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Gianluca Tosini
Title Chairman
Faculty Rank
Degree PhD
Institution Morehouse School of Medicine
Department Pharmacology
Clusters Neurological Disorders and Mental Health
Neurological Disorders and Mental Health
Morehouse Sch of Medicine
department of Pharmacology
720 Westview dr
City Atlanta
State ga
Postal Code 30310
Telephone 4047565214
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Title Professor (adjunt)
Institution Emory School of medicine
Department Ophthalmology

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  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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2018T32 Training Program for Institutions That Promote Diversity from Morehouse School of Medicine5T32HL103104-07
2017T32 Training Program for Institutions That Promote Diversity from Morehouse School of Medicine2T32HL103104-06A1
2017Circadian regulation of RPE functions5R01EY026291-02
2016Circadian regulation of RPE functions1R01EY026291-01A1
2015MSM Interdisciplinary Sleep/Clinical Cardiovascular Research Training Program5T32HL103104-05
2015Photic and Circadian Regulation of Retinal Melatonin5R01EY022216-12
2014MSM Interdisciplinary Sleep/Clinical Cardiovascular Research Training Program5T32HL103104-04
2014Photic and Circadian Regulation of Retinal Melatonin5R01EY022216-11
2013Photic and Circadian Regulation of Retinal Melatonin5R01EY022216-10
2013MSM Interdisciplinary Sleep/Clinical Cardiovascular Research Training Program5T32HL103104-03
2012Photic and Circadian Regulation of Retinal Melatonin2R01EY022216-09A1
2012Photic and Circadian Regulation of Retinal Melatonin3R01EY022216-09A1S1
2011Circadian Regulation of the PER2::LUC Bioluminescence Rhythm in the Mouse RPE5R21EY020821-02
2011Photic and circadian regulation of retinal melatonin2R56NS043459-09
2011MSM Interdisciplinary Sleep/Clinical Cardiovascular Research Training Program5T32HL103104-02
2010Circadian Regulation of the PER2::LUC Bioluminescence Rhythm in the Mouse RPE1R21EY020821-01
2010Photic and Circadian Regulation of Retinal Melatonin3R01NS043459-08S1
2010MSM Interdisciplinary Sleep/Clinical Cardiovascular Research Training Program1T32HL103104-01
2010Photic and Circadian Regulation of Retinal Melatonin5R01NS043459-08
2009Photic and Circadian Regulation of Retinal Melatonin5R01NS043459-07
2008Photic and Circadian Regulation of Retinal Melatonin5R01NS043459-06
2007Photic and Circadian Regulation of Retinal Melatonin2R01NS043459-05A2
2006Photic and circadian regulation of retinal melatonin.5R01NS043459-04
2005Photic and circadian regulation of retinal melatonin.5R01NS043459-03
2004Photic and circadian regulation of retinal melatonin.5R01NS043459-02
2003Photic and circadian regulation of retinal melatonin.1R01NS043459-01A1

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1. Owino S, Sánchez-Bretaño A, Tchio C, Cecon E, Karamitri A, Dam J, Jockers R, Piccione G, Noh HL, Kim T, Kim JK, Baba K, Tosini G. Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity. J Pineal Res. 2018 Apr; 64(3).
2. Sánchez-Bretaño A, Baba K, Janjua U, Piano I, Gargini C, Tosini G. Melatonin partially protects 661W cells from H2O2-induced death by inhibiting Fas/FasL-caspase-3. Mol Vis. 2017; 23:844-852.
3. Vancura P, Abdelhadi S, Csicsely E, Baba K, Tosini G, Iuvone PM, Spessert R. Gnaz couples the circadian and dopaminergic system to G protein-mediated signaling in mouse photoreceptors. PLoS One. 2017; 12(10):e0187411.
4. Laurent V, Sengupta A, Sánchez-Bretaño A, Hicks D, Tosini G. Melatonin signaling affects the timing in the daily rhythm of phagocytic activity by the retinal pigment epithelium. Exp Eye Res. 2017 12; 165:90-95.
5. Baba K, DeBruyne JP, Tosini G. Dopamine 2 Receptor Activation Entrains Circadian Clocks in Mouse Retinal Pigment Epithelium. Sci Rep. 2017 Jul 11; 7(1):5103.
6. Vancura P, Wolloscheck T, Baba K, Tosini G, Iuvone PM, Spessert R. Circadian and Dopaminergic Regulation of Fatty Acid Oxidation Pathway Genes in Retina and Photoreceptor Cells. PLoS One. 2016; 11(10):e0164665.
