Trypanosomiasis, African

"Trypanosomiasis, African" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.

Descriptor ID	D014353
MeSH Number(s)	C03.752.300.900.719
Concept/Terms	Trypanosomiasis, African Trypanosomiasis, African African Trypanosomiases Trypanosomiases, African African Trypanosomiasis African Sleeping Sickness African Sleeping Sicknesses Sickness, African Sleeping Sicknesses, African Sleeping Sleeping Sickness, African Sleeping Sicknesses, African Nagana Nagana

Below are MeSH descriptors whose meaning is more general than "Trypanosomiasis, African".

Diseases [C]
Parasitic Diseases [C03]
Protozoan Infections [C03.752]
Euglenozoa Infections [C03.752.300]
Trypanosomiasis [C03.752.300.900]
Trypanosomiasis, African [C03.752.300.900.719]

Below are MeSH descriptors whose meaning is related to "Trypanosomiasis, African".

Below are MeSH descriptors whose meaning is more specific than "Trypanosomiasis, African".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Trypanosomiasis, African" by people in this website by year, and whether "Trypanosomiasis, African" was a major or minor topic of these publications.

Bar chart showing 14 publications over 11 distinct years, with a maximum of 3 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	1	0	1
2006	0	1	1
2007	1	0	1
2009	2	1	3
2010	1	0	1
2013	1	0	1
2015	0	1	1
2016	1	1	2
2021	1	0	1
2022	1	0	1
2023	1	0	1

Below are the most recent publications written about "Trypanosomiasis, African" by people in Profiles.

Ajayi O, Metibemu DS, Crown O, Adeyinka OS, Kaiser M, Shoji N, Silva M, Rodriguez A, Ogungbe IV. Discovery of an orally active nitrothiophene-based antitrypanosomal agent. Eur J Med Chem. 2024 Jan 05; 263:115954.

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Chaudhuri M, Singha UK, Vanderloop BH, Tripathi A, Nes WD. Steroidal Antimetabolites Protect Mice against Trypanosoma brucei. Molecules. 2022 Jun 25; 27(13).

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Tripathi A, Singha UK, Cooley A, Gillyard T, Krystofiak E, Pratap S, Davis J, Chaudhuri M. Trypanosoma brucei Tim50 Possesses PAP Activity and Plays a Critical Role in Cell Cycle Regulation and Parasite Infectivity. mBio. 2021 10 26; 12(5):e0159221.

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Miller MB, Patkar P, Singha UK, Chaudhuri M, David Nes W. 24-Methylenecyclopropane steroidal inhibitors: A Trojan horse in ergosterol biosynthesis that prevents growth of Trypanosoma brucei. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Mar; 1862(3):305-313.

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Szempruch AJ, Sykes SE, Kieft R, Dennison L, Becker AC, Gartrell A, Martin WJ, Nakayasu ES, Almeida IC, Hajduk SL, Harrington JM. Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia. Cell. 2016 Jan 14; 164(1-2):246-257.

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Singha UK, Hamilton V, Chaudhuri M. Tim62, a Novel Mitochondrial Protein in Trypanosoma brucei, Is Essential for Assembly and Stability of the TbTim17 Protein Complex. J Biol Chem. 2015 Sep 18; 290(38):23226-39.

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Ferrins L, Rahmani R, Sykes ML, Jones AJ, Avery VM, Teston E, Almohaywi B, Yin J, Smith J, Hyland C, White KL, Ryan E, Campbell M, Charman SA, Kaiser M, Baell JB. 3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis. Eur J Med Chem. 2013 Aug; 66:450-65.

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Udensi UK, Fagbenro-Beyioku AF. Effect of ivermectin on Trypanosoma brucei brucei in experimentally infected mice. J Vector Borne Dis. 2012 Sep; 49(3):143-50.

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Emmer BT, Nakayasu ES, Souther C, Choi H, Sobreira TJ, Epting CL, Nesvizhskii AI, Almeida IC, Engman DM. Global analysis of protein palmitoylation in African trypanosomes. Eukaryot Cell. 2011 Mar; 10(3):455-63.

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Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR. Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. J Biol Chem. 2010 Jan 15; 285(3):1773-80.

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