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Muller Fabbri, MD, PhD

Faculty RankAssociate Professor
InstitutionUniversity of Hawaii
DepartmentCancer Biology
AddressUniversity of Hawaii Cancer Center
701 Ilalo St
Honolulu HI 96813
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    Collapse Research 
    Collapse research activities and funding
    R01CA219024     (FABBRI, MULLER)Jan 1, 2018 - Dec 31, 2022
    Clinical significance and mechanism of action of exosomal microRNAs in Neuroblastoma chemoresistance.
    Role: Principal Investigator

    R01CA215753     (FABBRI, MULLER)May 26, 2018 - May 31, 2022
    Role of microRNAs released by Tumor Associated Macrophages within Exosomes in the chemoresistance of Neuroblastoma
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cocks A, Martinez-Rodriguez V, Del Vecchio F, Schukking M, Broseghini E, Giannakopoulos S, Fabbri M. Diverse roles of EV-RNA in cancer progression. Semin Cancer Biol. 2021 Jan 10. PMID: 33440245.
      Citations:    Fields:    
    2. Shirinbak S, Chan RY, Shahani S, Muthugounder S, Kennedy R, Hung LT, Fernandez GE, Hadjidaniel MD, Moghimi B, Sheard MA, Epstein AL, Fabbri M, Shimada H, Asgharzadeh S. Combined immune checkpoint blockade increases CD8+CD28+PD-1+ effector T cells and provides a therapeutic strategy for patients with neuroblastoma. Oncoimmunology. 2021 Jan 04; 10(1):1838140. PMID: 33489468.
    3. Ludwig S, Sharma P, Wise P, Sposto R, Hollingshead D, Lamb J, Lang S, Fabbri M, Whiteside TL. mRNA and miRNA Profiles of Exosomes from Cultured Tumor Cells Reveal Biomarkers Specific for HPV16-Positive and HPV16-Negative Head and Neck Cancer. Int J Mol Sci. 2020 Nov 13; 21(22). PMID: 33202950.
      Citations:    Fields:    
    4. Bandini E, Fanini F, Vannini I, Rossi T, Plousiou M, Tumedei MM, Limarzi F, Maltoni R, Fabbri F, Hrelia S, Cho WCS, Fabbri M. miR-9-5p as a Regulator of the Androgen Receptor Pathway in Breast Cancer Cell Lines. Front Cell Dev Biol. 2020; 8:579160. PMID: 33282861.
    5. Terracciano D, Buonerba C, Scafuri L, De Berardinis P, Calin GA, Ferrajoli A, Fabbri M, Cimmino A. Perspective: Cancer Patient Management Challenges During the COVID-19 Pandemic. Front Oncol. 2020; 10:1556. PMID: 32984015.
    6. Fabbri M. Natural Killer Cell-Derived Vesicular miRNAs: A New Anticancer Approach? Cancer Res. 2020 01 01; 80(1):17-22. PMID: 31672842.
      Citations: 4     Fields:    Translation:HumansCells
    7. Fabbri M, Girnita L, Varani G, Calin GA. Decrypting noncoding RNA interactions, structures, and functional networks. Genome Res. 2019 09; 29(9):1377-1388. PMID: 31434680.
      Citations: 18     Fields:    Translation:HumansCells
    8. Vannini I, Fanini F, Fabbri M. Corrigendum to "MicroRNAs as lung cancer biomarkers and key players in lung carcinogenesis" Clinical Biochemistry 46 (2013) 918-925. Clin Biochem. 2019 06; 68:58. PMID: 31128843.
      Citations:    Fields:    
    9. Wu CH, Li J, Li L, Sun J, Fabbri M, Wayne AS, Seeger RC, Jong AY. Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells. J Extracell Vesicles. 2019; 8(1):1588538. PMID: 30891164.
    10. Vannini I, Fanini F, Fabbri M. Corrigendum to "MicroRNAs as lung cancer biomarkers and key players in lung carcinogenesis" [Clinical Biochemistry 46 (2013) 918-925]. Clin Biochem. 2019 01; 63:162. PMID: 30559003.
