Sterols

"Sterols" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Steroids with a hydroxyl group at C-3 and most of the skeleton of cholestane. Additional carbon atoms may be present in the side chain. (IUPAC Steroid Nomenclature, 1987)

Descriptor ID	D013261
MeSH Number(s)	D04.210.500.247.808 D10.570.938
Concept/Terms	Sterols Sterols

Below are MeSH descriptors whose meaning is more general than "Sterols".

Chemicals and Drugs [D]
Polycyclic Compounds [D04]
Fused-Ring Compounds [D04.210]
Steroids [D04.210.500]
Cholestanes [D04.210.500.247]
Sterols [D04.210.500.247.808]
Lipids [D10]
Membrane Lipids [D10.570]
Sterols [D10.570.938]

Below are MeSH descriptors whose meaning is related to "Sterols".

Below are MeSH descriptors whose meaning is more specific than "Sterols".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Sterols" by people in this website by year, and whether "Sterols" was a major or minor topic of these publications.

Bar chart showing 17 publications over 12 distinct years, with a maximum of 2 publications in 1999 and 2008 and 2009 and 2016 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	2	0	2
2006	1	0	1
2008	0	2	2
2009	0	2	2
2012	1	0	1
2015	1	0	1
2016	1	1	2
2017	1	1	2
2018	1	0	1
2019	1	0	1
2022	0	1	1
2024	1	0	1

Below are the most recent publications written about "Sterols" by people in Profiles.

Nes WD, Chaudhuri M, Leaver DJ. Druggable Sterol Metabolizing Enzymes in Infectious Diseases: Cell Targets to Therapeutic Leads. Biomolecules. 2024 Feb 20; 14(3).

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Chaudhuri M, Singha UK, Vanderloop BH, Tripathi A, Nes WD. Steroidal Antimetabolites Protect Mice against Trypanosoma brucei. Molecules. 2022 Jun 25; 27(13).

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Zhou W, Ramos E, Zhu X, Fisher PM, Kidane ME, Vanderloop BH, Thomas CD, Yan J, Singha U, Chaudhuri M, Nagel MT, Nes WD. Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications. J Lipid Res. 2019 05; 60(5):981-994.

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Zhou W, Debnath A, Jennings G, Hahn HJ, Vanderloop BH, Chaudhuri M, Nes WD, Podust LM. Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri. PLoS Pathog. 2018 09; 14(9):e1007245.

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Kidane ME, Vanderloop BH, Zhou W, Thomas CD, Ramos E, Singha U, Chaudhuri M, Nes WD. Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design. J Lipid Res. 2017 12; 58(12):2310-2323.

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Sharma AI, Olson CL, Mamede JI, Gazos-Lopes F, Epting CL, Almeida IC, Engman DM. Sterol targeting drugs reveal life cycle stage-specific differences in trypanosome lipid rafts. Sci Rep. 2017 08 22; 7(1):9105.

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Miller MB, Patkar P, Singha UK, Chaudhuri M, David Nes W. 24-Methylenecyclopropane steroidal inhibitors: A Trojan horse in ergosterol biosynthesis that prevents growth of Trypanosoma brucei. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Mar; 1862(3):305-313.

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Liu J, Zheng S, Akerstrom VL, Yuan C, Ma Y, Zhong Q, Zhang C, Zhang Q, Guo S, Ma P, Skripnikova EV, Bratton MR, Pannuti A, Miele L, Wiese TE, Wang G. Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD). J Med Chem. 2016 09 08; 59(17):8134-40.

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Leaver DJ, Patkar P, Singha UK, Miller MB, Haubrich BA, Chaudhuri M, Nes WD. Fluorinated Sterols Are Suicide Inhibitors of Ergosterol Biosynthesis and Growth in Trypanosoma brucei. Chem Biol. 2015 Oct 22; 22(10):1374-83.

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Nes CR, Singha UK, Liu J, Ganapathy K, Villalta F, Waterman MR, Lepesheva GI, Chaudhuri M, Nes WD. Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms. Biochem J. 2012 Apr 01; 443(1):267-77.

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