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Powell, Michael D.

One or more keywords matched the following properties of Powell, Michael D.

Property	Value
overview	My research centers around the HIV-1 protein Nef. Our research has shown that Nef protein is secreted by HIV-1 infected cells and is present in the plasma of infected individuals. Our studies suggest that Nef is secreted from cells in the form of exosomes, small membrane bound vesicles approximately 50-100nm in size. T cells that come in contact with Nef exosomes undego apoptosis. Macrophage can take up Nef exosomes, but their affect on these cells is largely unknown. Nef exosomes appear to play a significant role in the pathogenic effects of HIV-1 infection leading to AIDS. Most recently we have worked with Bruce Shiramizu at the U of Hawaii to investigate the potential of Nef exosomes to facilitate the pathogenesis of HIV Associated Neurologic Disorders (HAND). We have also been working with a traditional medicine group called ProMetra. Extracts of natural plants are used to treat HIV/AIDS patients. We have shown that these natural products have the ability to block entry of HIV into T cells. We are interested testing these herbal treatments in a clinical trial. We have recently worked with USAMRIID to also investigate the potential of these herbal treatments to inhibit Ebola virus. In another collaboration we are working with Carol Carter at SUNY Stonybrook to investigate host proteins involved in trafficking of Gag protein in HIV-1. Our most recent work has been investigating the host protein "Sprouty" in viral traffiicking, I am also the director of our local Proteomics facility we perform LC/MS protein identification and Luminex multiplex protein anaysis.. I would be happy to discuss potential projects with anyone looking for a collaborator.

Property

Value

overview

My research centers around the HIV-1 protein Nef. Our research has shown that Nef protein is secreted by HIV-1 infected cells and is present in the plasma of infected individuals. Our studies suggest that Nef is secreted from cells in the form of exosomes, small membrane bound vesicles approximately 50-100nm in size. T cells that come in contact with Nef exosomes undego apoptosis. Macrophage can take up Nef exosomes, but their affect on these cells is largely unknown. Nef exosomes appear to play a significant role in the pathogenic effects of HIV-1 infection leading to AIDS. Most recently we have worked with Bruce Shiramizu at the U of Hawaii to investigate the potential of Nef exosomes to facilitate the pathogenesis of HIV Associated Neurologic Disorders (HAND). We have also been working with a traditional medicine group called ProMetra. Extracts of natural plants are used to treat HIV/AIDS patients. We have shown that these natural products have the ability to block entry of HIV into T cells. We are interested testing these herbal treatments in a clinical trial. We have recently worked with USAMRIID to also investigate the potential of these herbal treatments to inhibit Ebola virus. In another collaboration we are working with Carol Carter at SUNY Stonybrook to investigate host proteins involved in trafficking of Gag protein in HIV-1. Our most recent work has been investigating the host protein "Sprouty" in viral traffiicking, I am also the director of our local Proteomics facility we perform LC/MS protein identification and Luminex multiplex protein anaysis.. I would be happy to discuss potential projects with anyone looking for a collaborator.

One or more keywords matched the following items that are connected to Powell, Michael D.

