PROFILES - Connect with RTRN Researchers

Bruce Shiramizu
Title Professor
Faculty Rank
Degree M.D.
Institution University of Hawaii
Department Tropical Medicine, Medical Microbiology & Pharmacology; Pediatrics; Hawaii Center for AIDS
Clusters Cancer
Neurological Disorders and Mental Health
University of Hawaii, John A. Burns School of Medicine
651 Ilalo St. BSB 325AA
City Honolulu
State HI
Postal Code 96813
Telephone (808) 692-1677
QR Barcode

Narrative icon

  Dr. Shiramizu is a Professor in the Departments of Pediatrics and Tropical Medicine, Medical Microbiology, Pharmacology; and Medicine; and a graduate faculty member in the Departments of TMMMP; Cell and Molecular Biology; and Physiology at the University of Hawaii (UH) John A. Burns School of Medicine (JABSOM). As a board-certified pediatrician, he has 20+ years clinical research experience at JABSOM (18 years) and had previous clinical translational research experience at the University of California, San Francisco (UCSF) (8 years). His pediatric clinical research experience includes being a member of the Children’s Oncology Group Non-Hodgkin Lymphoma (NHL) Committee and active in clinical trial study protocol development and implementation since 1993 (Children’s Cancer Group, Pediatric Oncology Group, Children’s Oncology Group). He has experience as PI and multiple-PI for adult and pediatric clinical studies locally and nationally, with involvement in study design, development, implementation, and coordination. He has extensive experience with mentoring students and faculty. He is involved in other research areas including HIV-associated co-morbidities (cognition, cancer) and childhood non-Hodgkin lymphoma. He collaborates with RCMI investigators across RTRN.

NIH Awarded Grants icon

  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

Please wait
2018Maraviroc and NeuroAIDS Pathogenesis5R01MH102196-05
2018RCMI Multidisciplinary And Translational Research Infrastructure EXpansion (RAMAT5U54MD007584-08
2018(PQ5) Informing anal neoplasia differences/similarities in HIV-serodiscordant individuals5R21CA216830-02
2018(PQ5) Informing anal neoplasia differences/similarities in HIV-serodiscordant individuals3R21CA216830-02S1
2017Maraviroc and NeuroAIDS Pathogenesis5R01MH102196-04
2017RCMI Multidisciplinary And Translational Research Infrastructure EXpansion (RAMAT5U54MD007584-07
2017(PQ5) Informing anal neoplasia differences/similarities in HIV-serodiscordant individuals1R21CA216830-01
2016Hawaii IDeA Center for Pediatric and Adolescent Clinical Trials (HIPACT)8UG1OD024948-02
2016Maraviroc and NeuroAIDS Pathogenesis3R01MH102196-03S1
2016Hawaii IDeA Center for Pediatric and Adolescent Clinical Trials (HIPACT)1UG1HD090879-01
2016Maraviroc and NeuroAIDS Pathogenesis5R01MH102196-03
2016Maraviroc and NeuroAIDS Pathogenesis3R01MH102196-03S2
2015Maraviroc and NeuroAIDS Pathogenesis5R01MH102196-02
2014Maraviroc and NeuroAIDS Pathogenesis1R01MH102196-01A1
2010Neuroimaging to Assess the Effects of Therapy in Children with Acute Lymphoblasti5R21CA139712-02
2010HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function5R01NS053345-05
2009HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function5R01NS053345-04
2009Neuroimaging to Assess the Effects of Therapy in Children with Acute Lymphoblasti1R21CA139712-01A1
2008HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function5R01NS053345-03
2008HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function3R01NS053345-03S1
2007HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function3R01NS053345-01A2S1
2007Real-time Minimal Residual Disease assay of Pediatric B-Cell Non-Hodgkin Lymphoma5R21CA121955-02
2007HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function5R01NS053345-02
2006Real-time Minimal Residual Disease assay of Pediatric B-Cell Non-Hodgkin Lymphoma1R21CA121955-01
2006HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function1R01NS053345-01A2
2004Activated Immune Parameters Associated with HIV &Aging5R21MH069173-02
2003Activated Immune Parameters Associated with HIV &Aging1R21MH069173-01

Publications icon

  Check NIH Public Access Policy Compliance

Please wait
1. Knight TE, Shiramizu B, Ly P, Thompson KS, Reddy V. Paroxysmal Nocturnal Dyspnea Secondary to Right Ventricular Myxoma: A Novel Presentation of an Unusual Tumor. Case Rep Pediatr. 2018; 2018:4791379.
