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Jason DeBruyne
Title Assistant Professor
Faculty Rank
Degree PhD
Institution Morehouse School of Medicine
Department Pharmacology and Toxicology
Clusters Neurological Disorders and Mental Health
Obesity and Metabolic Diseases
Dept of Pharmacology/Toxicology
RW 315
Morehouse School of Medicine
City Atlanta
State ga
Postal Code 30310
Telephone 404 756 5228
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  Qualifications and Previous Research Training: Dr. DeBruyne earned a Bachelor of Sciences in Biology from Truman State University in 1995 before completing his PhD in Molecular and Cellular Biology from the University of Houston in 2002. The focus of his doctoral work was in developing a high-throughput genetic screen for genes driving circadian behaviors in zebrafish. He completed his post-doctoral training 2002-2008 at the University of Massachusetts Medical School switching to mouse genetics and molecular biology, as was awarded an NIH/NIGMS individual postdoctoral fellowship to identify novel circadian clockwork proteins. In 2008, he joined the University of Pennsylvania School of Medicine as a staff scientist focused on developing novel high-throughput cell-based screens to discover post-translational mechanisms regulating protein stability, and in 2011 joined the MSM faculty as an Assistant Professor, where he has raised over 1.7 million dollars in peer-reviewed grant support to continue pursuing ‘discovery’ approaches aimed at understanding circadian rhythm and sleep regulation.

Activities and Research Interests: Organisms have evolved an inherent timing system – a ‘circadian’ clock – that optimizes daily patterns in sleep/wake state, and almost every other aspect of physiology, with the most optimal time of day or night.  Going against our internal circadian clocks, such as working on a rotating shift schedule, causes a wide-range of health problems, including cancer, heart disease and obesity. These problems are becoming more and more prominent as our society continues towards “open 24-hours” culture.

My lab is focused on identifying the genetic, molecular and biochemical mechanisms underlying circadian rhythms and sleep homeostasis. Currently, we are focused in three areas: 1) identifying post-translational mechanisms, and their roles, essential to normal rhythmicity and clock function and 2) genetic and neurological mechanisms underlying sleep homeostasis. Our ultimate goal is to discover new therapeutic avenues for manipulating the timing of circadian rhythms to counteract sleep-loss and clock-related disease risk.

Scholarship: Dr. DeBruyne is an expert in genetics, cell & molecular biology, and high-throughput biology. He has been a reviewer for many journals and has served on grant review panels for NSF and other agencies. He has chaired sessions at scientific conferences, and he or his lab has presented 17 abstracts in poster or slide-session format. He has presented 5 invited lectures on his work. He is also active in publishing, and is the first or corresponding author on 9 of 16 published manuscripts, many of which are in top journals (Neuron, Nature Neuroscience, PNAS, etc) and have been cited in press releases. One publication was even selected as a “Faculty of 1000” paper. Dr. DeBruyne is the Chair of the Research Development committee at MSM, and serves on several other research-oriented committees at MSM, teaches molecular biology and genetics in the Neuroscience program and has mentored several students. In 2015, Dr. DeBruyne became the Director of the Zebrafish Core facility.

NIH Awarded Grants icon

  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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2018Roles of protein degradation in the circadian clock1R35GM127044-01
2017Degradation Mechanisms of Mammalian Circadian Clock Proteins5SC1GM109861-04
2016Degradation Mechanisms of Mammalian Circadian Clock Proteins5SC1GM109861-03
2015Degradation Mechanisms of Mammalian Circadian Clock Proteins5SC1GM109861-02
2014Degradation Mechanisms of Mammalian Circadian Clock Proteins1SC1GM109861-01
2005Identification of the circadian clock proteome5F32GM074277-02
2004Identification of the circadian clock proteome1F32GM074277-01

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1. Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptácek LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB. Guidelines for Genome-Scale Analysis of Biological Rhythms. J Biol Rhythms. 2017 Oct; 32(5):380-393.
2. Ehlen JC, Brager AJ, Baggs J, Pinckney L, Gray CL, DeBruyne JP, Esser KA, Takahashi JS, Paul KN. Bmal1 function in skeletal muscle regulates sleep. Elife. 2017 Jul 20; 6.
3. Baba K, DeBruyne JP, Tosini G. Dopamine 2 Receptor Activation Entrains Circadian Clocks in Mouse Retinal Pigment Epithelium. Sci Rep. 2017 Jul 11; 7(1):5103.
4. Jones KA, Han JE, DeBruyne JP, Philpot BD. Persistent neuronal Ube3a expression in the suprachiasmatic nucleus of Angelman syndrome model mice. Sci Rep. 2016 06 16; 6:28238.
5. Ehlen JC, Jones KA, Pinckney L, Gray CL, Burette S, Weinberg RJ, Evans JA, Brager AJ, Zylka MJ, Paul KN, Philpot BD, DeBruyne JP. Maternal Ube3a Loss Disrupts Sleep Homeostasis But Leaves Circadian Rhythmicity Largely Intact. J Neurosci. 2015 Oct 07; 35(40):13587-98.
6. DeBruyne JP, Baggs JE, Sato TK, Hogenesch JB. Ubiquitin ligase Siah2 regulates RevErba degradation and the mammalian circadian clock. Proc Natl Acad Sci U S A. 2015 Oct 06; 112(40):12420-5.
7. DeBruyne JP, Weaver DR, Dallmann R. The hepatic circadian clock modulates xenobiotic metabolism in mice. J Biol Rhythms. 2014 Aug; 29(4):277-87.
8. Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW. The transcription factor encyclopedia. Genome Biol. 2012; 13(3):R24.
9. Dallmann R, DeBruyne JP, Weaver DR. Photic resetting and entrainment in CLOCK-deficient mice. J Biol Rhythms. 2011 Oct; 26(5):390-401.
10. DeBruyne JP, Hogenesch JB. A CRY in the Night. Dev Cell. 2011 Feb 15; 20(2):144-5.
11. Etchegaray JP, Machida KK, Noton E, Constance CM, Dallmann R, Di Napoli MN, DeBruyne JP, Lambert CM, Yu EA, Reppert SM, Weaver DR. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. 2009 Jul; 29(14):3853-66.
12. Debruyne JP. Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system. J Genet. 2008 Dec; 87(5):437-46.
13. Tan Y, DeBruyne J, Cahill GM, Wells DE. Identification of a mutation in the Clock1 gene affecting zebrafish circadian rhythms. J Neurogenet. 2008; 22(2):149-66.
14. DeBruyne JP, Weaver DR, Reppert SM. Peripheral circadian oscillators require CLOCK. Curr Biol. 2007 Jul 17; 17(14):R538-9.
15. DeBruyne JP, Weaver DR, Reppert SM. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci. 2007 May; 10(5):543-5.
16. Etchegaray JP, Yang X, DeBruyne JP, Peters AH, Weaver DR, Jenuwein T, Reppert SM. The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28; 281(30):21209-15.
17. Debruyne JP, Noton E, Lambert CM, Maywood ES, Weaver DR, Reppert SM. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron. 2006 May 04; 50(3):465-77.
18. DeBruyne J, Hurd MW, Gutiérrez L, Kaneko M, Tan Y, Wells DE, Cahill GM. Isolation and phenogenetics of a novel circadian rhythm mutant in zebrafish. J Neurogenet. 2004 Apr-Jun; 18(2):403-28.
19. Hurd MW, Debruyne J, Straume M, Cahill GM. Circadian rhythms of locomotor activity in zebrafish. Physiol Behav. 1998 Dec 01; 65(3):465-72.

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