"Ribonuclease H" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ribonuclease that specifically cleaves the RNA moiety of RNA:DNA hybrids. It has been isolated from a wide variety of prokaryotic and eukaryotic organisms as well as RETROVIRUSES.
| Descriptor ID |
D016914
|
| MeSH Number(s) |
D08.811.277.352.355.350.700 D08.811.277.352.700.350.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Ribonuclease H".
Below are MeSH descriptors whose meaning is more specific than "Ribonuclease H".
This graph shows the total number of publications written about "Ribonuclease H" by people in this website by year, and whether "Ribonuclease H" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2004 | 0 | 2 | 2 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ribonuclease H" by people in Profiles.
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Dash C, Scarth BJ, Badorrek C, G?tte M, Le Grice SF. Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids. Nucleic Acids Res. 2008 Nov; 36(20):6363-71.
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Mandal D, Dash C, Le Grice SF, Prasad VR. Analysis of HIV-1 replication block due to substitutions at F61 residue of reverse transcriptase reveals additional defects involving the RNase H function. Nucleic Acids Res. 2006; 34(10):2853-63.
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Dash C, Marino JP, Le Grice SF. Examining Ty3 polypurine tract structure and function by nucleoside analog interference. J Biol Chem. 2006 Feb 03; 281(5):2773-83.
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Misra S, Bennett J, Friew YN, Abdulghani J, Irvin-Wilson CV, Tripathi MK, Williams S, Chaudhuri M, Chaudhuri G. A type II ribonuclease H from Leishmania mitochondria: an enzyme essential for the growth of the parasite. Mol Biochem Parasitol. 2005 Oct; 143(2):135-45.
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Dash C, Yi-Brunozzi HY, Le Grice SF. Two modes of HIV-1 polypurine tract cleavage are affected by introducing locked nucleic acid analogs into the (-) DNA template. J Biol Chem. 2004 Aug 27; 279(35):37095-102.
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Dash C, Rausch JW, Le Grice SF. Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3' polypurine tract. Nucleic Acids Res. 2004; 32(4):1539-47.
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Arudchandran A, Cerritelli SM, Bowen NJ, Chen X, Krause MW, Crouch RJ. Multiple ribonuclease H-encoding genes in the Caenorhabditis elegans genome contrasts with the two typical ribonuclease H-encoding genes in the human genome. Mol Biol Evol. 2002 Nov; 19(11):1910-9.
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Georgescu RE, Alexov EG, Gunner MR. Combining conformational flexibility and continuum electrostatics for calculating pK(a)s in proteins. Biophys J. 2002 Oct; 83(4):1731-48.
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Mishra M, Porter-Kelley JM, Singh PK, Bennett JR, Chaudhuri G. Enhanced activity of antisense phosphorothioate oligos against leishmania amastigotes: augmented uptake of oligo, ribonuclease H activation, and efficient target intervention under altered growth conditions. Biochem Pharmacol. 2001 Sep 01; 62(5):569-80.
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Mishra M, Bennett JR, Chaudhuri G. Increased efficacy of antileishmanial antisense phosphorothioate oligonucleotides in Leishmania amazonensis overexpressing ribonuclease H. Biochem Pharmacol. 2001 Feb 15; 61(4):467-76.