2. Rasa M, Musgrave J, Abe K, Tanaka L, Xoinis K, Shiramizu B, Foskett G, Lau R. A Case of Escherichia coli Hemolytic Uremic Syndrome in a 10-Year-Old Male With Severe Neurologic Involvement Successfully Treated With Eculizumab. J Investig Med High Impact Case Rep. 2017 Oct-Dec; 5(4):2324709617741144.
3. Wirunsawanya K, Belyea L, Shikuma C, Watanabe RM, Kohorn L, Shiramizu B, Mitchell BI, Souza SA, Keating SM, Norris PJ, Ndhlovu LC, Chow D. Plasminogen Activator Inhibitor-1 Predicts Negative Alterations in Whole-Body Insulin Sensitivity in Chronic HIV Infection. AIDS Res Hum Retroviruses. 2017 Jul; 33(7):723-727.
4. Agsalda-Garcia MA, Sithinamsuwan P, Valcour VG, Chalermchai T, Tipsuk S, Kuroda J, Nakamura C, Ananworanich J, Zhang G, Schuetz A, Slike BM, Shiramizu B. Brief Report: CD14+ Enriched Peripheral Cells Secrete Cytokines Unique to HIV-Associated Neurocognitive Disorders. J Acquir Immune Defic Syndr. 2017 04 01; 74(4):454-458.
5. Shiramizu B, Shambaugh V, Petrovich H, Seto TB, Ho T, Mokuau N, Hedges JR. Leading by Success: Impact of a Clinical and Translational Research Infrastructure Program to Address Health Inequities. J Racial Ethn Health Disparities. 2016 Oct 28.
6. Lamers SL, Rose R, Maidji E, Agsalda-Garcia M, Nolan DJ, Fogel GB, Salemi M, Garcia DL, Bracci P, Yong W, Commins D, Said J, Khanlou N, Hinkin CH, Sueiras MV, Mathisen G, Donovan S, Shiramizu B, Stoddart CA, McGrath MS, Singer EJ. HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads. J Virol. 2016 10 15; 90(20):8968-83.
7. Chuang E, Lim E, Milne C, Zhu X, Agsalda M, Killeen J, Miller FD, Hernandez BY, Shiramizu B. Human Papillomavirus at Multiple Sites Associated with Anal Squamous Intraepithelial Lesions in HIV-Seropositive Individuals. Ann Clin Cytol Pathol. 2016; 2(4).
8. Shiramizu B, Mussolin L, Woessmann W, Klapper W. Paediatric non-Hodgkin lymphoma - perspectives in translational biology. Br J Haematol. 2016 05; 173(4):617-24.
9. Knight TE, Knight SW, Kyono W, Thompson K, Hicks J, Shiramizu B. Peripheral Primitive Neuroectodermal Tumor and Neurofibromatosis Type 1 in an Adolescent Male. Pediatr Blood Cancer. 2016 07; 63(7):1310-1.
10. Ka'opua LS, Cassel K, Shiramizu B, Stotzer RL, Robles A, Kapua C, Orton M, Milne C, Sesepasara M. Addressing Risk and Reluctance at the Nexus of HIV and Anal Cancer Screening. Health Promot Pract. 2016 Jan; 17(1):21-30.
11. Khan MB, Lang MJ, Huang MB, Raymond A, Bond VC, Shiramizu B, Powell MD. Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce Aß(1-42) secretion in SH-SY5Y neural cells. J Neurovirol. 2016 Apr; 22(2):179-90.
12. Ndhlovu LC, D'Antoni ML, Ananworanich J, Byron MM, Chalermchai T, Sithinamsuwan P, Tipsuk S, Ho E, Slike BM, Schuetz A, Zhang G, Agsalda-Garcia M, Shiramizu B, Shikuma CM, Valcour V. Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naïve HIV-infected Thais. J Neuroimmunol. 2015 Nov 15; 288:25-33.
13. Shiramizu B, Goldman S, Smith L, Agsalda-Garcia M, Galardy P, Perkins SL, Frazer JK, Sanger W, Anderson JR, Gross TG, Weinstein H, Harrison L, Barth MJ, Mussolin L, Cairo MS. Impact of persistent minimal residual disease post-consolidation therapy in children and adolescents with advanced Burkitt leukaemia: a Children's Oncology Group Pilot Study Report. Br J Haematol. 2015 Aug; 170(3):367-71.
