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Eddy Ríos-Olivares
Title RCMI Program Director and Chair- Department of Microbiology and Immunology
Faculty Rank Distinguished Research Professor
Degree PhD, M.P.H.
Institution Universidad Central Del Caribe
Department Microbiology and Immunology
Clusters HIV/AIDS
Infectious and Immunological Diseases
Universidad Central del Caribe
P.O. Box 60327
City Bayamon
State PR
Postal Code 00960-6032
Telephone (787) 798-4050
Fax (787) 740-4300
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Awards and Honors icon

Medical Technologists of Nicaragua, dedication of their graduation
2009 Universidad Central del Caribe Distinguished Research Professor Appointment
2011 Universidad Central del Caribe appointed member of the UCC Gamma Chapter of the Medical Honor Society

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1. Rodríguez-Valentín M, López S, Rivera M, Ríos-Olivares E, Cubano L, Boukli NM. Naturally Derived Anti-HIV Polysaccharide Peptide (PSP) Triggers a Toll-Like Receptor 4-Dependent Antiviral Immune Response. J Immunol Res. 2018; 2018:8741698.
2. Sepúlveda-Torres LDC, Rishishwar L, Rogers ML, Ríos-Olivares E, Boukli N, Jordan IK, Cubano LA. A decade of viral mutations and associated drug resistance in a population of HIV-1+ Puerto Ricans: 2002-2011. PLoS One. 2017; 12(5):e0177452.
3. Mayor AM, Santiago-Rodriguez EJ, Rios-Olivares E, Tortolero-Luna G, Hunter-Mellado RF. Malignancies Trends in a Hispanic Cohort of HIV Persons in Puerto Rico before and after cART. Int J Cancer Res. 2016; 12(2):92-100.
4. Fernandez-Santos DM, Miranda-Diaz C, Figueroa-Cosme WI, Ramon RO, Mayor AM, Rios-Olivares E, Hunter-Mellado RF. Impact of ASUMA Intervention on HIV Risk Behaviors among Puerto Rican Adolescents. Int J Environ Res Public Health. 2015 Dec 23; 13(1):ijerph13010060.
5. Maldonado-Martínez G, Hunter-Mellado RF, Fernández-Santos D, Ríos-Olivares E. Persistent HIV Viremia: Description of a Cohort of HIV Infected Individuals with ART Failure in Puerto Rico. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010050.
6. Sanabria-Ríos DJ, Rivera-Torres Y, Rosario J, Gutierrez R, Torres-García Y, Montano N, Ortíz-Soto G, Ríos-Olivares E, Rodríguez JW, Carballeira NM. Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria. Bioorg Med Chem Lett. 2015 Nov 15; 25(22):5067-71.
7. Martínez O, Miranda E, Ramírez M, Santos S, Rivera C, Vázquez L, Sánchez T, Tremblay RL, Ríos-Olivares E, Otero M. Immunomodulator-based enhancement of anti smallpox immune responses. PLoS One. 2015; 10(4):e0123113.
8. Sanabria-Ríos DJ, Rivera-Torres Y, Rosario J, Ríos C, Gutierrez R, Carballeira NM, Vélez C, Zayas B, Álvarez-Colón F, Ortiz-Soto G, Serrano V, Altieri-Rivera J, Ríos-Olivares E, Rodríguez JW. Synthesis of novel C5-curcuminoid-fatty acid conjugates and mechanistic investigation of their anticancer activity. Bioorg Med Chem Lett. 2015; 25(10):2174-80.
9. Ortiz AP, Reyes JC, Palefsky J, Negrón J, Da Costa M, Vázquez M, Rivera AI, Matos TD, Rios-Olivares E, Tortolero G. Oral human papillomavirus infection among drug users in Puerto Rico. P R Health Sci J. 2014 Dec; 33(4):190-6.
