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Maryam Foroozesh
Title Professor, Department of Chemistry
Faculty Rank
Degree Ph.D.
Institution Xavier University of Louisiana
Department
Clusters
Address
Xavier University
1 Drexel Drive
City New Orleans
State LA
Postal Code 70125
Telephone (504) 520-5078
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Email
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  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2019Ceramides for Breast Cancer Treatment1R15CA242991-01
2.
2019BUILD at Xavier, Project Pathways II2TL4GM118968-06
3.
2019BUILD at Xavier, Project Pathways II2UL1GM118967-06
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2019BUILD at Xavier, Project Pathways II2RL5GM118966-06
5.
2018Building Integrated Pathways to Independence for Diverse Biomedical Researchers5UL1GM118967-05
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2018PROJECT PATHWAYS: STUDENT TRAINING CORE5TL4GM118968-05
7.
2018Project Pathways: Research Enrichment Core5RL5GM118966-05
8.
2017Building Integrated Pathways to Independence for Diverse Biomedical Researchers5UL1GM118967-04
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2017PROJECT PATHWAYS: STUDENT TRAINING CORE5TL4GM118968-04
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2017Project Pathways: Research Enrichment Core5RL5GM118966-04
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2016PROJECT PATHWAYS: STUDENT TRAINING CORE5TL4GM118968-03
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2016Building Integrated Pathways to Independence for Diverse Biomedical Researchers5UL1GM118967-03
13.
2016Project Pathways: Research Enrichment Core5RL5GM118966-03
14.
2016RISE Option II at Xavier University of Louisiana4R25GM060926-13
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2015RISE Option II at Xavier University of Louisiana5R25GM060926-12
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2015Project Pathways: Research Enrichment Core8RL5GM118966-02
17.
2015Building Integrated Pathways to Independence for Diverse Biomedical Researchers8UL1GM118967-02
18.
2015PROJECT PATHWAYS: STUDENT TRAINING CORE8TL4GM118968-02
19.
2014RISE Option II at Xavier University of Louisiana5R25GM060926-11
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2013RISE Option II at Xavier University of Louisiana5R25GM060926-10
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2012RISE Option II at Xavier University of Louisiana2R25GM060926-09
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2011MBRS RISE Program at Xavier University5R25GM060926-08
23.
2011Multi-Target, Mechanism-Based Drug Design for the Treatment of Breast Cancer: Syn1R15CA159059-01
24.
2010MBRS RISE Program at Xavier University5R25GM060926-07
25.
2007Coumarin Acetylenes &Propargyl Ethers, a New Class of Cytochrome P450 Inhibitors5S06GM008008-36
26.
2006Coumarin Acetylenes &Propargyl Ethers, a New Class of Cytochrome P450 Inhibitors5S06GM008008-35
27.
2005Coumarin Acetylenes &Propargyl Ethers, a New Class of Cytochrome P450 Inhibitors5S06GM008008-34
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2004Coumarin Acetylenes &Propargyl Ethers, a New Class of Cytochrome P450 Inhibitors2S06GM008008-33
29.
2002SELECTIVE SUICIDE SUBSTRATES FOR CYTOCHROME P450 ISOZYMES5S06GM008008-31
30.
2001SELECTIVE SUICIDE SUBSTRATES FOR CYTOCHROME P450 ISOZYMES5S06GM008008-30
31.
2001SELECTIVE SUICIDE SUBSTRATES FOR CYTOCHROME P450 ISOZYMES3S06GM008008-30S1
32.
2000SELECTIVE SUICIDE SUBSTRATES FOR CYTOCHROME P450 ISOZYMES2S06GM008008-29

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1. Foroozesh M, Sridhar J, Goyal N, Liu J. Coumarins and P450s, Studies Reported to-Date. Molecules. 2019 Apr 24; 24(8).
2. Chen J, Foroozesh M, Qin Z. Transactivation of human endogenous retroviruses by tumor viruses and their functions in virus-associated malignancies. Oncogenesis. 2019 Jan 14; 8(1):6.
