2-Amino-5-phosphonovalerate
"2-Amino-5-phosphonovalerate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Descriptor ID |
D015763
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| MeSH Number(s) |
D12.125.070.950.100 D12.125.740.025
|
| Concept/Terms |
2-Amino-5-phosphonovalerate- 2-Amino-5-phosphonovalerate
- 2 Amino 5 phosphonovalerate
- 5-Phosphononorvaline
- 5 Phosphononorvaline
- 2-Amino-5-phosphonovaleric Acid
- 2 Amino 5 phosphonovaleric Acid
- 2-APV
- 2-Amino-5-phosphonopentanoate
- 2 Amino 5 phosphonopentanoate
- 2-Amino-5-phosphonopentanoic Acid
- 2 Amino 5 phosphonopentanoic Acid
|
Below are MeSH descriptors whose meaning is more general than "2-Amino-5-phosphonovalerate".
Below are MeSH descriptors whose meaning is more specific than "2-Amino-5-phosphonovalerate".
This graph shows the total number of publications written about "2-Amino-5-phosphonovalerate" by people in this website by year, and whether "2-Amino-5-phosphonovalerate" was a major or minor topic of these publications.
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Below are the most recent publications written about "2-Amino-5-phosphonovalerate" by people in Profiles.
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Nattie EE, Gdovin M, Li A. Retrotrapezoid nucleus glutamate receptors: control of CO2-sensitive phrenic and sympathetic output. J Appl Physiol (1985). 1993 Jun; 74(6):2958-68.
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Miyakawa H, Ross WN, Jaffe D, Callaway JC, Lasser-Ross N, Lisman JE, Johnston D. Synaptically activated increases in Ca2+ concentration in hippocampal CA1 pyramidal cells are primarily due to voltage-gated Ca2+ channels. Neuron. 1992 Dec; 9(6):1163-73.
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Benveniste M, Mayer ML. Effect of extracellular pH on the potency of N-methyl-D-aspartic acid receptor competitive antagonists. Mol Pharmacol. 1992 Oct; 42(4):679-86.
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Benveniste M, Mayer ML. Structure-activity analysis of binding kinetics for NMDA receptor competitive antagonists: the influence of conformational restriction. Br J Pharmacol. 1991 Sep; 104(1):207-21.
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Benveniste M, Mayer ML. Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Two binding sites each for glutamate and glycine. Biophys J. 1991 Mar; 59(3):560-73.
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Benveniste M, Mienville JM, Sernagor E, Mayer ML. Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons. J Neurophysiol. 1990 Jun; 63(6):1373-84.