Giant Cells

"Giant Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.

Descriptor ID	D015726
MeSH Number(s)	A11.500
Concept/Terms	Giant Cells Giant Cells Cell, Giant Cells, Giant Giant Cell Syncytium Polykaryocytes Polykaryocyte Syncytia Giant Cells, Multinucleated Cell, Multinucleated Giant Cells, Multinucleated Giant Giant Cell, Multinucleated Multinucleated Giant Cell Multinucleated Giant Cells

Below are MeSH descriptors whose meaning is more general than "Giant Cells".

Anatomy [A]
Cells [A11]
Giant Cells [A11.500]

Below are MeSH descriptors whose meaning is more specific than "Giant Cells".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Giant Cells" by people in this website by year, and whether "Giant Cells" was a major or minor topic of these publications.

Bar chart showing 7 publications over 6 distinct years, with a maximum of 2 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	1	0	1
2012	0	1	1
2014	0	1	1
2015	1	1	2
2022	0	1	1
2025	1	0	1

Below are the most recent publications written about "Giant Cells" by people in Profiles.

Andrade-Feraud CM, Acanda de la Rocha AM, Berlow NE, Duque S, Velazco A, Castillo D, Holcomb B, Coats ER, Ghurani YR, Lucey CM, Pearson B, Guilarte TR, Azzam DJ. Chronic arsenic exposure of ovarian surface and fallopian tube cultures induces giant and/or multinucleated cells with phagocytosis-like properties and an inflammatory phenotype. Toxicol Appl Pharmacol. 2025 Jul; 500:117394.

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Benedikt J, Malpica-Nieves CJ, Rivera Y, M?ndez-Gonz?lez M, Nichols CG, Veh RW, Eaton MJ, Skatchkov SN. The Polyamine Spermine Potentiates the Propagation of Negatively Charged Molecules through the Astrocytic Syncytium. Biomolecules. 2022 12 05; 12(12).

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Qiao JH, Mishra V, Fishbein MC, Sinha SK, Rajavashisth TB. Multinucleated giant cells in atherosclerotic plaques of human carotid arteries: Identification of osteoclast-like cells and their specific proteins in artery wall. Exp Mol Pathol. 2015 Dec; 99(3):654-62.

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Chiang CY, Ulrich RL, Ulrich MP, Eaton B, Ojeda JF, Lane DJ, Kota KP, Kenny TA, Ladner JT, Dickson SP, Kuehl K, Raychaudhuri R, Sun M, Bavari S, Wolcott MJ, Covell D, Panchal RG. Characterization of the murine macrophage response to infection with virulent and avirulent Burkholderia species. BMC Microbiol. 2015 Nov 06; 15:259.

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Nagahara T, Yoshimatsu S, Shiba H, Kawaguchi H, Takeda K, Iwata T, Mizuno N, Fujita T, Kurihara H. Introduction of a mixture of ?-tricalcium phosphate into a complex of bone marrow mesenchymal stem cells and type I collagen can augment the volume of alveolar bone without impairing cementum regeneration. J Periodontol. 2015 Mar; 86(3):456-64.

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Benedikt J, Inyushin M, Kucheryavykh YV, Rivera Y, Kucheryavykh LY, Nichols CG, Eaton MJ, Skatchkov SN. Intracellular polyamines enhance astrocytic coupling. Neuroreport. 2012 Dec 05; 23(17):1021-5.

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Walpita P, Barr J, Sherman M, Basler CF, Wang L. Vaccine potential of Nipah virus-like particles. PLoS One. 2011 Apr 06; 6(4):e18437.

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Kochar M, L?pez-Candales A, Ramani G, Rajagopalan N, Edelman K. Unusual echocardiographic features seen in a case of giant cell myocarditis. Can J Cardiol. 2008 Nov; 24(11):855-6.

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Benson J, Tschachler E, Gessain A, Yanagihara R, Gallo RC, Franchini G. Cross-neutralizing antibodies against cosmopolitan and Melanesian strains of human T cell leukemia/lymphotropic virus type I in sera from inhabitants of Africa and the Solomon Islands. AIDS Res Hum Retroviruses. 1994 Jan; 10(1):91-6.

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Yamaguchi M, Ogren L, Endo H, Thordarson G, Bigsby RM, Talamantes F. Production of mouse placental lactogen-I and placental lactogen-II by the same giant cell. Endocrinology. 1992 Oct; 131(4):1595-602.

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