7. Jockers R, Delagrange P, Dubocovich ML, Markus RP, Renault N, Tosini G, Cecon E, Zlotos DP. Update on melatonin receptors: IUPHAR Review 20. Br J Pharmacol. 2016 09; 173(18):2702-25.
8. Owino S, Contreras-Alcantara S, Baba K, Tosini G. Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks. PLoS One. 2016; 11(1):e0148214.
9. Tosini G, Ferguson I, Tsubota K. Effects of blue light on the circadian system and eye physiology. Mol Vis. 2016; 22:61-72.
10. Gianesini C, Hiragaki S, Laurent V, Hicks D, Tosini G. Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling. Invest Ophthalmol Vis Sci. 2016 Jan 01; 57(1):94-104.
11. Kunst S, Wolloscheck T, Kelleher DK, Wolfrum U, Sargsyan SA, Iuvone PM, Baba K, Tosini G, Spessert R. Pgc-1a and Nr4a1 Are Target Genes of Circadian Melatonin and Dopamine Release in Murine Retina. Invest Ophthalmol Vis Sci. 2015 Sep; 56(10):6084-94.
12. Gianesini C, Clesse D, Tosini G, Hicks D, Laurent V. Unique Regulation of the Melatonin Synthetic Pathway in the Retina of Diurnal Female Arvicanthis ansorgei (Rodentia). Endocrinology. 2015 Sep; 156(9):3292-308.
13. Baba K, Davidson AJ, Tosini G. Melatonin Entrains PER2::LUC Bioluminescence Circadian Rhythm in the Mouse Cornea. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4753-8.
14. Evans JA, Suen TC, Callif BL, Mitchell AS, Castanon-Cervantes O, Baker KM, Kloehn I, Baba K, Teubner BJ, Ehlen JC, Paul KN, Bartness TJ, Tosini G, Leise T, Davidson AJ. Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body. BMC Biol. 2015 Jun 23; 13:43.
15. Hiragaki S, Baba K, Coulson E, Kunst S, Spessert R, Tosini G. Melatonin signaling modulates clock genes expression in the mouse retina. PLoS One. 2014; 9(9):e106819.
16. Tosini G, Owino S, Guillaume JL, Jockers R. Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease. Bioessays. 2014 Aug; 36(8):778-87.
17. Iuvone PM, Boatright JH, Tosini G, Ye K. N-acetylserotonin: circadian activation of the BDNF receptor and neuroprotection in the retina and brain. Adv Exp Med Biol. 2014; 801:765-71.
18. McMahon DG, Iuvone PM, Tosini G. Circadian organization of the mammalian retina: from gene regulation to physiology and diseases. Prog Retin Eye Res. 2014 Mar; 39:58-76.
19. Baba K, Benleulmi-Chaachoua A, Journé AS, Kamal M, Guillaume JL, Dussaud S, Gbahou F, Yettou K, Liu C, Contreras-Alcantara S, Jockers R, Tosini G. Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function. Sci Signal. 2013 Oct 08; 6(296):ra89.
20. Tosini G, Iuvone M, Boatright JH. Is the melatonin receptor type 1 involved in the pathogenesis of glaucoma? J Glaucoma. 2013 Jun-Jul; 22 Suppl 5:S49-50.
21. Dortch-Carnes J, Tosini G. Melatonin receptor agonist-induced reduction of SNP-released nitric oxide and cGMP production in isolated human non-pigmented ciliary epithelial cells. Exp Eye Res. 2013 Feb; 107:1-10.
22. Tosini G, Baba K, Hwang CK, Iuvone PM. Melatonin: an underappreciated player in retinal physiology and pathophysiology. Exp Eye Res. 2012 Oct; 103:82-9.
23. Baba K, Mazzoni F, Owino S, Contreras-Alcantara S, Strettoi E, Tosini G. Age-related changes in the daily rhythm of photoreceptor functioning and circuitry in a melatonin-proficient mouse strain. PLoS One. 2012; 7(5):e37799.
24. Tosini G, Ye K, Iuvone PM. N-acetylserotonin: neuroprotection, neurogenesis, and the sleepy brain. Neuroscientist. 2012 Dec; 18(6):645-53.
25. Peachey NS, Ray TA, Florijn R, Rowe LB, Sjoerdsma T, Contreras-Alcantara S, Baba K, Tosini G, Pozdeyev N, Iuvone PM, Bojang P, Pearring JN, Simonsz HJ, van Genderen M, Birch DG, Traboulsi EI, Dorfman A, Lopez I, Ren H, Goldberg AF, Nishina PM, Lachapelle P, McCall MA, Koenekoop RK, Bergen AA, Kamermans M, Gregg RG. GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet. 2012 Feb 10; 90(2):331-9.