10. Sanabria-Ríos DJ, Rivera-Torres Y, Maldonado-Domínguez G, Domínguez I, Ríos C, Díaz D, Rodríguez JW, Altieri-Rivera JS, Ríos-Olivares E, Cintrón G, Montano N, Carballeira NM. Antibacterial activity of 2-alkynoic fatty acids against multidrug-resistant bacteria. Chem Phys Lipids. 2014 Feb; 178:84-91.
11. Thompson KJ, Ríos-Olivares E. Making a difference: steps to develop a research pipeline in Puerto Rico. J Health Care Poor Underserved. 2013 Nov; 24(4 Suppl):4-7.
12. Maldonado-Martínez G, Fernández-Santos DM, Ríos-Olivares E, Mayor AM, Hunter-Mellado RF. HIV/AIDS in the Puerto Rican elderly: immunological changes between gender and body mass index. J Health Care Poor Underserved. 2013 Nov; 24(4 Suppl):94-105.
13. Sepúlveda-Torres Ldel C, De La Rosa A, Cumba L, Boukli N, Ríos-Olivares E, Cubano LA. Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006-2010. AIDS Res Treat. 2012; 2012:934041.
14. Mayor AM, Fernández Santos DM, Dworkin MS, Ríos-Olivares E, Hunter-Mellado RF. Toxoplasmic encephalitis in an AIDS cohort at Puerto Rico before and after highly active antiretroviral therapy (HAART). Am J Trop Med Hyg. 2011 May; 84(5):838-41.
15. Boukli NM, Saiyed ZM, Ricaurte M, Rodriguez JW, Ríos Olivares E, Cubano LA, Nair MP. Implications of ER stress, the unfolded protein response, and pro- and anti-apoptotic protein fingerprints in human monocyte-derived dendritic cells treated with alcohol. Alcohol Clin Exp Res. 2010 Dec; 34(12):2081-8.
16. Cubano LA, Cumba L, del Sepúlveda-Torres LC, Boukli N, Ríos-Olivares E. Prevalence of drug resistance and associated mutations in a population of Hiv-1+ Puerto Ricans in 2005. Bol Asoc Med P R. 2010 Jul-Sep; 102(3):13-7.
17. Fernández Santos DM, Figueroa-Cosme WI, Gómez Mde L, Maysonet-Cruz J, Miranda-Díaz C, Septúlveda-Santiago M, Ríos-Olivares E, Hunter-Mellado RF. Changes in developmental factors and HIV risk behaviors among early adolescents in Puerto Rico. Ethn Dis. 2010; 20(1 Suppl 1):S1-122-6.
18. Mayor AM, Dworkin M, Quesada L, Ríos-Olivares E, Hunter-Mellado RF. The morbidity and mortality associated with kidney disease in an HIV-infected cohort in Puerto Rico. Ethn Dis. 2010; 20(1 Suppl 1):S1-163-7.
19. Ríos G, Mayor AM. Clinical and sociodemographic features of Puerto Ricans with systemic sclerosis. Ethn Dis. 2010; 20(1 Suppl 1):S1-185-9.
20. Colon HM, Finlinson HA, Negron J, Sosa I, Rios-Olivares E, Robles RR. Pilot trial of an intervention aimed at modifying drug preparation practices among injection drug users in Puerto Rico. AIDS Behav. 2009 Jun; 13(3):523-31.
21. Delgado-Vélez M, Lugo-Chinchilla A, Lizardo L, Morales I, Robles Y, Bruno N, Rodríguez JW, Ríos-Olivares E, Correa M, Renaud FL. Chronic exposure of human macrophages in vitro to morphine and methadone induces a putative tolerant/dependent state. J Neuroimmunol. 2008 May 30; 196(1-2):94-100.
22. Báez Feliciano DV, Gómez MA, Fernández-Santos DM, Quintana R, Rios-Olivares E, Hunter-Mellado RF. Profile of Puerto Rican HIV/AIDS patients with early and non-early initiation of injection drug use. Ethn Dis. 2008; 18(2 Suppl 2):S2-99-104.