14. Ndhlovu LC, Umaki T, Chew GM, Chow DC, Agsalda M, Kallianpur KJ, Paul R, Zhang G, Ho E, Hanks N, Nakamoto B, Shiramizu BT, Shikuma CM. Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing monocytes in cART-suppressed chronic HIV-infected subjects and is associated with improvements in neurocognitive test performance: implications for HIV-associated neurocognitive disease (HAND). J Neurovirol. 2014 Dec; 20(6):571-82.
15. Goldman S, Smith L, Galardy P, Perkins SL, Frazer JK, Sanger W, Anderson JR, Gross TG, Weinstein H, Harrison L, Shiramizu B, Barth M, Cairo MS. Rituximab with chemotherapy in children and adolescents with central nervous system and/or bone marrow-positive Burkitt lymphoma/leukaemia: a Children's Oncology Group Report. Br J Haematol. 2014 Nov; 167(3):394-401.
16. Kallianpur KJ, Valcour VG, Lerdlum S, Busovaca E, Agsalda M, Sithinamsuwan P, Chalermchai T, Fletcher JL, Tipsuk S, Shikuma CM, Shiramizu BT, Ananworanich J. HIV DNA in CD14+ reservoirs is associated with regional brain atrophy in patients naive to combination antiretroviral therapy. AIDS. 2014 Jul 17; 28(11):1619-24.
17. Shikuma CM, Gangcuangco LM, Killebrew DA, Libutti DE, Chow DC, Nakamoto BK, Liang CY, Milne CI, Ndhlovu LC, Barbour JD, Shiramizu BT, Gerschenson M. The role of HIV and monocytes/macrophages in adipose tissue biology. J Acquir Immune Defic Syndr. 2014 Feb 01; 65(2):151-9.
18. Agsalda-Garcia M, Shiramizu B, Melendez L, Plaud M, Liang CY, Wojna V. Different levels of HIV DNA copy numbers in cerebrospinal fluid cellular subsets. J Health Care Poor Underserved. 2013 Nov; 24(4 Suppl):8-16.
19. Nakamoto BK, Shikuma CM, Ogata-Arakaki D, Umaki T, Neuwelt EA, Shiramizu BT, Chow DC, Parikh NI, Kallianpur KJ, Hamilton BE. Feasibility and potential role of ferumoxytol-enhanced neuroimaging in HIV-associated neurocognitive disorder. J Neurovirol. 2013 Dec; 19(6):601-5.
20. Valcour VG, Ananworanich J, Agsalda M, Sailasuta N, Chalermchai T, Schuetz A, Shikuma C, Liang CY, Jirajariyavej S, Sithinamsuwan P, Tipsuk S, Clifford DB, Paul R, Fletcher JL, Marovich MA, Slike BM, DeGruttola V, Shiramizu B. HIV DNA reservoir increases risk for cognitive disorders in cART-naïve patients. PLoS One. 2013; 8(7):e70164.
21. Barth MJ, Goldman S, Smith L, Perkins S, Shiramizu B, Gross TG, Harrison L, Sanger W, Geyer MB, Giulino-Roth L, Cairo MS. Rituximab pharmacokinetics in children and adolescents with de novo intermediate and advanced mature B-cell lymphoma/leukaemia: a Children's Oncology Group report. Br J Haematol. 2013 Sep; 162(5):678-83.
22. Kallianpur KJ, Shikuma C, Kirk GR, Shiramizu B, Valcour V, Chow D, Souza S, Nakamoto B, Sailasuta N. Peripheral blood HIV DNA is associated with atrophy of cerebellar and subcortical gray matter. Neurology. 2013 May 07; 80(19):1792-9.
23. Shikuma CM, Nakamoto B, Shiramizu B, Liang CY, DeGruttola V, Bennett K, Paul R, Kallianpur K, Chow D, Gavegnano C, Hurwitz SJ, Schinazi RF, Valcour VG. Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV. Antivir Ther. 2012; 17(7):1233-42.
24. Goldman S, Smith L, Anderson JR, Perkins S, Harrison L, Geyer MB, Gross TG, Weinstein H, Bergeron S, Shiramizu B, Sanger W, Barth M, Zhi J, Cairo MS. Rituximab and FAB/LMB 96 chemotherapy in children with Stage III/IV B-cell non-Hodgkin lymphoma: a Children's Oncology Group report. Leukemia. 2013 Apr; 27(5):1174-7.
