7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.
| Descriptor ID |
D015123
|
| MeSH Number(s) |
D02.455.426.559.847.799.306.400.350 D04.615.799.306.400.350
|
| Concept/Terms |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- 7,8-Dihydroxy-9,10-Epoxy-7,8,9,10-Tetrahydrobenzo(a)pyrene
- BPDE
- Benzo(a)pyrene 7,8-Dihydrodiol 9,10-Epoxide
- Benzo(a)pyrene-7,8-diol 9,10-Epoxide
- 7,8-BaP-9,10-Diol Epoxide
- Anti-BaPDE
- Anti BaPDE
|
Below are MeSH descriptors whose meaning is more general than "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide".
Below are MeSH descriptors whose meaning is more specific than "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide".
This graph shows the total number of publications written about "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide" by people in this website by year, and whether "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 3 | 0 | 3 |
| 1999 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2007 | 1 | 1 | 2 |
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Below are the most recent publications written about "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide" by people in Profiles.
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Nwagbara O, Darling-Reed SF, Tucker A, Harris C, Abazinge M, Thomas RD, Gragg RD. Induction of cell death, DNA strand breaks, and cell cycle arrest in DU145 human prostate carcinoma cell line by benzo[a]pyrene and benzo[a]pyrene-7,8-diol-9,10-epoxide. Int J Environ Res Public Health. 2007 Mar; 4(1):10-4.
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Lakshman MK, Keeler JC, Ngassa FN, Hilmer JH, Pradhan P, Zajc B, Thomasson KA. Highly diastereoselective synthesis of nucleoside adducts from the carcinogenic benzo[a]pyrene diol epoxide and a computational analysis. J Am Chem Soc. 2007 Jan 10; 129(1):68-76.
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Kramata P, Zajc B, Sayer JM, Jerina DM, Wei CS. A single site-specific trans-opened 7,8,9,10-tetrahydrobenzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct induces mutations at multiple sites in DNA. J Biol Chem. 2003 Apr 25; 278(17):14940-8.
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Simhadri S, Kramata P, Zajc B, Sayer JM, Jerina DM, Hinkle DC, Wei CS. Benzo[a]pyrene diol epoxide-deoxyguanosine adducts are accurately bypassed by yeast DNA polymerase zeta in vitro. Mutat Res. 2002 Oct 31; 508(1-2):137-45.
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Rodriguez JW, Kohan MJ, King LC, Kirlin WG. Detection of DNA adducts in developing CD4+ CD8+ thymocytes and splenocytes following in utero exposure to benzo[a]pyrene. Immunopharmacol Immunotoxicol. 2002 Aug; 24(3):365-81.
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Custer L, Zajc B, Sayer JM, Cullinane C, Phillips DR, Cheh AM, Jerina DM, Bohr VA, Mazur SJ. Stereospecific differences in repair by human cell extracts of synthesized oligonucleotides containing trans-opened 7,8,9, 10-tetrahydrobenzo[a]pyrene 7,8-diol 9,10-epoxide N2-dG adduct stereoisomers located within the human K-ras codon 12 sequence. Biochemistry. 1999 Jan 12; 38(2):569-81.
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Song Q, Negrete GR, Wolfe AR, Wang K, Meehan T. Synthesis and characterization of bay region halohydrins derived from Benzo[a]pyrene diol epoxide and their role as intermediates in halide-catalyzed cis adduct formation. Chem Res Toxicol. 1998 Sep; 11(9):1057-66.
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Lipinski LJ, Ross HL, Zajc B, Sayer JM, Jerina DM, Dipple A. Effect of single benzo[a]pyrene diol epoxide-deoxyguanosine adducts on the action of DNA polymerases in vitro. Int J Oncol. 1998 Aug; 13(2):269-73.
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Page JE, Zajc B, Oh-hara T, Lakshman MK, Sayer JM, Jerina DM, Dipple A. Sequence context profoundly influences the mutagenic potency of trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide-purine nucleoside adducts in site-specific mutation studies. Biochemistry. 1998 Jun 23; 37(25):9127-37.
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Meehan T, Wolfe AR, Negrete GR, Song Q. Benzo[a]pyrene diol epoxide-DNA cis adduct formation through a trans chlorohydrin intermediate. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1749-54.