      Citations:    Fields:    
    11. Neviani P, Wise PM, Murtadha M, Liu CW, Wu CH, Jong AY, Seeger RC, Fabbri M. Natural Killer-Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms. Cancer Res. 2019 03 15; 79(6):1151-1164. PMID: 30541743.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    12. Marks DL, Olson RL, Urrutia R, Billadeau DD, Roy N, Calin GA, Fabbri M, Koutsioumpa M, Iliopoulos D, Ordog T, Huebert R, Sarmento O, Bamidele AO, Faubion W, Lomberk GL, Siveke J, Ahuja N, Iovanna J, Hlady RA, Robertson K, Kisiel J, Pin CL, Fernandez-Zapico ME. Epigenetics of gastrointestinal diseases: notes from a workshop. Epigenetics. 2018; 13(4):449-457. PMID: 30056798.
      Citations: 1     Fields:    Translation:HumansCells
    13. Shah MY, Ferracin M, Pileczki V, Chen B, Redis R, Fabris L, Zhang X, Ivan C, Shimizu M, Rodriguez-Aguayo C, Dragomir M, Van Roosbroeck K, Almeida MI, Ciccone M, Nedelcu D, Cortez MA, Manshouri T, Calin S, Muftuoglu M, Banerjee PP, Badiwi MH, Parker-Thornburg J, Multani A, Welsh JW, Estecio MR, Ling H, Tomuleasa C, Dima D, Yang H, Alvarez H, You MJ, Radovich M, Shpall E, Fabbri M, Rezvani K, Girnita L, Berindan-Neagoe I, Maitra A, Verstovsek S, Fodde R, Bueso-Ramos C, Gagea M, Manero GG, Calin GA. Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations. Genome Res. 2018 04; 28(4):432-447. PMID: 29567676.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    14. Vannini I, Fanini F, Fabbri M. Emerging roles of microRNAs in cancer. Curr Opin Genet Dev. 2018 02; 48:128-133. PMID: 29429825.
      Citations: 30     Fields:    Translation:HumansAnimals
    15. Vannini I, Wise PM, Challagundla KB, Plousiou M, Raffini M, Bandini E, Fanini F, Paliaga G, Crawford M, Ferracin M, Ivan C, Fabris L, Davuluri RV, Guo Z, Cortez MA, Zhang X, Chen L, Zhang S, Fernandez-Cymering C, Han L, Carloni S, Salvi S, Ling H, Murtadha M, Neviani P, Gitlitz BJ, Laird-Offringa IA, Nana-Sinkam P, Negrini M, Liang H, Amadori D, Cimmino A, Calin GA, Fabbri M. Publisher Correction: Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs. Nat Commun. 2018 01 08; 9(1):160. PMID: 29311577.
      Citations: 2     Fields:    
    16. Fabbri M. MicroRNAs and miRceptors: a new mechanism of action for intercellular communication. Philos Trans R Soc Lond B Biol Sci. 2018 Jan 05; 373(1737). PMID: 29158315.
      Citations: 9     Fields:    Translation:HumansCells
    17. Samuel P, Mulcahy LA, Furlong F, McCarthy HO, Brooks SA, Fabbri M, Pink RC, Carter DRF. Cisplatin induces the release of extracellular vesicles from ovarian cancer cells that can induce invasiveness and drug resistance in bystander cells. Philos Trans R Soc Lond B Biol Sci. 2018 Jan 05; 373(1737). PMID: 29158318.
      Citations: 19     Fields:    Translation:HumansCells
    18. Vannini I, Wise PM, Challagundla KB, Plousiou M, Raffini M, Bandini E, Fanini F, Paliaga G, Crawford M, Ferracin M, Ivan C, Fabris L, Davuluri RV, Guo Z, Cortez MA, Zhang X, Chen L, Zhang S, Fernandez-Cymering C, Han L, Carloni S, Salvi S, Ling H, Murtadha M, Neviani P, Gitlitz BJ, Laird-Offringa IA, Nana-Sinkam P, Negrini M, Liang H, Amadori D, Cimmino A, Calin GA, Fabbri M. Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs. Nat Commun. 2017 11 27; 8(1):1801. PMID: 29180617.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    19. Wen C, Seeger RC, Fabbri M, Wang L, Wayne AS, Jong AY. Biological roles and potential applications of immune cell-derived extracellular vesicles. J Extracell Vesicles. 2017; 6(1):1400370. PMID: 29209467.
