RCMI Coordinating Center (RCMI CC) Header Logo

Linda Spatz

TitleAssociate Professor, Department of Microbiology
InstitutionCity College, CUNY
DepartmentDepartment of Pathobiology at Sophie Davis
AddressCity College, CUNY, Harris Hall Rm 210 C
160 Convent Avenue
New York NY 10031
Phone212-650-77-3
Fax212-650-7797
vCardDownload vCard

    Collapse Biography 
    Collapse awards and honors
    2014President''s award for outstanding faculty service, CNY

    Collapse Overview 
    Collapse overview
    Dr. Linda Spatz is interested in understanding how anti-double stranded (anti-dsDNA) antibodies which are the hallmark of the autoimmune disease Systemic Lupus Erythematosus (SLE), arise. Her laboratory is studying the regulation of anti-dsDNA B-cells. Normally these B cells are kept from secreting transgenic anti-ds DNA antibodies by regulatory mechanisms, collectively known as B cell tolerance. When one or more of these regulatory mechanisms goes awry, a breakdown in tolerance ensues and anti-dsDNA antibodies are secreted at elevated levels. These antibodies can deposit in various organs of the body including the skin, joints, and kidney where they can induce tissue damage. Dr. Spatz's laboratory is investigating potential genetic and environmental factors that can lead to a breakdown in anti-dsDNA B cell tolerance. Using an anti-dsDNA transgenic mouse model she is currently studying how the overexpression of a B cell survival factor known as BAFF, can lead to the loss of B cell tolerance and the secretion of transgenic anti-dsDNA antibodies.