3. Ponnapakkam T, Saulsberry T, Hill T, Hill-Odom M, Goyal N, Anbalagan M, Liu J, Foroozesh M. Inhibition of breast tumor growth in mice after treatment with ceramide analog 315. Anticancer Drugs. 2018 10; 29(9):898-903.
4. Goyal N, Donahue JP, Do C, Perry T, Bongay-Williams K, Foroozesh M. A dibenzofuran derivative: 2-(pentyloxy)dibenzo[b,d]furan. IUCrdata. 2018 Sep; 3(9).
5. Goyal N, Do C, Donahue JP, Mague JT, Foroozesh M. Ethyl 2-[2-(4-oxo-4H-chromen-2-yl)phenoxy]acetate. IUCrdata. 2018 Jul; 3(7).
6. Dai L, Smith CD, Foroozesh M, Miele L, Qin Z. The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo. Int J Cancer. 2018 05 15; 142(10):2153-2162.
7. Goyal N, Bongay-Williams K, Do C, Perry T, Kantrow E, Hill-Odom M, Sridhar J, Foroozesh M. DESIGN AND SYNTHESIS OF DIBENZYLFURAN BASED ETHER AND ESTER DERIVATIVES AS POTENTIAL P450 INHIBITORS. J Undergrad Chem Res. 2018; 17(4):102-104.
8. Foroozesh M, Giguette M, Morgan K, Johanson K, D''Amour G, Coston T, Wilkins-Green C. Building integrated pathways to independence for diverse biomedical researchers: Project Pathways, the BUILD program at Xavier University of Louisiana. BMC Proc. 2017; 11(Suppl 12):28.
9. Sridhar J, Goyal N, Liu J, Foroozesh M. Review of Ligand Specificity Factors for CYP1A Subfamily Enzymes from Molecular Modeling Studies Reported to-Date. Molecules. 2017 Jul 08; 22(7).
10. Foroozesh M, Goyal N, Jackson T, Do C, Booker S, Hill T, Liu J. OPTIMIZATION OF SCALE-UP SYNTHESIS OF ANTI-CANCER CERAMIDE ANALOG 315. J Undergrad Chem Res. 2017; 16(3):89-90.
11. Sridhar J, Liu J, Komati R, Schroeder R, Jiang Q, Tram P, Riley K, Foroozesh M. Ortho-Methylarylamines as Time-Dependent Inhibitors of Cytochrome P450 1A1 Enzyme. Drug Metab Lett. 2017; 10(4):270-277.
12. Shimada T, Takenaka S, Kakimoto K, Murayama N, Lim YR, Kim D, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6. Chem Res Toxicol. 2016 06 20; 29(6):1029-40.
13. Schroeder RL, Tram P, Liu J, Foroozesh M, Sridhar J. Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome P450 inhibition: a patent evaluation WO2015048311 (A1). Expert Opin Ther Pat. 2016; 26(1):139-47.
14. Liu J, Pham PT, Skripnikova EV, Zheng S, Lovings LJ, Wang Y, Goyal N, Bellow SM, Mensah LM, Chatters AJ, Bratton MR, Wiese TE, Zhao M, Wang G, Foroozesh M. A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2. J Med Chem. 2015 Aug 27; 58(16):6481-93.
15. Shimada T, Takenaka S, Murayama N, Kramlinger VM, Kim JH, Kim D, Liu J, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13. Xenobiotica. 2016; 46(3):211-24.
16. Goyal N, Liu J, Lovings L, Dupart P, Taylor S, Bellow S, Mensah L, McClain E, Dotson B, Sridhar J, Zhang X, Zhao M, Foroozesh M. Ethynylflavones, highly potent, and selective inhibitors of cytochrome P450 1A1. Chem Res Toxicol. 2014 Aug 18; 27(8):1431-9.