    20. Samuel P, Fabbri M, Carter DRF. Mechanisms of Drug Resistance in Cancer: The Role of Extracellular Vesicles. Proteomics. 2017 Dec; 17(23-24). PMID: 28941129.
      Citations: 12     Fields:    Translation:HumansCells
    21. Guo J, Jayaprakash P, Dan J, Wise P, Jang GB, Liang C, Chen M, Woodley DT, Fabbri M, Li W. PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion. Mol Cell Biol. 2017 Oct 01; 37(19). PMID: 28674187.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    22. Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Di Leva G, Fabbri M, Birk DE, Raso C, Green-Church K, Spagnoli LG, Venuta S, Huebner K, Croce CM. Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells. J Biol Chem. 2017 08 25; 292(34):14279. PMID: 28842474.
      Citations: 1     Fields:    
    23. Nakata R, Shimada H, Fernandez GE, Fanter R, Fabbri M, Malvar J, Zimmermann P, DeClerck YA. Contribution of neuroblastoma-derived exosomes to the production of pro-tumorigenic signals by bone marrow mesenchymal stromal cells. J Extracell Vesicles. 2017; 6(1):1332941. PMID: 28717423.
    24. Sempere LF, Keto J, Fabbri M. Exosomal MicroRNAs in Breast Cancer towards Diagnostic and Therapeutic Applications. Cancers (Basel). 2017 Jun 24; 9(7). PMID: 28672799.
    25. Jong AY, Wu CH, Li J, Sun J, Fabbri M, Wayne AS, Seeger RC. Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells. J Extracell Vesicles. 2017; 6(1):1294368. PMID: 28326171.
    26. Ranganathan P, Ngankeu A, Zitzer NC, Leoncini P, Yu X, Casadei L, Challagundla K, Reichenbach DK, Garman S, Ruppert AS, Volinia S, Hofstetter J, Efebera YA, Devine SM, Blazar BR, Fabbri M, Garzon R. Serum miR-29a Is Upregulated in Acute Graft-versus-Host Disease and Activates Dendritic Cells through TLR Binding. J Immunol. 2017 03 15; 198(6):2500-2512. PMID: 28159900.
      Citations: 13     Fields:    Translation:HumansCells
    27. Barbato S, Solaini G, Fabbri M. MicroRNAs in Oncogenesis and Tumor Suppression. Int Rev Cell Mol Biol. 2017; 333:229-268. PMID: 28729026.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    28. Fanini F, Fabbri M. Cancer-derived exosomic microRNAs shape the immune system within the tumor microenvironment: State of the art. Semin Cell Dev Biol. 2017 07; 67:23-28. PMID: 27956165.
      Citations: 17     Fields:    Translation:HumansCells
    29. Van Roosbroeck K, Fanini F, Setoyama T, Ivan C, Rodriguez-Aguayo C, Fuentes-Mattei E, Xiao L, Vannini I, Redis RS, D'Abundo L, Zhang X, Nicoloso MS, Rossi S, Gonzalez-Villasana V, Rupaimoole R, Ferracin M, Morabito F, Neri A, Ruvolo PP, Ruvolo VR, Pecot CV, Amadori D, Abruzzo L, Calin S, Wang X, You MJ, Ferrajoli A, Orlowski R, Plunkett W, Lichtenberg TM, Davuluri RV, Berindan-Neagoe I, Negrini M, Wistuba II, Kantarjian HM, Sood AK, Lopez-Berestein G, Keating MJ, Fabbri M, Calin GA. Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers. Clin Cancer Res. 2017 06 01; 23(11):2891-2904. PMID: 27903673.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    30. Giza DE, Fuentes-Mattei E, Bullock MD, Tudor S, Goblirsch MJ, Fabbri M, Lupu F, Yeung SJ, Vasilescu C, Calin GA. Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications. Cell Death Differ. 2016 12; 23(12):1906-1918. PMID: 27740627.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    31. Frediani JN, Fabbri M. Essential role of miRNAs in orchestrating the biology of the tumor microenvironment. Mol Cancer. 2016 05 26; 15(1):42. PMID: 27231010.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    32. Olivieri M, Ferro M, Terreri S, Durso M, Romanelli A, Avitabile C, De Cobelli O, Messere A, Bruzzese D, Vannini I, Marinelli L, Novellino E, Zhang W, Incoronato M, Ilardi G, Staibano S, Marra L, Franco R, Perdonà S, Terracciano D, Czerniak B, Liguori GL, Colonna V, Fabbri M, Febbraio F, Calin GA, Cimmino A. Long non-coding RNA containing ultraconserved genomic region 8 promotes bladder cancer tumorigenesis. Oncotarget. 2016 Apr 12; 7(15):20636-54. PMID: 26943042.
