"Locus Control Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A regulatory region first identified in the human beta-globin locus but subsequently found in other loci. The region is believed to regulate GENETIC TRANSCRIPTION by opening and remodeling CHROMATIN structure. It may also have enhancer activity.
| Descriptor ID |
D019901
|
| MeSH Number(s) |
G02.111.570.080.689.450 G05.360.080.689.450 G05.360.340.024.380.249
|
| Concept/Terms |
Locus Control Region- Locus Control Region
- Control Region, Locus
- Control Regions, Locus
- Locus Control Regions
- Region, Locus Control
- Regions, Locus Control
|
Below are MeSH descriptors whose meaning is more general than "Locus Control Region".
Below are MeSH descriptors whose meaning is more specific than "Locus Control Region".
This graph shows the total number of publications written about "Locus Control Region" by people in this website by year, and whether "Locus Control Region" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Locus Control Region" by people in Profiles.
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Lahiji A, Kucerov?-Levisohn M, Holmes R, Z??iga-Pfl?cker JC, Ortiz BD. Adapting in vitro embryonic stem cell differentiation to the study of locus control regions. J Immunol Methods. 2014 May; 407:135-45.
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Lahiji A, Kucerov?-Levisohn M, Lovett J, Holmes R, Z??iga-Pfl?cker JC, Ortiz BD. Complete TCR-a gene locus control region activity in T cells derived in vitro from embryonic stem cells. J Immunol. 2013 Jul 01; 191(1):472-9.
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Knirr S, Gomos-Klein J, Andino BE, Harrow F, Erhard KF, Kovalovsky D, Sant'Angelo DB, Ortiz BD. Ectopic T cell receptor-a locus control region activity in B cells is suppressed by direct linkage to two flanking genes at once. PLoS One. 2010 Nov 22; 5(11):e15527.
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Gomos-Klein J, Harrow F, Alarc?n J, Ortiz BD. CTCF-independent, but not CTCF-dependent, elements significantly contribute to TCR-alpha locus control region activity. J Immunol. 2007 Jul 15; 179(2):1088-95.
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Harrow F, Ortiz BD. The TCRalpha locus control region specifies thymic, but not peripheral, patterns of TCRalpha gene expression. J Immunol. 2005 Nov 15; 175(10):6659-67.
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Garrett FE, Emelyanov AV, Sepulveda MA, Flanagan P, Volpi S, Li F, Loukinov D, Eckhardt LA, Lobanenkov VV, Birshtein BK. Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites. Mol Cell Biol. 2005 Feb; 25(4):1511-25.
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Harrow F, Amuta JU, Hutchinson SR, Akwaa F, Ortiz BD. Factors binding a non-classical Cis-element prevent heterochromatin effects on locus control region activity. J Biol Chem. 2004 Apr 23; 279(17):17842-9.
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Ortiz BD, Harrow F, Cado D, Santoso B, Winoto A. Function and factor interactions of a locus control region element in the mouse T cell receptor-alpha/Dad1 gene locus. J Immunol. 2001 Oct 01; 167(7):3836-45.