25. Shiramizu B, Liang CY, Agsalda-Garcia M, Nagata I, Milne C, Zhu X, Killeen J, Berry JM, Goodman MT. Presence of high-risk human papillomavirus genotype and human immunodeficiency virus DNA in anal high-grade and low-grade squamous intraepithelial lesions. AIDS Res Hum Retroviruses. 2013 Jan; 29(1):178-81.
26. Shiramizu B, Milne C, Terada K, Cassel K, Matsuno RK, Killeen J, Liang CY, Tachibana F, Sheeran T, Weihe J, Goodman MT. A Community-Based Approach to Enhancing Anal Cancer Screening in Hawaii's HIV-Infected Ethnic Minorities. J AIDS Clin Res. 2012 Aug 01; 3(6).
27. Kusao IK, Troelstrup DL, Agsalda MA, Shiramizu BT. Effective use of small-interfering RNA to characterize residual B-cell non-Hodgkin lymphoma cells following chemotherapy. J Hematol Malig. 2012 Mar 01; 2(1):5-12.
28. Kusao I, Shiramizu B, Liang CY, Grove J, Agsalda M, Troelstrup D, Velasco VN, Marshall A, Whitenack N, Shikuma C, Valcour V. Cognitive performance related to HIV-1-infected monocytes. J Neuropsychiatry Clin Neurosci. 2012; 24(1):71-80.
29. Shiramizu B, Ananworanich J, Chalermchai T, Siangphoe U, Troelstrup D, Shikuma C, De Grutolla V, Sithinamsuwan P, Praihirunkit P, Rattanamanee S, Valcour V. Failure to clear intra-monocyte HIV infection linked to persistent neuropsychological testing impairment after first-line combined antiretroviral therapy. J Neurovirol. 2012 Feb; 18(1):69-73.
30. Kallianpur KJ, Kirk GR, Sailasuta N, Valcour V, Shiramizu B, Nakamoto BK, Shikuma C. Regional cortical thinning associated with detectable levels of HIV DNA. Cereb Cortex. 2012 Sep; 22(9):2065-75.
31. Shiramizu B, Goldman S, Kusao I, Agsalda M, Lynch J, Smith L, Harrison L, Morris E, Gross TG, Sanger W, Perkins S, Cairo MS. Minimal disease assessment in the treatment of children and adolescents with intermediate-risk (Stage III/IV) B-cell non-Hodgkin lymphoma: a children's oncology group report. Br J Haematol. 2011 Jun; 153(6):758-63.
32. Payam A, Shiramizu B, Shikuma C, Milne C, Terada K, Kajioka E, Ka'opua LS, Cassel K, Chow D. HIV-associated anal dysplasia: experience from a multiethnic-HIV clinic in Hawaii. J Health Care Poor Underserved. 2011; 22(4 Suppl):16-22.
33. Hedges JR, Shiramizu B, Seto T. RMATRIX - Clinical Translational Research Award. Hawaii Med J. 2011 Jan; 70(1):18-9.
34. Egan K, Kusao I, Troelstrup D, Agsalda M, Shiramizu B. Mitochondrial DNA in residual leukemia cells in cerebrospinal fluid in children with acute lymphoblastic leukemia. J Clin Med Res. 2010 Oct 11; 2(5):225-9.
35. Nakamoto BK, McMurtray A, Davis J, Valcour V, Watters MR, Shiramizu B, Chow DC, Kallianpur K, Shikuma CM. Incident neuropathy in HIV-infected patients on HAART. AIDS Res Hum Retroviruses. 2010 Jul; 26(7):759-65.
36. Brown A, Shiramizu B, Nath A, Wojna V. Translational research in NeuroAIDS: a neuroimmune pharmacology-related course. J Neuroimmune Pharmacol. 2011 Mar; 6(1):80-8.
37. Chow DC, Stein JH, Seto TB, Mitchell C, Sriratanaviriyakul N, Grandinetti A, Gerschenson M, Shiramizu B, Souza S, Shikuma C. Short-term effects of extended-release niacin on endothelial function in HIV-infected patients on stable antiretroviral therapy. AIDS. 2010 Apr 24; 24(7):1019-23.
38. Valcour VG, Shiramizu BT, Shikuma CM. HIV DNA in circulating monocytes as a mechanism to dementia and other HIV complications. J Leukoc Biol. 2010 Apr; 87(4):621-6.