      Citations: 24     Fields:    Translation:HumansCells
    33. Neviani P, Fabbri M. Exosomic microRNAs in the Tumor Microenvironment. Front Med (Lausanne). 2015; 2:47. PMID: 26258125.
    34. Challagundla KB, Wise PM, Neviani P, Chava H, Murtadha M, Xu T, Kennedy R, Ivan C, Zhang X, Vannini I, Fanini F, Amadori D, Calin GA, Hadjidaniel M, Shimada H, Jong A, Seeger RC, Asgharzadeh S, Goldkorn A, Fabbri M. Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy. J Natl Cancer Inst. 2015 Jul; 107(7). PMID: 25972604.
      Citations: 122     Fields:    Translation:HumansCells
    35. Fei F, Joo EJ, Tarighat SS, Schiffer I, Paz H, Fabbri M, Abdel-Azim H, Groffen J, Heisterkamp N. B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3. Oncotarget. 2015 May 10; 6(13):11378-94. PMID: 25869099.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    36. Ling H, Pickard K, Ivan C, Isella C, Ikuo M, Mitter R, Spizzo R, Bullock M, Braicu C, Pileczki V, Vincent K, Pichler M, Stiegelbauer V, Hoefler G, Almeida MI, Hsiao A, Zhang X, Primrose J, Packham G, Liu K, Bojja K, Gafà R, Xiao L, Rossi S, Song JH, Vannini I, Fanini F, Kopetz S, Zweidler-McKay P, Wang X, Ionescu C, Irimie A, Fabbri M, Lanza G, Hamilton SR, Berindan-Neagoe I, Medico E, Mirnezami A, Calin GA, Nicoloso MS. The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis. Gut. 2016 06; 65(6):977-989. PMID: 25804630.
      Citations: 53     Fields:    Translation:HumansAnimals
    37. de Rosa F, Fanini F, Guidoboni M, Vannini I, Amadori D, Ridolfi R, Ridolfi L, Fabbri M. MicroRNAs and dendritic cell-based vaccination in melanoma patients. Melanoma Res. 2014 Jun; 24(3):181-9. PMID: 24638153.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    38. Challagundla KB, Fanini F, Vannini I, Wise P, Murtadha M, Malinconico L, Cimmino A, Fabbri M. microRNAs in the tumor microenvironment: solving the riddle for a better diagnostics. Expert Rev Mol Diagn. 2014 Jun; 14(5):565-74. PMID: 24844135.
      Citations: 23     Fields:    Translation:HumansCells
    39. Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Cascione L, Sumani KM, Veronese A, Fabbri M, Carasi S, Alder H, Lanza G, Gafa' R, Moyer MP, Ridgway RA, Cordero J, Nuovo GJ, Frankel WL, Rugge M, Fassan M, Groden J, Vogt PK, Karin M, Sansom OJ, Croce CM. MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell. 2014 Apr 14; 25(4):469-83. PMID: 24735923.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    40. Ling H, Fabbri M, Calin GA. MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov. 2013 Nov; 12(11):847-65. PMID: 24172333.
      Citations: 439     Fields:    Translation:Humans
    41. Aalaei-Andabili SH, Fabbri M, Rezaei N. Reciprocal effects of Toll-like receptors and miRNAs on biological processes in human health and disease: a systematic review. Immunotherapy. 2013 Oct; 5(10):1127-42. PMID: 24088081.
      Citations: 7     Fields:    Translation:Humans
    42. Liu SV, Fabbri M, Gitlitz BJ, Laird-Offringa IA. Epigenetic therapy in lung cancer. Front Oncol. 2013; 3:135. PMID: 23755372.
