DNA-(Apurinic or Apyrimidinic Site) Lyase

"DNA-(Apurinic or Apyrimidinic Site) Lyase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.

Descriptor ID	D043603
MeSH Number(s)	D08.811.074.750 D08.811.520.241.225
Concept/Terms	DNA-(Apurinic or Apyrimidinic Site) Lyase DNA-(Apurinic or Apyrimidinic Site) Lyase AP Endonuclease Endonuclease, AP Endodeoxyribonuclease (Apurinic or Apyrimidinic) Apurine-Apyrimidine Endonuclease Apurine Apyrimidine Endonuclease Endonuclease, Apurine-Apyrimidine Apurinic DNA Endonuclease DNA Endonuclease, Apurinic Endonuclease, Apurinic DNA Apurinic Endonuclease Endonuclease, Apurinic DNA Lyase (Apurinic or Apyrimidinic) AP Lyase

Below are MeSH descriptors whose meaning is more general than "DNA-(Apurinic or Apyrimidinic Site) Lyase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
DNA Repair Enzymes [D08.811.074]
DNA-(Apurinic or Apyrimidinic Site) Lyase [D08.811.074.750]
Lyases [D08.811.520]
Carbon-Oxygen Lyases [D08.811.520.241]
DNA-(Apurinic or Apyrimidinic Site) Lyase [D08.811.520.241.225]

Below are MeSH descriptors whose meaning is related to "DNA-(Apurinic or Apyrimidinic Site) Lyase".

Below are MeSH descriptors whose meaning is more specific than "DNA-(Apurinic or Apyrimidinic Site) Lyase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DNA-(Apurinic or Apyrimidinic Site) Lyase" by people in this website by year, and whether "DNA-(Apurinic or Apyrimidinic Site) Lyase" was a major or minor topic of these publications.

Bar chart showing 13 publications over 12 distinct years, with a maximum of 2 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2000	0	1	1
2002	1	0	1
2003	1	0	1
2004	1	1	2
2006	0	1	1
2011	1	0	1
2012	1	0	1
2013	1	0	1
2017	1	0	1
2019	0	1	1
2020	1	0	1

Below are the most recent publications written about "DNA-(Apurinic or Apyrimidinic Site) Lyase" by people in Profiles.

Choi YD, Jung JY, Baek M, Khan S, Song PI, Ryu S, Koo JY, Chauhan SC, Tsin A, Choi C, Kim WJ, Kim M. APE1 Promotes Pancreatic Cancer Proliferation through GFRa1/Src/ERK Axis-Cascade Signaling in Response to GDNF. Int J Mol Sci. 2020 May 19; 21(10).

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Choi JE, Matthews AJ, Michel G, Vuong BQ. AID Phosphorylation Regulates Mismatch Repair-Dependent Class Switch Recombination and Affinity Maturation. J Immunol. 2020 01 01; 204(1):13-22.

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Ballista-Hern?ndez J, Mart?nez-Ferrer M, V?lez R, Climent C, S?nchez-V?zquez MM, Torres C, Rodr?guez-Mu?oz A, Ayala-Pe?a S, Torres-Ramos CA. Mitochondrial DNA Integrity Is Maintained by APE1 in Carcinogen-Induced Colorectal Cancer. Mol Cancer Res. 2017 07; 15(7):831-841.

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Vuong BQ, Herrick-Reynolds K, Vaidyanathan B, Pucella JN, Ucher AJ, Donghia NM, Gu X, Nicolas L, Nowak U, Rahman N, Strout MP, Mills KD, Stavnezer J, Chaudhuri J. A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination. Nat Immunol. 2013 Nov; 14(11):1183-1189.

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Siddiqui A, Rivera-S?nchez S, Castro Mdel R, Acevedo-Torres K, Rane A, Torres-Ramos CA, Nicholls DG, Andersen JK, Ayala-Torres S. Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease. Free Radic Biol Med. 2012 Oct 01; 53(7):1478-88.

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Vogel KS, Perez M, Momand JR, Acevedo-Torres K, Hildreth K, Garcia RA, Torres-Ramos CA, Ayala-Torres S, Prihoda TJ, McMahan CA, Walter CA. Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice. Mol Reprod Dev. 2011 Dec; 78(12):906-19.

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Li W, Luo Y, Zhang F, Signore AP, Gobbel GT, Simon RP, Chen J. Ischemic preconditioning in the rat brain enhances the repair of endogenous oxidative DNA damage by activating the base-excision repair pathway. J Cereb Blood Flow Metab. 2006 Feb; 26(2):181-98.

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Guzder SN, Torres-Ramos C, Johnson RE, Haracska L, Prakash L, Prakash S. Requirement of yeast Rad1-Rad10 nuclease for the removal of 3'-blocked termini from DNA strand breaks induced by reactive oxygen species. Genes Dev. 2004 Sep 15; 18(18):2283-91.

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Huamani J, McMahan CA, Herbert DC, Reddick R, McCarrey JR, MacInnes MI, Chen DJ, Walter CA. Spontaneous mutagenesis is enhanced in Apex heterozygous mice. Mol Cell Biol. 2004 Sep; 24(18):8145-53.

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Ray SK, Nishitani J, Petry MW, Fessing MY, Leiter AB. Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1. Mol Cell Biol. 2003 Jan; 23(1):259-71.

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