39. Hu W, Yu Q, Hu N, Byrd D, Amet T, Shikuma C, Shiramizu B, Halperin JA, Qin X. A high-affinity inhibitor of human CD59 enhances complement-mediated virolysis of HIV-1: implications for treatment of HIV-1/AIDS. J Immunol. 2010 Jan 01; 184(1):359-68.
40. Agsalda M, Kusao I, Troelstrup D, Shiramizu B. Screening for residual disease in pediatric burkitt lymphoma using consensus primer pools. Adv Hematol. 2009; 2009:412163.
41. Valcour VG, Shiramizu BT, Sithinamsuwan P, Nidhinandana S, Ratto-Kim S, Ananworanich J, Siangphoe U, Kim JH, de Souza M, Degruttola V, Paul RH, Shikuma CM. HIV DNA and cognition in a Thai longitudinal HAART initiation cohort: the SEARCH 001 Cohort Study. Neurology. 2009 Mar 17; 72(11):992-8.
42. Hu N, Yu R, Shikuma C, Shiramizu B, Ostrwoski MA, Yu Q. Role of cell signaling in poxvirus-mediated foreign gene expression in mammalian cells. Vaccine. 2009 May 14; 27(22):2994-3006.
43. Griffin TC, Weitzman S, Weinstein H, Chang M, Cairo M, Hutchison R, Shiramizu B, Wiley J, Woods D, Barnich M, Gross TG. A study of rituximab and ifosfamide, carboplatin, and etoposide chemotherapy in children with recurrent/refractory B-cell (CD20+) non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2009 Feb; 52(2):177-81.
44. Shiramizu B, Williams AE, Shikuma C, Valcour V. Amount of HIV DNA in peripheral blood mononuclear cells is proportional to the severity of HIV-1-associated neurocognitive disorders. J Neuropsychiatry Clin Neurosci. 2009; 21(1):68-74.
45. Munsaka SM, Agsalda M, Troelstrup D, Hu N, Yu Q, Shiramizu B. Characteristics of Activated Monocyte Phenotype Support R5-Tropic Human Immunodeficiency Virus. Immunol Immunogenet Insights. 2009; 1:15-20.
46. Chow DC, Tasaki A, Ono J, Shiramizu B, Souza SA. Effect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with HIV-associated lipodystrophy syndrome. Biologics. 2008 Dec; 2(4):917-21.
47. Kusao I, Troelstrup D, Shiramizu B. Possible Mitochondria-Associated Enzymatic Role in Non-Hodgkin Lymphoma Residual Disease. Cancer Growth Metastasis. 2008 Nov 24; 1:3-8.
48. Valcour V, Shiramizu B, Shikuma C. Frequency of apolipoprotein E4 among older compared with younger HIV patients: support for detrimental effect of E4 on survival. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):E66; author reply E67-8.
49. Shiramizu B, Maeshiro M. At the crossroads: past, current, and future of the University of Hawai'i John A. Burns School of Medicine-Okinawa Chubu Hospital partnership. Hawaii Med J. 2008 Sep; 67(9):246, 251.
50. Kusao I, Agsalda M, Troelstrup D, Villanueva N, Shiramizu B. Chemotoxicity recovery of mitochondria in non-Hodgkin lymphoma resulting in minimal residual disease. Pediatr Blood Cancer. 2008 Aug; 51(2):193-7.
51. Ratto-Kim S, Chuenchitra T, Pulliam L, Paris R, Sukwit S, Gongwon S, Sithinamsuwan P, Nidhinandana S, Thitivichianlert S, Shiramizu BT, de Souza MS, Chitpatima ST, Sun B, Rempel H, Nitayaphan S, Williams K, Kim JH, Shikuma CM, Valcour VG. Expression of monocyte markers in HIV-1 infected individuals with or without HIV associated dementia and normal controls in Bangkok Thailand. J Neuroimmunol. 2008 Mar; 195(1-2):100-7.
52. Sacktor N, Skolasky R, Selnes OA, Watters M, Poff P, Shiramizu B, Shikuma C, Valcour V. Neuropsychological test profile differences between young and old human immunodeficiency virus-positive individuals. J Neurovirol. 2007 Jun; 13(3):203-9.