    In addition, Dr. Spatz is working in collaboration with Dr. Paul Gottlieb to study the role of the Epstein Barr virus (EBV) in the etiology of SLE. They have observed that immunization of mice with a major nuclear protein of EBV known as EBNA-1 can elicit the production of pathogenic anti-dsDNA antibodies that can deposit in the kidney. Future studies are addressing the mechanism by which EBNA-1 can elicit these anti-dsDNA antibodies.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Spatz LA, Silverman GJ, James JA. Editorial: Pathogens, Pathobionts, and Autoimmunity. Front Immunol. 2021; 12:752980. PMID: 34567014.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Singh D, Oudit O, Hajtovic S, Sarbaugh D, Salis R, Adebowale T, James J, Spatz LA. Antibodies to an Epstein Barr Virus protein that cross-react with dsDNA have pathogenic potential. Mol Immunol. 2021 04; 132:41-52. PMID: 33545624.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    3. Yadav P, Carr MT, Yu R, Mumbey-Wafula A, Spatz LA. Mapping an epitope in EBNA-1 that is recognized by monoclonal antibodies to EBNA-1 that cross-react with dsDNA. Immun Inflamm Dis. 2016 Sep; 4(3):362-75. PMID: 27621818.
      Citations: 11     Fields:    
    4. Alimova A, Wei H, Katz A, Spatz L, Gottlieb P. The ?6 cystovirus protein P7 becomes accessible to antibodies in the transcribing nucleocapsid: a probe for viral structural elements. PLoS One. 2015; 10(3):e0122160. PMID: 25799314.
      Citations: 2     Fields:    Translation:AnimalsCells
    5. Klein F, Halper-Stromberg A, Horwitz JA, Gruell H, Scheid JF, Bournazos S, Mouquet H, Spatz LA, Diskin R, Abadir A, Zang T, Dorner M, Billerbeck E, Labitt RN, Gaebler C, Marcovecchio P, Incesu RB, Eisenreich TR, Bieniasz PD, Seaman MS, Bjorkman PJ, Ravetch JV, Ploss A, Nussenzweig MC. HIV therapy by a combination of broadly neutralizing antibodies in humanized mice. Nature. 2012 Dec 06; 492(7427):118-22. PMID: 23103874.
      Citations: 330     Fields:    Translation:HumansAnimalsCells
    6. Klein F, Halper-Stromberg A, Horwitz JA, Gruell H, Scheid JF, Bournazos S, Mouquet H, Spatz LA, Diskin R, Abadir A, Zang T, Dorner M, Billerbeck E, Labitt RN, Gaebler C, Marcovecchio PM, Incesu RB, Eisenreich TR, Bieniasz PD, Seaman MS, Bjorkman PJ, Ravetch JV, Ploss A, Nussenzweig MC. . Nature. HIV therapy by a combination of broadly neutralizing antibodies in humanized mice. 2012; 492:118-122.
    7. Yadav P, Tran H, Ebegbe R, Gottlieb P, Wei H, Lewis RH, Mumbey-Wafula A, Kaplan A, Kholdarova E, Spatz L. Antibodies elicited in response to EBNA-1 may cross-react with dsDNA. PLoS One. 2011 Jan 04; 6(1):e14488. PMID: 21245919.
      Citations: 26     Fields:    Translation:Animals
    8. Crupi R, Cambiaghi M, Spatz L, Hen R, Thorn M, Friedman E, Vita G, Battaglia F. Reduced adult neurogenesis and altered emotional behaviors in autoimmune-prone B-cell activating factor transgenic mice. Biol Psychiatry. 2010 Mar 15; 67(6):558-66. PMID: 20185032.
      Citations: 29     Fields:    Translation:AnimalsCells
    9. Thorn M, Lewis RH, Mumbey-Wafula A, Kantrowitz S, Spatz LA. BAFF overexpression promotes anti-dsDNA B-cell maturation and antibody secretion. Cell Immunol. 2010; 261(1):9-22. PMID: 19914608.
      Citations: 12     Fields:    Translation:AnimalsCells
    10. Spatz, L. Tolerance and Autoimmunity (chapter). Immunology, A Short Course. 2009.
    11. Taylor DK, Ito E, Thorn M, Sundar K, Tedder T, Spatz LA. Loss of tolerance of anti-dsDNA B cells in mice overexpressing CD19. Mol Immunol. 2006 Apr; 43(11):1776-90. PMID: 16430962.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    12. Sundar K, Jacques S, Gottlieb P, Villars R, Benito ME, Taylor DK, Spatz LA. Expression of the Epstein-Barr virus nuclear antigen-1 (EBNA-1) in the mouse can elicit the production of anti-dsDNA and anti-Sm antibodies. J Autoimmun. 2004 Sep; 23(2):127-40. PMID: 15324931.
      Citations: 40     Fields:    Translation:AnimalsCells
    13. Chu YP, Spatz L, Diamond B. A second heavy chain permits survival of high affinity autoreactive B cells. Autoimmunity. 2004 Feb; 37(1):27-32. PMID: 15115308.
      Citations: 5     Fields:    Translation:AnimalsCells
    14. Chu YP, Taylor D, Yan HG, Diamond B, Spatz L. Persistence of partially functional double-stranded (ds) DNA binding B cells in mice transgenic for the IgM heavy chain of an anti-dsDNA antibody. Int Immunol. 2002 Jan; 14(1):45-54. PMID: 11751751.
      Citations: 3     Fields:    Translation:AnimalsCells
    15. Peeva E, Grimaldi C, Spatz L, Diamond B. Bromocriptine restores tolerance in estrogen-treated mice. J Clin Invest. 2000 Dec; 106(11):1373-9. PMID: 11104790.
      Citations: 18     Fields:    Translation:AnimalsCells
    16. Bynoe MS, Spatz L, Diamond B. Characterization of anti-DNA B cells that escape negative selection. Eur J Immunol. 1999 04; 29(4):1304-13. PMID: 10229098.
      Citations: 16     Fields:    Translation:AnimalsCells
    17. Khalil, M., L. Spatz, and B. Diamond. Systemic Lupus Erythematosus (R. G. Lahita, Ed.), Academic Press, San Diego. Amto-DNA antibodies. 1998.
    18. Spatz L, Saenko V, Iliev A, Jones L, Geskin L, Diamond B. Light chain usage in anti-double-stranded DNA B cell subsets: role in cell fate determination. J Exp Med. 1997 Apr 07; 185(7):1317-26. PMID: 9104818.
      Citations: 18     Fields:    Translation:AnimalsCells
    19. Gaynor B, Putterman C, Valadon P, Spatz L, Scharff MD, Diamond B. Peptide inhibition of glomerular deposition of an anti-DNA antibody. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1955-60. PMID: 9050886.
      Citations: 68     Fields:    Translation:AnimalsCells
