investigator
    R15CA159209     (WILLIAMS, KEVIN PETER)Mar 1, 2011 - Feb 28, 2015
    NIH
    Identification of Specific Antagonists that Bind Hedgehog and Block its Activity
    Role: Principal Investigator
    R41CA174097     (WILLIAMS, KEVIN PETER)May 1, 2013 - Oct 30, 2014
    NIH
    Identification of potent and selective GLI1 inhibitors
    Role: Principal Investigator
    R15CA208651     (WILLIAMS, KEVIN PETER)Sep 1, 2016 - Apr 30, 2021
    NIH
    Targeting DYRK1A Modulation of GLI1 for Anti-Tumor Efficacy
    Role: Principal Investigator
    P20CA202925     (PATIERNO, STEVEN R)Sep 16, 2016 - Aug 31, 2021
    NIH
    2/2 NCCU-DUKE Cancer Disparities Translational Research Partnership
    Role: Co-Principal Investigator
    P20CA202924     (WILLIAMS, KEVIN PETER)Sep 20, 2016 - Aug 31, 2021
    NIH
    1/2 NCCU-DUKE Cancer Disparities Translational Research Partnership
    Role: Principal Investigator
    R01MD017405     (KIMBRO, KEVIN SEAN ;NAVARRO, HERNAN A;WILLIAMS, KEVIN PETER)Sep 20, 2021 - May 31, 2026
    NIH
    Addressing the Biology of Health Disparities by Targeting Geographical Ancestry-driven Variants of Immunity
    Role: Co-Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ji X, Williams KP, Zheng W. Applying a Gene Reversal Rate Computational Methodology to Identify Drugs for a Rare Cancer: Inflammatory Breast Cancer. Cancer Inform. 2023; 22:11769351231202588. PMID: 37846218.
      Citations:    
    2. Paiboonrungruang C, Xiong Z, Lamson D, Li Y, Bowman B, Chembo J, Huang C, Li J, Livingston EW, Frank JE, Chen V, Li Y, Weissman B, Yuan H, Williams KP, Ben Major M, Chen X. Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia. Redox Biol. 2023 11; 67:102901. PMID: 37776708.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Olsson LT, Walens A, Hamilton AM, Benefield HC, Fleming JM, Carey LA, Hursting SD, Williams KP, Troester MA. Obesity and Breast Cancer Metastasis across Genomic Subtypes. Cancer Epidemiol Biomarkers Prev. 2022 10 04; 31(10):1944-1951. PMID: 35973227.
      Citations: 1     Fields:    Translation:Humans
    4. Al Abo M, Gearhart-Serna L, Van Laere S, Freedman JA, Patierno SR, Hwang ES, Krishnamurthy S, Williams KP, Devi GR. Adaptive stress response genes associated with breast cancer subtypes and survival outcomes reveal race-related differences. NPJ Breast Cancer. 2022 Jun 13; 8(1):73. PMID: 35697736.
      Citations:    
    5. Jones GS, Hoadley KA, Benefield H, Olsson LT, Hamilton AM, Bhattacharya A, Kirk EL, Tipaldos HJ, Fleming JM, Williams KP, Love MI, Nichols HB, Olshan AF, Troester MA. Racial differences in breast cancer outcomes by hepatocyte growth factor pathway expression. Breast Cancer Res Treat. 2022 Apr; 192(2):447-455. PMID: 35034243.
      Citations:    Fields:    Translation:Humans
    6. Burton DF, Boa-Amponsem OM, Dixon MS, Hopkins MJ, Herbin TA, Toney S, Tarpley M, Rodriguez BV, Fish EW, Parnell SE, Cole GJ, Williams KP. Pharmacological activation of the Sonic hedgehog pathway with a Smoothened small molecule agonist ameliorates the severity of alcohol-induced morphological and behavioral birth defects in a zebrafish model of fetal alcohol spectrum disorder. J Neurosci Res. 2022 08; 100(8):1585-1601. PMID: 35014067.
      Citations: 4     Fields:    Translation:HumansAnimals
    7. Tarpley M, Oladapo H, Caligan TB, Onyenwoke RU, Williams KP. Data supporting a pilot high-throughput screen of a drug library for identification of DYRK1A inhibitors and high-content imaging analysis of identified harmine analogs. Data Brief. 2021 Aug; 37:107189. PMID: 34141844.
      Citations:    
    8. Tarpley M, Caligan TB, Onyenwoke RU, Williams KP. Optimization and validation of a DYRK1A TR-FRET assay for high-throughput screening. MethodsX. 2021; 8:101383. PMID: 34430279.
      Citations:    
    9. Tarpley M, Oladapo HO, Strepay D, Caligan TB, Chdid L, Shehata H, Roques JR, Thomas R, Laudeman CP, Onyenwoke RU, Darr DB, Williams KP. Identification of harmine and ?-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies. Eur J Pharm Sci. 2021 Jul 01; 162:105821. PMID: 33781856.