26. Sengupta A, Baba K, Mazzoni F, Pozdeyev NV, Strettoi E, Iuvone PM, Tosini G. Localization of melatonin receptor 1 in mouse retina and its role in the circadian regulation of the electroretinogram and dopamine levels. PLoS One. 2011; 6(9):e24483.
27. Sompol P, Liu X, Baba K, Paul KN, Tosini G, Iuvone PM, Ye K. N-acetylserotonin promotes hippocampal neuroprogenitor cell proliferation in sleep-deprived mice. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8844-9.
28. Alcantara-Contreras S, Baba K, Tosini G. Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse. Neurosci Lett. 2011 Apr 20; 494(1):61-4.
29. Baba K, Sengupta A, Tosini M, Contreras-Alcantara S, Tosini G. Circadian regulation of the PERIOD 2::LUCIFERASE bioluminescence rhythm in the mouse retinal pigment epithelium-choroid. Mol Vis. 2010 Dec 07; 16:2605-11.
30. Pinotti M, Bertolucci C, Frigato E, Branchini A, Cavallari N, Baba K, Contreras-Alcantara S, Ehlen JC, Bernardi F, Paul KN, Tosini G. Chronic sleep deprivation markedly reduces coagulation factor VII expression. Haematologica. 2010 Aug; 95(8):1429-32.
31. Contreras-Alcantara S, Baba K, Tosini G. Removal of melatonin receptor type 1 induces insulin resistance in the mouse. Obesity (Silver Spring). 2010 Sep; 18(9):1861-3.
32. Jang SW, Liu X, Pradoldej S, Tosini G, Chang Q, Iuvone PM, Ye K. N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3876-81.
33. Paul KN, Saafir TB, Tosini G. The role of retinal photoreceptors in the regulation of circadian rhythms. Rev Endocr Metab Disord. 2009 Dec; 10(4):271-8.
34. Baba K, Pozdeyev N, Mazzoni F, Contreras-Alcantara S, Liu C, Kasamatsu M, Martinez-Merlos T, Strettoi E, Iuvone PM, Tosini G. Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor. Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):15043-8.
35. Tosini G, Pozdeyev N, Sakamoto K, Iuvone PM. The circadian clock system in the mammalian retina. Bioessays. 2008 Jul; 30(7):624-33.
36. Pozdeyev N, Tosini G, Li L, Ali F, Rozov S, Lee RH, Iuvone PM. Dopamine modulates diurnal and circadian rhythms of protein phosphorylation in photoreceptor cells of mouse retina. Eur J Neurosci. 2008 May; 27(10):2691-700.
37. Bertolucci C, Cavallari N, Colognesi I, Aguzzi J, Chen Z, Caruso P, Foá A, Tosini G, Bernardi F, Pinotti M. Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators. Mol Cell Biol. 2008 May; 28(9):3070-5.
38. Fukuhara C, Tosini G. Analysis of daily and circadian gene expression in the rat pineal gland. Neurosci Res. 2008 Feb; 60(2):192-8.
39. Tosini G, Davidson AJ, Fukuhara C, Kasamatsu M, Castanon-Cervantes O. Localization of a circadian clock in mammalian photoreceptors. FASEB J. 2007 Dec; 21(14):3866-71.
40. Tosini G, Kasamatsu M, Sakamoto K. Clock gene expression in the rat retina: effects of lighting conditions and photoreceptor degeneration. Brain Res. 2007 Jul 23; 1159:134-40.
41. Tosini G, Aguzzi J, Bullock NM, Liu C, Kasamatsu M. Effect of photoreceptor degeneration on circadian photoreception and free-running period in the Royal College of Surgeons rat. Brain Res. 2007 May 07; 1148:76-82.
42. Dunlap KL, Reynolds AJ, Tosini G, Kerr WW, Duffy LK. Seasonal and diurnal melatonin production in exercising sled dogs. Comp Biochem Physiol A Mol Integr Physiol. 2007 Aug; 147(4):863-7.
43. Tosini G. Locomotor activity in rodents. Methods Mol Biol. 2007; 362:95-101.
44. Bellingham J, Chaurasia SS, Melyan Z, Liu C, Cameron MA, Tarttelin EE, Iuvone PM, Hankins MW, Tosini G, Lucas RJ. Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates. PLoS Biol. 2006 Jul; 4(8):e254.