Item Type	Name
Academic Article	Genetic characterization of HIV type 1 Nef-induced vesicle secretion.
Academic Article	HIV Nef-M1 Effects on Colorectal Cancer Growth in Tumor-induced Spleens and Hepatic Metastasis.
Academic Article	Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling.
Academic Article	Peptide-based identification of functional motifs and their binding partners.
Academic Article	Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce A?(1-42) secretion in SH-SY5Y neural cells.
Academic Article	Characterizing the HIV/AIDS Epidemic in the United States and China.
Academic Article	Micro RNA in Exosomes from HIV-Infected Macrophages.
Academic Article	Secretion modification region-derived peptide blocks exosome release and mediates cell cycle arrest in breast cancer cells.
Academic Article	Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals.
Academic Article	Detection of HIV-1 and Human Proteins in Urinary Extracellular Vesicles from HIV+ Patients.
Academic Article	The molecular epidemiology and drug resistance determination of HIV type 1 subtype B infection in Barbados.
Academic Article	Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors.
Academic Article	Apoptotic effects in primary human umbilical vein endothelial cell cultures caused by exposure to virion-associated and cell membrane-associated HIV-1 gp120.
Academic Article	Treatment of human immunodeficiency virus type 1 virions depleted of cyclophilin A by natural endogenous reverse transcription restores infectivity.
Academic Article	Effects of HIV-1 Nef, a cytotoxic viral protein, on the growth of primary colorectal cancer.
Academic Article	HLA-G DNA sequence variants and risk of perinatal HIV-1 transmission.
Academic Article	Examination of HIV type 1 variants in mother-child pairs.
Academic Article	CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth.
Concept	HIV Seropositivity
Concept	HIV-1
Concept	HIV-2
Concept	HIV Infections
Concept	HIV Envelope Protein gp120
Concept	HIV Long Terminal Repeat
Concept	Anti-HIV Agents
Concept	nef Gene Products, Human Immunodeficiency Virus
Academic Article	Chimeric human immunodeficiency virus type 1 (HIV-1) virions containing HIV-2 or simian immunodeficiency virus Nef are resistant to cyclosporine treatment.
Academic Article	Chimeric human immunodeficiency virus type 1 virions that contain the simian immunodeficiency virus nef gene are cyclosporin A resistant.
Academic Article	Effect of polypurine tract (PPT) mutations on human immunodeficiency virus type 1 replication: a virus with a completely randomized PPT retains low infectivity.
Academic Article	HIV-1 Nef protein is secreted into vesicles that can fuse with target cells and virions.
Academic Article	Apoptotic peptides derived from HIV-1 Nef induce lymphocyte depletion in mice.
Academic Article	HIV Type 1 Nef is released from infected cells in CD45(+) microvesicles and is present in the plasma of HIV-infected individuals.
Academic Article	Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release.
Academic Article	Association of Cytokines With Exosomes in the Plasma of HIV-1-Seropositive Individuals.
Academic Article	Hallmarks of HIV-1 pathogenesis are modulated by Nef's Secretion Modification Region.
Academic Article	Phylogenetic examination of HIV type 1 glycoprotein 120-V3 sequences in patients from rural Georgia.
Academic Article	HIV type 1 envelope sequences from seroconverting patients in Barbados.
Academic Article	Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase.
Academic Article	Proceedings of the 2017 ISEV symposium on "HIV, NeuroHIV, drug abuse, & EVs".
Academic Article	Proceedings of the ISEV symposium on "HIV, NeuroAIDS, drug abuse & EVs".
Academic Article	Small molecule CXCR4 antagonists block the HIV-1 Nef/CXCR4 axis and selectively initiate the apoptotic program in breast cancer cells.
Academic Article	HIV-2 infection detected in Canada.
Academic Article	Effect of extracellular human immunodeficiency virus type 1 glycoprotein 120 on primary human vascular endothelial cell cultures.
Academic Article	Effects of the human immunodeficiency virus type 1 Rev protein on reporter gene and host T-cell gene expression.
Academic Article	Epidemiology of HIV-1 infection in rural Georgia: demographic trends and analysis at the Medical College of Georgia.
Academic Article	Application of random amplified polymorphic DNA PCR for genomic analysis of HIV-1-infected individuals.
Academic Article	Characterization of a third CCR5 amplicon from CCR5-delta32-heterozygous HIV-1-infected individuals.
Academic Article	Effects of extracellular human immunodeficiency virus type 1 vpr protein in primary rat cortical cell cultures.
Academic Article	Identification of non-B human immunodeficiency virus type 1 subtypes in rural Georgia.
Academic Article	Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium.
Academic Article	Mother-to-child discordance in HLA-G exon 2 is associated with a reduced risk of perinatal HIV-1 transmission.
Academic Article	Identification of a Novel Anti-HIV-1 Protein from Momordica balsamina Leaf Extract.
Academic Article	Anti-human immunodeficiency virus-1 activity of MoMo30 protein isolated from the traditional African medicinal plant Momordica balsamina.

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