53. Shiramizu B, Hu N, Frisque RJ, Nerurkar VR. High prevalence of human polyomavirus JC VP1 gene sequences in pediatric malignancies. Cell Mol Biol (Noisy-le-grand). 2007 May 15; 53(3):4-12.
54. Valcour VG, Sithinamsuwan P, Nidhinandana S, Thitivichianlert S, Ratto-Kim S, Apateerapong W, Shiramizu BT, Desouza MS, Chitpatima ST, Watt G, Chuenchitra T, Robertson KR, Paul RH, McArthur JC, Kim JH, Shikuma CM. Neuropsychological abnormalities in patients with dementia in CRF 01_AE HIV-1 infection. Neurology. 2007 Feb 13; 68(7):525-7.
55. Shiramizu B, Paul R, Williams A, Shikuma C, Watters M, Grove J, Valcour V. HIV proviral DNA associated with decreased neuropsychological function. J Neuropsychiatry Clin Neurosci. 2007; 19(2):157-63.
56. Shiramizu B, Ratto-Kim S, Sithinamsuwan P, Nidhinandana S, Thitivichianlert S, Watt G, deSouza M, Chuenchitra T, Sukwit S, Chitpatima S, Robertson K, Paul R, Shikuma C, Valcour V. HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand. Int J Med Sci. 2006 Dec 06; 4(1):13-8.
57. Valcour VG, Sacktor NC, Paul RH, Watters MR, Selnes OA, Shiramizu BT, Williams AE, Shikuma CM. Insulin resistance is associated with cognition among HIV-1-infected patients: the Hawaii Aging With HIV cohort. J Acquir Immune Defic Syndr. 2006 Dec 01; 43(4):405-10.
58. Shiramizu B, Lau E, Tamamoto A, Uniatowski J, Troelstrup D. Feasibility assessment of cerebrospinal fluid from HIV-1-infected children for HIV proviral DNA and monocyte chemoattractant protein 1 alleles. J Investig Med. 2006 Dec; 54(8):468-72.
59. Valcour V, Yee P, Williams AE, Shiramizu B, Watters M, Selnes O, Paul R, Shikuma C, Sacktor N. Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection--The Hawaii Aging with HIV Cohort. J Neurovirol. 2006 Oct; 12(5):387-91.
60. Killebrew DA, Troelstrup D, Valcour V, Williams A, Aguon J, Sapalo D, Shikuma C, Ratto-Kim S, Shiramizu B. Discordant plasma and cerebral spinal fluid cytokines/chemokines in relation to HIV-1-associated dementia. Cell Mol Biol (Noisy-le-grand). 2005 Sep 02; 51 Suppl:OL745-54.
61. Shikuma CM, Valcour VG, Ratto-Kim S, Williams AE, Souza S, Gerschenson M, Day L, Kim JH, Shiramizu B. HIV-associated wasting in the era of highly active antiretroviral therapy: a syndrome of residual HIV infection in monocytes and macrophages? Clin Infect Dis. 2005 Jun 15; 40(12):1846-8.
62. Hernandez B, Shiramizu B. Viruses and cancer. Hawaii Med J. 2005 Apr; 64(4):106-8.
63. Shiramizu B, Gartner S, Williams A, Shikuma C, Ratto-Kim S, Watters M, Aguon J, Valcour V. Circulating proviral HIV DNA and HIV-associated dementia. AIDS. 2005 Jan 03; 19(1):45-52.
64. Valcour VG, Shikuma CM, Shiramizu BT, Williams AE, Watters MR, Poff PW, Grove JS, Selnes OA, Sacktor NC. Diabetes, insulin resistance, and dementia among HIV-1-infected patients. J Acquir Immune Defic Syndr. 2005 Jan 01; 38(1):31-6.
65. Gerschenson M, Shiramizu B, LiButti DE, Shikuma CM. Mitochondrial DNA levels of peripheral blood mononuclear cells and subcutaneous adipose tissue from thigh, fat and abdomen of HIV-1 seropositive and negative individuals. Antivir Ther. 2005; 10 Suppl 2:M83-9.
66. Shiramizu B, Perkins SL, Bergeron S, Lones M, Kelly K, Weiner M, Cairo MS. Assessing immunoglobulin heavy chain rearrangements in pediatric CD20-positive and CD20-negative classic Hodgkin's disease. Clin Lymphoma. 2004 Dec; 5(3):184-9.