    43. Galli R, Paone A, Fabbri M, Zanesi N, Calore F, Cascione L, Acunzo M, Stoppacciaro A, Tubaro A, Lovat F, Gasparini P, Fadda P, Alder H, Volinia S, Filippini A, Ziparo E, Riccioli A, Croce CM. Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RARß and tumor regression. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9812-7. PMID: 23716670.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    44. Vannini I, Fanini F, Fabbri M. MicroRNAs as lung cancer biomarkers and key players in lung carcinogenesis. Clin Biochem. 2013 Jul; 46(10-11):918-25. PMID: 23396164.
      Citations: 17     Fields:    Translation:HumansAnimals
    45. Kang HW, Crawford M, Fabbri M, Nuovo G, Garofalo M, Nana-Sinkam SP, Friedman A. A mathematical model for microRNA in lung cancer. PLoS One. 2013; 8(1):e53663. PMID: 23365639.
      Citations: 16     Fields:    Translation:HumansCells
    46. Fabbri M, Paone A, Calore F, Galli R, Croce CM. A new role for microRNAs, as ligands of Toll-like receptors. RNA Biol. 2013 Feb; 10(2):169-74. PMID: 23296026.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    47. Fabbri M, Calore F, Paone A, Galli R, Calin GA. Epigenetic regulation of miRNAs in cancer. Adv Exp Med Biol. 2013; 754:137-48. PMID: 22956499.
      Citations: 35     Fields:    Translation:HumansAnimals
    48. Fabbri M. TLRs as miRNA receptors. Cancer Res. 2012 Dec 15; 72(24):6333-7. PMID: 23222301.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    49. Gaudio E, Paduano F, Ngankeu A, Lovat F, Fabbri M, Sun HL, Gasparini P, Efanov A, Peng Y, Zanesi N, Shuaib MA, Rassenti LZ, Kipps TJ, Li C, Aqeilan RI, Lesinski GB, Trapasso F, Croce CM. Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas. Blood. 2013 Jan 10; 121(2):351-9. PMID: 23160471.
      Citations: 3     Fields:    Translation:HumansAnimals
    50. McCleary-Wheeler AL, Lomberk GA, Weiss FU, Schneider G, Fabbri M, Poshusta TL, Dusetti NJ, Baumgart S, Iovanna JL, Ellenrieder V, Urrutia R, Fernandez-Zapico ME. Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis. Cancer Lett. 2013 Jan 28; 328(2):212-21. PMID: 23073473.
      Citations: 36     Fields:    Translation:HumansCells
    51. Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, Lovat F, Fadda P, Mao C, Nuovo GJ, Zanesi N, Crawford M, Ozer GH, Wernicke D, Alder H, Caligiuri MA, Nana-Sinkam P, Perrotti D, Croce CM. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):E2110-6. PMID: 22753494.
      Citations: 511     Fields:    Translation:HumansAnimalsCells
    52. Almeida MI, Nicoloso MS, Zeng L, Ivan C, Spizzo R, Gafà R, Xiao L, Zhang X, Vannini I, Fanini F, Fabbri M, Lanza G, Reis RM, Zweidler-McKay PA, Calin GA. Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells. Gastroenterology. 2012 Apr; 142(4):886-896.e9. PMID: 22240480.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    53. Fanini F, Vannini I, Amadori D, Fabbri M. Clinical implications of microRNAs in lung cancer. Semin Oncol. 2011 Dec; 38(6):776-80. PMID: 22082763.
      Citations: 12     Fields:    Translation:Humans
    54. Paone A, Galli R, Fabbri M. MicroRNAs as New Characters in the Plot between Epigenetics and Prostate Cancer. Front Genet. 2011; 2:62. PMID: 22303357.
    55. Fabbri M, Croce CM. Role of microRNAs in lymphoid biology and disease. Curr Opin Hematol. 2011 Jul; 18(4):266-72. PMID: 21519241.
      Citations: 20     Fields:    Translation:HumansAnimals
    56. Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M. MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. Clin Cancer Res. 2011 May 01; 17(9):2725-33. PMID: 21220473.
      Citations: 104     Fields:    Translation:HumansCells
    57. Fabbri M, Bottoni A, Shimizu M, Spizzo R, Nicoloso MS, Rossi S, Barbarotto E, Cimmino A, Adair B, Wojcik SE, Valeri N, Calore F, Sampath D, Fanini F, Vannini I, Musuraca G, Dell'Aquila M, Alder H, Davuluri RV, Rassenti LZ, Negrini M, Nakamura T, Amadori D, Kay NE, Rai KR, Keating MJ, Kipps TJ, Calin GA, Croce CM. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA. 2011 Jan 05; 305(1):59-67. PMID: 21205967.