45. Gamble KL, Paul KN, Karom MC, Tosini G, Albers HE. Paradoxical effects of NPY in the suprachiasmatic nucleus. Eur J Neurosci. 2006 May; 23(9):2488-94.
46. Aguzzi J, Bullock NM, Tosini G. Spontaneous internal desynchronization of locomotor activity and body temperature rhythms from plasma melatonin rhythm in rats exposed to constant dim light. J Circadian Rhythms. 2006 Apr 04; 4:6.
47. Sakamoto K, Liu C, Kasamatsu M, Iuvone PM, Tosini G. Intraocular injection of kainic acid does not abolish the circadian rhythm of arylalkylamine N-acetyltransferase mRNA in rat photoreceptors. Mol Vis. 2006 Feb 23; 12:117-24.
48. Tosini G, Chaurasia SS, Michael Iuvone P. Regulation of arylalkylamine N-acetyltransferase (AANAT) in the retina. Chronobiol Int. 2006; 23(1-2):381-91.
49. Sakamoto K, Liu C, Kasamatsu M, Pozdeyev NV, Iuvone PM, Tosini G. Dopamine regulates melanopsin mRNA expression in intrinsically photosensitive retinal ganglion cells. Eur J Neurosci. 2005 Dec; 22(12):3129-36.
50. Steele CT, Tosini G, Siopes T, Underwood H. Time keeping by the quail's eye: circadian regulation of melatonin production. Gen Comp Endocrinol. 2006 Feb; 145(3):232-6.
51. Paul KN, Fukuhara C, Karom M, Tosini G, Albers HE. AMPA/kainate receptor antagonist DNQX blocks the acute increase of Per2 mRNA levels in most but not all areas of the SCN. Brain Res Mol Brain Res. 2005 Sep 13; 139(1):129-36.
52. Iuvone PM, Tosini G, Pozdeyev N, Haque R, Klein DC, Chaurasia SS. Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Prog Retin Eye Res. 2005 Jul; 24(4):433-56.
53. Chaurasia SS, Rollag MD, Jiang G, Hayes WP, Haque R, Natesan A, Zatz M, Tosini G, Liu C, Korf HW, Iuvone PM, Provencio I. Molecular cloning, localization and circadian expression of chicken melanopsin (Opn4): differential regulation of expression in pineal and retinal cell types. J Neurochem. 2005 Jan; 92(1):158-70.
54. Fukuhara C, Aguzzi J, Bullock N, Tosini G. Effect of long-term exposure to constant dim light on the circadian system of rats. Neurosignals. 2005; 14(3):117-25.
55. Tosini G, Aguzzi J. Effect of space flight on circadian rhythms. Adv Space Biol Med. 2005; 10:165-74.
56. Sakamoto K, Liu C, Tosini G. Classical photoreceptors regulate melanopsin mRNA levels in the rat retina. J Neurosci. 2004 Oct 27; 24(43):9693-7.
57. Sakamoto K, Liu C, Tosini G. Circadian rhythms in the retina of rats with photoreceptor degeneration. J Neurochem. 2004 Aug; 90(4):1019-24.
58. Liang J, Wessel JH, Iuvone PM, Tosini G, Fukuhara C. Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina. Neuroreport. 2004 Jun 28; 15(9):1497-500.
59. Paul KN, Gamble KL, Fukuhara C, Novak CM, Tosini G, Albers HE. Tetrodotoxin administration in the suprachiasmatic nucleus prevents NMDA-induced reductions in pineal melatonin without influencing Per1 and Per2 mRNA levels. Eur J Neurosci. 2004 May; 19(10):2808-14.
60. Fukuhara C, Liu C, Ivanova TN, Chan GC, Storm DR, Iuvone PM, Tosini G. Gating of the cAMP signaling cascade and melatonin synthesis by the circadian clock in mammalian retina. J Neurosci. 2004 Feb 25; 24(8):1803-11.
61. Liu C, Fukuhara C, Wessel JH, Iuvone PM, Tosini G. Localization of Aa-nat mRNA in the rat retina by fluorescence in situ hybridization and laser capture microdissection. Cell Tissue Res. 2004 Feb; 315(2):197-201.
62. Fukuhara C, Dirden JC, Tosini G. Analysis of gene expression following norepinephrine stimulation in the rat pineal gland using DNA microarray technique. J Pineal Res. 2003 Oct; 35(3):196-203.
