PROFILES - Connect with RTRN Researchers

Carlos A. Torres-Ramos
Title Principal Investigator
Faculty Rank Associate Professor
Degree Ph.D.
Institution University of Puerto Rico
Department Department of Physiology
Clusters Cancer
Genes and Environmental Health/Toxicology
Obesity and Metabolic Syndromes
Address
PO Box 365067
City San Juan
State PR
Postal Code 00936-5067
Telephone 787-758-2525 x1393
Fax
Email
QR Barcode

Narrative icon

  I am interested in understanding how mitochondrial DNA repair processes contribute to physiological functions. Studies in aging and pathological conditions such as cancer and some neurodegenerative disorders have revealed that maintenance of mitochondrial DNA integrity is essential for physiological processes. I am interested in understand how DNA repair contributes to mitochondrial function and how this relates to aging and cancer. In addition, my laboratory studies how environmental factors may affect mitochondrial DNA integrity and mitochondrial function. My laboratory uses a variety of experimental models such as yeast cells, mice, and human cells to ask questions about DNA repair and mitochondrial function.

NIH Awarded Grants icon

  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

Loading
Please wait
1.
2018HEAD START CONNECTS: INDIVIDUALIZING AND CONNECTS FAMILIES TO FAMILY SUPPORT SERVICESHHSP233201500059I/HHSP233201500059I
2.
2018 EARLY CARE AND EDUCATION LEADERSHIP STUDY (EXCELS)HHSP233201500035I / HHSP23337038T
3.
2018WHAT WORKS CLEARINGHOUSE OF PROVEN AND PROMISING APPROACHES TO MOVE WELFARE RECIPIENTS TO WORKHHSP233201500035I_HHSP23337034T
4.
2018RACIAL AND ETHNIC DISPARITIES IN HUMAN SERVICES ANALYSIS EXECUTION PROJECTHHSP233201500064I_HHSP23337020T
5.
2018ASSESSING MODELS OF COORDINATED SERVICES FOR LOW-INCOME CHILDREN AND THEIR FAMILIESHHSP233201500035I/HHSP23337028T
6.
2018CHILD CARE INTERSTATE BACKGROUND CHECKS (CC-IBACS)HHSP233201500045I
7.
2018MOTHER AND INFANT HOME VISITING PROGRAM EVALUATION, LONG-TERM FOLLOW-UP 2 (MIHOPE-LT2)HHSP233201500059I/ HHSP23337010T
8.
2017EXPLORING THE RELATION BETWEEN POSITIVE BEHAVIOR SUPPORT AND LANGUAGE LEARNING OPPORTUNITIES IN PRESCHOOL CLASSROOMS.90YR0101-01
9.
2017ADDRESSING THE NEEDS OF INFANTS AND TODDLERS EXPOSED TO MALTREATMENT: EXAMINING THE IMPACT OF AN INTEGRATED EARLY HEAD START & CHILDREN AND YOUTH SERVICES PROGRAM90YR0102-01
10.
2017LEVERAGING HOME LANGUAGES TO PROMOTE EXECUTIVE FUNCTIONING90YR0103-01
11.
2017A STRENGTHS-BASED APPROACH TO EXAMINING SUPPORTS FOR SELF-REGULATION SKILLS OF LATINO CHILDREN RAISED IN POVERTY90YR0104-01
12.
2017OBSERVING SELF-REGULATION IN CONTEXT IN HEAD START CLASSROOMS AND DUAL LANGUAGE LEARNERS SCHOOL READINESS90YR0105-01
13.
2017IMPLEMENTATION AND ASSESSMENT OF COMPETENCIES FOR TEACHERS AND CAREGIVERS SERVING INFANTS AND TODDLERSHHSP233201500035I/HHSP23337021T