17. Ponnapakam AP, Liu J, Bhinge KN, Drew BA, Wang TL, Antoon JW, Nguyen TT, Dupart PS, Wang Y, Zhao M, Liu YY, Foroozesh M, Beckman BS. 3-Ketone-4,6-diene ceramide analogs exclusively induce apoptosis in chemo-resistant cancer cells. Bioorg Med Chem. 2014 Feb 15; 22(4):1412-20.
18. Liu J, Sridhar J, Foroozesh M. Cytochrome P450 family 1 inhibitors and structure-activity relationships. Molecules. 2013 Nov 25; 18(12):14470-95.
19. Foroozesh M, Jiang Q, Sridhar J, Liu J, Dotson B, McClain E. DESIGN, SYNTHESIS, AND EVALUATION OF CARBAZOLE ANALOGS AS POTENTIAL CYTOCHROME P450 INHIBITORS. J Undergrad Chem Res. 2013 Sep; 12(4):92-95.
20. Liu J, Beckman BS, Foroozesh M. A review of ceramide analogs as potential anticancer agents. Future Med Chem. 2013 Aug; 5(12):1405-21.
21. Liu J, Taylor SF, Dupart PS, Arnold CL, Sridhar J, Jiang Q, Wang Y, Skripnikova EV, Zhao M, Foroozesh M. Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1. J Med Chem. 2013 May 23; 56(10):4082-92.
22. Shimada T, Kim D, Murayama N, Tanaka K, Takenaka S, Nagy LD, Folkman LM, Foroozesh MK, Komori M, Yamazaki H, Guengerich FP. Binding of diverse environmental chemicals with human cytochromes P450 2A13, 2A6, and 1B1 and enzyme inhibition. Chem Res Toxicol. 2013 Apr 15; 26(4):517-28.
23. Zhang H, Gay SC, Shah M, Foroozesh M, Liu J, Osawa Y, Zhang Q, Stout CD, Halpert JR, Hollenberg PF. Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis. Biochemistry. 2013 Jan 15; 52(2):355-64.
24. Foroozesh M, Jiang Q, Sridhar J, Liu J. DESIGN, SYNTHESIS, AND EVALUATION OF A FAMILY OF PROPARGYL PYRIDINYL ETHERS AS POTENTIAL CYTOCHROME P450 INHIBITORS. J Undergrad Chem Res. 2013; 12(4):91-94.
25. Sridhar J, Liu J, Foroozesh M, Stevens CL. Insights on cytochrome p450 enzymes and inhibitors obtained through QSAR studies. Molecules. 2012 Aug 03; 17(8):9283-305.
26. Liu J, Nguyen TT, Dupart PS, Sridhar J, Zhang X, Zhu N, Stevens CL, Foroozesh M. 7-Ethynylcoumarins: selective inhibitors of human cytochrome P450s 1A1 and 1A2. Chem Res Toxicol. 2012 May 21; 25(5):1047-57.
27. Sridhar J, Liu J, Foroozesh M, Klein Stevens CL. Inhibition of cytochrome p450 enzymes by quinones and anthraquinones. Chem Res Toxicol. 2012 Feb 20; 25(2):357-65.
28. Sridhar J, Ellis J, Dupart P, Liu J, Stevens CL, Foroozesh M. Development of flavone propargyl ethers as potent and selective inhibitors of cytochrome P450 enzymes 1A1 and 1A2. Drug Metab Lett. 2012; 6(4):275-84.
29. Sridhar J, Foroozesh M, Stevens CL. QSAR models of cytochrome P450 enzyme 1A2 inhibitors using CoMFA, CoMSIA and HQSAR. SAR QSAR Environ Res. 2011 Oct; 22(7-8):681-97.
30. Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Chem Res Toxicol. 2010 Dec 20; 23(12):1921-35.
31. Liu J, Antoon JW, Ponnapakkam A, Beckman BS, Foroozesh M. Novel anti-viability ceramide analogs: design, synthesis, and structure-activity relationship studies of substituted (S)-2-(benzylideneamino)-3-hydroxy-N-tetradecylpropanamides. Bioorg Med Chem. 2010 Jul 15; 18(14):5316-22.