63. Fukuhara C, Tosini G. Induction of photosensitivity in cultured rat pineal affects Aa-nat regulation. Brain Res Dev Brain Res. 2003 May 14; 142(2):219-21.
64. Fukuhara C, Tosini G. Peripheral circadian oscillators and their rhythmic regulation. Front Biosci. 2003 May 01; 8:d642-51.
65. Tosini G, Fukuhara C. Photic and circadian regulation of retinal melatonin in mammals. J Neuroendocrinol. 2003 Apr; 15(4):364-9.
66. Paul KN, Fukuhara C, Tosini G, Albers HE. Transduction of light in the suprachiasmatic nucleus: evidence for two different neurochemical cascades regulating the levels of Per1 mRNA and pineal melatonin. Neuroscience. 2003; 119(1):137-44.
67. Tosini G, Fukuhara C. The mammalian retina as a clock. Cell Tissue Res. 2002 Jul; 309(1):119-26.
68. Fukuhara C, Dirden JC, Tosini G. Regulation of period 1 expression in cultured rat pineal. Neurosignals. 2002 Mar-Apr; 11(2):103-14.
69. Fukuhara C, Dirden JC, Tosini G. Photic regulation of melatonin in rat retina and the role of proteasomal proteolysis. Neuroreport. 2001 Dec 04; 12(17):3833-7.
70. Fukuhara C, Brewer JM, Dirden JC, Bittman EL, Tosini G, Harrington ME. Neuropeptide Y rapidly reduces Period 1 and Period 2 mRNA levels in the hamster suprachiasmatic nucleus. Neurosci Lett. 2001 Nov 16; 314(3):119-22.
71. Herzog ED, Tosini G. The mammalian circadian clock shop. Semin Cell Dev Biol. 2001 Aug; 12(4):295-303.
72. Wang Y, Osterbur DL, Megaw PL, Tosini G, Fukuhara C, Green CB, Besharse JC. Rhythmic expression of Nocturnin mRNA in multiple tissues of the mouse. BMC Dev Biol. 2001; 1:9.
73. Tosini G, Bertolucci C, Foà A. The circadian system of reptiles: a multioscillatory and multiphotoreceptive system. Physiol Behav. 2001 Mar; 72(4):461-71.
74. Tosini G, Doyle S, Geusz M, Menaker M. Induction of photosensitivity in neonatal rat pineal gland. Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21):11540-4.
75. Tosini G. Melatonin circadian rhythm in the retina of mammals. Chronobiol Int. 2000 Sep; 17(5):599-612.
76. Zordan M, Costa R, Macino G, Fukuhara C, Tosini G. Circadian clocks: what makes them tick? Chronobiol Int. 2000 Jul; 17(4):433-51.
77. Fukuhara C, Dirden JC, Tosini G. Circadian expression of period 1, period 2, and arylalkylamine N-acetyltransferase mRNA in the rat pineal gland under different light conditions. Neurosci Lett. 2000 Jun 09; 286(3):167-70.
78. Tosini G, Dirden JC. Dopamine inhibits melatonin release in the mammalian retina: in vitro evidence. Neurosci Lett. 2000 Jun 02; 286(2):119-22.
79. Tosini G, Menaker M. The tau mutation affects temperature compensation of hamster retinal circadian oscillators. Neuroreport. 1998 Apr 20; 9(6):1001-5.
80. Tosini G, Menaker M. The clock in the mouse retina: melatonin synthesis and photoreceptor degeneration. Brain Res. 1998 Apr 13; 789(2):221-8.
81. Tosini G, Menaker M. Multioscillatory circadian organization in a vertebrate, iguana iguana. J Neurosci. 1998 Feb 01; 18(3):1105-14.
82. Menaker M, Moreira LF, Tosini G. Evolution of circadian organization in vertebrates. Braz J Med Biol Res. 1997 Mar; 30(3):305-13.
83. Tosini G, Menaker M. Circadian rhythms in cultured mammalian retina. Science. 1996 Apr 19; 272(5260):419-21.
84. Tosini G, Avery RA. Dermal photoreceptors regulate basking behavior in the lizard Podarcis muralis. Physiol Behav. 1996 Jan; 59(1):195-8.
85. Tosini G, Menaker M. The pineal complex and melatonin affect the expression of the daily rhythm of behavioral thermoregulation in the green iguana. J Comp Physiol A. 1996; 179(1):135-42.
86. Tosini G, Menaker M. Circadian rhythm of body temperature in an ectotherm (Iguana iguana). J Biol Rhythms. 1995 Sep; 10(3):248-55.

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