14.
2017ASSESSMENT AND MAPPING OF COMMUNITY CONNECTIONS IN HOME VISITING (AMC-HV)HHSP233201500034I/HHSP23337002T
15.
2017CHILD MALTREATMENT INCIDENCE DATA LINKAGES (CMI DATA LINKAGES)HHSP233201500035I/HHSP23337022T
16.
2017EVIDENCE BUILDING IN TANF: ADVANCING INNOVATIONS TO PROMOTE EMPLOYMENT AND ECONOMIC SECURITY FOR LOW-INCOME INDIVIDUALSHHSP233201500059I/HHSP23337006T
17.
2017HEAD START FAMILY AND CHILD EXPERIENCES SURVEY (FACES) 2019HHSP233201500035I/HHSP23337024T
18.
2016TWO-GENERATION APPROACHES TO IMPROVING FAMILY SELF-SUFFICIENCYHHSP233201500035I/HHSP23337003T
19.
2016BUILDING CAPACITY TO EVALUATE INTERVENTIONS FOR YOUTH/YOUNG ADULTS WITH CHILD WELFARE INVOLVEMENT AT-RISK OF HOMELESSNESS: PHASE IIHHSP233201500035I/HHSP23337013T
20.
2016PROFESSIONAL DEVELOPMENT TOOLS TO IMPROVE THE QUALITY OF INFANT AND TODDLER CAREHHSP233201500035I/HHSP23337007T
21.
2016ASSESSING THE EVIDENCE: HOME VISITING EVIDENCE OF EFFECTIVENESSGS-10F-0050L/HHSP233201500115G
22.
2016TRIBAL HOME VISITING EVALUATION INSTITUTEGS-10F-0204K/HHSP233201500114G
23.
2016FAMILY SELF-SUFFICIENCY DATA CENTER90PD0272-04
24.
2016EVALUATION OF GOAL-DIRECTED PSYCHOLOGICAL CAPITAL AND EMPLOYER COACHING IN HEALTH PROFESSION OPPORTUNITY DEVELOPMENT90HG1003-01
25.
2016CULTURE OF CONTINUOUS LEARNING PROJECT: A BREAKTHROUGH SERIES COLLABORATIVE FOR IMPROVING CHILD CARE AND HEAD START QUALITYHHSP233201500034I/HHSP23337001T
26.
2016DOMESTIC HUMAN TRAFFICKING AND THE CHILD WELFARE POPULATIONHHSP23320150039I/HHSP23337011T
27.
2016EVALUATION OF COACHING-FOCUSED INTERVENTIONS FOR HARD-TO-EMPLOY TANF CLIENTS AND OTHER LOW-INCOME POPULATIONSHHSP233201500035I/HHSP23337018T
28.
2016EVALUATION OF THE NATIONAL HUMAN TRAFFICKING HOTLINE PROGRAMHHSP233201500039I/ HHSP23337007T
29.
2016MULTI-SITE IMPLEMENTATION EVALUATION OF TRIBAL HOME VISITING (MUSE)HHSP233201500133I/HHSP23337004T
30.
2016VARIATIONS IN IMPLEMENTATION OF QUALITY INTERVENTIONS: EXAMINING THE QUALITY-CHILD OUTCOMES RELATIONSHIP IN CHILD CARE AND EARLY EDUCATION (VIQI)HHSP233201500059I/HHSP23337002T
31.
2016DESIGN OPTIONS FOR HOME VISITING EVALUATION (DOHVE) 2.0HHSP233201500133I/HHSP23337002T
32.
2016ADVANCING WELFARE AND FAMILY SELF-SUFFICIENCY RESEARCH PROJECT (FOLLOW-ON) HHSP233201500035I/HHSP23337017T
33.
2016HPOG UNIVERSITY PARTNERSHIPS 2.0 RESEARCH SUPPORTHHSP233201500071I/HHSP23337011T
34.
2015THE CHANGING LANDSCAPE OF PUBLICLY-FUNDED CENTER-BASED CHILD CARE: 1990 AND 2012.90YE0165-01
35.
2015SUBSIDY UTILIZATION AND IMPACT ON EARLY CARE AND EDUCATION OF LOW-INCOME CHILDREN WITH SPECIAL NEEDS90YE0166-01
36.
2015PROMOTING SOCIAL COMPETENCE IN ECE: PREDICTING THE DEVELOPMENT OF PROSOCIAL BEHAVIOR FROM EARLY EXPERIENCES IN CHILD CARE AND FAMILIES90YE0168-01
37.
