Tissue Fixation

"Tissue Fixation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The technique of using FIXATIVES in the preparation of cytologic, histologic, or pathologic specimens for the purpose of maintaining the existing form and structure of all the constituent elements.

Descriptor ID	D016707
MeSH Number(s)	E01.370.225.500.620.760.720 E01.370.225.750.600.760.720 E05.200.500.620.760.720 E05.200.750.600.760.720
Concept/Terms	Tissue Fixation Tissue Fixation Fixation, Tissue

Below are MeSH descriptors whose meaning is more general than "Tissue Fixation".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Diagnosis [E01]
Diagnostic Techniques and Procedures [E01.370]
Clinical Laboratory Techniques [E01.370.225]
Cytological Techniques [E01.370.225.500]
Histocytological Preparation Techniques [E01.370.225.500.620]
Tissue Preservation [E01.370.225.500.620.760]
Tissue Fixation [E01.370.225.500.620.760.720]
Histological Techniques [E01.370.225.750]
Histocytological Preparation Techniques [E01.370.225.750.600]
Tissue Preservation [E01.370.225.750.600.760]
Tissue Fixation [E01.370.225.750.600.760.720]
Investigative Techniques [E05]
Clinical Laboratory Techniques [E05.200]
Cytological Techniques [E05.200.500]
Histocytological Preparation Techniques [E05.200.500.620]
Tissue Preservation [E05.200.500.620.760]
Tissue Fixation [E05.200.500.620.760.720]
Histological Techniques [E05.200.750]
Histocytological Preparation Techniques [E05.200.750.600]
Tissue Preservation [E05.200.750.600.760]
Tissue Fixation [E05.200.750.600.760.720]

Below are MeSH descriptors whose meaning is related to "Tissue Fixation".

Below are MeSH descriptors whose meaning is more specific than "Tissue Fixation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tissue Fixation" by people in this website by year, and whether "Tissue Fixation" was a major or minor topic of these publications.

Bar chart showing 14 publications over 10 distinct years, with a maximum of 3 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2009	0	1	1
2010	0	1	1
2014	0	1	1
2015	2	0	2
2016	2	0	2
2017	1	0	1
2019	1	0	1
2020	0	3	3
2021	0	1	1

Below are the most recent publications written about "Tissue Fixation" by people in Profiles.

Chambers JK, Watanabe K, Michishita M, Hatai H, Tanaka Y, Doge S, Ochiai K, Kato S, Goto-Koshino Y, Tanaka M, Izawa T. Standardization of tissue handling in veterinary pathology: How fixation affects morphological and molecular examination results. Vet Pathol. 2025 Nov; 62(6):949-962.

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Yuan Y, Van Dyke AL, Petkov VI, Hussey S, Moravec R, Altekruse SF, Sandoval M, Cress RD, Mueller LM, Mogi A, Hernandez BY, Selk FR, Lynch CF, Tucker TC, Lynch MA, Lefante C, Wu XC, Sweeney C, Doherty JA, Penberthy LS. Pathology Laboratory Policies and Procedures for Releasing Diagnostic Tissue for Cancer Research. Arch Pathol Lab Med. 2021 02 01; 145(2):222-226.

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Hsu CH, Lin S, Ho AC, Johnson TD, Wang PC, Scafidi J, Tu TW. Comparison of in vivo and in situ detection of hippocampal metabolites in mouse brain using 1 H-MRS. NMR Biomed. 2021 02; 34(2):e4451.

View in: PubMed
Kelley AR, Colley M, Dyer S, Bach SBH, Zhu X, Perry G. Ethanol-Fixed, Paraffin-Embedded Tissue Imaging: Implications for Alzheimer's Disease Research. J Am Soc Mass Spectrom. 2020 Dec 02; 31(12):2416-2420.

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Colley M, Liang S, Tan C, Trobough KP, Bach SBH, Chun YP. Mapping and Identification of Native Proteins of Developing Teeth in Mouse Mandibles. Anal Chem. 2020 06 02; 92(11):7630-7637.

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Manolopoulou M, Matlock BK, Nlandu-Khodo S, Simmons AJ, Lau KS, Phillips-Mignemi M, Ivanova A, Alford CE, Flaherty DK, Gewin LS. Novel kidney dissociation protocol and image-based flow cytometry facilitate improved analysis of injured proximal tubules. Am J Physiol Renal Physiol. 2019 05 01; 316(5):F847-F855.

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Shiga T, Uchida K, Chambers JK, Nakayama H. Immunohistochemical analysis of canine and feline muscle disorders using formalin-fixed, paraffin-embedded tissues. J Vet Diagn Invest. 2017 Nov; 29(6):805-813.

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Chang CW, Atkinson G, Gandhi N, Farrell ML, Labrash S, Smith AB, Norton NS, Matsui T, Lozanoff S. Cone beam computed tomography of plastinated hearts for instruction of radiological anatomy. Surg Radiol Anat. 2016 Sep; 38(7):843-53.

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Schikorski T. Functional Nanoscale Imaging of Synaptic Vesicle Cycling with Superfast Fixation. Methods Mol Biol. 2016; 1474:343-58.

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Isidro RA, Isidro AA, Cruz ML, Hernandez S, Appleyard CB. Double immunofluorescent staining of rat macrophages in formalin-fixed paraffin-embedded tissue using two monoclonal mouse antibodies. Histochem Cell Biol. 2015 Dec; 144(6):613-21.

View in: PubMed

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