67. Valcour V, Shikuma C, Shiramizu B, Watters M, Poff P, Selnes OA, Grove J, Liu Y, Abdul-Majid KB, Gartner S, Sacktor N. Age, apolipoprotein E4, and the risk of HIV dementia: the Hawaii Aging with HIV Cohort. J Neuroimmunol. 2004 Dec; 157(1-2):197-202.
68. Valcour V, Shikuma C, Shiramizu B, Watters M, Poff P, Selnes O, Holck P, Grove J, Sacktor N. Higher frequency of dementia in older HIV-1 individuals: the Hawaii Aging with HIV-1 Cohort. Neurology. 2004 Sep 14; 63(5):822-7.
69. Killebrew D, Shiramizu B. Pathogenesis of HIV-associated non-Hodgkin lymphoma. Curr HIV Res. 2004 Jul; 2(3):215-21.
70. Valcour V, Shiramizu B. HIV-associated dementia, mitochondrial dysfunction, and oxidative stress. Mitochondrion. 2004 Jul; 4(2-3):119-29.
71. Kamemoto LE, Shiramizu B, Gerschenson M. HIV-associated mitochondrial toxicity in pregnancy. Mitochondrion. 2004 Jul; 4(2-3):153-62.
72. Watters MR, Poff PW, Shiramizu BT, Holck PS, Fast KM, Shikuma CM, Valcour VG. Symptomatic distal sensory polyneuropathy in HIV after age 50. Neurology. 2004 Apr 27; 62(8):1378-83.
73. Shiramizu B, Gartner S, Cho M, Liu Y, Pyron N, Valcour V, Shikuma C. Assessment of HIV-1 DNA copies per cell by real-time polymerase chain reaction. Front Biosci. 2004 Jan 01; 9:255-61.
74. Killebrew DA, Troelstrup D, Shiramizu B. Preferential HIV-1 integration sites in macrophages and HIV-associated malignancies. Cell Mol Biol (Noisy-le-grand). 2004; 50 Online Pub:OL581-9.
75. Shiramizu B, Mick P. Epigenetic changes in the DAP-kinase CpG island in pediatric lymphoma. Med Pediatr Oncol. 2003 Dec; 41(6):527-31.
76. Shiramizu B, Theodore D, Bassett R, Coel M, Sherman KE, Glesby MJ, Chow D, Alston B, Colquhoun D, Merigan TC, Reichman RC, Berggren R, Burning WJ, Brobst S. Correlation of single photon emission computed tomography parameters as a noninvasive alternative to liver biopsies in assessing liver involvement in the setting of HIV and hepatitis C virus coinfection: a multicenter trial of the Adult AIDS Clinical Trials Group. J Acquir Immune Defic Syndr. 2003 Jul 01; 33(3):329-35.
77. Shiramizu B, Shikuma KM, Kamemoto L, Gerschenson M, Erdem G, Pinti M, Cossarizza A, Shikuma C. Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy. J Acquir Immune Defic Syndr. 2003 Apr 01; 32(4):370-4.
78. Sabesan V, Cairo MS, Lones MA, Perkins SL, Morris E, Sposto R, Van De Ven C, Shiramizu B. Assessment of minimal residual disease in childhood non-hodgkin lymphoma by polymerase chain reaction using patient-specific primers. J Pediatr Hematol Oncol. 2003 Feb; 25(2):109-13.
79. Shiramizu B, Yu Q, Hu N, Yanagihara R, Nerurkar VR. Investigation of TT virus in the etiology of pediatric acute lymphoblastic leukemia. Pediatr Hematol Oncol. 2002 Dec; 19(8):543-51.
80. Cabalo E, Wilkinson R, Lu NT, Shimizu S, Melish M, McClain KL, Jenson HB, Shiramizu B. Molecular analysis and pathology of a second pediatric HIV-associated Burkitt lymphoma. Pediatr Pathol Mol Med. 2002 Nov-Dec; 21(6):525-30.
81. Yu Q, Shiramizu B, Nerurkar VR, Hu N, Shikuma CM, Melish ME, Cascio K, Imrie A, Lu Y, Yanagihara R. TT virus: preferential distribution in CD19(+) peripheral blood mononuclear cells and lack of viral integration. J Med Virol. 2002 Feb; 66(2):276-84.
82. Shikuma CM, Shiramizu B. Mitochondrial Toxicity Associated with Nucleoside Reverse Transcriptase Inhibitor Therapy. Curr Infect Dis Rep. 2001 Dec; 3(6):553-560.