2015THE IMPACT OF EARLY CARE AND EDUCATION IN CHILD NUTRITION, SEDENTARY BEHAVIOR AND OBESITY BY KINDERGARTEN90YE0170-01
38.
2015HOW PARENTAL PREFERENCES AND SUBSIDY RECEIPT SHAPE IMMIGRANT FAMILIES? CHILD CARE CHOICES90YE0171-01
39.
2015SUPPORTING LOW-INCOME FAMILIES: STATE VARIATIONS IN CHILD CARE SUBSIDIES AND TANF POLICIES AND CHILDREN'S DEVELOPMENTAL ECOLOGIES90YE0173-01
40.
2015MITIGATING SUSCEPTIBILITY WITH THE CHILD CARE DEVELOPMENT FUND: USING FOUR LARGE DATA SETS TO CLASSIFY RISK PROFILES AND RISK TRANSMISSION BY MODIFIABLE FACTORS90YE0175-01
41.
2015ARE HIGHER SUBSIDY PAYMENT RATES AND PROVIDER-FRIENDLY PAYMENT POLICIES ASSOCIATED WITH CHILD CARE QUALITY?90YE0177-01
42.
2015CHILD CARE FACTORS THAT INFLUENCE PARENTAL ENGAGEMENT: UNDERSTANDING LONGITUDINAL PATHWAYS TO CHILDREN?S SCHOOL READINESS90YE0178-01
43.
2015CONSTELLATIONS OF SUPPORT: TEACHER PROFESSIONAL DEVELOPMENT IN HEAD START AND CHILD OUTCOMES90YE0179-01
44.
2015SUHMRE: SAME-SEX RELATIONSHIPS: UPDATES TO HEALTHY MARRIAGE AND RELATIONSHIP EDUCATION PROGRAMMINGHHSP233201500064I/HHSP23337001T
45.
2014ASSESSING THE COST AND IMPLEMENTATION OF HIGH QUALITY EARLY CARE AND EDUCATION (ACIHQECE)HHSP23320095642WC-01
46.
2014INTERMEDIATE OUTCOMES OF CAREER PATHWAYS PROGRAMSHHSP233200956WC-01
47.
2014CHILD CARE AND DEVELOPMENT FUND (CCDF) POLICIES DATABASE PROJECTHHSP23320095654WC-01
48.
2014EVALUATION OF DOMESTIC HUMAN TRAFFICKING DEMONSTRATION PROJECTSHHSP23320095651WC-01
49.
2014HOMELESS FAMILIES RESEARCH BRIEFSHHSP23320095624WC-01
50.
2014RESPONDING TO INTIMATE VIOLENCE IN RELATIONSHIP PROGRAMS (RIVIR)HHSP23320095651WC-01
51.
2014UNDERSTANDING THE INTERSECTION BETWEEN TANF AND REFUGEE CASH ASSISTANCE SERVICESHHSP23320095624WC-01
52.
2014IMPROVING CHILDREN?S WELL-BEING: IDENTIFYING MECHANISMS AND TIMING OF FAMILY STRENGTHENING PROGRAMS FOR LOW-INCOME FAMILIES THROUGH DIFFERENTIAL EQUATION MODELING90PD0285-01
53.
2013MOTHER AND INFANT HOME VISITING PROGRAM EVALUATION (MIHOPE)HHSP23337003T-03
54.
2013STUDY OF EMPLOYMENT AND ADVANCEMENT OF RACIAL, ETHNIC AND LINGUISTIC MINORITIES90PH0021-02
55.
2013CHILD CARE AND EARLY EDUCATION POLICY AND RESEARCH ANALYSES (CCEEPRA)HHSP23320095631WC-01
56.
2013EARLY HEAD START-CHILD CARE PARTNERSHIPS STUDYHHSP23320095642WC-01
57.
2013EMPLOYMENT AND TRAINING EVIDENCE REVIEWHHSP23320095642WC-01
58.
2013MATERNAL, INFANT AND EARLY CHILDHOOD HOME VISITING EVALUATION (MIHOPE) IIHHSP23320095644WC-01
59.
2013JOB SEARCH ASSISTANCE EVALUATIONHHSP23320095624WC-01
60.
2013CHILD CARE ADMINISTRATIVE DATA ANALYSIS90YE0148-01
61.
2013HEAD START UNIVERSITY PARTNERSHIPS: DUAL GENERATION APPROACHES90YR0073-01
62.
2013HEAD START UNIVERSITY PARTNERSHIPS: DUAL GENERATION APPROACHES90YR0075-01
63.
2013HUMAN SERVICES RESEARCH PARTNERSHIPS: PUERTO RICO 90YR0072-01