23. Cubano LA, Sepúlveda-Torres Ldel C, Sosa G, Boukli N, Robles R, Rodriguez JW, Guzmán L, Ríos-Olivares E. Prevalence of drug resistance and associated mutations in HIV-positive Puerto Ricans: sex variations. Ethn Dis. 2008; 18(2 Suppl 2):S2-132-6.
24. Fernández DM, Figueroa WI, Gómez Mde L, Maysonet J, Olivares ER, Hunter RF. Changes in HIV/AIDS knowledge among early adolescents in Puerto Rico. Ethn Dis. 2008; 18(2 Suppl 2):S2-146-50.
25. Mayor AM, Gómez MA, Ríos-Olivares E, Hunter-Mellado RF. AIDS-defining neoplasm prevalence in a cohort of HIV-infected patients, before and after highly active antiretroviral therapy. Ethn Dis. 2008; 18(2 Suppl 2):S2-189-94.
26. Rodríguez JW, Pagan NO, Ocasio MC, Ríos Z, Cubano LA, Boukli NM, Otero M, Hunter R, Nair MP, Rios-Olivares E. Induction of a Soluble Anti-HIV-1 factor (s) with IFN-?, IL-10, and ß-Chemokine Modulating Activity by an Influenza-Bacterial Polyantigenic Mixture. Am J Infect Dis. 2007; 3(4).
27. Ríos-Olivares E, Vilá LM, Reyes JC, Rodríguez JW, Colón JH, Pagán NO, Marrero A, Ríos-Orraca ZM, Boukli NM, Shapshak P, Robles RR. Impaired cytokine production and suppressed lymphocyte proliferation activity in HCV-infected cocaine and heroin ("speedball") users. Drug Alcohol Depend. 2006 Dec 01; 85(3):236-43.
28. Reyes JC, Colón HM, Robles RR, Rios E, Matos TD, Negrón J, Marrero CA, Calderón JM, Shepard E. Prevalence and correlates of hepatitis C virus infection among street-recruited injection drug users in San Juan, Puerto Rico. J Urban Health. 2006 Nov; 83(6):1105-13.
29. Vilá LM, Molina MJ, Mayor AM, Cruz JJ, Ríos-Olivares E, Ríos Z. Association of serum MIP-1alpha, MIP-1beta, and RANTES with clinical manifestations, disease activity, and damage accrual in systemic lupus erythematosus. Clin Rheumatol. 2007 May; 26(5):718-22.
30. Mayor AM, Gomez MA, Fernandez DM, Rios-Olivares E, Thomas JC, Hunter RF. Morbidity and mortality profile of human immunodeficiency virus-infected patients with and without hepatitis C co-infection. Am J Trop Med Hyg. 2006 Feb; 74(2):239-45.
31. Rivera-Matos IR, Rios-Olivares E. A multicenter hospital surveillance of invasive Streptococcus pneumoniae, Puerto Rico, 2001. P R Health Sci J. 2005 Sep; 24(3):185-9.
32. Báez-Feliciano DV, Thomas JC, Gómez MA, Miranda S, Fernández DM, Velázquez M, Ríos-Olivares E, Hunter-Mellado RF. Changes in the AIDS epidemiologic situation in Puerto Rico following health care reform and the introduction of HAART. Rev Panam Salud Publica. 2005 Feb; 17(2):92-101.
33. Mayor AM, Gómez MA, Ríos-Oliveras E, Hunter-Mellado RF. Mortality trends of HIV-infected patients after the introduction of highly active antiretroviral therapy: analysis of a cohort of 3,322 HIV-infected persons. Ethn Dis. 2005; 15(4 Suppl 5):S5-57-62.
