beta-Thalassemia

"beta-Thalassemia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.

Descriptor ID	D017086
MeSH Number(s)	C15.378.071.141.150.875.150 C15.378.420.826.150 C16.320.070.875.150 C16.320.365.826.150
Concept/Terms	beta-Thalassemia beta-Thalassemia Microcytemia, beta Type Microcytemias, beta Type Type Microcytemia, beta Type Microcytemias, beta beta Type Microcytemia beta Type Microcytemias beta Thalassemia Thalassemia, beta Thalassemias, beta beta Thalassemias Thalassemia, beta Type Thalassemias, beta Type Type Thalassemia, beta Type Thalassemias, beta beta Type Thalassemia beta Type Thalassemias Thalassemia Intermedia Thalassemia Intermedia Intermedia, Thalassemia Intermedias, Thalassemia Thalassemia Intermedias Thalassemia Minor Thalassemia Minor Thalassemia Minor (beta-Thalassemia Minor) Minor, Thalassemia (beta-Thalassemia Minor) Minors, Thalassemia (beta-Thalassemia Minor) Thalassemia Minor (beta Thalassemia Minor) Thalassemia Minors (beta-Thalassemia Minor) Hemoglobin F Disease Hemoglobin F Disease Disease, Hemoglobin F Thalassemia Major Thalassemia Major Anemia, Erythroblastic Anemias, Erythroblastic Erythroblastic Anemia Thalassemia Major (beta-Thalassemia Major) Major, Thalassemia (beta-Thalassemia Major) Majors, Thalassemia (beta-Thalassemia Major) Thalassemia Major (beta Thalassemia Major) Thalassemia Majors (beta-Thalassemia Major) Mediterranean Anemia Anemias, Mediterranean Mediterranean Anemias Anemia, Cooley's Anemia, Cooley Anemia, Cooleys Cooley's Anemia Anemia, Mediterranean

Below are MeSH descriptors whose meaning is more general than "beta-Thalassemia".

Diseases [C]
Hemic and Lymphatic Diseases [C15]
Hematologic Diseases [C15.378]
Anemia [C15.378.071]
Anemia, Hemolytic [C15.378.071.141]
Anemia, Hemolytic, Congenital [C15.378.071.141.150]
Thalassemia [C15.378.071.141.150.875]
beta-Thalassemia [C15.378.071.141.150.875.150]
Hemoglobinopathies [C15.378.420]
Thalassemia [C15.378.420.826]
beta-Thalassemia [C15.378.420.826.150]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Anemia, Hemolytic, Congenital [C16.320.070]
Thalassemia [C16.320.070.875]
beta-Thalassemia [C16.320.070.875.150]
Hemoglobinopathies [C16.320.365]
Thalassemia [C16.320.365.826]
beta-Thalassemia [C16.320.365.826.150]

Below are MeSH descriptors whose meaning is related to "beta-Thalassemia".

Below are MeSH descriptors whose meaning is more specific than "beta-Thalassemia".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "beta-Thalassemia" by people in this website by year, and whether "beta-Thalassemia" was a major or minor topic of these publications.

Bar chart showing 7 publications over 5 distinct years, with a maximum of 2 publications in 1998 and 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Total
1998	2	2
2003	2	2
2004	1	1
2011	1	1
2021	1	1

Below are the most recent publications written about "beta-Thalassemia" by people in Profiles.

MacKenzie TC, Amid A, Angastiniotis M, Butler C, Gilbert S, Gonzalez J, Keller RL, Kharbanda S, Kirby-Allen M, Koenig BA, Kyono W, Lal A, Lianoglou BR, Norton ME, Ogasawara KK, Panchalee T, Rosner M, Schwab M, Thompson A, Waye JS, Vichinsky E. Consensus statement for the perinatal management of patients with a thalassemia major. Blood Adv. 2021 12 28; 5(24):5636-5639.

View in: PubMed
Nouraie M, Little JA, Hildesheim M, Gibbs JSR, Morris CR, Machado RF, Kato GJ, Gordeuk VR, Gladwin MT. Validation of a composite vascular high-risk profile for adult patients with sickle cell disease. Am J Hematol. 2019 12; 94(12):E312-E314.

View in: PubMed
Niihara Y, Miller ST, Kanter J, Lanzkron S, Smith WR, Hsu LL, Gordeuk VR, Viswanathan K, Sarnaik S, Osunkwo I, Guillaume E, Sadanandan S, Sieger L, Lasky JL, Panosyan EH, Blake OA, New TN, Bellevue R, Tran LT, Razon RL, Stark CW, Neumayr LD, Vichinsky EP. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med. 2018 Jul 19; 379(3):226-235.

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Martin L, Douet V, VanWart CM, Heller MB, Le Saux O. A mouse model of ?-thalassemia shows a liver-specific down-regulation of Abcc6 expression. Am J Pathol. 2011 Feb; 178(2):774-83.

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Alekperova GA, Orudzhev AG, Javadov SA. Analysis of erythrocyte and platelet membrane proteins in various forms of beta-thalassemia. Biochemistry (Mosc). 2004 Jul; 69(7):748-53.

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Hamlin N, Beck K, Bacchelli B, Cianciulli P, Pasquali-Ronchetti I, Le Saux O. Acquired Pseudoxanthoma elasticum-like syndrome in beta-thalassaemia patients. Br J Haematol. 2003 Sep; 122(5):852-4.

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Orudzhev AG, Guseinova EE, Khalilova IS, Dzhavadov SA. [Assessment of endogenous intoxication and thrombocyte functions in beta-thalassemia]. Klin Lab Diagn. 2003 Mar; (3):39-41.

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Gordeuk VR, Delanghe JR, Langlois MR, Boelaert JR. Iron status and the outcome of HIV infection: an overview. J Clin Virol. 2001 Feb; 20(3):111-5.

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Adamkiewicz TV, Berkovitch M, Krishnan C, Polsinelli C, Kermack D, Olivieri NF. Infection due to Yersinia enterocolitica in a series of patients with beta-thalassemia: incidence and predisposing factors. Clin Infect Dis. 1998 Dec; 27(6):1362-6.

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Kutlar F, Adamkiewicz TV, Markowitz RB, Holley L, Kutlar A. An alpha-2 globin gene initiation codon mutation in a Vietnamese patient with Hb H disease. Ann N Y Acad Sci. 1998 Jun 30; 850:398-400.

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