Publications icon

  Check NIH Public Access Policy Compliance

Loading
Please wait
1. Forestier-Román IS, López-Rivas A, Sánchez-Vázquez MM, Rohena-Rivera K, Nieves-Burgos G, Ortiz-Zuazaga H, Torres-Ramos CA, Martínez-Ferrer M. Andrographolide induces DNA damage in prostate cancer cells. Oncotarget. 2019 Feb 01; 10(10):1085-1101.
2. Ramírez Lugo JS, Torres-Ramos CA. Rebuilding Caribbean science. Science. 2017 Oct 13; 358(6360):151.
3. Ballista-Hernández J, Martínez-Ferrer M, Vélez R, Climent C, Sánchez-Vázquez MM, Torres C, Rodríguez-Muñoz A, Ayala-Peña S, Torres-Ramos CA. Mitochondrial DNA Integrity Is Maintained by APE1 in Carcinogen-Induced Colorectal Cancer. Mol Cancer Res. 2017 07; 15(7):831-841.
4. Barreto-Torres G, Hernandez JS, Jang S, Rodríguez-Muñoz AR, Torres-Ramos CA, Basnakian AG, Javadov S. The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARa-cyclophilin D interaction in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2015 Apr 01; 308(7):H749-58.
5. Jansen RJ, Fonseca-Williams S, Bamlet WR, Ayala-Peña S, Oberg AL, Petersen GM, Torres-Ramos CA. Detection of DNA damage in peripheral blood mononuclear cells from pancreatic cancer patients. Mol Carcinog. 2015 Oct; 54(10):1220-6.
6. López-López L, Nieves-Plaza M, Castro Mdel R, Font YM, Torres-Ramos CA, Vilá LM, Ayala-Peña S. Mitochondrial DNA damage is associated with damage accrual and disease duration in patients with systemic lupus erythematosus. Lupus. 2014 Oct; 23(11):1133-41.
7. Siddiqui A, Rivera-Sánchez S, Castro Mdel R, Acevedo-Torres K, Rane A, Torres-Ramos CA, Nicholls DG, Andersen JK, Ayala-Torres S. Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington''s disease. Free Radic Biol Med. 2012 Oct 01; 53(7):1478-88.
8. Vogel KS, Perez M, Momand JR, Acevedo-Torres K, Hildreth K, Garcia RA, Torres-Ramos CA, Ayala-Torres S, Prihoda TJ, McMahan CA, Walter CA. Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice. Mol Reprod Dev. 2011 Dec; 78(12):906-19.
9. Acevedo-Torres K, Fonseca-Williams S, Ayala-Torres S, Torres-Ramos CA. Requirement of the Saccharomyces cerevisiae APN1 gene for the repair of mitochondrial DNA alkylation damage. Environ Mol Mutagen. 2009 May; 50(4):317-27.
10. Acevedo-Torres K, Berríos L, Rosario N, Dufault V, Skatchkov S, Eaton MJ, Torres-Ramos CA, Ayala-Torres S. Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington''s disease. DNA Repair (Amst). 2009 Jan 01; 8(1):126-36.
11. Guzder SN, Torres-Ramos C, Johnson RE, Haracska L, Prakash L, Prakash S. Requirement of yeast Rad1-Rad10 nuclease for the removal of 3''-blocked termini from DNA strand breaks induced by reactive oxygen species. Genes Dev. 2004 Sep 15; 18(18):2283-91.
12. Haracska L, Torres-Ramos CA, Johnson RE, Prakash S, Prakash L. Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae. Mol Cell Biol. 2004 May; 24(10):4267-74.
13. Torres-Ramos CA, Prakash S, Prakash L. Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae. Mol Cell Biol. 2002 Apr; 22(7):2419-26.
14. Torres-Ramos CA, Johnson RE, Prakash L, Prakash S. Evidence for the involvement of nucleotide excision repair in the removal of abasic sites in yeast. Mol Cell Biol. 2000 May; 20(10):3522-8.
15. Johnson RE, Torres-Ramos CA, Izumi T, Mitra S, Prakash S, Prakash L. Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. Genes Dev. 1998 Oct 01; 12(19):3137-43.
16. Torres-Ramos CA, Prakash S, Prakash L. Requirement of yeast DNA polymerase delta in post-replicational repair of UV-damaged DNA. J Biol Chem. 1997 Oct 10; 272(41):25445-8.
17. Torres-Ramos CA, Yoder BL, Burgers PM, Prakash S, Prakash L. Requirement of proliferating cell nuclear antigen in RAD6-dependent postreplicational DNA repair. Proc Natl Acad Sci U S A. 1996 Sep 03; 93(18):9676-81.
18. Grompe M, Lindstedt S, al-Dhalimy M, Kennaway NG, Papaconstantinou J, Torres-Ramos CA, Ou CN, Finegold M. Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I. Nat Genet. 1995 Aug; 10(4):453-60.
19. Rabek JP, Zhang DE, Torres-Ramos CA, Papaconstantinou J. Analysis of the mechanism of glucocorticoid-mediated down regulation of the mouse alpha-fetoprotein gene. Biochim Biophys Acta. 1994 Jun 21; 1218(2):136-44.
20. Zhang DE, Rabek JP, Hsieh CC, Torres-Ramos C, Papaconstantinou J. Functional analysis of the mouse alpha-fetoprotein enhancers and their subfragments in primary mouse hepatocyte cultures. J Biol Chem. 1992 May 25; 267(15):10676-82.

Research Resources icon

Publications Timeline

Top MeSH Keywords

Tree Map of Keyword Semantic Groups (Categories)

Left-click a node to move down the tree, right-click the graph to move back up the tree

Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile:
 
Keyword
Last Name
Institution
 
See all (6) people See all (60) people
Feedback

RTRN Collaboration and Professional Networking Feedback