    20. Spatz L, Iliev A, Saenko V, Jones L, Irigoyen M, Manheimer-Lory A, Gaynor B, Putterman C, Bynoe M, Kowal C, Kuo P, Newman J, Diamond B. Studies on the structure, regulation, and pathogenic potential of anti-dsDNA antibodies. Methods. 1997 Jan; 11(1):70-8. PMID: 8990091.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    21. Iliev A, Spatz L, Ray S, Diamond B. Lack of allelic exclusion permits autoreactive B cells to escape deletion. J Immunol. 1994 Oct 15; 153(8):3551-6. PMID: 7930577.
      Citations: 23     Fields:    Translation:AnimalsCells
    22. Hohmann, A. W., L. Spatz, M. Irigoyen, and A. Manheimer-Lory. Monoclonal Antibodies, The Second Generation. Human monoclonal antibodies from immortalized B cells. 1994; 43-66.
    23. Offen D, Spatz L, Escowitz H, Factor S, Diamond B. Induction of tolerance to an IgG autoantibody. Proc Natl Acad Sci U S A. 1992 Sep 01; 89(17):8332-6. PMID: 1518867.
      Citations: 23     Fields:    Translation:AnimalsCells
    24. Spatz LA, Daugherty BL, DeMartino JA, Mark GE, Latov N. Expression of recombinant human anti-MAG antibodies in non-lymphoid mammalian cells. Hum Antibodies Hybridomas. 1992 Apr; 3(2):107-11. PMID: 1378765.
      Citations:    Fields:    Translation:HumansAnimalsCells
    25. Spatz LA, Williams M, Brender B, Desai R, Latov N. DNA sequence analysis and comparison of the variable heavy and light chain regions of two IgM, monoclonal, anti-myelin associated glycoprotein antibodies. J Neuroimmunol. 1992 Jan; 36(1):29-39. PMID: 1370957.
      Citations: 2     Fields:    Translation:HumansCells
    26. Lee KW, Inghirami G, Spatz L, Knowles DM, Latov N. The B-cells that express anti-MAG antibodies in neuropathy and non-malignant IgM monoclonal gammopathy belong to the CD5 subpopulation. J Neuroimmunol. 1991 Jan; 31(1):83-8. PMID: 1701449.
      Citations: 4     Fields:    Translation:HumansCells
    27. Desai R, Spatz L, Matsuda T, Ilyas AA, Berman JE, Alt FW, Kabat EA, Latov N. Molecular cloning of a human immunoglobulin heavy chain variable (vh) region with anti-myelin-associated glycoprotein activity. J Neuroimmunol. 1990 Dec; 30(2-3):245. PMID: 1699976.
      Citations:    Fields:    Translation:Cells
    28. Spatz LA, Wong KK, Williams M, Desai R, Golier J, Berman JE, Alt FW, Latov N. Cloning and sequence analysis of the VH and VL regions of an anti-myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia. J Immunol. 1990 Apr 01; 144(7):2821-8. PMID: 2156935.
      Citations: 8     Fields:    Translation:HumansCells
    29. Desai R, Spatz L, Matsuda T, Ilyas AA, Berman JE, Alt FW, Kabat EA, Latov N. Molecular cloning of a human immunoglobulin heavy chain variable (VH) region with anti-myelin-associated glycoprotein activity. J Neuroimmunol. 1990 Jan; 26(1):35-41. PMID: 1688442.
      Citations:    Fields:    Translation:HumansCells
    30. Spatz L, Lieberson B, Abraham J, Miller OJ, Miller DA, Latov N. Generation of human B-cell hybridomas secreting monoclonal anti-myelin-associated glycoprotein antibodies from a patient with neuropathy. Ann Neurol. 1987 Feb; 21(2):207-11. PMID: 2435225.
      Citations: 1     Fields:    Translation:HumansCells
    31. Freddo L, Hays AP, Nickerson KG, Spatz L, McGinnis S, Lieberson R, Vedeler CA, Shy ME, Autilio-Gambetti L, Grauss FC, et al. Monoclonal anti-DNA IgM kappa in neuropathy binds to myelin and to a conformational epitope formed by phosphatidic acid and gangliosides. J Immunol. 1986 Dec 15; 137(12):3821-5. PMID: 2431044.
      Citations: 5     Fields:    Translation:HumansCells
    32. Spatz L, Latov N. Secretions of anti-myelin-associated glycoprotein antibodies by B cells from patients with neuropathy and nonmalignant monoclonal gammopathy. Cell Immunol. 1986 Dec; 103(2):434-40. PMID: 2433053.
      Citations:    Fields:    Translation:HumansCells
    33. Friedman E, Nilaver G, Carmel P, Perlow M, Spatz L, Latov N. Myelination by transplanted fetal and neonatal oligodendrocytes in a dysmyelinating mutant. Brain Res. 1986 Jul 16; 378(1):142-6. PMID: 2427154.
      Citations: 2     Fields:    Translation:AnimalsCells
    34. Latov N, Godfrey M, Thomas Y, Nobile-Orazio E, Spatz L, Abraham J, Perman G, Freddo L, Chess L. Neuropathy and anti-myelin-associated glycoprotein IgM M proteins: T cell regulation of M protein secretion in vitro. Ann Neurol. 1985 Aug; 18(2):182-8. PMID: 2412486.
      Citations: 3     Fields:    Translation:HumansCells
    35. Latov, N., M. Godfrey, Y. Thomas, E. Nobile-Orazio, L. Spatz, J. Abraham, G. Perman, L. Freddo, and L. Chess. Ann. Neurol. Regulation of anti-MAG M-protein secretion in a patient with neuropathy and macroglobulinemia: T and B cell interactions in vitro. 1985; 18:182-188.
    36. Spatz, L., L. Whitman, M.-J. Messito, G. Nilaver, S. Ginsberg, and N. Latov. Immunol. Comm. Measurement of myelin basic protein antibodies by ELISA utilizing biotinylated antibodies. 1983; 12:31-37.
    37. Spatz L, Whitman L, Messito MJ, Nilaver G, Ginsberg S, Latov N. Measurement of myelin basic protein and of anti-basic protein antibodies by ELISA utilizing biotinylated antibodies. Immunol Commun. 1983; 12(1):31-7. PMID: 6194103.
      Citations: 2     Fields:    Translation:HumansAnimals
    38. Spatz L, Strittmatter P. A form of reduced nicotinamide adenine dinucleotide-cytochrome b 5 reductase containing both the catalytic site and an additional hydrophobic membrane-binding segment. J Biol Chem. 1973 Feb 10; 248(3):793-9. PMID: 4346350.
      Citations: 39     Fields:    Translation:AnimalsCells
    Spatz's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (201)
    Explore
    _
    Co-Authors (1)
    Explore
    _
    Similar People (60)
    Explore
    _
    RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

    For technical support please contact support