      Citations: 9     Fields:    Translation:Humans
    10. Lamson DR, Hughes MA, Adcock AF, Smith GR, Williams KP. Development and validation of a hedgehog heparin-binding assay for high-throughput screening. MethodsX. 2021; 8:101207. PMID: 34434730.
      Citations:    
    11. Oldham CE, Gathings MJ, Devi GR, Patierno SR, Williams KP, Hough HJ, Barrett NJ. An innovative educational program for addressing health disparities in translational cancer research. J Clin Transl Sci. 2020 Nov 05; 5(1):e65. PMID: 33948284.
      Citations:    
    12. Ji X, Jin C, Dong X, Dixon MS, Williams KP, Zheng W. Literature-Wide Association Studies (LWAS) for a Rare Disease: Drug Repurposing for Inflammatory Breast Cancer. Molecules. 2020 Aug 28; 25(17). PMID: 32872166.
      Citations: 3     Fields:    Translation:Humans
    13. Boa-Amponsem O, Zhang C, Burton D, Williams KP, Cole GJ. Ethanol and Cannabinoids Regulate Zebrafish GABAergic Neuron Development and Behavior in a Sonic Hedgehog and Fibroblast Growth Factor-Dependent Mechanism. Alcohol Clin Exp Res. 2020 07; 44(7):1366-1377. PMID: 32472575.
      Citations: 9     Fields:    Translation:AnimalsCells
    14. Ahmad S, He Q, Williams KP, Scott JE. Identification of a Triple Drug Combination That Is Synergistically Cytotoxic for Triple-Negative Breast Cancer Cells Using a Novel Combination Discovery Approach. SLAS Discov. 2020 09; 25(8):923-938. PMID: 32441190.
      Citations: 6     Fields:    Translation:HumansAnimals
    15. Fish EW, Murdaugh LB, Zhang C, Boschen KE, Boa-Amponsem O, Mendoza-Romero HN, Tarpley M, Chdid L, Mukhopadhyay S, Cole GJ, Williams KP, Parnell SE. Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog Interaction. Sci Rep. 2019 11 05; 9(1):16057. PMID: 31690747.
      Citations: 55     Fields:    Translation:AnimalsCells
    16. Widatalla SE, Korolkova OY, Whalen DS, Goodwin JS, Williams KP, Ochieng J, Sakwe AM. Lapatinib-induced annexin A6 upregulation as an adaptive response of triple-negative breast cancer cells to EGFR tyrosine kinase inhibitors. Carcinogenesis. 2019 08 22; 40(8):998-1009. PMID: 30590459.
      Citations: 16     Fields:    Translation:HumansCells
    17. Devi GR, Hough H, Barrett N, Cristofanilli M, Overmoyer B, Spector N, Ueno NT, Woodward W, Kirkpatrick J, Vincent B, Williams KP, Finley C, Duff B, Worthy V, McCall S, Hollister BA, Palmer G, Force J, Westbrook K, Fayanju O, Suneja G, Dent SF, Hwang ES, Patierno SR, Marcom PK. Perspectives on Inflammatory Breast Cancer (IBC) Research, Clinical Management and Community Engagement from the Duke IBC Consortium. J Cancer. 2019; 10(15):3344-3351. PMID: 31293637.
      Citations:    
    18. Ma S, Paiboonrungruan C, Yan T, Williams KP, Major MB, Chen XL. Targeted therapy of esophageal squamous cell carcinoma: the NRF2 signaling pathway as target. Ann N Y Acad Sci. 2018 12; 1434(1):164-172. PMID: 29752726.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    19. Ehe BK, Lamson DR, Tarpley M, Onyenwoke RU, Graves LM, Williams KP. Data on peptides identified by mass spectrometry analysis of in vitro DYRK1A-mediated phosphorylation sites on GLI1. Data Brief. 2017 Dec; 15:577-583. PMID: 29071296.
      Citations:    
    20. Oladapo HO, Tarpley M, Sauer SJ, Addo KA, Ingram SM, Strepay D, Ehe BK, Chdid L, Trinkler M, Roques JR, Darr DB, Fleming JM, Devi GR, Williams KP. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in?vivo tumor growth of inflammatory breast cancer cells. Cancer Lett. 2017 12 28; 411:136-149. PMID: 28965853.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    21. Ehe BK, Lamson DR, Tarpley M, Onyenwoke RU, Graves LM, Williams KP. Identification of a DYRK1A-mediated phosphorylation site within the nuclear localization sequence of the hedgehog transcription factor GLI1. Biochem Biophys Res Commun. 2017 09 23; 491(3):767-772. PMID: 28735864.
      Citations: 19     Fields:    Translation:HumansCells
    22. Brantley SJ, Cotten SW, Lamson DR, Smith GR, Liu R, Williams KP. Discovery of small molecule inhibitors for the C.?elegans caspase CED-3 by high-throughput screening. Biochem Biophys Res Commun. 2017 09 23; 491(3):773-779. PMID: 28733033.