83. Shikuma CM, Hu N, Milne C, Yost F, Waslien C, Shimizu S, Shiramizu B. Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy. AIDS. 2001 Sep 28; 15(14):1801-9.
84. Lyn D, Bennett NA, Shiramizu BT, Herndier BG, Igietseme JU. Sequence analysis of HIV-1 insertion sites in peripheral blood lymphocytes. Cell Mol Biol (Noisy-le-grand). 2001 Sep; 47(6):981-6.
85. Shiramizu B, Chang CW, Cairo MS. Absence of human herpesvirus-6 genome by polymerase chain reaction in children with Hodgkin disease: a Children's Cancer Group Lymphoma Biology Study. J Pediatr Hematol Oncol. 2001 Jun-Jul; 23(5):282-5.
86. Kaplan LD, Shiramizu B, Herndier B, Hahn J, Meeker TC, Ng V, Volberding PA, McGrath MS. Influence of molecular characteristics on clinical outcome in human immunodeficiency virus-associated non-Hodgkin's lymphoma: identification of a subgroup with favorable clinical outcome. Blood. 1995 Apr 01; 85(7):1727-35.
87. McGrath MS, Shiramizu BT, Herndier BG. Identification of a clonal form of HIV in early Kaposi's sarcoma: evidence for a novel model of oncogenesis, "sequential neoplasia". J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 01; 8(4):379-85.
88. Marsh JW, Herndier B, Tsuzuki A, Ng VL, Shiramizu B, Abbey N, McGrath MS. Cytokine expression in large cell lymphoma associated with acquired immunodeficiency syndrome. J Interferon Cytokine Res. 1995 Mar; 15(3):261-8.
89. Shiramizu B, Herndier BG, McGrath MS. Identification of a common clonal human immunodeficiency virus integration site in human immunodeficiency virus-associated lymphomas. Cancer Res. 1994 Apr 15; 54(8):2069-72.
90. Grossman M, Shiramizu B. Evaluation of lymphadenopathy in children. Curr Opin Pediatr. 1994 Feb; 6(1):68-76.
91. Gunthel CJ, Ng V, McGrath M, Herndier B, Shiramizu B. Association of Epstein-Barr virus types 1 and 2 with acquired immunodeficiency syndrome-related primary central nervous system lymphomas. Blood. 1994 Jan 15; 83(2):618-9.
92. Herndier BG, Shiramizu BT, Jewett NE, Aldape KD, Reyes GR, McGrath MS. Acquired immunodeficiency syndrome-associated T-cell lymphoma: evidence for human immunodeficiency virus type 1-associated T-cell transformation. Blood. 1992 Apr 01; 79(7):1768-74.
93. Shiramizu B, Herndier B, Meeker T, Kaplan L, McGrath M. Molecular and immunophenotypic characterization of AIDS-associated, Epstein-Barr virus-negative, polyclonal lymphoma. J Clin Oncol. 1992 Mar; 10(3):383-9.
94. Herndier BG, Shiramizu BT, McGrath MS. AIDS associated non-Hodgkin's lymphomas represent a broad spectrum of monoclonal and polyclonal lymphoproliferative processes. Curr Top Microbiol Immunol. 1992; 182:385-94.
95. Meeker TC, Shiramizu B, Kaplan L, Herndier B, Sanchez H, Grimaldi JC, Baumgartner J, Rachlin J, Feigal E, Rosenblum M, et al. Evidence for molecular subtypes of HIV-associated lymphoma: division into peripheral monoclonal, polyclonal and central nervous system lymphoma. AIDS. 1991 Jun; 5(6):669-74.
96. Shiramizu B, McGrath MS. Molecular pathogenesis of AIDS-associated non-Hodgkin's lymphoma. Hematol Oncol Clin North Am. 1991 Apr; 5(2):323-30.
97. Shiramizu B, Barriga F, Neequaye J, Jafri A, Dalla-Favera R, Neri A, Guttierez M, Levine P, Magrath I. Patterns of chromosomal breakpoint locations in Burkitt's lymphoma: relevance to geography and Epstein-Barr virus association. Blood. 1991 Apr 01; 77(7):1516-26.
98. McGrath MS, Shiramizu B, Meeker TC, Kaplan LD, Herndier B. AIDS-associated polyclonal lymphoma: identification of a new HIV-associated disease process. J Acquir Immune Defic Syndr. 1991; 4(4):408-15.
99. Shir