      Citations: 108     Fields:    Translation:HumansCells
    58. Fabbri M. Targeting ncRNAs to combat metastases. Epigenomics. 2010 Dec; 2(6):719-21. PMID: 22122076.
      Citations: 1     Fields:    Translation:Humans
    59. Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM. MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci U S A. 2010 Dec 07; 107(49):21098-103. PMID: 21078976.
      Citations: 148     Fields:    Translation:HumansCells
    60. Nana-Sinkam SP, Fabbri M, Croce CM. MicroRNAs in cancer: personalizing diagnosis and therapy. Ann N Y Acad Sci. 2010 Oct; 1210:25-33. PMID: 20973796.
      Citations: 15     Fields:    Translation:HumansCells
    61. Gatto S, Della Ragione F, Cimmino A, Strazzullo M, Fabbri M, Mutarelli M, Ferraro L, Weisz A, D'Esposito M, Matarazzo MR. Epigenetic alteration of microRNAs in DNMT3B-mutated patients of ICF syndrome. Epigenetics. 2010 Jul 01; 5(5):427-43. PMID: 20448464.
      Citations: 15     Fields:    Translation:HumansCells
    62. Fabbri M. miRNAs as molecular biomarkers of cancer. Expert Rev Mol Diagn. 2010 May; 10(4):435-44. PMID: 20465498.
      Citations: 43     Fields:    Translation:Humans
    63. Volinia S, Galasso M, Costinean S, Tagliavini L, Gamberoni G, Drusco A, Marchesini J, Mascellani N, Sana ME, Abu Jarour R, Desponts C, Teitell M, Baffa R, Aqeilan R, Iorio MV, Taccioli C, Garzon R, Di Leva G, Fabbri M, Catozzi M, Previati M, Ambs S, Palumbo T, Garofalo M, Veronese A, Bottoni A, Gasparini P, Harris CC, Visone R, Pekarsky Y, de la Chapelle A, Bloomston M, Dillhoff M, Rassenti LZ, Kipps TJ, Huebner K, Pichiorri F, Lenze D, Cairo S, Buendia MA, Pineau P, Dejean A, Zanesi N, Rossi S, Calin GA, Liu CG, Palatini J, Negrini M, Vecchione A, Rosenberg A, Croce CM. Reprogramming of miRNA networks in cancer and leukemia. Genome Res. 2010 May; 20(5):589-99. PMID: 20439436.
      Citations: 151     Fields:    Translation:HumansAnimalsCells
    64. Fabbri M, Calin GA. Beyond genomics: interpreting the 93% of the human genome that does not encode proteins. Curr Opin Drug Discov Devel. 2010 May; 13(3):350-8. PMID: 20443168.
      Citations: 5     Fields:    Translation:HumansCells
    65. Cohn DE, Fabbri M, Valeri N, Alder H, Ivanov I, Liu CG, Croce CM, Resnick KE. Comprehensive miRNA profiling of surgically staged endometrial cancer. Am J Obstet Gynecol. 2010 Jun; 202(6):656.e1-8. PMID: 20400061.
      Citations: 36     Fields:    Translation:HumansCells
    66. Rossi S, Shimizu M, Barbarotto E, Nicoloso MS, Dimitri F, Sampath D, Fabbri M, Lerner S, Barron LL, Rassenti LZ, Jiang L, Xiao L, Hu J, Secchiero P, Zauli G, Volinia S, Negrini M, Wierda W, Kipps TJ, Plunkett W, Coombes KR, Abruzzo LV, Keating MJ, Calin GA. microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival. Blood. 2010 Aug 12; 116(6):945-52. PMID: 20393129.
      Citations: 76     Fields:    Translation:HumansCells
    67. Valeri N, Gasparini P, Fabbri M, Braconi C, Veronese A, Lovat F, Adair B, Vannini I, Fanini F, Bottoni A, Costinean S, Sandhu SK, Nuovo GJ, Alder H, Gafa R, Calore F, Ferracin M, Lanza G, Volinia S, Negrini M, McIlhatton MA, Amadori D, Fishel R, Croce CM. Modulation of mismatch repair and genomic stability by miR-155. Proc Natl Acad Sci U S A. 2010 Apr 13; 107(15):6982-7. PMID: 20351277.
