Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
"Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.
| Descriptor ID |
D020875
|
| MeSH Number(s) |
D12.644.400.575.281.075 D12.776.631.650.575.281.075
|
| Concept/Terms |
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
- 2-Ala-4-MePhe-5-Gly-Enkephalin
- 2 Ala 4 MePhe 5 Gly Enkephalin
- Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin
- DAGO
- DAMGE
- D-Ala2-NMe-Phe4-Gly-ol Enkephalin
- D Ala2 NMe Phe4 Gly ol Enkephalin
- Enkephalin, D-Ala2-NMe-Phe4-Gly-ol
- DAGOL
- Tyr-Ala-Gly-(NMe)Phe-Gly-ol
- Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-
- D-Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin
- DAMGO
|
Below are MeSH descriptors whose meaning is more general than "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-".
Below are MeSH descriptors whose meaning is more specific than "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-".
This graph shows the total number of publications written about "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" by people in this website by year, and whether "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1996 | 0 | 4 | 4 |
| 2000 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" by people in Profiles.
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Sun X, Th?rn P?rez C, Halemani D N, Shao XM, Greenwood M, Heath S, Feldman JL, Kam K. Opioids modulate an emergent rhythmogenic process to depress breathing. Elife. 2019 12 16; 8.
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Vel?zquez-Marrero C, Ortiz-Miranda S, Marrero HG, Custer EE, Treistman SN, Lemos JR. ?-Opioid inhibition of Ca2+ currents and secretion in isolated terminals of the neurohypophysis occurs via ryanodine-sensitive Ca2+ stores. J Neurosci. 2014 Mar 05; 34(10):3733-42.
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Roman-Vendrell C, Yu YJ, Yudowski GA. Fast modulation of ?-opioid receptor (MOR) recycling is mediated by receptor agonists. J Biol Chem. 2012 Apr 27; 287(18):14782-91.
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Vel?zquez-Marrero CM, Marrero HG, Lemos JR. Voltage-dependent kappa-opioid modulation of action potential waveform-elicited calcium currents in neurohypophysial terminals. J Cell Physiol. 2010 Oct; 225(1):223-32.
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Ortiz-Miranda SI, Dayanithi G, Vel?zquez-Marrero C, Custer EE, Treistman SN, Lemos JR. Differential modulation of N-type calcium channels by micro-opioid receptors in oxytocinergic versus vasopressinergic neurohypophysial terminals. J Cell Physiol. 2010 Oct; 225(1):276-88.
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Ortiz-Miranda S, Dayanithi G, Custer E, Treistman SN, Lemos JR. Micro-opioid receptor preferentially inhibits oxytocin release from neurohypophysial terminals by blocking R-type Ca2+ channels. J Neuroendocrinol. 2005 Sep; 17(9):583-90.
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Wang XM, Zhang KM, Long LO, Flores CA, Mokha SS. Endomorphin-1 and endomorphin-2 modulate responses of trigeminal neurons evoked by N-methyl-D-aspartic acid and somatosensory stimuli. J Neurophysiol. 2000 Jun; 83(6):3570-4.
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Wang XM, Yan JQ, Zhang KM, Mokha SS. Role of opioid receptors (mu, delta 1, delta 2) in modulating responses of nociceptive neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat. Brain Res. 1996 Nov 11; 739(1-2):235-43.
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Wang XM, Mokha SS. Opioids modulate N-methyl-D-aspartic acid (NMDA)-evoked responses of trigeminothalamic neurons. J Neurophysiol. 1996 Sep; 76(3):2093-6.
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Derrick BE, Martinez JL. Associative, bidirectional modifications at the hippocampal mossy fibre-CA3 synapse. Nature. 1996 May 30; 381(6581):429-34.