34. Fernández DM, Gómez Mde L, Figueroa W, Velázquez M, Báez DV, Ríos-Olivares E, Hunter RF. A comparison of the sociodemographic, risk-behavior, and substance-abuse profile of young vs older HIV-infected Puerto Rican patients. Ethn Dis. 2005; 15(4 Suppl 5):S5-25-9.
35. Martínez A, Vilá LM, Ríos-Olivares E. Predominance of CD4+ T cells and Th2 cytokines in the pericardial fluid of a dermatomyositis patient with cardiac tamponade. Clin Exp Rheumatol. 2004 Jan-Feb; 22(1):135.
36. Mayor AM, Gomez MA, Rios E, Hunter RF. Recurrent pneumonia mortality risk in a HIV/AIDS Puerto Rican cohort. Cell Mol Biol (Noisy-le-grand). 2003 Dec; 49(8):1199-204.
37. Torres Rivera B, Vallés V, Ríos Olivares E. Prevalence of primary and secondary resistant mutations to antiretroviral drug in a population of Puerto Rican infected with HIV. P R Health Sci J. 2002 Dec; 21(4):329-36.
38. Roman M, Rodriguez JW, Pagán NO, Rios-Olivares E, Amill A, Hunter R. Distribution of naïve (CD45RA+) and memory (CD45RO+) T-cells in HIV-infected Puerto Rican population. P R Health Sci J. 2002 Sep; 21(3):195-201.
39. Ríos-Olivares E, Yamamura Y, Gómez MA, Guzmán L, Rodríguez N, Fernández D, Hunter Mellado R. HCV genotype analysis in HCV-HIV-co-infected Puerto Ricans who are injecting drug users: undetermined and mixed infections. Cell Mol Biol (Noisy-le-grand). 2001 Sep; 47(6):1017-24.
40. Vilá LM, Ríos-Olivares E, Ríos Z, Meléndez M, García M, Pichardo B. Abnormal immunological response to Mycobacterium tuberculosis antigens in a patient with chronic myelocytic leukemia and active tuberculosis. P R Health Sci J. 1998 Dec; 17(4):345-52.
41. Frame AD, Ríos-Olivares E, De Jesús L, Ortiz D, Pagán J, Méndez S. Plants from Puerto Rico with anti-Mycobacterium tuberculosis properties. P R Health Sci J. 1998 Sep; 17(3):243-52.
42. Vila LM, Ríos-Olivares E, Vila S, Ríos Z, Rivera E, Robles R, Reyes JC, Castillo X. Correlation of the suppressive activity of a biological response modifier on the proliferation of peripheral blood mononuclear cells and the reduction of HIV titer. Cell Mol Biol (Noisy-le-grand). 1997 Nov; 43(7):981-8.
43. Orraca ZM, Ríos-Olivares E, Carrasco-Canales JA, Aquino E, Marchand AM, Colón JI. Characterization of the antitumor activity of a polyantigenic immunomodulator (PAI): II--Involvement of NK cells and adoptive immunotherapy. Bol Asoc Med P R. 1989 Jul; 81(7):254-8.
44. Ríos-Olivares E, Orraca ZM, Carrasco-Canales JA, Alvarado L, Marchand AM, Colón JI. Characterization of the antitumor activity of a polyantigenic immunomodulator (PAI): I--Utilization of cimetidine and cyclosporine A. Bol Asoc Med P R. 1989 Jul; 81(7):246-53.
45. Kaplan JE, Yamamura Y, Ríos-Olivares EO, Cannon RO, Khabbaz RF, Gubler DJ, Kaiselburd EN, Hartley TM, Lairmore MD. Seroprevalence of human T lymphotropic virus type I in Puerto Rico. Am J Trop Med Hyg. 1989 Jun; 40(6):659-62.
46. Ríos-Olivares EO. [1st human case of coccidioidomycosis in Nicaragua]. Rev Latinoam Microbiol. 1979 Oct-Dec; 21(4):215-8.

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