      Citations: 124     Fields:    Translation:HumansCells
    68. Fabbri M, Calin GA. Epigenetics and miRNAs in human cancer. Adv Genet. 2010; 70:87-99. PMID: 20920746.
      Citations: 63     Fields:    Translation:HumansCells
    69. Fabbri M, Spizzo R, Calin GA. High-throughput profiling in the hematopoietic system. Methods Mol Biol. 2010; 667:79-91. PMID: 20827528.
      Citations:    Fields:    Translation:HumansAnimals
    70. Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, Croce CM. MicroRNA 29b functions in acute myeloid leukemia. Blood. 2009 Dec 17; 114(26):5331-41. PMID: 19850741.
      Citations: 194     Fields:    Translation:HumansAnimals
    71. Valeri N, Vannini I, Fanini F, Calore F, Adair B, Fabbri M. Epigenetics, miRNAs, and human cancer: a new chapter in human gene regulation. Mamm Genome. 2009 Sep-Oct; 20(9-10):573-80. PMID: 19697081.
      Citations: 33     Fields:    Translation:HumansAnimals
    72. Valeri N, Croce CM, Fabbri M. Pathogenetic and clinical relevance of microRNAs in colorectal cancer. Cancer Genomics Proteomics. 2009 Jul-Aug; 6(4):195-204. PMID: 19656996.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    73. Fabbri M, Valeri N, Calin GA. MicroRNAs and genomic variations: from Proteus tricks to Prometheus gift. Carcinogenesis. 2009 Jun; 30(6):912-7. PMID: 19293341.
      Citations: 12     Fields:    Translation:HumansCells
    74. Garzon R, Liu S, Fabbri M, Liu Z, Heaphy CE, Callegari E, Schwind S, Pang J, Yu J, Muthusamy N, Havelange V, Volinia S, Blum W, Rush LJ, Perrotti D, Andreeff M, Bloomfield CD, Byrd JC, Chan K, Wu LC, Croce CM, Marcucci G. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood. 2009 Jun 18; 113(25):6411-8. PMID: 19211935.
      Citations: 326     Fields:    Translation:HumansCells
    75. Fabbri M, Croce CM, Calin GA. MicroRNAs in the ontogeny of leukemias and lymphomas. Leuk Lymphoma. 2009 Feb; 50(2):160-70. PMID: 19160125.
      Citations: 27     Fields:    Translation:HumansAnimals
    76. Fabbri M. MicroRNAs and cancer epigenetics. Curr Opin Investig Drugs. 2008 Jun; 9(6):583-90. PMID: 18516758.
      Citations: 16     Fields:    Translation:HumansAnimals
    77. Calin GA, Cimmino A, Fabbri M, Ferracin M, Wojcik SE, Shimizu M, Taccioli C, Zanesi N, Garzon R, Aqeilan RI, Alder H, Volinia S, Rassenti L, Liu X, Liu CG, Kipps TJ, Negrini M, Croce CM. MiR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci U S A. 2008 Apr 01; 105(13):5166-71. PMID: 18362358.
      Citations: 277     Fields:    Translation:HumansAnimalsCells
    78. Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Di Leva G, Fabbri M, Birk DE, Raso C, Green-Church K, Spagnoli LG, Venuta S, Huebner K, Croce CM. Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells. J Biol Chem. 2008 May 16; 283(20):13736-44. PMID: 18319262.
      Citations: 29     Fields:    Translation:HumansCells
    79. Garzon R, Volinia S, Liu CG, Fernandez-Cymering C, Palumbo T, Pichiorri F, Fabbri M, Coombes K, Alder H, Nakamura T, Flomenberg N, Marcucci G, Calin GA, Kornblau SM, Kantarjian H, Bloomfield CD, Andreeff M, Croce CM. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood. 2008 Mar 15; 111(6):3183-9. PMID: 18187662.
      Citations: 260     Fields:    Translation:HumansCells
    80. Fabbri M, Croce CM, Calin GA. MicroRNAs. Cancer J. 2008 Jan-Feb; 14(1):1-6. PMID: 18303474.
      Citations: 92     Fields:    Translation:HumansCells
    81. Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, Adair B, Fabbri M, Alder H, Liu CG, Calin GA, Croce CM. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol. 2007 Oct 15; 179(8):5082-9. PMID: 17911593.
