"Saposins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of four homologous sphingolipid activator proteins that are formed from proteolytic cleavage of a common protein precursor molecule referred to as prosaposin.
| Descriptor ID |
D049231
|
| MeSH Number(s) |
D08.211.790.500
|
| Concept/Terms |
Saposin B- Saposin B
- Sphingolipid Activator Protein 1
- Sphingolipid Activator Protein-1
- SAP-1 Sphingolipid Activator
- SAP 1 Sphingolipid Activator
- Sphingolipid Activator, SAP-1
Saposin C- Saposin C
- beta-Glucosidase Stimulating Protein
- beta Glucosidase Stimulating Protein
- Co-beta-Glucosidase
- Co beta Glucosidase
- Sphingolipid Activator Protein 2
- Gaucher Activator Protein
- Glucosylceramidase Activator
- SAP-C Protein
- SAP C Protein
- beta-Glucosidase Activator Protein
- beta Glucosidase Activator Protein
- Coglucosidase
|
Below are MeSH descriptors whose meaning is more general than "Saposins".
Below are MeSH descriptors whose meaning is more specific than "Saposins".
This graph shows the total number of publications written about "Saposins" by people in this website by year, and whether "Saposins" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Saposins" by people in Profiles.
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Yu J, Li J, Matei N, Wang W, Tang L, Pang J, Li X, Fang L, Tang J, Zhang JH, Yan M. Intranasal administration of recombinant prosaposin attenuates neuronal apoptosis through GPR37/PI3K/Akt/ASK1 pathway in MCAO rats. Exp Neurol. 2024 Mar; 373:114656.
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Ramos-Ben?tez MJ, Lopez-Cruz LM, Aguayo V, Ruiz-Jimenez C, Espino AM. Cell-free expression, purification and immunoreactivity assessment of recombinant Fasciola hepatica saposin-like protein-2. Mol Biol Rep. 2018 Oct; 45(5):1551-1556.
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Cab?n-Hern?ndez K, Espino AM. Differential expression and localization of saposin-like protein 2 of Fasciola hepatica. Acta Trop. 2013 Dec; 128(3):591-7.
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Espino AM, Morales A, Delgado B, Rivera FM, Figueroa O, Su?rez E. Partial immunity to Fasciola hepatica in mice after vaccination with FhSAP2 delivered as recombinant protein or DNA construct. Ethn Dis. 2010; 20(1 Suppl 1):S1-17-23.
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Espino AM, Torres D, Morales A, Delgado B, Quetel J, Osuna A. Fasciola hepatica: identification of CD4+ T-helper epitopes from the 11.5 kDa saposin-like protein SAP-2 using synthetic peptides. Exp Parasitol. 2007 Sep; 117(1):65-73.
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Torres D, Espino AM. Mapping of B-cell epitopes on a novel 11.5-kilodalton Fasciola hepatica-Schistosoma mansoni cross-reactive antigen belonging to a member of the F. hepatica saposin-like protein family. Infect Immun. 2006 Aug; 74(8):4932-8.
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Espino AM, Osuna A, Gil R, Hillyer GV. Fasciola hepatica: humoral and cytokine responses to a member of the saposin-like protein family following delivery as a DNA vaccine in mice. Exp Parasitol. 2005 Aug; 110(4):374-83.
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Espino AM, Hillyer GV. A novel Fasciola hepatica saposinlike recombinant protein with immunoprophylactic potential. J Parasitol. 2004 Aug; 90(4):876-9.
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Espino AM, Hillyer GV. Molecular cloning of a member of the Fasciola hepatica saposin-like protein family. J Parasitol. 2003 Jun; 89(3):545-52.
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Godbold GD, Ahn K, Yeyeodu S, Lee LF, Ting JP, Erickson AH. Biosynthesis and intracellular targeting of the lysosomal aspartic proteinase cathepsin D. Adv Exp Med Biol. 1998; 436:153-62.