      Citations: 3     Fields:    
    23. Fish EW, Murdaugh LB, Sulik KK, Williams KP, Parnell SE. Genetic vulnerabilities to prenatal alcohol exposure: Limb defects in sonic hedgehog and GLI2 heterozygous mice. Birth Defects Res. 2017 Jul 03; 109(11):860-865. PMID: 28504423.
      Citations: 10     Fields:    Translation:AnimalsCells
    24. Arora J, Sauer SJ, Tarpley M, Vermeulen P, Rypens C, Van Laere S, Williams KP, Devi GR, Dewhirst MW. Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies. Oncotarget. 2017 Apr 18; 8(16):25848-25863. PMID: 28460441.
      Citations: 24     Fields:    Translation:HumansCells
    25. Sauer SJ, Tarpley M, Shah I, Save AV, Lyerly HK, Patierno SR, Williams KP, Devi GR. Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells. Carcinogenesis. 2017 03 01; 38(3):252-260. PMID: 28426875.
      Citations: 31     Fields:    Translation:HumansCells
    26. Fish EW, Parnell SE, Sulik KK, Baker LK, Murdaugh LB, Lamson D, Williams KP. Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice. Birth Defects Res. 2017 01 20; 109(1):49-54. PMID: 27801979.
      Citations: 7     Fields:    Translation:AnimalsCells
    27. House AJ, Daye LR, Tarpley M, Addo K, Lamson DS, Parker MK, Bealer WE, Williams KP. Design and characterization of a photo-activatable hedgehog probe that mimics the natural lipidated form. Arch Biochem Biophys. 2015 Feb 01; 567:66-74. PMID: 25529135.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    28. Williams KP, Allensworth JL, Ingram SM, Smith GR, Aldrich AJ, Sexton JZ, Devi GR. Quantitative high-throughput efficacy profiling of approved oncology drugs in inflammatory breast cancer models of acquired drug resistance and re-sensitization. Cancer Lett. 2013 Aug 28; 337(1):77-89. PMID: 23689139.
      Citations: 19     Fields:    Translation:HumansCells
    29. Rangwala F, Williams KP, Smith GR, Thomas Z, Allensworth JL, Lyerly HK, Diehl AM, Morse MA, Devi GR. Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines. BMC Cancer. 2012 Sep 10; 12:402. PMID: 22963400.
      Citations: 13     Fields:    Translation:HumansCells
    30. Sexton JZ, Danshina PV, Lamson DR, Hughes M, House AJ, Yeh LA, O'Brien DA, Williams KP. Development and Implementation of a High Throughput Screen for the Human Sperm-Specific Isoform of Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDHS). Curr Chem Genomics. 2011; 5:30-41. PMID: 21760877.
      Citations:    
    31. Lamson DR, House AJ, Danshina PV, Sexton JZ, Sanyang K, O'Brien DA, Yeh LA, Williams KP. Recombinant human sperm-specific glyceraldehyde-3-phosphate dehydrogenase (GAPDHS) is expressed at high yield as an active homotetramer in baculovirus-infected insect cells. Protein Expr Purif. 2011 Jan; 75(1):104-13. PMID: 20828617.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    32. Williams KP, Scott JE. Enzyme assay design for high-throughput screening. Methods Mol Biol. 2009; 565:107-26. PMID: 19551359.
      Citations: 11     Fields:    
    33. Ricci L, Williams KP. Development of fluorescence polarization assays for the molecular chaperone Hsp70 family members: Hsp72 and DnaK. Curr Chem Genomics. 2008 Dec 30; 2:90-5. PMID: 20161846.
      Citations:    
    34. Jarov A, Williams KP, Ling LE, Koteliansky VE, Duband JL, Fournier-Thibault C. A dual role for Sonic hedgehog in regulating adhesion and differentiation of neuroepithelial cells. Dev Biol. 2003 Sep 15; 261(2):520-36. PMID: 14499657.
      Citations: 16     Fields:    Translation:Animals
    35. Adkins HB, Bianco C, Schiffer SG, Rayhorn P, Zafari M, Cheung AE, Orozco O, Olson D, De Luca A, Chen LL, Miatkowski K, Benjamin C, Normanno N, Williams KP, Jarpe M, LePage D, Salomon D, Sanicola M. Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo. J Clin Invest. 2003 Aug; 112(4):575-87. PMID: 12925698.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    36. Reilly JO, Karavanova ID, Williams KP, Mahanthappa NK, Allendoerfer KL. Cooperative effects of Sonic Hedgehog and NGF on basal forebrain cholinergic neurons. Mol Cell Neurosci. 2002 Jan; 19(1):88-96. PMID: 11817900.
      Citations: 18     Fields:    Translation:AnimalsCells
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