alpha-Thalassemia

"alpha-Thalassemia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted.

Descriptor ID	D017085
MeSH Number(s)	C15.378.071.141.150.875.100 C15.378.420.826.100 C16.320.070.875.100 C16.320.365.826.100
Concept/Terms	alpha-Thalassemia alpha-Thalassemia alpha-Thalassemias Alpha Thalassemia Thalassemia, Alpha Thalassemia-alpha Thalassemia alpha A-Thalassemia Hemoglobin H Disease Disease, Hemoglobin H

Below are MeSH descriptors whose meaning is more general than "alpha-Thalassemia".

Diseases [C]
Hemic and Lymphatic Diseases [C15]
Hematologic Diseases [C15.378]
Anemia [C15.378.071]
Anemia, Hemolytic [C15.378.071.141]
Anemia, Hemolytic, Congenital [C15.378.071.141.150]
Thalassemia [C15.378.071.141.150.875]
alpha-Thalassemia [C15.378.071.141.150.875.100]
Hemoglobinopathies [C15.378.420]
Thalassemia [C15.378.420.826]
alpha-Thalassemia [C15.378.420.826.100]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Anemia, Hemolytic, Congenital [C16.320.070]
Thalassemia [C16.320.070.875]
alpha-Thalassemia [C16.320.070.875.100]
Hemoglobinopathies [C16.320.365]
Thalassemia [C16.320.365.826]
alpha-Thalassemia [C16.320.365.826.100]

Below are MeSH descriptors whose meaning is related to "alpha-Thalassemia".

Below are MeSH descriptors whose meaning is more specific than "alpha-Thalassemia".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "alpha-Thalassemia" by people in this website by year, and whether "alpha-Thalassemia" was a major or minor topic of these publications.

Bar chart showing 4 publications over 4 distinct years, with a maximum of 1 publications in 2008 and 2011 and 2014 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	1	1
2011	0	1	1
2014	1	0	1
2021	1	0	1

Below are the most recent publications written about "alpha-Thalassemia" by people in Profiles.

MacKenzie TC, Amid A, Angastiniotis M, Butler C, Gilbert S, Gonzalez J, Keller RL, Kharbanda S, Kirby-Allen M, Koenig BA, Kyono W, Lal A, Lianoglou BR, Norton ME, Ogasawara KK, Panchalee T, Rosner M, Schwab M, Thompson A, Waye JS, Vichinsky E. Consensus statement for the perinatal management of patients with a thalassemia major. Blood Adv. 2021 12 28; 5(24):5636-5639.

View in: PubMed
Raffield LM, Ulirsch JC, Naik RP, Lessard S, Handsaker RE, Jain D, Kang HM, Pankratz N, Auer PL, Bao EL, Smith JD, Lange LA, Lange EM, Li Y, Thornton TA, Young BA, Abecasis GR, Laurie CC, Nickerson DA, McCarroll SA, Correa A, Wilson JG, Lettre G, Sankaran VG, Reiner AP. Common a-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease. PLoS Genet. 2018 03; 14(3):e1007293.

View in: PubMed
Saraf SL, Shah BN, Zhang X, Han J, Tayo BO, Abbasi T, Ostrower A, Guzman E, Molokie RE, Gowhari M, Hassan J, Jain S, Cooper RS, Machado RF, Lash JP, Gordeuk VR. APOL1, a-thalassemia, and BCL11A variants as a genetic risk profile for progression of chronic kidney disease in sickle cell anemia. Haematologica. 2017 01; 102(1):e1-e6.

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Griffin PJ, Sebastiani P, Edward H, Baldwin CT, Gladwin MT, Gordeuk VR, Chui DH, Steinberg MH. The genetics of hemoglobin A2 regulation in sickle cell anemia. Am J Hematol. 2014 Nov; 89(11):1019-23.

View in: PubMed
Darbari DS, Nouraie M, Taylor JG, Brugnara C, Castro O, Ballas SK. Alpha-thalassaemia and response to hydroxyurea in sickle cell anaemia. Eur J Haematol. 2014 Apr; 92(4):341-5.

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Darbari DS, Onyekwere O, Nouraie M, Minniti CP, Luchtman-Jones L, Rana S, Sable C, Ensing G, Dham N, Campbell A, Arteta M, Gladwin MT, Castro O, Taylor JG, Kato GJ, Gordeuk V. Markers of severe vaso-occlusive painful episode frequency in children and adolescents with sickle cell anemia. J Pediatr. 2012 Feb; 160(2):286-90.

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Nouraie M, Reading NS, Campbell A, Minniti CP, Rana SR, Luchtman-Jones L, Kato GJ, Gladwin MT, Castro OL, Prchal JT, Gordeuk VR. Association of G6PD with lower haemoglobin concentration but not increased haemolysis in patients with sickle cell anaemia. Br J Haematol. 2010 Jul; 150(2):218-25.

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Taylor JG, Ackah D, Cobb C, Orr N, Percy MJ, Sachdev V, Machado R, Castro O, Kato GJ, Chanock SJ, Gladwin MT. Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease. Am J Hematol. 2008 Jan; 83(1):6-14.

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