7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.
| Descriptor ID |
D015123
|
| MeSH Number(s) |
D02.455.426.559.847.799.306.400.350 D04.615.799.306.400.350
|
| Concept/Terms |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- 7,8-Dihydroxy-9,10-Epoxy-7,8,9,10-Tetrahydrobenzo(a)pyrene
- BPDE
- Benzo(a)pyrene 7,8-Dihydrodiol 9,10-Epoxide
- Benzo(a)pyrene-7,8-diol 9,10-Epoxide
- 7,8-BaP-9,10-Diol Epoxide
- Anti-BaPDE
- Anti BaPDE
|
Below are MeSH descriptors whose meaning is more general than "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide".
Below are MeSH descriptors whose meaning is more specific than "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide".
This graph shows the total number of publications written about "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide" by people in this website by year, and whether "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2007 | 1 | 1 | 2 |
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Below are the most recent publications written about "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide" by people in Profiles.
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Nwagbara O, Darling-Reed SF, Tucker A, Harris C, Abazinge M, Thomas RD, Gragg RD. Induction of cell death, DNA strand breaks, and cell cycle arrest in DU145 human prostate carcinoma cell line by benzo[a]pyrene and benzo[a]pyrene-7,8-diol-9,10-epoxide. Int J Environ Res Public Health. 2007 Mar; 4(1):10-4.
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Lakshman MK, Keeler JC, Ngassa FN, Hilmer JH, Pradhan P, Zajc B, Thomasson KA. Highly diastereoselective synthesis of nucleoside adducts from the carcinogenic benzo[a]pyrene diol epoxide and a computational analysis. J Am Chem Soc. 2007 Jan 10; 129(1):68-76.
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Kramata P, Zajc B, Sayer JM, Jerina DM, Wei CS. A single site-specific trans-opened 7,8,9,10-tetrahydrobenzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct induces mutations at multiple sites in DNA. J Biol Chem. 2003 Apr 25; 278(17):14940-8.
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Simhadri S, Kramata P, Zajc B, Sayer JM, Jerina DM, Hinkle DC, Wei CS. Benzo[a]pyrene diol epoxide-deoxyguanosine adducts are accurately bypassed by yeast DNA polymerase zeta in vitro. Mutat Res. 2002 Oct 31; 508(1-2):137-45.
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Rodriguez JW, Kohan MJ, King LC, Kirlin WG. Detection of DNA adducts in developing CD4+ CD8+ thymocytes and splenocytes following in utero exposure to benzo[a]pyrene. Immunopharmacol Immunotoxicol. 2002 Aug; 24(3):365-81.
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Song Q, Negrete GR, Wolfe AR, Wang K, Meehan T. Synthesis and characterization of bay region halohydrins derived from Benzo[a]pyrene diol epoxide and their role as intermediates in halide-catalyzed cis adduct formation. Chem Res Toxicol. 1998 Sep; 11(9):1057-66.