      Citations: 527     Fields:    Translation:HumansAnimalsCells
    82. Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E, Liu S, Alder H, Costinean S, Fernandez-Cymering C, Volinia S, Guler G, Morrison CD, Chan KK, Marcucci G, Calin GA, Huebner K, Croce CM. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15805-10. PMID: 17890317.
      Citations: 650     Fields:    Translation:HumansCells
    83. Calin GA, Liu CG, Ferracin M, Hyslop T, Spizzo R, Sevignani C, Fabbri M, Cimmino A, Lee EJ, Wojcik SE, Shimizu M, Tili E, Rossi S, Taccioli C, Pichiorri F, Liu X, Zupo S, Herlea V, Gramantieri L, Lanza G, Alder H, Rassenti L, Volinia S, Schmittgen TD, Kipps TJ, Negrini M, Croce CM. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell. 2007 Sep; 12(3):215-29. PMID: 17785203.
      Citations: 296     Fields:    Translation:HumansCells
    84. Fabbri M, Ivan M, Cimmino A, Negrini M, Calin GA. Regulatory mechanisms of microRNAs involvement in cancer. Expert Opin Biol Ther. 2007 Jul; 7(7):1009-19. PMID: 17665990.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    85. Sever NI, Younan S, E Wojcik S, Spizzo R, Fabbri M, Calin GA. Use of miRNA expression profiling to identify novel biomarkers. Per Med. 2007 May; 4(2):147-155. PMID: 29788626.
      Citations:    Fields:    
    86. Donati V, Fontanini G, Dell'Omodarme M, Prati MC, Nuti S, Lucchi M, Mussi A, Fabbri M, Basolo F, Croce CM, Aqeilan RI. WWOX expression in different histologic types and subtypes of non-small cell lung cancer. Clin Cancer Res. 2007 Feb 01; 13(3):884-91. PMID: 17289881.
      Citations: 26     Fields:    Translation:Humans
    87. Iliopoulos D, Fabbri M, Druck T, Qin HR, Han SY, Huebner K. Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression. Clin Cancer Res. 2007 Jan 01; 13(1):268-74. PMID: 17200365.
      Citations: 34     Fields:    Translation:HumansCells
    88. Garzon R, Fabbri M, Cimmino A, Calin GA, Croce CM. MicroRNA expression and function in cancer. Trends Mol Med. 2006 Dec; 12(12):580-7. PMID: 17071139.
      Citations: 300     Fields:    Translation:HumansAnimals
    89. Qin HR, Iliopoulos D, Semba S, Fabbri M, Druck T, Volinia S, Croce CM, Morrison CD, Klein RD, Huebner K. A role for the WWOX gene in prostate cancer. Cancer Res. 2006 Jul 01; 66(13):6477-81. PMID: 16818616.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    90. Calin GA, Garzon R, Cimmino A, Fabbri M, Croce CM. MicroRNAs and leukemias: how strong is the connection? Leuk Res. 2006 Jun; 30(6):653-5. PMID: 16330098.
      Citations: 18     Fields:    Translation:HumansCells
    91. Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE, Iorio MV, Visone R, Sever NI, Fabbri M, Iuliano R, Palumbo T, Pichiorri F, Roldo C, Garzon R, Sevignani C, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 2005 Oct 27; 353(17):1793-801. PMID: 16251535.
      Citations: 856     Fields:    Translation:HumansCells
    92. Fabbri M, Iliopoulos D, Trapasso F, Aqeilan RI, Cimmino A, Zanesi N, Yendamuri S, Han SY, Amadori D, Huebner K, Croce CM. WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Proc Natl Acad Sci U S A. 2005 10 25; 102(43):15611-6. PMID: 16223882.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    93. Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, Wojcik SE, Aqeilan RI, Zupo S, Dono M, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13944-9. PMID: 16166262.
      Citations: 1255     Fields:    Translation:HumansCells
    94. Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, Ménard S, Palazzo JP, Rosenberg A, Musiani P, Volinia S, Nenci I, Calin GA, Querzoli P, Negrini M, Croce CM. MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 2005 Aug 15; 65(16):7065-70. PMID: 16103053.
      Citations: 1500     Fields:    Translation:Humans
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