32. Zhu N, Lightsey D, Liu J, Foroozesh M, Morgan KM, Stevens ED, Klein Stevens CL. Ethynyl and Propynylpyrene Inhibitors of Cytochrome P450. J Chem Crystallogr. 2010 Apr 01; 40(4):343-352.
33. Sridhar J, Jin P, Liu J, Foroozesh M, Stevens CL. In silico studies of polyaromatic hydrocarbon inhibitors of cytochrome P450 enzymes 1A1, 1A2, 2A6, and 2B1. Chem Res Toxicol. 2010 Mar 15; 23(3):600-7.
34. Antoon JW, Liu J, Ponnapakkam AP, Gestaut MM, Foroozesh M, Beckman BS. Novel D: -erythro N-octanoyl sphingosine analogs as chemo- and endocrine-resistant breast cancer therapeutics. Cancer Chemother Pharmacol. 2010 May; 65(6):1191-5.
35. Antoon JW, Liu J, Gestaut MM, Burow ME, Beckman BS, Foroozesh M. Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells. J Med Chem. 2009 Sep 24; 52(18):5748-52.
36. Shimada T, Tanaka K, Takenaka S, Foroozesh MK, Murayama N, Yamazaki H, Guengerich FP, Komori M. Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. Chem Res Toxicol. 2009 Jul; 22(7):1325-33.
37. Shimada T, Murajama N, Tanaka K, Takenaka S, Imai Y, Hopkins NE, Foroozesh MK, Alworth WL, Yamazaki H, Guengerich FP, Komori M. Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity. Chem Res Toxicol. 2008 Dec; 21(12):2313-23.
38. Sridar C, Kent UM, Noon K, McCall A, Alworth B, Foroozesh M, Hollenberg PF. Differential inhibition of cytochromes P450 3A4 and 3A5 by the newly synthesized coumarin derivatives 7-coumarin propargyl ether and 7-(4-trifluoromethyl)coumarin propargyl ether. Drug Metab Dispos. 2008 Nov; 36(11):2234-43.
39. Bergander L, Wincent E, Rannug A, Foroozesh M, Alworth W, Rannug U. Metabolic fate of the Ah receptor ligand 6-formylindolo[3,2-b]carbazole. Chem Biol Interact. 2004 Oct 15; 149(2-3):151-64.
40. Alexander DL, Zhang L, Foroozesh M, Alworth WL, Jefcoate CR. Metabolism-based polycyclic aromatic acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl hydrocarbon receptor activity. Toxicol Appl Pharmacol. 1999 Dec 01; 161(2):123-39.
41. Strobel SM, Szklarz GD, He Y, Foroozesh M, Alworth WL, Roberts ES, Hollenberg PF, Halpert JR. Identification of selective mechanism-based inactivators of cytochromes P-450 2B4 and 2B5, and determination of the molecular basis for differential susceptibility. J Pharmacol Exp Ther. 1999 Jul; 290(1):445-51.
42. Cantrell CL, Nuñez IS, Castañeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG. Antimycobacterial activities of dehydrocostus lactone and its oxidation products. J Nat Prod. 1998 Oct; 61(10):1181-6.
43. Shimada T, Yamazaki H, Foroozesh M, Hopkins NE, Alworth WL, Guengerich FP. Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1. Chem Res Toxicol. 1998 Sep; 11(9):1048-56.
44. Roberts ES, Hopkins NE, Foroozesh M, Alworth WL, Halpert JR, Hollenberg PF. Inactivation of cytochrome P450s 2B1, 2B4, 2B6, and 2B11 by arylalkynes. Drug Metab Dispos. 1997 Nov; 25(11):1242-8.
45. Foroozesh M, Primrose G, Guo Z, Bell LC, Alworth WL, Guengerich FP. Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes. Chem Res Toxicol. 1997 Jan; 10(1):91-102.
46. Hopkins NE, Foroozesh MK, Alworth WL. Suicide inhibitors of cytochrome P450 1A1 and P450 2B1. Biochem Pharmacol. 1992 Aug 18; 44(4):787-96.

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